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Jean-Michel Mansuy
CHU Toulouse, Hôpital Purpan, Virology Laboratory, 31300 France

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Journal article
Published: 15 July 2021 in Diagnostic Microbiology and Infectious Disease
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Control of the rapid spread of the SARS-CoV-2 virus requires efficient testing. We collected paired nasopharyngeal swab (NPs) and saliva samples from 303 subjects (52.8% symptomatic) at a drive-through testing center; 18% of whom tested positive. The NPs, salivas and five saliva pools were tested for SARS-CoV-2 RNA using the Aptima™ assay and a laboratory-developed test (LDT) on the Panther-Fusion™ Hologic® platform. The saliva sensitivity was 80% (LDT) and 87.5% (Aptima™) whereas that of NPs was 96.4% in both assays. The pooled saliva sensitivity of 72.7% (LDT) and 75% (Aptima™) was not significantly different of that of individual saliva testing. Saliva specimens appear to be suitable for sensitive non-invasive assays to detect SARS-CoV-2 nucleic acid; pooling them for a single test will improve laboratory throughput.

ACS Style

M. Migueres; C. Vellas; F. Abravanel; I. Da Silva; C. Dimeglio; V. Ferrer; S. Raymond; Jm. Mansuy; J. Izopet. Testing individual and pooled saliva samples for sars-cov-2 nucleic acid: a prospective study. Diagnostic Microbiology and Infectious Disease 2021, 115478 .

AMA Style

M. Migueres, C. Vellas, F. Abravanel, I. Da Silva, C. Dimeglio, V. Ferrer, S. Raymond, Jm. Mansuy, J. Izopet. Testing individual and pooled saliva samples for sars-cov-2 nucleic acid: a prospective study. Diagnostic Microbiology and Infectious Disease. 2021; ():115478.

Chicago/Turabian Style

M. Migueres; C. Vellas; F. Abravanel; I. Da Silva; C. Dimeglio; V. Ferrer; S. Raymond; Jm. Mansuy; J. Izopet. 2021. "Testing individual and pooled saliva samples for sars-cov-2 nucleic acid: a prospective study." Diagnostic Microbiology and Infectious Disease , no. : 115478.

Journal article
Published: 12 May 2021 in Viruses
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The spread of SARS-CoV-2 and the resulting disease COVID-19 has killed over 2.6 million people as of 18 March 2021. We have used a modified susceptible, infected, recovered (SIR) epidemiological model to predict how the spread of the virus in regions of France will vary depending on the proportions of variants and on the public health strategies adopted, including anti-COVID-19 vaccination. The proportion of SARS-CoV-2 variant B.1.1.7, which was not detected in early January, increased to become 60% of the forms of SARS-CoV-2 circulating in the Toulouse urban area at the beginning of February 2021, but there was no increase in positive nucleic acid tests. Our prediction model indicates that maintaining public health measures and accelerating vaccination are efficient strategies for the sustained control of SARS-CoV-2.

ACS Style

Chloé Dimeglio; Marine Milhes; Jean-Michel Loubes; Noémie Ranger; Jean-Michel Mansuy; Pauline Trémeaux; Nicolas Jeanne; Justine Latour; Florence Nicot; Cécile Donnadieu; Jacques Izopet. Influence of SARS-CoV-2 Variant B.1.1.7, Vaccination, and Public Health Measures on the Spread of SARS-CoV-2. Viruses 2021, 13, 898 .

AMA Style

Chloé Dimeglio, Marine Milhes, Jean-Michel Loubes, Noémie Ranger, Jean-Michel Mansuy, Pauline Trémeaux, Nicolas Jeanne, Justine Latour, Florence Nicot, Cécile Donnadieu, Jacques Izopet. Influence of SARS-CoV-2 Variant B.1.1.7, Vaccination, and Public Health Measures on the Spread of SARS-CoV-2. Viruses. 2021; 13 (5):898.

Chicago/Turabian Style

Chloé Dimeglio; Marine Milhes; Jean-Michel Loubes; Noémie Ranger; Jean-Michel Mansuy; Pauline Trémeaux; Nicolas Jeanne; Justine Latour; Florence Nicot; Cécile Donnadieu; Jacques Izopet. 2021. "Influence of SARS-CoV-2 Variant B.1.1.7, Vaccination, and Public Health Measures on the Spread of SARS-CoV-2." Viruses 13, no. 5: 898.

Letter to the editor
Published: 23 March 2021 in Journal of Medical Virology
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Since the beginning of the SARS‐CoV‐2 pandemic, health authorities have been advocating for the generalization of non‐pharmaceutical measures to fight the spread of the disease. Such measures such as physical distancing, mask wearing, tightened basic hygiene, quarantine and even curfews are effective to limit the transmission of SARS‐CoV‐2 and to decrease the virus reproductive number R0. At the same time, these measures have had a drastic effect on influenza viruses and RSV, which are currently absent. In contrast and surprisingly, Rhinoviruses continue to circulate but in younger people, unlike in previous years when they were found in all age groups. The effectiveness of non‐pharmaceutical measures is therefore not uniform and depends on the epidemiology of pathogens, their incidence and circulation

ACS Style

Jean‐Michel Mansuy; Maximin Bourcier; Pauline Trémeaux; Chloé Dimeglio; Jacques Izopet. COVID‐19 pandemic period, where are the seasonal viruses? Journal of Medical Virology 2021, 93, 4097 -4098.

AMA Style

Jean‐Michel Mansuy, Maximin Bourcier, Pauline Trémeaux, Chloé Dimeglio, Jacques Izopet. COVID‐19 pandemic period, where are the seasonal viruses? Journal of Medical Virology. 2021; 93 (7):4097-4098.

Chicago/Turabian Style

Jean‐Michel Mansuy; Maximin Bourcier; Pauline Trémeaux; Chloé Dimeglio; Jacques Izopet. 2021. "COVID‐19 pandemic period, where are the seasonal viruses?" Journal of Medical Virology 93, no. 7: 4097-4098.

Short communication
Published: 06 July 2020 in Journal of Clinical Virology
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The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which appeared in late 2019, has been limited by isolating infected individuals. However, identifying such individuals requires accurate diagnostic tools. This study evaluates the capacity of the Aptima™ Transcription-Mediated Amplification (TMA) assay (Hologic® Panther System) to detect the virus in clinical samples. We compared the Aptima™ assay to two in-house real-time RT-PCR techniques, one running on the Panther Fusion™ module and the other on the MagNA Pure 96 and Light-Cycler 480 instruments. We included a total of 200 respiratory specimens: 100 tested prospectively and 100 retrospectively (25 -ve/75 +ve). The final Cohen’s kappa coefficients were: κ = 0.978 between the Aptima™ and Panther Fusion™ assays, κ = 0.945 between the Aptima™ and MagNA/LC480 assays and κ = 0.956 between the MagNA/LC480 and Panther Fusion™ assays. These findings indicate that the Aptima™ SARS-CoV-2 TMA assay data agree well with those obtained with our routine methods and that this assay can be used to diagnose coronavirus disease 2019 (COVID-19).

ACS Style

Pauline Trémeaux; Sébastien Lhomme; Florence Abravanel; Stéphanie Raymond; Catherine Mengelle; Jean-Michel Mansuy; Jacques Izopet. Evaluation of the Aptima™ transcription-mediated amplification assay (Hologic®) for detecting SARS-CoV-2 in clinical specimens. Journal of Clinical Virology 2020, 129, 104541 -104541.

AMA Style

Pauline Trémeaux, Sébastien Lhomme, Florence Abravanel, Stéphanie Raymond, Catherine Mengelle, Jean-Michel Mansuy, Jacques Izopet. Evaluation of the Aptima™ transcription-mediated amplification assay (Hologic®) for detecting SARS-CoV-2 in clinical specimens. Journal of Clinical Virology. 2020; 129 ():104541-104541.

Chicago/Turabian Style

Pauline Trémeaux; Sébastien Lhomme; Florence Abravanel; Stéphanie Raymond; Catherine Mengelle; Jean-Michel Mansuy; Jacques Izopet. 2020. "Evaluation of the Aptima™ transcription-mediated amplification assay (Hologic®) for detecting SARS-CoV-2 in clinical specimens." Journal of Clinical Virology 129, no. : 104541-104541.

Correspondence
Published: 29 June 2020 in Journal of Clinical Virology
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ACS Style

Florence Abravanel; Marcel Miédouge; Sabine Chapuy-Regaud; Jean-Michel Mansuy; Jacques Izopet. Clinical performance of a rapid test compared to a microplate test to detect total anti SARS-CoV-2 antibodies directed to the spike protein. Journal of Clinical Virology 2020, 130, 104528 -104528.

AMA Style

Florence Abravanel, Marcel Miédouge, Sabine Chapuy-Regaud, Jean-Michel Mansuy, Jacques Izopet. Clinical performance of a rapid test compared to a microplate test to detect total anti SARS-CoV-2 antibodies directed to the spike protein. Journal of Clinical Virology. 2020; 130 ():104528-104528.

Chicago/Turabian Style

Florence Abravanel; Marcel Miédouge; Sabine Chapuy-Regaud; Jean-Michel Mansuy; Jacques Izopet. 2020. "Clinical performance of a rapid test compared to a microplate test to detect total anti SARS-CoV-2 antibodies directed to the spike protein." Journal of Clinical Virology 130, no. : 104528-104528.

Correspondence
Published: 20 May 2020 in Journal of Clinical Virology
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ACS Style

Chloé Dimeglio; Jean-Michel Mansuy; Sandrine Charpentier; Isabelle Claudet; Jacques Izopet. Children are protected against SARS-CoV-2 infection. Journal of Clinical Virology 2020, 128, 104451 -104451.

AMA Style

Chloé Dimeglio, Jean-Michel Mansuy, Sandrine Charpentier, Isabelle Claudet, Jacques Izopet. Children are protected against SARS-CoV-2 infection. Journal of Clinical Virology. 2020; 128 ():104451-104451.

Chicago/Turabian Style

Chloé Dimeglio; Jean-Michel Mansuy; Sandrine Charpentier; Isabelle Claudet; Jacques Izopet. 2020. "Children are protected against SARS-CoV-2 infection." Journal of Clinical Virology 128, no. : 104451-104451.

Letter to the editor
Published: 06 May 2020 in Public Health
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J.M. Mansuy; J. Izopet. We must not forget the most disadvantaged people facing the COVID-19 crisis. Public Health 2020, 183, 118 -118.

AMA Style

J.M. Mansuy, J. Izopet. We must not forget the most disadvantaged people facing the COVID-19 crisis. Public Health. 2020; 183 ():118-118.

Chicago/Turabian Style

J.M. Mansuy; J. Izopet. 2020. "We must not forget the most disadvantaged people facing the COVID-19 crisis." Public Health 183, no. : 118-118.

Research letter
Published: 01 April 2019 in Emerging Infectious Diseases
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We assessed Zika virus RNA and select cytokine levels in semen, blood, and plasma samples from an infected patient in South America. Viral RNA was detected in semen >2 months after viremia clearance; cytokine profiles differed in semen and plasma. After viremia, Zika virus appears to become compartmentalized in the male reproductive tract.

ACS Style

Jean-Michel Mansuy; Hicham EL Costa; Jordi Gouilly; Catherine Mengelle; Christophe Pasquier; Guillaume Martin-Blondel; Jacques Izopet; Nabila Jabrane-Ferrat. Peripheral Plasma and Semen Cytokine Response to Zika Virus in Humans. Emerging Infectious Diseases 2019, 25, 823 -825.

AMA Style

Jean-Michel Mansuy, Hicham EL Costa, Jordi Gouilly, Catherine Mengelle, Christophe Pasquier, Guillaume Martin-Blondel, Jacques Izopet, Nabila Jabrane-Ferrat. Peripheral Plasma and Semen Cytokine Response to Zika Virus in Humans. Emerging Infectious Diseases. 2019; 25 (4):823-825.

Chicago/Turabian Style

Jean-Michel Mansuy; Hicham EL Costa; Jordi Gouilly; Catherine Mengelle; Christophe Pasquier; Guillaume Martin-Blondel; Jacques Izopet; Nabila Jabrane-Ferrat. 2019. "Peripheral Plasma and Semen Cytokine Response to Zika Virus in Humans." Emerging Infectious Diseases 25, no. 4: 823-825.

Journal article
Published: 28 June 2018 in Diagnostic Microbiology and Infectious Disease
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Zika (ZIKV), Dengue (DENV) and Chikungunya viruses (CHIKV) co-circulate in the same geographical areas during the same seasonal period through the same biting arthropods. Therefore a rapid sensitive and specific molecular assay for these viruses would be a considerable help in the disease management and the epidemiological survey. We developed a one-step multiplex real-time PCR for the simultaneous detection of these viruses. Intra and inter-reproducibilities varied from 0.41% to 3.29% and from 1.13% to 4.93% for each virus respectively. The specificity was 100%. Whole blood, plasma and urines were used for comparison with commercially available monoplex assays (RealStar® kits, Altona Diagnostics GmbH, Hamburg, Germany). The concordance was 96%, 92.9% and 95.7% for ZIKV, DENV and CHIKV respectively. No cross reaction and no PCR inhibition were observed for any of the clinical samples. This test can thus be used as a rapid molecular assay for ZIKV, DENV1–4 and CHIKV infections.

ACS Style

Jean-Michel Mansuy; Sébastien Lhomme; Michelle Cazabat; Christophe Pasquier; Guillaume Martin-Blondel; Jacques Izopet. Detection of Zika, dengue and chikungunya viruses using single-reaction multiplex real-time RT-PCR. Diagnostic Microbiology and Infectious Disease 2018, 92, 284 -287.

AMA Style

Jean-Michel Mansuy, Sébastien Lhomme, Michelle Cazabat, Christophe Pasquier, Guillaume Martin-Blondel, Jacques Izopet. Detection of Zika, dengue and chikungunya viruses using single-reaction multiplex real-time RT-PCR. Diagnostic Microbiology and Infectious Disease. 2018; 92 (4):284-287.

Chicago/Turabian Style

Jean-Michel Mansuy; Sébastien Lhomme; Michelle Cazabat; Christophe Pasquier; Guillaume Martin-Blondel; Jacques Izopet. 2018. "Detection of Zika, dengue and chikungunya viruses using single-reaction multiplex real-time RT-PCR." Diagnostic Microbiology and Infectious Disease 92, no. 4: 284-287.

Journal article
Published: 01 January 2018 in Journal of Emerging Diseases and Virology
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Rousset S; Gauthier M; Huynh A; Mansuy Jm. Sapovirus-Associated Severe, Prolonged Diarrhoea in an Autologous Stem-Cell Transplant Patient: Case Report and Literature Review. Journal of Emerging Diseases and Virology 2018, 4, 1 .

AMA Style

Rousset S, Gauthier M, Huynh A, Mansuy Jm. Sapovirus-Associated Severe, Prolonged Diarrhoea in an Autologous Stem-Cell Transplant Patient: Case Report and Literature Review. Journal of Emerging Diseases and Virology. 2018; 4 (2):1.

Chicago/Turabian Style

Rousset S; Gauthier M; Huynh A; Mansuy Jm. 2018. "Sapovirus-Associated Severe, Prolonged Diarrhoea in an Autologous Stem-Cell Transplant Patient: Case Report and Literature Review." Journal of Emerging Diseases and Virology 4, no. 2: 1.

Journal article
Published: 01 May 2017 in Emerging Infectious Diseases
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We tested whole-blood and plasma samples from immunocompetent patients who had had benign Zika virus infections and found that Zika virus RNA persisted in whole blood substantially longer than in plasma. This finding may have implications for diagnosis of acute symptomatic and asymptomatic infections and for testing of blood donations.

ACS Style

Jean Michel Mansuy; Catherine Mengelle; Christophe Pasquier; Sabine Chapuy-Regaud; Pierre Delobel; Guillaume Martin-Blondel; Jacques Izopet. Zika Virus Infection and Prolonged Viremia in Whole-Blood Specimens. Emerging Infectious Diseases 2017, 23, 863 -865.

AMA Style

Jean Michel Mansuy, Catherine Mengelle, Christophe Pasquier, Sabine Chapuy-Regaud, Pierre Delobel, Guillaume Martin-Blondel, Jacques Izopet. Zika Virus Infection and Prolonged Viremia in Whole-Blood Specimens. Emerging Infectious Diseases. 2017; 23 (5):863-865.

Chicago/Turabian Style

Jean Michel Mansuy; Catherine Mengelle; Christophe Pasquier; Sabine Chapuy-Regaud; Pierre Delobel; Guillaume Martin-Blondel; Jacques Izopet. 2017. "Zika Virus Infection and Prolonged Viremia in Whole-Blood Specimens." Emerging Infectious Diseases 23, no. 5: 863-865.

Journal article
Published: 01 April 2017 in Vaccine
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Vaccine-induced protection against influenza is not optimal, however it has been suggested that the vaccine may reduce the severity of symptoms among those who develop illness despite being vaccinated. We tested this hypothesis within a countrywide, sentinel general practitioners-based surveillance system in France. We included 2277 individuals aged 65years or older (of whom 1293 had been vaccinated against influenza, 56.8%) who consulted a general practitioner because of an acute respiratory infection (ARI) during 2003-2014. All patients were taken a nasopharyngeal swab, and information was collected on demographic characteristics and symptoms at disease onset. All specimens were tested for respiratory viruses and, if positive for influenza, the virus type and subtype were determined. We compared the average maximum temperature and the frequency of each symptom, between non-vaccinated and vaccinated influenza patients. We then used logistic regression models to calculate the odds of presenting with each symptom between vaccinated vs. non-vaccinated patients, adjusting by age group, virus (sub)type and season. Overall, 675 ARI patients (29.6%) tested positive for influenza. The A(H3) virus caused the majority of cases (55.1%), followed by influenza B (22.9%), A not-subtyped (11.7%), and A(H1) (10.3%) viruses. Compared to non-vaccinated influenza patients, those who had been vaccinated had a slightly reduced maximum temperature and presented less frequently with myalgia, shivering and headache. In stratified analyses, the observed effect was limited to patients infected with A(H3) or type B viruses. After adjusting by age group, virus (sub)type and season, the difference remained statistically significant only for headache, which was less frequent among vaccinated individuals (odds ratio 0.69, 95% confidence intervals 0.48-0.98). In conclusion, the vaccine was found to be modestly associated with less severe clinical presentation of influenza among the elderly. Our findings reinforce the need for influenza vaccines providing better protection.

ACS Style

Anne Mosnier; Isabelle Daviaud; Saverio Caini; Hervé Berche; Jean-Michel Mansuy; Sylvie van der Werf; Jean Marie Cohen; Bruno Lina. Does seasonal vaccination affect the clinical presentation of influenza among the elderly? A cross-sectional analysis in the outpatient setting in France, 2003–2014. Vaccine 2017, 35, 2076 -2083.

AMA Style

Anne Mosnier, Isabelle Daviaud, Saverio Caini, Hervé Berche, Jean-Michel Mansuy, Sylvie van der Werf, Jean Marie Cohen, Bruno Lina. Does seasonal vaccination affect the clinical presentation of influenza among the elderly? A cross-sectional analysis in the outpatient setting in France, 2003–2014. Vaccine. 2017; 35 (16):2076-2083.

Chicago/Turabian Style

Anne Mosnier; Isabelle Daviaud; Saverio Caini; Hervé Berche; Jean-Michel Mansuy; Sylvie van der Werf; Jean Marie Cohen; Bruno Lina. 2017. "Does seasonal vaccination affect the clinical presentation of influenza among the elderly? A cross-sectional analysis in the outpatient setting in France, 2003–2014." Vaccine 35, no. 16: 2076-2083.

Journal article
Published: 01 October 2016 in The Lancet Infectious Diseases
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Jean Michel Mansuy; Elsa Suberbielle; Sabine Chapuy-Regaud; Catherine Mengelle; Louis Bujan; Bruno Marchou; Pierre Delobel; Daniel Dunia; Cécile Malnou; Jacques Izopet; Guillaume Martin-Blondel. Zika virus in semen and spermatozoa. The Lancet Infectious Diseases 2016, 16, 1106 -1107.

AMA Style

Jean Michel Mansuy, Elsa Suberbielle, Sabine Chapuy-Regaud, Catherine Mengelle, Louis Bujan, Bruno Marchou, Pierre Delobel, Daniel Dunia, Cécile Malnou, Jacques Izopet, Guillaume Martin-Blondel. Zika virus in semen and spermatozoa. The Lancet Infectious Diseases. 2016; 16 (10):1106-1107.

Chicago/Turabian Style

Jean Michel Mansuy; Elsa Suberbielle; Sabine Chapuy-Regaud; Catherine Mengelle; Louis Bujan; Bruno Marchou; Pierre Delobel; Daniel Dunia; Cécile Malnou; Jacques Izopet; Guillaume Martin-Blondel. 2016. "Zika virus in semen and spermatozoa." The Lancet Infectious Diseases 16, no. 10: 1106-1107.

Correspondence
Published: 01 August 2016 in The Lancet Infectious Diseases
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The tropical pathogen Zika virus has been neglected for decades because it generally results in moderate or clinically asymptomatic infections in Africa and Asia. However, the 2015 outbreak in Brazil has focused attention on the impact of Zika virus on human health, as evidence accumulated indicating that it causes severe neurological injuries and adverse fetal outcomes.1Musso D Gubler DJ Zika virus.Clin Microbiol Rev. 2016; 29: 487-524Crossref PubMed Scopus (388) Google Scholar

ACS Style

Jean Michel Mansuy; Christophe Pasquier; Myriam Daudin; Sabine Chapuy-Regaud; Nathalie Moinard; Christine Chevreau; Jacques Izopet; Catherine Mengelle; Louis Bujan. Zika virus in semen of a patient returning from a non-epidemic area. The Lancet Infectious Diseases 2016, 16, 894 -895.

AMA Style

Jean Michel Mansuy, Christophe Pasquier, Myriam Daudin, Sabine Chapuy-Regaud, Nathalie Moinard, Christine Chevreau, Jacques Izopet, Catherine Mengelle, Louis Bujan. Zika virus in semen of a patient returning from a non-epidemic area. The Lancet Infectious Diseases. 2016; 16 (8):894-895.

Chicago/Turabian Style

Jean Michel Mansuy; Christophe Pasquier; Myriam Daudin; Sabine Chapuy-Regaud; Nathalie Moinard; Christine Chevreau; Jacques Izopet; Catherine Mengelle; Louis Bujan. 2016. "Zika virus in semen of a patient returning from a non-epidemic area." The Lancet Infectious Diseases 16, no. 8: 894-895.

Case reports
Published: 22 June 2016 in Journal of Clinical Virology
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While the rapid spread of Zika virus (ZIKV) in South America has been declared a public health emergency few data are available on the kinetics of the virus load and the specific antibodies in individual patients. This report describes the kinetics of ZIKV decay in the body compartments and the kinetics of anti ZIKV IgG and IgM of two people returning from Martinique, French West Indies. ZIKV remained detectable in the plasma for roughly 2 weeks indicating that mosquito control measures should be prolonged accordingly. Remarkably, their urine samples consistently tested positive for even longer. The antibodies responses were different between the two patients but for both the rapid onset of IgM allowed a diagnosis from the end of the first week.

ACS Style

Camille Fourcade; Jean-Michel Mansuy; Marine Dutertre; Marie Delpech; Bruno Marchou; Pierre Delobel; Jacques Izopet; Guillaume Martin-Blondel. Viral load kinetics of Zika virus in plasma, urine and saliva in a couple returning from Martinique, French West Indies. Journal of Clinical Virology 2016, 82, 1 -4.

AMA Style

Camille Fourcade, Jean-Michel Mansuy, Marine Dutertre, Marie Delpech, Bruno Marchou, Pierre Delobel, Jacques Izopet, Guillaume Martin-Blondel. Viral load kinetics of Zika virus in plasma, urine and saliva in a couple returning from Martinique, French West Indies. Journal of Clinical Virology. 2016; 82 ():1-4.

Chicago/Turabian Style

Camille Fourcade; Jean-Michel Mansuy; Marine Dutertre; Marie Delpech; Bruno Marchou; Pierre Delobel; Jacques Izopet; Guillaume Martin-Blondel. 2016. "Viral load kinetics of Zika virus in plasma, urine and saliva in a couple returning from Martinique, French West Indies." Journal of Clinical Virology 82, no. : 1-4.

Correspondence
Published: 03 March 2016 in The Lancet Infectious Diseases
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The recent, rapid spread of Zika virus in South America and increasing reports of cases of congenital abnormalities spatiotemporally associated with Zika virus infections led WHO to declare a Public Health Emergency of International Concern on Feb 1. WHO also recently described measures that pregnant women should take to avoid infection.

ACS Style

Jean Michel Mansuy; Marine Dutertre; Catherine Mengelle; Camille Fourcade; Bruno Marchou; Pierre Delobel; Jacques Izopet; Guillaume Martin-Blondel. Zika virus: high infectious viral load in semen, a new sexually transmitted pathogen? The Lancet Infectious Diseases 2016, 16, 405 .

AMA Style

Jean Michel Mansuy, Marine Dutertre, Catherine Mengelle, Camille Fourcade, Bruno Marchou, Pierre Delobel, Jacques Izopet, Guillaume Martin-Blondel. Zika virus: high infectious viral load in semen, a new sexually transmitted pathogen? The Lancet Infectious Diseases. 2016; 16 (4):405.

Chicago/Turabian Style

Jean Michel Mansuy; Marine Dutertre; Catherine Mengelle; Camille Fourcade; Bruno Marchou; Pierre Delobel; Jacques Izopet; Guillaume Martin-Blondel. 2016. "Zika virus: high infectious viral load in semen, a new sexually transmitted pathogen?" The Lancet Infectious Diseases 16, no. 4: 405.

Viral hepatitis
Published: 11 January 2016 in Hepatology
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Most cases of hepatitis E viral (HEV) infection in developed countries are autochthonous. Nevertheless, the reported seroprevalence of HEV varies greatly depending on the geographical area and the performance of the immunoassay used. We used validated assays to determine the prevalence of anti‐HEV immunoglobulin G (IgG) and IgM among 10,569 French blood donors living in mainland France and three overseas areas. Epidemiological information was collected using a specific questionnaire. We found an overall IgG seroprevalence of 22.4% (8%‐86.4%) depending on the geographical area (P < 0.001). The presence of anti‐HEV IgG was associated with increasing age (P < 0.001) and eating pork meat (P = 0.03), pork liver sausages (P < 0.001), game meat (P < 0.01), offal (P < 0.001), and oysters (P = 0.02). Conversely, drinking bottled water was associated with a lower rate of anti‐HEV IgG (P = 0.02). Overall IgM seroprevalence was 1% (0%‐4.6%). The frequency of anti‐HEV IgM was higher in donors living in a high anti‐HEV IgG seroprevalence area (1.9% versus 0.7%, P < 0.001) and in those eating pork liver sausage (1.4% versus 0.7%, P < 0.01), pâté (1% versus 0.4, P = 0.04), and wild boar (1.3% versus 0.7%, P < 0.01). Conclusion: HEV is endemic in France and hyperendemic in some areas; eating habits alone cannot totally explain the exposure to HEV, and contaminated water could contribute to the epidemiology of HEV infection in France. (Hepatology 2016;63:1145–1154)

ACS Style

Jean Michel Mansuy; Pierre Gallian; Chloé DiMeglio; Karine Sauné; Catherine Arnaud; Bertrand Pelletier; Pascal Morel; Dominique Legrand; Pierre Tiberghien; Jacques Izopet. A nationwide survey of hepatitis E viral infection in French blood donors. Hepatology 2016, 63, 1145 -1154.

AMA Style

Jean Michel Mansuy, Pierre Gallian, Chloé DiMeglio, Karine Sauné, Catherine Arnaud, Bertrand Pelletier, Pascal Morel, Dominique Legrand, Pierre Tiberghien, Jacques Izopet. A nationwide survey of hepatitis E viral infection in French blood donors. Hepatology. 2016; 63 (4):1145-1154.

Chicago/Turabian Style

Jean Michel Mansuy; Pierre Gallian; Chloé DiMeglio; Karine Sauné; Catherine Arnaud; Bertrand Pelletier; Pascal Morel; Dominique Legrand; Pierre Tiberghien; Jacques Izopet. 2016. "A nationwide survey of hepatitis E viral infection in French blood donors." Hepatology 63, no. 4: 1145-1154.

Journal article
Published: 01 October 2015 in The Lancet Infectious Diseases
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Jean Michel Mansuy. Mobile laboratories for Ebola and other pathogens. The Lancet Infectious Diseases 2015, 15, 1135 -1135.

AMA Style

Jean Michel Mansuy. Mobile laboratories for Ebola and other pathogens. The Lancet Infectious Diseases. 2015; 15 (10):1135-1135.

Chicago/Turabian Style

Jean Michel Mansuy. 2015. "Mobile laboratories for Ebola and other pathogens." The Lancet Infectious Diseases 15, no. 10: 1135-1135.

Comparative study
Published: 25 July 2012 in Scandinavian Journal of Infectious Diseases
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Background: Multiplex assays are a new strategy for diagnosing respiratory infections. These assays are better than those based on cultures or antigen detection, but few data are available for comparing them to monoplex polymerase chain reactions (PCRs). This study evaluated the performance of the Luminex xTAG Respiratory Viral Panel (RVP) Fast assay with reference to 2 real-time PCR assays for detecting type A influenza H1 viruses and human enteroviruses and rhinoviruses. Methods: This was an analysis of nasal swab specimens obtained from 590 outpatients suffering from acute respiratory tract disease between September 2009 and February 2010. Results: The RVP Fast assay performed well in less than 4 h for detecting type A influenza H1 viruses, particularly (H1N1)pdm09, and human entero/rhinoviruses, with 95.2% and 90.05% agreement, respectively, when compared to monoplex real-time PCR assays. This multiplex assay also detected at least 1 virus in 69.3% of the specimens and detected multiple infections in 40 samples. Conclusions: The multiplex assay detected clinically important viruses in a single genomic test. It will thus be useful for detecting several viruses causing respiratory tract disorders.

ACS Style

Jean-Michel Mansuy; Catherine Mengelle; Isabelle Da Silva; Isidore Grog; Karine Sauné; Jacques Izopet. Performance of a rapid molecular multiplex assay for the detection of influenza and picornaviruses. Scandinavian Journal of Infectious Diseases 2012, 44, 963 -968.

AMA Style

Jean-Michel Mansuy, Catherine Mengelle, Isabelle Da Silva, Isidore Grog, Karine Sauné, Jacques Izopet. Performance of a rapid molecular multiplex assay for the detection of influenza and picornaviruses. Scandinavian Journal of Infectious Diseases. 2012; 44 (12):963-968.

Chicago/Turabian Style

Jean-Michel Mansuy; Catherine Mengelle; Isabelle Da Silva; Isidore Grog; Karine Sauné; Jacques Izopet. 2012. "Performance of a rapid molecular multiplex assay for the detection of influenza and picornaviruses." Scandinavian Journal of Infectious Diseases 44, no. 12: 963-968.

Journal article
Published: 30 June 2009 in Archives de Pédiatrie
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J.-M. Mansuy; C. Mengelle; M. Miédougé; F. Abravanel; J. Izopet. L’hépatite virale E. Archives de Pédiatrie 2009, 16, 717 -720.

AMA Style

J.-M. Mansuy, C. Mengelle, M. Miédougé, F. Abravanel, J. Izopet. L’hépatite virale E. Archives de Pédiatrie. 2009; 16 (6):717-720.

Chicago/Turabian Style

J.-M. Mansuy; C. Mengelle; M. Miédougé; F. Abravanel; J. Izopet. 2009. "L’hépatite virale E." Archives de Pédiatrie 16, no. 6: 717-720.