The technological foundation of smart manufacturing consists of cyber-physical systems and the Internet-of-Things (IoT). Each IoT device in a smart factory can be coupled with a digital twin, that is, a dynamic virtual representation of the physical system across its life-cycle using real-time sensor data. Currently, the manufacturing process itself, the involved devices, and how they interact, is designed by human experts in a traditional way. We envision an architecture where humans can instead specify a goal and take advantage of technologies such as digital twins to automatically compose the corresponding physical processes, sharing some analogies with the notion of Web service composition

As Big Data Analysis meets healthcare applications, domain-specific challenges and opportunities materialize in all aspects of data science. Advanced statistical methods and Artificial Intelligence (AI) on Electronic Health Records (EHRs) are used both for knowledge discovery purposes and clinical decision support. Such techniques enable the emerging Predictive, Preventative, Personalized, and Participatory Medicine (P4M) paradigm. Working with the Infectious Disease Clinic of the University Hospital of Modena, Italy, we have developed a range of Data–Driven (DD) approaches to solve critical clinical applications using statistics, Machine Learning (ML) and Big Data Analytics on real-world EHR. Here, we describe our perspective on the challenges we encountered. Some are connected to medical data and their sparse, scarce, and unbalanced nature. Others are bound to the application environment, as medical AI tools can affect people's health and life. For each of these problems, we report some available techniques to tackle them, present examples drawn from our experience, and propose which approaches, in our opinion, could lead to successful real-world, end-to-end implementations.DESY report number: DESY-22-153.