The integration of three-dimensional (3D) printing techniques into the domains of biomedical research and personalized medicine highlights the evolving paradigm shifts within contemporary healthcare. This technological advancement signifies potential breakthroughs in patient-specific therapeutic interventions and innovations. This systematic review offers a critical assessment of the existing literature, elucidating the present status, inherent challenges, and prospective avenues of 3D printing in augmenting biomedical applications and formulating tailored medical strategies. Based on an exhaustive literature analysis comprising empirical studies, case studies, and extensive reviews from the past decade, pivotal sectors including tissue engineering, prosthetic development, drug delivery systems, and customized medical apparatuses are delineated. The advent of 3D printing provides precision in the fabrication of patient-centric implants, bio-structures, and devices, thereby mitigating associated risks. Concurrently, it facilitates the ideation of individualized drug delivery paradigms to optimize therapeutic outcomes. Notwithstanding these advancements, issues concerning material biocompatibility, regulatory compliance, and the economic implications of avant-garde printing techniques persist. To fully harness the transformative potential of 3D printing in healthcare, collaborative endeavors amongst academicians, clinicians, industrial entities, and regulatory bodies are paramount. With continued research and innovation, 3D printing is poised to redefine the trajectories of biomedical science and patient-centric care. The paper aims to justify the research objective of whether to what extent the integration of 3D printing technology in biomedicine enhances patient-specific treatment and contributes to improved healthcare outcomes.

The advent of 3D printing technology has revolutionized various manufacturing sectors, including the medical field, particularly in the production of prosthetic limbs. Traditional prosthetic manufacturing processes are often time-consuming and expensive, causing amputees to endure long waiting periods and high costs. In contrast, 3D printing offers a rapid, cost-effective alternative, enabling the creation of custom-made prosthetics tailored to the specific needs and measurements of each wearer. Integrating 3D printing technology into prosthetics and orthopedics has ushered in a new era of customization and innovation. This advanced approach facilitates the creation of personalized prosthetics and bone replacements tailored to individual patients’ needs. With the latest advancements in software and 3D printing, the use of custom orthopedic implants for complex surgical cases has gained significant popularity. This paper explores the advantages of using 3D printing for prosthetic limb production, highlighting its ability to significantly reduce the production time and costs while maintaining high functionality and quality. By leveraging 3D scanning and computer-aided design (CAD), precise digital models of a patient’s residual limb can be created, ensuring a perfect fit and improved comfort. Additionally, the flexibility of 3D printing allows for the incorporation of advanced materials and design features, enhancing the durability and performance of the prosthetics. The study also examines the potential for 3D printing to democratize access to prosthetic care, especially in low-resource settings. The affordability and accessibility of 3D printers, coupled with open-source designs, empower local communities and healthcare providers to produce prosthetics on demand, reducing dependency on centralized manufacturing facilities. By addressing the current limitations and challenges, including material constraints and regulatory hurdles, this paper highlights the transformative impact of 3D printing on the prosthetics industry.

Enzyme-based biosensors have emerged as a transformative technology, leveraging the specificity and catalytic efficiency of enzymes across various domains, including medical diagnostics, environmental monitoring, food safety, and industrial processes. These biosensors integrate biological recognition elements with advanced transduction mechanisms to provide highly sensitive, selective, and portable solutions for real-time analysis. This review explores the key components, detection mechanisms, applications, and future trends in enzyme-based biosensors. Artificial enzymes, such as nanozymes, play a crucial role in enhancing enzyme-based biosensors by mimicking natural enzyme activity while offering improved stability, cost-effectiveness, and scalability. Their integration can significantly boost sensor performance by increasing the catalytic efficiency and durability. Additionally, lab-on-a-chip and microfluidic devices enable the miniaturization of biosensors, allowing for the development of compact, portable devices that require minimal sample volumes for complex diagnostic tests. The functionality of enzyme-based biosensors is built on three essential components: enzymes as biocatalysts, transducers, and immobilization techniques. Enzymes serve as the biological recognition elements, catalyzing specific reactions with target molecules to produce detectable signals. Transducers, including electrochemical, optical, thermal, and mass-sensitive types, convert these biochemical reactions into measurable outputs. Effective immobilization strategies, such as physical adsorption, covalent bonding, and entrapment, enhance the enzyme stability and reusability, enabling consistent performance. In medical diagnostics, they are widely used for glucose monitoring, cholesterol detection, and biomarker identification. Environmental monitoring benefits from these biosensors by detecting pollutants like pesticides, heavy metals, and nerve agents. The food industry employs them for quality control and contamination monitoring. Their advantages include high sensitivity, rapid response times, cost-effectiveness, and adaptability to field applications. Enzyme-based biosensors face challenges such as enzyme instability, interference from biological matrices, and limited operational lifespans. Addressing these issues involves innovations like the use of synthetic enzymes, advanced immobilization techniques, and the integration of nanomaterials, such as graphene and carbon nanotubes. These advancements enhance the enzyme stability, improve sensitivity, and reduce detection limits, making the technology more robust and scalable.

Bioinspired nanocarriersare emerging as transformative tools in drug delivery, leveraging natural biological structures and functions to overcome critical limitations of conventional therapeutic systems. This review critically examines three leading approaches, e.g., cell membrane-coated nanoparticles (CMNPs), exosome-mimicking nanocarriers (EMNCs), and peptide-functionalized nanocarriers, highlighting their design principles, functionalization strategies, and biomedical applications. By systematically analyzing recent advances, we identify common advantages such as improved pharmacokinetics, enhanced targeting specificity, and increased biocompatibility, as well as persistent challenges including rapid clearance, non-specific biodistribution, and suboptimal intracellular delivery. Comparative evaluation reveals that CMNPs excel in immune evasion and circulation time, EMNCs show superior performance in crossing complex biological barriers such as the blood–brain barrier, and peptide-functionalized systems offer enhanced selective accumulation and intracellular delivery of therapeutic agents. We further outline key translational hurdles, including scaling up production, ensuring batch-to-batch consistency, meeting regulatory standards, and long-term stability. Overall, this review provides a framework for integrating biomimetic strategies into next-generation nanomedicine, offering guidance for the rational design of safer, and clinically translatable personalized drug delivery systems.

An ideal engine today is considered to be one with low emission, low fuel consumption and high specific power output. Engine downsizing by turbocharging provides an answer toall the three. Though the traditional problems of poor low end torque and inadequate transient response have been overcome to a great extent using variable geometry turbine turbocharger in diesel engine, the application of variable geometry turbine turbocharger is in quite a nascent stage when it comes to gasoline engine. This article primarily describes all the important aspects of application of VGTs to gasoline engines right from when VGT’s were restricted to only very expensive research prototypes to the very recent application in cost sensitive production engines. Also at the same time,it highlights the need and development in the flow range of the turbocharger compressor, addressing problems of choke and surge in the turbo chargers compressor.