Stroke is among the leading causes of morbidity and mortality. Chronic inflammatory conditions may lead to atherosclerosis and a subsequent stroke. This systematic review and meta-analysis aimed to review the association of periodontitis and gingivitis with stroke. An electronic search of PubMed, Ovid EMBASE, Ovid MEDLINE, Web of Science, Cochrane Central Register of Controlled Trials (CENTRAL), Science Citation Index, Database of Abstracts and Reviews of Effects (DARE), and various clinical trial registries was conducted to include studies published up to February 2022. Data was retrieved by 2 independent reviewers. The Stata software, v. 13, was used to conduct a meta-analysis. Thirteen studies stated an association between periodontitis, determined based on clinical attachment loss (CAL), and stroke. Meanwhile, 6 studies described an association between gingivitis, determined based on the gingival index (GI), and stroke. Out of the 6 studies on gingivitis, 5 also investigated CAL, which means the meta-analysis included 14 studies in total. The total number of participants from the included studies was 35,937, and they were all above 17 years of age. There was a significant association between periodontitis and gingivitis and stroke and its all types. There was a significant association between periodontitis and stroke and its all types in 13 studies (ES (effect size): 1.32; 95% CI (confidence interval): 1.04-1.60), and between gingivitis and all stroke types in 6 studies (ES: 1.17; 95% CI: 0.42-1.92). This systematic review indicated a significant association between stroke and periodontal disease in case-control, cohort and cross-sectional studies. The findings need to be further substantiated in prospective cohort studies with an optimal sample size.

Objective: This study analyzed clinical parameters to assess whether dental implant material is a risk factor for peri-implantitis. Methods: A literature search was performed on PubMed Central, Cochrane, PubMed/MEDLINE, Embase, and Scopus. The PICO strategy involved healthy patient, partially or fully edentulous, receiving at least one dental implant; zirconia or titanium dental implants; comparison involving assessment of whether there were differences in the risk of peri-implantitis among different materials used for dental implants; clinical parameters. Quality assessment was performed using the modified Jadad scale. Results: Nineteen articles met the inclusion criteria. BoP did not have statistically significant differences comparing zirconia and titanium implants or natural teeth. MBL had diversified results; sometimes, it was higher in zirconia implants than titanium; otherwise, there was no significant difference. Comparing implants with natural teeth, MBL was lower in titanium implants over prolonged observation periods, and greater severity was found in the zirconia group. Notably, natural teeth had minimal bone loss. Zirconia implants demonstrated reduced plaque accumulation and minimal microbial contamination compared to titanium implants and control teeth. The quality assessment was considered poor to low in 9 studies and good to excellent in 10. The development of peri-implantitis was influenced by several patient-specific and clinical factors, underscoring the need to adopt a comprehensive and personalized approach to implant dentistry and peri-implantitis prevention. Conclusion: It was not possible to draft any solid conclusion for the relationship between implant material and peri-implantitis.

4D printing is an innovative digital manufacturing technology that originated by adding a fourth dimension, i.e., time, to pre-existing 3D technology or additive manufacturing (AM). AM is a fast-growing technology used in many fields, which develops accurate 3D objects based on models designed by computers. Dentistry is one such field in which 3D technology is used for manufacturing objects in periodontics (scaffolds, local drug-delivering agents, augmentation of ridges), implants, prosthodontics (partial and complete dentures, obturators), oral surgery for reconstructing jaw, and orthodontics. Dynamism is a vital property needed for the survival of materials used in the oral cavity since the oral cavity is constantly subjected to various insults. 4D printing technology has overcome the disadvantages of 3D printing technology, i.e., it cannot create dynamic objects. Therefore, constant knowledge of 4D technology is required. 3D printing technology has shortcomings, which are discussed in this review. This review summaries various printing technologies, materials used, stimuli, and potential applications of 4D technology in dentistry.