Objective: This study analyzed clinical parameters to assess whether dental implant material is a risk factor for peri-implantitis. Methods: A literature search was performed on PubMed Central, Cochrane, PubMed/MEDLINE, Embase, and Scopus. The PICO strategy involved healthy patient, partially or fully edentulous, receiving at least one dental implant; zirconia or titanium dental implants; comparison involving assessment of whether there were differences in the risk of peri-implantitis among different materials used for dental implants; clinical parameters. Quality assessment was performed using the modified Jadad scale. Results: Nineteen articles met the inclusion criteria. BoP did not have statistically significant differences comparing zirconia and titanium implants or natural teeth. MBL had diversified results; sometimes, it was higher in zirconia implants than titanium; otherwise, there was no significant difference. Comparing implants with natural teeth, MBL was lower in titanium implants over prolonged observation periods, and greater severity was found in the zirconia group. Notably, natural teeth had minimal bone loss. Zirconia implants demonstrated reduced plaque accumulation and minimal microbial contamination compared to titanium implants and control teeth. The quality assessment was considered poor to low in 9 studies and good to excellent in 10. The development of peri-implantitis was influenced by several patient-specific and clinical factors, underscoring the need to adopt a comprehensive and personalized approach to implant dentistry and peri-implantitis prevention. Conclusion: It was not possible to draft any solid conclusion for the relationship between implant material and peri-implantitis.

Quantifying and optimizing the polyphenol content of Phyllanthus maderaspatensis was accomplished using a single-solvent HPTLC system. Analyzing hydroalcoholic extracts for kaempferol, rutin, ellagic acid, quercetin, catechin, and gallic acid, we simultaneously quantified and optimized their concentration. In the experiment, the methanol to water ratio (%), temperature (°C), and time of extraction (min) were all optimized using a Box-Behnken statistical design. Kaempferol, rutin, ellagic acid, quercetin, catechin, and gallic acid were among the dependent variables analyzed. In the HPTLC separation, silica gel 60F254 plates were used, and toluene, ethyl acetate, and formic acid (5:4:1) made up the mobile phase. For kaempferol, rutin, ellagic acid, quercetin, catechin, and gallic acid, densitometric measurements were carried out using the absorbance mode at 254 nm. Hydroalcoholic extract of P. maderaspatensis contains rutin (0.344), catechin (2.62), gallic acid (0.93), ellagic acid (0.172), quercetin (0.0108) and kaempferol (0.06). Further, it may be affected by more than one factor at a time, resulting in a varying degree of reaction. A negative correlation was found between X1 (extraction time (min)) and X2 (temperature), as well as X1 and X3 (solvent ratios). Taking these characteristics into consideration, the method outlined here is a validated HPTLC method for measuring kaempferol, rutin, ellagic acid, quercetin, catechin, and gallic acid.

The management of facial fractures in the pediatric population represents a unique challenge in facial fracture care, where fixation must strike a balance between stability and interference with growth and the need for secondary implant removal procedures. Bioresorbable fixation systems have been increasingly applied in this population; however, their pooled safety and performance data and clinical advantages over titanium fixation in the pediatric population are not well described. This systematic review and meta-analysis aimed to comprehensively assess the clinical outcomes and complication rates associated with the use of resorbable fixation systems in the management of pediatric facial fractures. The PubMed, Cochrane Library, Scopus, Web of Science, and ScienceDirect databases were searched for articles published until March 2025. The selection criteria were as follows: randomized controlled trials (RCTs), cohort studies, and comparative clinical studies of patients aged ≤18 years who received resorbable fixation systems for any facial fracture. The primary outcomes were infection, malocclusion, implant palpability, and plate removals. Study quality was assessed using the ROBINS-I risk of bias tool. A meta-analysis was conducted using a random-effects model and reported as log OR and logit event rate with 95% CI. Twenty-six studies reporting on nearly 620 patients were included in this review. The pooled infection rate was 3.2% (95% CI: 0.63-7.5%; I² = 0%), malocclusion rate was 8.7% (95% CI: 1.88-15.7%; I² = 0%), and implant palpability was observed in 11.8% of patients (95% CI: 6.42-17.2%; I² = 0%). Compared with titanium fixation, resorbable systems were associated with a 96% reduction in the odds of plate removal (log OR: -3.287; 95% CI: -4.968 to -1.607; p = 0.00013). Statistical heterogeneity was low for all outcomes (I² < 20%). No evidence of a significant publication bias was found. Resorbable fixation systems are safe, functionally effective, and growth-accommodating alternatives to titanium plates for managing facial fractures in children and adolescents. The greatly reduced risk of requiring secondary implant removal and low complication rates support their use as a first-line fixation strategy for facial fractures in the pediatric population.

Orofacial clefts (OFCs) are one of the most prevalent congenital abnormalities that affect the lip and/or palate and can cause significant growth retardati