An accurate seizure prediction system enables early warnings before seizure onset of epileptic patients. It is extremely important for drug-refractory patients. Conventional seizure prediction works usually rely on features extracted from Electroencephalography (EEG) recordings and classification algorithms such as regression or support vector machine (SVM) to locate the short time before seizure onset. However, such methods cannot achieve high-accuracy prediction due to information loss of the hand-crafted features and the limited classification ability of regression and SVM algorithms. We propose an end-to-end deep learning solution using a convolutional neural network (CNN) in this paper. One and two dimensional kernels are adopted in the early- and late-stage convolution and max-pooling layers, respectively. The proposed CNN model is evaluated on Kaggle intracranial and CHB-MIT scalp EEG datasets. Overall sensitivity, false prediction rate, and area under receiver operating characteristic curve reaches 93.5%, 0.063/h, 0.981 and 98.8%, 0.074/h, 0.988 on two datasets respectively. Comparison with state-of-the-art works indicates that the proposed model achieves exceeding prediction performance.

Epilepsy is a chronic neurological disorder affecting 1% of people worldwide, deep learning (DL) algorithms-based electroencephalograph (EEG) analysis provides the possibility for accurate epileptic seizure (ES) prediction, thereby benefiting patients suffering from epilepsy. To identify the preictal region that precedes the onset of seizure, a large number of annotated EEG signals are required to train DL algorithms. However, the scarcity of seizure onsets leads to significant insufficiency of data for training the DL algorithms. To overcome this data insufficiency, in this paper, we propose a preictal artificial signal synthesis algorithm based on a generative adversarial network to generate synthetic multichannel EEG preictal samples. A high-quality single-channel architecture, determined by visual and statistical evaluations, is used to train the generators of multichannel samples. The effectiveness of the synthetic samples is evaluated by comparing the ES prediction performances without and with synthetic preictal sample augmentation. The leave-one-seizure-out cross validation ES prediction accuracy and corresponding area under the receiver operating characteristic curve evaluation improve from 73.0% and 0.676 to 78.0% and 0.704 by 10x synthetic sample augmentation, respectively. The obtained results indicate that synthetic preictal samples are effective for enhancing ES prediction performance.

Nowadays, several deep learning methods are proposed to tackle the challenge of epileptic seizure prediction. However, these methods still cannot be implemented as part of implantable or efficient wearable devices due to their large hardware and corresponding high-power consumption. They usually require complex feature extraction process, large memory for storing high precision parameters and complex arithmetic computation, which greatly increases required hardware resources. Moreover, available yield poor prediction performance, because they adopt network architecture directly from image recognition applications fails to accurately consider the characteristics of EEG signals. We propose in this paper a hardware-friendly network called Binary Single-dimensional Convolutional Neural Network (BSDCNN) intended for epileptic seizure prediction. BSDCNN utilizes 1D convolutional kernels to improve prediction performance. All parameters are binarized to reduce the required computation and storage, except the first layer. Overall area under curve, sensitivity, and false prediction rate reaches 0.915, 89.26%, 0.117/h and 0.970, 94.69%, 0.095/h on American Epilepsy Society Seizure Prediction Challenge (AES) dataset and the CHB-MIT one respectively. The proposed architecture outperforms recent works while offering 7.2 and 25.5 times reductions on the size of parameter and computation, respectively.

We describe a machine learning (ML) approach to processing the signals collected from a COVID-19 optical-based detector. Multilayer perceptron (MLP) and support vector machine (SVM) were used to process both the raw data and the feature engineering data, and high performance for the qualitative detection of the SARS-CoV-2 virus with concentration down to 1 TCID₅₀/mL was achieved. Valid detection experiments contained 486 negative and 108 positive samples, and control experiments, in which biosensors without antibody functionalization were used to detect SARS-CoV-2, contained 36 negative samples and 732 positive samples. The data distribution patterns of the valid and control detection dataset, based on T-distributed stochastic neighbor embedding (t-SNE), were used to study the distinguishability between positive and negative samples and explain the ML prediction performance. This work demonstrates that ML can be a generalized effective approach to process the signals and the datasets of biosensors dependent on resonant modes as biosensing mechanism.