Emollients are valued ingredients of many cosmetic products and medical devices used to support the treatment and prevention of many skin diseases. Despite the fact that they are one of the oldest cosmetic ingredients, raw materials as well as new recipe solutions are constantly being sought, the main goal of which is to obtain products with the most favorable physicochemical properties while improving the hydration of the stratum corneum and softening and smoothing the skin. It should be noted that there are few scientific articles on the effect of emollients on the physicochemical and usable properties of emollient preparations of the body-oils type. The obtained formulations were subjected to physicochemical tests (dynamic viscosity, surface tension, contact angle, and color evaluation), and the degree of skin hydration and lubrication after application of the developed cosmetic oils was evaluated. Cosmetic oils based on natural emollients were characterized by weaker spreading abilities, which was confirmed by their higher viscosity, surface tension, and contact-angle results relative to those obtained for cosmetic oils based on synthetic emollients. In addition, it was found that the use of both groups of cosmetic oils based on natural and synthetic emollients leads to an increase in the degree of hydration of the skin and an increase in its oiliness. However, a higher increase in the degree of hydration and a lower decrease in the level of skin lubrication are observed after the application of body oils based on natural emollients.

Nanotechnology offers innovative methodologies for enhancing the diagnosis and treatment of ovarian cancer by utilizing specialized nanoparticles. The utilization of nanoparticles offers distinct advantages, specifically that these entities enhance the bioavailability of therapeutic agents and facilitate the targeted delivery of pharmacological agents to neoplastic cells. A diverse array of nanoparticles, including but not limited to liposomes, dendrimers, and gold nanoparticles, function as proficient carriers for drug delivery. Nevertheless, notwithstanding the auspicious potential of these applications, challenges pertaining to toxicity, biocompatibility, and the necessity for comprehensive clinical evaluations pose considerable barriers to the widespread implementation of these technologies. The incorporation of nanotechnology into clinical practice holds the promise of significantly transforming the management of ovarian cancer, offering novel diagnostic tools and therapeutic strategies that enhance patient outcomes and prognoses. In summary, the deployment of nanotechnology in the context of ovarian cancer epitomizes a revolutionary paradigm in medical science, amalgamating sophisticated materials and methodologies to enhance both diagnostic and therapeutic outcomes. Continued research and development endeavors are essential to fully realize the extensive potential of these innovative solutions and address the existing challenges associated with their application in clinical settings.

Introduction: The study hypothesis was that serum analysis of high-sensitivity troponin T in newborns could be a diagnostic tool to predict the health risks caused by intrauterine growth restriction and preterm birth. Material and methods: A total of n = 107 newborns were stratified into three groups: 52 healthy (26 male and 26 female), that is, newborns with body weight ≥ 10th percentile, born in good condition [Apgar score (APG) 8–10 pts] of pregnancy not complicated by diabetes, 21 (10 male and 11 female) with intrauterine growth restriction, that is, weight < 10th centile in centile grids for sex and gestational age of the newborn, and 34 (19 male and 15 female) preterm infants, that is, children born between 22 and 36 weeks from gestation counted from the first day of the last menstrual period. The lowest minimum troponin levels of 0.004 ng/mL defined the preterm group. Results: The healthy group was defined by the highest maximal troponin levels (0.895 ng/mL), while the intrauterine growth restriction group had the lowest maximal troponin level of 0.539 ng/mL. A significant difference was observed between the IUGR and premature groups, p = 0.00413. Conclusions: cTnT levels between IUGR and preterm newborns reflect developmental differences between these two groups that can influence future child development. Keywords: troponin T neonates intrauterine growth restriction preterm diagnostics

Background. Alcohol is one of the leading causes of liver hepatitis and liver cirrhosis. Both medical conditions are defined by a combination of specific symptoms whose interaction allows for a diagnosis with reasonable precision. Aims. This study aimed to differentiate between acute alcoholic hepatitis and alcoholic cirrhosis at the molecular level. Methods. This report analyzed changes in levels of vitamin D3, TNF-alpha, IL-1B, IL-6, IL-8, IL-12, and adiponectin determined using a chemiluminescent microparticle immunoassay and Luminex xMap technology. The study population consisted of 42 male patients with acute alcoholic hepatitis and 50 male patients with alcoholic cirrhosis. Results. The result revealed a statistically significant difference in TNF-alpha, IL-8, and IL-12 between acute alcoholic hepatitis and alcoholic cirrhosis. It also revealed distinct correlation patterns that differentiate acute alcoholic hepatitis and alcoholic cirrhosis. A network of significant cross-correlations between the cytokines studied defines alcoholic cirrhosis. Conclusion. This report revealed that the studied medical conditions can be differentiated by specific levels of cytokines and by cross-correlation between cytokines.