Background: The aim of this study is to histologically and biomechanically investigate the effects of local PRP and ozone therapy (O₂O₃) on tendon-to-bone healing in a rabbit model of the supraspinatus tendon tear.Methods: Four groups were formed to have seven rabbits in each group: repair, R; repair + PRP, RP; repair + ozone, RO; and repair + PRP + ozone, RPO. The supraspinatus tendon was detached by sharp dissection from the footprint and an acute tear pattern was created. Thereafter, tendon repair was performed with the transosseous technique. In the RP group, PRP, and in the RPO group, PRP + O2O3 mixture was injected to the tendon repair site. In the RO group, O₂O₃gas mixture was injected into subacromial space three times a week for a total of 4 weeks. The study was ended at postoperative 6th week.Results: When compared with the R group, a statistically significant increase was observed in the biomechanical strength of the RP and RPO groups. The highest increase in biomechanical strength was detected in the RPO group. The histology of the RO and RPO groups showed better collagen fiber continuity and orientation than the R and RP groups.Conclusions: The results obtained from this study show that the ozonized PRP can be used as biological support to increase tendon-to-bone healing. However, these results need to be supported by clinical studies.

The positive effects of grape seed proanthocyanidin extract (GSPE) on bone health, which is a potent antioxidant, are known but its effects on fracture healing are not sufficiently covered in the literature. This study aims to investigate the effects of GSPE on fracture healing and biomechanics of healing bone. Sixty-four adult Wistar-Albino male rats were divided into 8 groups of 8 animals in each group. Osteotomy was performed to the right femurs of all groups except the negative control (G1) and positive control (G2) groups, and intramedullary Kirchner wire was used for fixation. GSPE was given to half of the rats (G2-G4-G6-G8) 100 mg/kg/day by oral gavage. The rats were sacrificed on the tenth (G3–G4), twentieth (G5–G6), and thirtieth (G1–G2–G7–G8) days, respectively, and histopathological, radiological, and biomechanical examinations were performed. Histopathological examination of the specimens from the callus tissues revealed that bone healing was more prominent in the groups supplemented with GSPE (G4, G6, G8). There was a statistically significant improvement in radiological recovery scores and callus volumes in groups with GSPE. When biomechanical strengths were evaluated, it was found that GSPE increased bone strength not only in fracture groups but also in the positive control group (G2). As a result, this study showed that GSPE, a potent anti-oxidant, had a positive effect on bone healing and improved mechanical strength of the healing bone.

Madenler insanlık tarihi boyunca hep vazgeçilmez bir öneme sahip olmuştur. Tarih boyunca toplumlarda madencilik faaliyetleri ile gelişmişlik düzeyi ve dolayısıyla refah seviyesi arasında doğrudan bir ilişki kurulabilir. Dünyada stratejik olarak bilinen hammadde kaynaklarından biri de nadir toprak mineralleridir. Zenginleştirme ve saflaştırma proseslerinde sonra nadir toprak elementleri (NTE’ler), nadir toprak metalleri (NTM’ler) ve nadir toprak oksitleri (NTO’lar) gibi çeşitli isimlerle tanımlanmaktadır. Nadir toprak elementlerinin (NTE) keşfi ve beraberinde getirdiği teknolojik gelişmeler de neredeyse hayatımızın her alanında etkisini göstermektedir. Nadir toprak malzemeleri eşsiz fiziksel ve kimyasal özelliklere sahiptir. Nadir toprak elementleri mıknatıs, katalizör, metal alaşımları, elektronik aygıtlar, lazerler, cam-seramikler, şarj edilebilir piller, medikal görüntüleme, telekominikasyon, aydınlatma ve yeni nesil yarıiletken aygıtlar içeren yüksek teknolojik uygulamalarda komponent olarak kullanılmaktadır. Ek olarak, samaryum (Sm), neodimium (Nd) disprosyum (Dy), praseodimium (Pr) ve erbiyum (Er) gibi bazı önemli NTE’ler savunma sanayi ve yenilenebilir enerji teknolojilerinde (rüzgar ve güneş enerjisi) kullanılmaktadır. Kritik teknolojilerde kullanılan bu hammaddelere olan talep gelecekte büyük oranda artacaktır. Bu makalede, nadir toprak elementlerinin önemli uygulamaları, kullanım alanları ve kritik önemleri kapsamlı bir şekilde tartışılmıştır.

Total deformation and stability of straight and helical compression plates were studied by means of the finite element method (FEM) and in vitro biomechanical experiments. Fixations of transverse (TF) and oblique (45°) bone (OF) fractures have been a