Alexandros Giakoustidis

Prof. Alexandros Giakoustidis

orcid

Research Focus & Metrics

Academic Career Length

17Years (2010-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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6 August 2025 in Journal of Clinical Medicine
Verified
Journal Article
Open access
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Sophia TsokkouSophia Tsokkou
Sophia Tsokkou
IKIoannis Konstantinidis
Ioannis Konstantinidis
Menelaos PapakonstantinouMenelaos Papakonstantinou
Menelaos Papakonstantinou
PCParaskevi Chatzikomnitsa
Paraskevi Chatzikomnitsa
ELEftychia Liampou
Eftychia Liampou
Alexandros GiakoustidisAlexandros Giakoustidis
Alexandros Giakoustidis
Colorectal cancer (CRC) constitutes a major global health concern, ranking as the third most common cancer and the second leading cause of cancer-related mortality. The current review explores sex-based differences in CRC epidemiology, risk factors, tumor biology, and clinical outcomes. Males exhibit a higher incidence and mortality rate, with left-sided (distal) CRC predominating, while females are more frequently diagnosed with right-sided (proximal) tumors, which tend to be more aggressive and less responsive to conventional chemotherapy. Genetic disparities, including microsatellite instability and X-chromosome tumor suppressor genes, contribute to sex-specific differences in tumor progression and treatment response. Immune variations also influence disease outcomes, with females exhibiting stronger immune surveillance but higher exhaustion markers. Lifestyle factors such as body mass index (BMI), smoking, and hormonal influences further modulate CRC risk. While males are more vulnerable to obesity-related CRC, central obesity (waist-to-hip ratio) emerges as a stronger predictor in females. Additionally, smoking increases CRC risk differentially by tumor location. These findings underscore the importance of sex-specific approaches in CRC prevention, screening, and treatment, advocating for personalized medicine strategies tailored to gender-based biological and clinical distinctions.

1 January 2015 in Canadian Journal of Gastroenterology and Hepatology
Verified
Journal Article
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Alexandros GiakoustidisAlexandros Giakoustidis
Alexandros Giakoustidis
DGDimitrios Giakoustidis
Dimitrios Giakoustidis
SMSatvinder Mudan
Satvinder Mudan
ASArgyrios Sklavos
Argyrios Sklavos
RWRoger Williams
Roger Williams
Hepatocellular carcinoma is the sixth most common cancer worldwide. In the majority of cases, there is evidence of existing chronic liver disease from a variety of causes including viral hepatitis B and C, alcoholic liver disease and nonalcoholic steatohepatitis. Identification of the signalling pathways used by hepatocellular carcinoma cells to proliferate, invade or metastasize is of paramount importance in the discovery and implementation of successfully targeted therapies. Activation of Wnt/β-catenin, Notch and Hedgehog pathways play a critical role in regulating liver cell proliferation during development and in controlling crucial functions of the adult liver in the initiation and progression of human cancers. β-catenin was identified as a protein interacting with the cell adhesion molecule E-cadherin at the cell-cell junction, and has been shown to be one of the most important mediators of the Wnt signalling pathway in tumourigenesis. Investigations into the role of Dikkopf-1 in hepatocellular carcinoma have demonstrated controversial results, with a decreased expression of Dickkopf-1 and soluble frizzled-related protein in various cancers on one hand, and as a possible negative prognostic indicator of hepatocellular carcinoma on the other. In the present review, the authors focus on the Wnt/β-catenin, Notch and Sonic Hedgehog pathways, and their interaction with Dikkopf-1 in hepatocellular carcinoma.

13 March 2015 in Annals of Surgical Oncology
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Journal Article
Closed access
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KNKyriakos Neofytou
Kyriakos Neofytou
EElizabeth Smyth
Elizabeth Smyth
Alexandros GiakoustidisAlexandros Giakoustidis
Alexandros Giakoustidis
AKAamir Z. Khan
Aamir Z. Khan
RWRoger Williams
Roger Williams
SMSatvinder Mudan
Satvinder Mudan

29 December 2014 in Journal of Surgical Oncology
Verified
Journal Article
Closed access
PDF file
Alexandros GiakoustidisAlexandros Giakoustidis
Alexandros Giakoustidis
KNKyriakos Neofytou
Kyriakos Neofytou
AKAamir Z. Khan
Aamir Z. Khan
SMSatvinder Mudan
Satvinder Mudan

1 January 2018 in Annals of Hepato-Biliary-Pancreatic Surgery
Verified
Journal Article
Open access
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Alexandros GiakoustidisAlexandros Giakoustidis
Alexandros Giakoustidis
KNKyriakos Neofytou
Kyriakos Neofytou
MNMafalda Costa Neves
Mafalda Costa Neves
DGDimitrios Giakoustidis
Dimitrios Giakoustidis
ELEleni Louri
Eleni Louri
SMSatvinder Mudan
Satvinder Mudan
Giakoustidis A, et al. Ann Hepatobiliary Pancreat Surg. 2018 Aug;22(3):197-207. https://doi.org/10.14701/ahbps.2018.22.3.197

23 September 2014 in World Journal of Surgery
Verified
Journal Article
Closed access
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SMS. Mudan
S. Mudan
Alexandros GiakoustidisAlexandros Giakoustidis
Alexandros Giakoustidis
DMD. Morrison
D. Morrison
SIS. Iosifidou
S. Iosifidou
RRR. Raobaikady
R. Raobaikady
JSJustin Stebbing
Justin Stebbing