Adolescents are especially vulnerable to experiencing depression and anxiety. This longitudinal study, from within- and between-person perspectives, explores how self-esteem relates to depressive and anxiety symptoms in Chinese adolescents and identifies the mediating factors impacting this relationship. Data were collected from 1025 junior and high school students in Southwestern China at three points over an 18-month period. This study utilized both traditional and random-intercept cross-lagged panel models to understand the dynamic developmental relationships. The general occurrence of depressive and anxiety symptoms increased longitudinally, with a more pronounced upward trend among female students. Between-person level analyses indicated bidirectional associations among self-esteem, life satisfaction, and depressive and anxiety symptoms. Moreover, life satisfaction emerged as a significant mediator. At the within-person level, self-esteem uniquely predicted both life satisfaction and subsequent depressive and anxiety symptoms. This study clarifies the longitudinal interplay between these constructs. Self-esteem, which denotes internal self-assessments, and life satisfaction, which denotes external evaluations of life, both significantly buffer the emergence of depressive and anxiety symptoms.

This study explores the relative contributions and psychological mechanisms of the effects of family (father–child and mother–child) and school (teacher–student and student–student) interpersonal relationships on depression in elementary school children. The participants (n = 20,629) were elementary school children (48.19% male) aged nine to 13 years from Southwest China during the COVID-19 pandemic. They voluntarily completed questionnaires regarding parent–child, teacher–student, and student–student relationships, as well as academic stress and self-esteem. The results indicate that the effect of family interpersonal relationships on children’s depression was stronger than that of school interpersonal relationships. The predictive effects of father–child and mother–child relationships on children’s depression did not significantly differ; however, the effect of student–student relationships was significantly stronger than that of teacher–student relationships. Academic stress partially mediated the effect of interpersonal relationships on depression in elementary school children. The effects of family interpersonal relationships and academic stress on depression were moderated by self-esteem. These findings underscore the disparities and mechanisms pertaining to the impacts of diverse interpersonal associations on children’s depression, thus signifying significant implications for the advancement of research and intervention strategies aimed at addressing this issue.