Despite the international significance attached to climate change adaptation, there remains a lack of understanding of the barriers that impede the effective implementation of adaptation strategies by households across sub-Saharan Africa (SSA). Better understanding of the vulnerability of agriculture-dependent households to climate variability requires exploration of the barriers that constrain the implementation of adaptation strategies. This paper uses case studies from northeast Ghana and a systematic literature review to assess the barriers that restrict effective implementation of climate adaptations in SSA. Results suggest that households are constrained by financial barriers, socio-cultural barriers, institutional barriers, technological barriers and a lack of information on climate change characteristics. We examine how the various barriers interact at different levels to influence the adaptation process. Findings highlight that the development of early warning systems, effective communication of climate information and an understanding of the local context within which adaptations take place, are necessary pre-requisites to enhance climate adaptations and rural livelihoods. Households need to be supported through the provision of micro-credit schemes, community empowerment and extension initiatives aimed at enhancing social networks within farming communities in order to reduce their vulnerability to the adverse impacts of climate change and variability.