Background: The Aral Sea crisis has led to harmful effects on human habitat. In recent years, mild cognitive impairment is a growing problem. Objectives: This article provides the results of studying the neuropsychological state of residents living in the crisis zone of the Aral Sea region in the case of Shalkar city. We have provided an assessment of the neuropsychological state of examined population and determined the leading pathology in this region. Methods: The survey sample included 344 persons of reproductive age from 21 to 45 years. We have obtained results in biochemical studies, indicating perturbations of proteometabolism and lipid metabolism. Results: A correlation analysis showed dependence between a decrease of albumin and high-density lipoproteins, an increase of low-density lipoproteins and parameters of cognitive function. Conclusions: The research suggests a high prevalence of cerebrovascular pathology among the population, changes in cognitive function parameters, long-term and short-term memory problems and high levels of depression.

The article presents the results of a study of chromosomal mutations in residents living in the Aral Sea disaster zone. The present study was designed to evaluate the impact of the combined effect of a chemical mutagen (nickel) and bacterial microflora on the level of chromosomal aberrations (CA) in peripheral blood lymphocytes. This study used classical methods of cell cultivation, methods for determining chromosomal aberrations, a cytomorphological method for assessing epithelial cells, and an atomic absorption method for determining trace elements in the blood. The article shows that with an increase of chemical agent in the blood, the number of cells with features of damage and cells with contamination by microflora increases. Both of these factors cause an increase in the frequency of chromosomal aberrations. The article demonstrates how being exposed to a chemical factor increases chromosomal mutations, and also damages membrane components, which leads to a decrease in the barrier and protective function of the cell, and as a result also affects the level of chromosomal aberrations.

Risk factors in Aral Sea region include toxic metals that competitively interact with essential elements influencing their metabolism, affecting metabolic and cognitive functions. According to epidemiological data, cerebrovascular disease and thyroid function abnormality are the leading disorders. Cognitive and metabolic disorders are considered as risk factors in cerebrovascular diseases. Thus, the objective of current work was to determine the metabolic and cognitive state of people in Aralsk, associated with an imbalance of essential trace elements and find correlation between toxic metals load and psychoemotional status. 275 people between the ages of 21 and 45 years were involved. In evaluating cognitive state, a decrease in short-term memory for numbers and an increase in depression among subjects was found. An inverse correlation between the copper level in blood and short-term memory for numbers, between depression and iodine level in blood, between the zinc level in blood and the “attentional capacity” was also found. The results showed a significant metabolic stress among subjects during adaptation to a high chemical load. Data represent a cross-sectional age-dependent review of metabolic and cognitive processes and microelement metabolism among population, living in the Aral Sea region for a long time.

The article discusses environmental and industrial risks caused by the activities of various industrial enterprises. It highlights the significant proportion of workers engaged in hazardous working conditions and the negative impact of polluted environments on public health. A comprehensive prevention model is proposed. The need for a specialized scientific and methodological center is substantiated.

Background. It is necessary to monitor the health disorders of healthcare practitioners exposed to a complex of occupational hazards to optimize their activities and substantiation of preventive health measures. The purpose of the study was the hygienic assessment of occupational hazards, analysis of data on self-assessment of the state of health (SASH questionnaire) among healthcare practitioners (MRI diagnostics specialists, ultrasound diagnostics specialists, and ophthalmologists, as a control group) exposed to nonionizing radiation, ultrasound, and noise. Materials and Methods. An analysis of hygienic parameters of the working environment (workplace) and questionnaire data of healthcare practitioners were carried out. The number of illnesses and absences from work, the level of quality of life, the level of depression, and the self-assessment of the state of health were evaluated according to the questionnaire. Results. An analysis of workloads made it possible to rank the severity and intensity of labor. Health disorders (according to the self-assessment of the state of health), the number of absences from work due to illness, an increase in complaints and level of depression, and a decrease in the level of quality of life were corresponded to the severity of labor. It was revealed that healthcare practitioners were exposed to a number of hazards during their work (above the threshold limit value (TLV)), which caused an increase in health disorders. Conclusions. During the organization of workplace ergonomics and implementation of preventive measures directed to maintaining health and early diagnosis of diseases, one should take into account the hygienic indicators of the working environment that exceed TLV, the results of self-assessment of the state of health (complaints) and morbidity of healthcare practitioners, the level of quality of life and the level of depression.

Objective: This study aims to assess the impact of prolonged occupational exposure to chrysotile asbestos on the epithelial cells of the upper respiratory tract and the levels of surfactant protein D (SP-D) in female workers. Methods: Buccal epithelial cell samples were collected from 40 workers at JSC “Kostanay Minerals”, fixed using the May–Grünwald method, and stained with the Romanowsky–Giemsa technique. SP-D levels were measured using an enzyme-linked immunosorbent assay (ELISA). Results: Workers exposed to asbestos dust exhibited a significant increase in cytological abnormalities and higher SP-D levels compared to the control group. Conclusion: Prolonged exposure to chrysotile-containing dust leads to degenerative changes in upper respiratory tract epithelial cells, characterized by cytological and cytogenetic abnormalities, alongside elevated SP-D levels, highlighting the need for preventive health measures.