Anca Sava

Anca Sava


Research Focus & Metrics

Academic Career Length

3Years (2024-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 September 2024 in Diagnostics
Verified
Journal Article
Open access
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AMAlexandru Misăiloaie
Alexandru Misăiloaie
Ionut TaraboantaIonut Taraboanta
Ionut Taraboanta
CBCristian-Constantin Budacu
Cristian-Constantin Budacu
ASAnca Sava
Anca Sava
This study aimed to evaluate the pathological factors and anatomical variations in the maxillary sinus in patients undergoing dental implant treatment using cone beam computed tomography (CBCT). CBCT, as a key imaging technique in dentistry, offers high-resolution images to assess bone morphology and quality, crucial for preoperative dental implant planning. Material and methods: The study included a cohort of 200 patients recommended for CBCT as part of their preoperative evaluation. The methodology involved detailed CBCT image analysis to identify and document various anatomical variations due to pneumatization, exostosis, hypoplasia, polyps, cysts, foreign bodies, and anthroliths within the maxillary sinus. Results: Pneumatization was the most common variation, present in 77.5% of subjects. Polypoid lesions were found in 17.5% of patients, with a higher prevalence in younger age groups (57.1% in ages 20–35). Cysts and polyps affected 17.5% of subjects, predominantly males (65.7%). Anthroliths were observed in a minimal percentage (2%), and foreign bodies were found in 1.5% of the patients. Positive correlations were observed between the patient’s age and both mucosal thickness and polypoid lesions and between the patient’s gender and bone thickening (p-values < 0.05). Conclusions: The study concluded that CBCT is essential in the preoperative assessment of the maxillary sinus in dental implant candidates due to its superior imaging capabilities, allowing for the identification of critical anatomical variations and pathologies. This thorough evaluation is imperative to ensure the success of implant placement and to mitigate potential complications. However, further research with larger, more diverse populations is recommended to confirm these findings.

19 November 2024 in Diagnostics
Verified
Journal Article
Open access
PDF file
AMAlexandru Misăiloaie
Alexandru Misăiloaie
Ionut TaraboantaIonut Taraboanta
Ionut Taraboanta
CSCristinel Ionel Stan
Cristinel Ionel Stan
CBCristian-Constantin Budacu
Cristian-Constantin Budacu
MMMisailoaie Denisa- Mihaela
Misailoaie Denisa- Mihaela
ASAnca Sava
Anca Sava
Background: This study aimed to compare the accuracy of linear measurements obtained using the classical (manual) method versus cone-beam computed tomography (CBCT) in craniofacial anthropometry, specifically targeting the infraorbital foramen (IOF). Methods: This study involved two sample groups: one of 40 dry skulls measured manually using digital calipers, and the other of 40 CBCT 3D images digitally measured. Measurements included IOF height, distances between the IOF and nasion (N), IOF and frontomalar orbital (FMO), and between the two IOFs. Statistical analysis was performed using an ANOVA, t-test, and Fisher’s test with a significance level of 0.05. Results: The manual method recorded a mean IOF height of 2.1 mm, while CBCT showed a mean of 3.52 mm. Significant differences were recorded between the two methods when measuring IOF height, with a p < 0.001. However, CBCT measurements generally yielded higher accuracy and lower variance due to the absence of significant differences (p > 0.05). The distance between the two IOFs measured by both methods differed significantly (p = 0.03157), with CBCT measurements showing higher values. Conclusions: In conclusion, although no significant differences were found in the overall accuracy of the two methods, CBCT proved to be a more reliable tool for detailed craniofacial measurements due to its higher accuracy and reproducibility. CBCT demonstrated superior consistency in measurements, offering enhanced precision in assessing craniofacial structures. These findings support the growing preference for CBCT in maxillofacial surgery, where precision is critical for successful outcomes. Nonetheless, manual techniques remain valuable in settings where advanced imaging is not accessible.

26 April 2024 in Journal of Clinical Medicine
Verified
Journal Article
Open access
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AZAlexandra-Simona Zamfir
Alexandra-Simona Zamfir
CRISTIAN STATESCUCRISTIAN STATESCU
CRISTIAN STATESCU
RSRadu Andy Sascau
Radu Andy Sascau
GTGrigore Tinica
Grigore Tinica
CZCarmen Zamfir
Carmen Zamfir
ASAnca Sava
Anca Sava
Background and Objectives: Coronary artery anomalies (CAAs) represent a group of rare cardiac abnormalities with an incidence of up to 1.2%. The aim of this retrospective study was to conduct a comprehensive epidemiological assessment of the prevalence of hypoplastic coronary arteries using coronary computed tomography angiography (CCTA) in patients with diagnosed CAAs and individuals presenting with cardiovascular manifestations in the north-eastern region of Romania. This study was motivated by the limited investigation of the CAAs conducted in this area. Methods: We analyzed data collected from 12,758 coronary computed tomography angiography (CCTA) records available at the “Prof. Dr. George I.M. Georgescu” Cardiovascular Diseases Institute, spanning the years 2012 to 2022. Results: Among 350 individuals with CAAs (2.7% of the total cohort), 71 patients (20.3% of the anomaly presenting group and 0.5% of the entire CCTA cohort) exhibited at least one hypoplastic coronary artery. The mean age of individuals diagnosed with hypoplastic coronary artery disease (HCAD) was 61 years, while the age distribution among them ranged from 22 to 84 years. Nearly equal cases of right and left dominance (33 and 31, respectively) were observed, with only 7 cases of co-dominance. Conclusions: HCAD may be considered underexplored in current published research, despite its potentially significant implications ranging to an increased risk of sudden cardiac arrest. The specific prevalence of HCAD among CAAs might be higher than previously reported, possibly reflecting better diagnostic accuracy of CCTA over classic coronary imaging. The absence of standard diagnostic and therapeutic protocols for HCAD underscores the necessity of a personalized approach for such cases.

26 May 2024 in Healthcare
Verified
Journal Article
Open access
PDF file
AZAlexandra-Simona Zamfir
Alexandra-Simona Zamfir
TCTudor Andrei Cernomaz
Tudor Andrei Cernomaz
BCBogdan Mihnea Ciuntu
Bogdan Mihnea Ciuntu
DADoina Azoicai
Doina Azoicai
CZCarmen Zamfir
Carmen Zamfir
ASAnca Sava
Anca Sava
Background: In the wake of the coronavirus disease 19 (COVID-19) pandemic, affecting healthcare systems globally, urgent research is needed to understand its potential repercussions on the diagnosis and management of cardiovascular disorders. This emphasises the importance of detecting coronary artery anomalies (CAAs), rare conditions that can range from benign to potentially life-threatening manifestations. We aimed to retrospectively assess the impact of the COVID-19 pandemic on the detection of various coronary anomalies using Coronary Computed Tomography Angiography (CCTA) within a regional tertiary cardiology unit in north-eastern Romania, focusing on perceived occurrence in the population under study, types, and related demographic and clinical factors. Methods: We analysed CCTA scans and investigated the trends in CAA detection among cardiology patients over a decade. We compared pre-COVID-19 and pandemic-era data to assess the impact of healthcare utilisation, patient behaviour, and diagnostic approaches on anomaly detection. Results: Our analysis revealed a higher detection rate of CAAs during the pandemic (3.9% versus 2.2%), possibly highlighting differences in patient clinical profile and addressability changes presentation compared to the previous period. Origination and course anomalies, often linked to severe symptoms, were significantly higher pre-COVID-19 (64.1% versus 51.3%). Conversely, intrinsic CAAs, typically asymptomatic or manifesting later in life, notably increased during the pandemic (49.0% versus 61.4%; p = 0.020). Conclusions: Our study underscores a significant rise in CAA detection during the COVID-19 era, potentially linked to changes in cardiovascular and respiratory clinical patterns, with advanced imaging modalities like CCTA offering accuracy in identification.

18 August 2025 in NeuroSci
Verified
Journal Article
Open access
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ADAna Maria DUMITRESCU
Ana Maria DUMITRESCU
DCDragos Andrei Chiran
Dragos Andrei Chiran
CSCristinel Ionel Stan
Cristinel Ionel Stan
CPCringuta Mariana Paraschiv
Cringuta Mariana Paraschiv
DNDOBRIN N Nicolaie
DOBRIN N Nicolaie
ASAnca Sava
Anca Sava
Background: The literature shows that anterior communicating artery (AcoA) aneurysms are the most common intracranial aneurysms. To date, there has only been one postmortem study focused on the correlations between autopsy findings and imaging results in cases of intracranial aneurysms associated with anatomical variants of the circle of Willis (CW). Methods: We investigated the anatomical variants of the CW associated with the occurrence and rupture of AcoA aneurysms by performing comparative analyses, in the same patients, of postmortem autopsy data with antemortem computed tomography–angiography (CTA) results obtained in the first 48 h after the onset of subarachnoid hemorrhage. Our retrospective observational study identified the anatomical variants of the CW at autopsy in 16 deceased adult Romanian patients with AcoA aneurysms over a 12-year period (2010–2022). Results: The autopsy findings revealed that the AcoA ruptured aneurysms had a mean external diameter of 9.50 mm, and 71.4% of them presented three or four anatomical variants inside the same CW. The initial antemortem CTA examination correctly located the AcoA aneurysms in all cases (100%), and an anatomical variant of the CW was only noted in 18.75% of patients. The final postmortem re-analyzed the same CTA images identified in all cases (100%), focusing on both the AcoA aneurysm and all anatomical variants of the CW found during the autopsies. Conclusions: Although it was previously thought that the occurrence of AcoA aneurysms is related only to the hemodynamic changes induced by the nearby arterial anatomical variants, we identified the simultaneous involvement of at least one hypoplastic artery and one or two PCA fetal-type anatomical variants that were located in both the anterior and posterior parts of the CW. Furthermore, if sufficient time is devoted to the CT–angiography analysis and interpretation of the images, anatomical variants of the circle of Willis associated with AcoA aneurysms can be identified as accurately as they are in invasive postmortem autopsy examinations.

24 November 2025 in Life
Verified
Journal Article
Open access
PDF file
ACAndrei Ionut Cucu
Andrei Ionut Cucu
CBCatalin Mihai Buzduga
Catalin Mihai Buzduga
ACAlexandru Carauleanu
Alexandru Carauleanu
SASorin Axinte
Sorin Axinte
ANAlexandru Nemtoi
Alexandru Nemtoi
ASAngela Simalcsik
Angela Simalcsik
Background: The styloid process is a slender, cylindrical bony projection of the temporal bone, showing marked interindividual variability in length, orientation, and degree of ossification. Its abnormal elongation, defined as exceeding 30 mm, is often associated with Eagle’s syndrome but may also occur as an incidental anatomical variant. Objective: This study reports two rare cases of abnormally long styloid processes without ossification of the stylohyoid ligament, identified in adult dry skulls from the osteological collection of the “Olga Necrasov” Centre of Anthropological Research, Iași, Romania, and provides morphological and CT-based characterization. Materials and Methods: Both skulls were examined macroscopically and by CT, with 3D reconstructions being used for morphometric analysis. Results: In Case 1, the left SP measured 62 mm, corresponding to Langlais type I elongation, with no evidence of pseudoarticulation or ligamentous ossification. In Case 2, the left SP was elongated to 33 mm and fusiform in shape, while the contralateral (right) SP was completely absent, a highly uncommon anatomical variation scarcely reported in the literature. Both findings were confirmed by CT imaging. Conclusions: The coexistence shows that the stylohyoid complex cand vary greatly during development. Such findings expand the spectrum of known anatomical variants of the stylohyoid complex and underscore the importance of detailed morphologic and imaging evaluation of the styloid region in both anatomical and clinical contexts.