Cristian-Constantin Budacu

Dr. Cristian-Constantin Budacu


Research Focus & Metrics

Academic Career Length

3Years (2024-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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21 May 2025 in Dentistry Journal
Verified
Journal Article
Open access
PDF file
CDCaterina Dumitru
Caterina Dumitru
Mariana LupoaeMariana Lupoae
Mariana Lupoae
CBCristian-Constantin Budacu
Cristian-Constantin Budacu
MGMitea Gabriela
Mitea Gabriela
MRMarius-Daniel Radu
Marius-Daniel Radu
GTGabi Topor
Gabi Topor
Background/Objectives: Oral health is a complex concept involving physical, psychological, emotional, and social components. A key factor in maintaining oral tissue integrity is redox balance, which is disrupted by oxidative stress (OS) through an imbalance between reactive oxygen species (ROS) and antioxidant defenses. This study examines the contribution of endogenous and exogenous sources to OS and explores the therapeutic potential of medicinal plants from the Asteraceae and Lamiaceae families in restoring redox homeostasis and improving oral health. Methods: A literature review was conducted, analyzing the role of OS in oral diseases and the antioxidant mechanisms of selected Asteraceae species. Special attention was given to their phytochemical contents—polyphenols, flavonoids, and essential oils—and their biological relevance to oral health. Results: OS plays a critical role in the onset and progression of oral conditions such as caries, periodontitis, gingivitis, aphthous ulcers, abscesses, precancerous lesions, and oral cancers. ROS and reactive nitrogen species (RNS) cause inflammation, tissue breakdown, and salivary gland dysfunction. Asteraceae plants like Matricaria chamomilla, Calendula officinalis, Cichorium intybus, Taraxacum officinale, Arctium lappa, Achillea millefolium, and Solidago virgaurea demonstrate notable antioxidant, anti-inflammatory, and antimicrobial properties that help counteract OS and support oral homeostasis. Conclusions: Asteraceae and Lamiaceae species show high therapeutic potential in addressing OS-related oral disorders. Their bioactive compounds aid in restoring redox balance and protecting oral tissues. These findings support the integration of phytotherapeutic agents into oral healthcare and call for further clinical validation of plant-based strategies for disease prevention and management.

1 September 2024 in Diagnostics
Verified
Journal Article
Open access
PDF file
AMAlexandru Misăiloaie
Alexandru Misăiloaie
Ionut TaraboantaIonut Taraboanta
Ionut Taraboanta
CBCristian-Constantin Budacu
Cristian-Constantin Budacu
ASAnca Sava
Anca Sava
This study aimed to evaluate the pathological factors and anatomical variations in the maxillary sinus in patients undergoing dental implant treatment using cone beam computed tomography (CBCT). CBCT, as a key imaging technique in dentistry, offers high-resolution images to assess bone morphology and quality, crucial for preoperative dental implant planning. Material and methods: The study included a cohort of 200 patients recommended for CBCT as part of their preoperative evaluation. The methodology involved detailed CBCT image analysis to identify and document various anatomical variations due to pneumatization, exostosis, hypoplasia, polyps, cysts, foreign bodies, and anthroliths within the maxillary sinus. Results: Pneumatization was the most common variation, present in 77.5% of subjects. Polypoid lesions were found in 17.5% of patients, with a higher prevalence in younger age groups (57.1% in ages 20–35). Cysts and polyps affected 17.5% of subjects, predominantly males (65.7%). Anthroliths were observed in a minimal percentage (2%), and foreign bodies were found in 1.5% of the patients. Positive correlations were observed between the patient’s age and both mucosal thickness and polypoid lesions and between the patient’s gender and bone thickening (p-values < 0.05). Conclusions: The study concluded that CBCT is essential in the preoperative assessment of the maxillary sinus in dental implant candidates due to its superior imaging capabilities, allowing for the identification of critical anatomical variations and pathologies. This thorough evaluation is imperative to ensure the success of implant placement and to mitigate potential complications. However, further research with larger, more diverse populations is recommended to confirm these findings.

19 November 2024 in Diagnostics
Verified
Journal Article
Open access
PDF file
AMAlexandru Misăiloaie
Alexandru Misăiloaie
Ionut TaraboantaIonut Taraboanta
Ionut Taraboanta
CSCristinel Ionel Stan
Cristinel Ionel Stan
CBCristian-Constantin Budacu
Cristian-Constantin Budacu
MMMisailoaie Denisa- Mihaela
Misailoaie Denisa- Mihaela
ASAnca Sava
Anca Sava
Background: This study aimed to compare the accuracy of linear measurements obtained using the classical (manual) method versus cone-beam computed tomography (CBCT) in craniofacial anthropometry, specifically targeting the infraorbital foramen (IOF). Methods: This study involved two sample groups: one of 40 dry skulls measured manually using digital calipers, and the other of 40 CBCT 3D images digitally measured. Measurements included IOF height, distances between the IOF and nasion (N), IOF and frontomalar orbital (FMO), and between the two IOFs. Statistical analysis was performed using an ANOVA, t-test, and Fisher’s test with a significance level of 0.05. Results: The manual method recorded a mean IOF height of 2.1 mm, while CBCT showed a mean of 3.52 mm. Significant differences were recorded between the two methods when measuring IOF height, with a p < 0.001. However, CBCT measurements generally yielded higher accuracy and lower variance due to the absence of significant differences (p > 0.05). The distance between the two IOFs measured by both methods differed significantly (p = 0.03157), with CBCT measurements showing higher values. Conclusions: In conclusion, although no significant differences were found in the overall accuracy of the two methods, CBCT proved to be a more reliable tool for detailed craniofacial measurements due to its higher accuracy and reproducibility. CBCT demonstrated superior consistency in measurements, offering enhanced precision in assessing craniofacial structures. These findings support the growing preference for CBCT in maxillofacial surgery, where precision is critical for successful outcomes. Nonetheless, manual techniques remain valuable in settings where advanced imaging is not accessible.

1 April 2026 in Diagnostics
Verified
Journal Article
Open access
PDF file
EKEarar Kamel
Earar Kamel
CDCiprian Adrian Dinu
Ciprian Adrian Dinu
Marius Valeriu Valeriu HinganuMarius Valeriu Valeriu Hinganu
Marius Valeriu Valeriu Hinganu
GLGabriela Leață
Gabriela Leață
Corneliu MunteanuCorneliu Munteanu
Corneliu Munteanu
CBCristian-Constantin Budacu
Cristian-Constantin Budacu
Background: Biodegradable magnesium-based alloys are increasingly explored as emerging biomaterials for dental and maxillofacial applications due to their osteoconductive properties and potential to reduce long-term implant-related complications. However, early-stage evaluation requires predictive diagnostic screening methods capable of assessing cytocompatibility and cellular response under clinically relevant extract conditions. Objectives: In this study, Mg–0.5Ca alloys modified with increasing strontium concentrations (0.5–3 wt.%) were investigated through an in vitro diagnostic framework using MG-63 osteoblast-like cells. Methods: Cell viability was quantitatively assessed via MTT assays after 24 and 72 h of exposure, while fluorescence-based live-cell imaging provided complementary morphological insights. Results: demonstrated a composition-associated cytocompatibility profile, with Sr-enriched compositions showing improved cellular metabolic activity and adhesion patterns compared to lower-Sr compositions. Conclusions: These findings support the role of strontium as a functional alloying element and highlight the importance of standardized diagnostic screening workflows for emerging dental biomaterials. Overall, this study proposes a simplified predictive platform for early biocompatibility diagnostics, contributing to the integration of biomaterial evaluation into future digitalized dental regeneration workflows.

4 November 2026 in Diagnostics
Verified
Journal Article
Open access
PDF file
Cristina-Mihaela PopescuCristina-Mihaela Popescu
Cristina-Mihaela Popescu
Ada StefanescuAda Stefanescu
Ada Stefanescu
IPIrina Profir
Irina Profir
DCDorin Ioan Cocoș
Dorin Ioan Cocoș
MCMehedinti Roxana Cristina
Mehedinti Roxana Cristina
CBCristian-Constantin Budacu
Cristian-Constantin Budacu
Background/Objectives: Pediatric paranasal sinus fractures are often reported within broader craniofacial trauma series. This retrospective cross-sectional descriptive study focused on fracture distribution across the four sinus groups, injury mechanisms, initial management, and associated traumatic intracranial hemorrhage. Methods: Written head CT reports and clinical records from a pediatric emergency hospital in Romania were reviewed retrospectively for 2021–2025. Thirty-eight patients with documented sinus fractures were included. Sinus involvement was coded by anatomical group, with bilateral involvement counted once per group. Traumatic intracranial hemorrhage was defined as hemorrhage documented on the index CT. Analyses were descriptive. Results: Median age was 13 years; 25 patients (65.8%) were male. Maxillary fractures occurred in 31/38 patients (81.6%), frontal fractures in 13 (34.2%), ethmoid fractures in 12 (31.6%), and sphenoid fractures in four patients (10.5%). Eighteen patients had isolated maxillary fractures, three had isolated frontal fractures, and 17 (44.7%) had multisinus fractures. Motor vehicle accidents accounted for 19 injuries (50.0%). Traumatic intracranial hemorrhage was documented in 10 patients (26.3%), including two of seven with posterior table involvement. Eight hemorrhage cases lacked posterior table fractures. Twenty patients received conservative management, 10 underwent other operative interventions, and eight were transferred; no sinus-specific operation was documented at the study institution. Among the 30 non-transferred patients, median hospital stay was six days. Conclusions: Maxillary involvement predominated in this selected pediatric sinus-fracture cohort. Traumatic intracranial hemorrhage occurred with both isolated and multisinus fractures and was usually documented without posterior table involvement. Report-based ascertainment, exclusions with unknown fracture status, and unavailable post-transfer outcomes limit interpretation. These findings support further descriptive investigation in larger cohorts with standardized image review.