Aquaculture has become one of the most attractive food production activities as it provides high-quality protein for the growing human population. However, the abiotic chronic stress of fish in intensive fish farming leads to a detrimental condition that affects their health and somatic growth, comprising productive performance. This work aims to comprehensively review the impact of alternative and novel dietary protein sources on fish somatic growth, metabolism, and antioxidative capacity under environmental/abiotic stressors. The documental research indicates that ingredients from rendered animal by-products, insects, bacteria as single-cell proteins, and fungal organisms (e.g., yeast, filamentous fungus, and mushrooms) benefit fish health and performance. A set of responses allows fish growth, health, and survival to remain unaffected by feeding with alternative ingredients during chronic environmental stress. Those ingredients stimulate the production of enzymes such as catalase, glutathione peroxidase, and selenoproteins that counteract ROS effects. In addition, the humoral immune system promotes immunoglobulin production (IgM) and cortisol plasmatic reduction. Further investigation must be carried out to establish the specific effect by species. Additionally, the mixture and the pre-treatment of ingredients such as hydrolysates, solid fermentations, and metabolite extraction potentialize the beneficial effects of diets in chronically stressed fish.

Meeting the demand for food through sustainable agro-industrial systems has become a concern due to the current state of the planet’s natural resources, population growth, and climate change. To address this, the 2030 Agenda has laid out several strategies to enhance human well-being and protect the planet. This paper focuses on Goal 2, which aims to end hunger, achieve food security, improve nutrition, and promote sustainable agriculture. The first three targets of this goal are as follows: 2.1, ending hunger and ensuring access to nutritious food; 2.2, ending all forms of malnutrition; and 2.3, doubling the agricultural productivity of small-scale food producers. The purpose of this manuscript is to demonstrate how aquaponics can positively impact these three targets by guaranteeing food security through the production of high-quality protein. Aquaponic crops are enriched with organic nutrients from the water they grow in. This not only increases their nutrient content but also their bioactive molecule content, making them excellent for fighting hunger and malnutrition. Moreover, these practices can be adjusted to different scales, making them a viable option for small farmers, women, and rural communities to produce their own food. Consequently, aquaponics can play a crucial role in achieving Zero Hunger locally, with appropriate support.