Francesco Pardo

Dr. Francesco Pardo


Research Focus & Metrics

Academic Career Length

6Years (2021-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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15 July 2022 in Journal of Orthopaedics and Traumatology
Verified
Journal Article
Open access
PDF file
FCFrancesco Castagnini
Francesco Castagnini
SLStefano Lucchini
Stefano Lucchini
BBBarbara Bordini
Barbara Bordini
MCMonica Cosentino
Monica Cosentino
FPFrancesco Pardo
Francesco Pardo
Francesco TrainaFrancesco Traina
Francesco Traina
Background: Stem choice in total hip arthroplasty (THA) for hip dysplasia is still controversial. The aims of the study were to evaluate (1) which stem design provided the highest percentage of adequate reconstructions in THA for dysplasia and (2) any correlation between the reconstructions provided by the stems and the native femoral morphology. Materials and methods: 150 CT scans including 200 adult dysplastic hips were randomly selected. Using the 3D CT-based software Hip-Op for surgical planning, the native hip anatomy was studied. Then, a single wedge tapered stem, an anatomical stem and a conical tapered stem were simulated in every hip. An adequate reconstruction of hip biomechanics was obtained when combined anteversion, offset restoration, coronal and sagittal tilt, canal filling and leg lengthening were inside the normal ranges. Results: Conical stems achieved the highest percentage of adequate reconstructions (87%, p < 0.0001). The anatomical stem was the worst performer. Single wedge and anatomical stem acceptability was mainly influenced by the combined anteversion. Stem anteversion was correlated with the femoral anteversion (fair correlation), the calcar femorale (fair) and the mediolateral femoral diameter at isthmus (poor). When the femoral anteversion was ≥ 25°, combined anteversion was very acceptable for the conical stem (99.2%), whereas the rate of acceptable combined anteversion for the single wedge tapered stem was 71.4%, and that for the anatomical stem was 51.6% (p < 0.0001). Conclusions: Stem choice in developmental hip dysplasia is mainly driven by appropriate combined anteversion, which is dependent on the coronal and axial femoral morphologies. As a rule of thumb, tapered stems are adequate when femoral anteversion is < 25°; conical stems should be adopted for higher anteversions. Level of evidence: IV.

21 January 2024 in Journal of Clinical Medicine
Verified
Journal Article
Open access
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FCFrancesco Castagnini
Francesco Castagnini
FPFrancesco Pardo
Francesco Pardo
SLStefano Lucchini
Stefano Lucchini
MRMarco Rotini
Marco Rotini
BCBruno Cavalieri
Bruno Cavalieri
Francesco TrainaFrancesco Traina
Francesco Traina
Cementless primary stems in revision hip arthroplasties may be conservative options to preserve bone stock and provide adequate reconstruction of the hip biomechanics. However, there is still little evidence about indications, limitations, and outcomes. This narrative review showed that conventional standard stems were adopted in different revision settings, up to Paprosky IIIA grade bone defects. In cases of acceptable metaphyseal bone stock, when a scratch fit of at least 4 cm can be achieved, a conventional cementless stem may be an adequate solution. Mid-term clinical and radiographic outcomes and survival rates were similar to long revision stems, whereas complications, surgical time, and costs were lower among conventional stems. However, unsuitable contexts for conventional stems included canal diameters larger than 18 mm and failed revision stems with cortical weakening. Even short stems can be considered in revisions, in order to preserve bone stock and stay proximal to femoral remodeling zones and bone/cement plugs. Short stems were successfully adopted up to Paprosky IIIA bone defects, achieving mid-term survival rates not inferior to long revision stems. Ageing, osteoporosis, and intraoperative femoral fractures were the main negative prognostic factors. In very select cases, a downsizing technique (from longer to shorter stems) may be adopted to simplify the procedure and reduce complications.

27 November 2023 in Journal of Clinical Medicine
Verified
Journal Article
Open access
PDF file
SLStefano Lucchini
Stefano Lucchini
FCFrancesco Castagnini
Francesco Castagnini
FPFrancesco Perdisa
Francesco Perdisa
GFGiuseppe Filardo
Giuseppe Filardo
FPFrancesco Pardo
Francesco Pardo
Francesco TrainaFrancesco Traina
Francesco Traina
Background: There is a paucity of data regarding the post-operative influence of total hip arthroplasty (THA) on the axial and coronal alignments of the ipsilateral knee. A CT study was designed to assess the post-THA changes in axial and coronal knee alignments in low-grade dysplastic hips. Methods: Forty Crowe I–II dysplastic hips in 37 patients were assessed: a pre-operative CT scan from the fourth lumbar vertebra to the tibial plateaus was compared to a similar post-operative CT scan performed after a minimum of 2 years after THA. Results: THA implantation caused significant post-operative changes in terms of the rotation height (2 mm lowering; p = 0.003); center of rotation medialization (10 mm medialization; p < 0.001); femoral offset (11 mm increase; p < 0.001); femoral antetorsion (22° internal rotation; p < 0.001), and hip internal rotation (9° internal rotation; p < 0.001). The femoral axis angle deviated in the valgus (5.5° ± 1.1°, p < 0.001) and the mechanical lateral distal femoral angle deviated in the varus (86° ± 2.7°, p = 0.001). The pelvic–tibial alignment changed from 88.2° ± 11.7° to 96° ± 9.3° (p < 0.001). Patellar alignment was not influenced. Conclusions: In conclusion, THA imposes significant changes in low-grade dysplastic hips: all the modifications tend to neutralize the coronal alignment and, mostly, the rotational alignment, without substantial and durable variations of the patellofemoral joint. Large clinical trials should confirm whether radiological changes impact anterior knee pain and patellar stability.

23 February 2026 in European Radiology Experimental
Verified
Journal Article
Open access
PDF file
MZMoreno Zanardo
Moreno Zanardo
Domenico AlbanoDomenico Albano
Domenico Albano
VMValentina Molinari
Valentina Molinari
RFRenato Fabrizio
Renato Fabrizio
MCMartina Conca
Martina Conca
LSLuca Maria Sconfienza
Luca Maria Sconfienza
Background: To compare the quality and clinical usefulness of large language model (LLM)-generated lumbar spine magnetic resonance imaging (MRI) reports with radiologist-written ones and assess whether medical professionals can distinguish between them. Materials and methods: This retrospective observational single-center study was approved by the local ethics committee. A total of 125 lumbar spine MRI reports (104 human-written, 21 LLM-generated using ChatGPT-4o) were anonymized, randomized, and blindly evaluated by five medical professionals (one board-certified radiologist, two radiology residents, one general practitioner, one orthopedic surgeon), all with basic familiarity with LLM. Each report was scored on a five-point Likert scale for clinical relevance, clarity, completeness, diagnostic accuracy, and intelligibility, whereas general practitioner and orthopedic surgeon evaluated intelligibility only. Evaluators also classified each report as AI-generated or human-written. Accuracy was defined as the proportion of correctly classified reports in distinguishing LLM-generated from radiologist-written texts. Mann-Whitney U or Student's t- tests were used. Results: Radiologists' reports consistently received higher median scores across all domains ( p < 0.001). No differences were found in the description of the imaging technique ( p > 0.175). No clinically false statements were identified in the LLM-generated reports. Identification accuracy varied widely among evaluators: Board-certified radiologist achieved 88.0% accuracy (sensitivity 66.7%, specificity 92.3%), Resident 1 65.6% (14.3%, 76.0%), Resident 2 94.4% (66.7%, 100%), orthopedic surgeon 78.4% (90.5%, 76.0%) and general practitioner 65.6% (81.0%, 62.5%). Conclusion: Radiologist-written lumbar spine MRI reports outperform LLM-generated reports in quality and structure. However, some AI-generated reports were indistinguishable from human ones, particularly for non-specialized readers. LLMs may support radiologists in structured reporting and improve workflow efficiency, while maintaining diagnostic reliability. Relevance statement: Large language models can draft lumbar spine MRI reports, but currently lack the quality and consistency of radiologist reports. With radiologist supervision, large language models may improve reporting efficiency while preserving diagnostic reliability and supporting clinical decision-making. Key Points: LLM-generated reports are clinically coherent and stylistically comparable to those written by expert radiologists. Radiologist-written reports scored significantly higher for clinical relevance, findings, and structure. LLM-generated reports were sometimes misclassified as human-written by clinicians. Graphical

1 June 2023 in Archives of orthopaedic and trauma surgery
Verified
Journal Article
Closed access
PDF file
FPFrancesco Pardo
Francesco Pardo
FGFederico Giardina
Federico Giardina
CACristina Ancarani
Cristina Ancarani
BBBarbara Bordini
Barbara Bordini
FCFrancesco Castagnini
Francesco Castagnini
Francesco TrainaFrancesco Traina
Francesco Traina

20 January 2021 in Journal of Materials Science: Materials in Medicine
Verified
Journal Article
Open access
PDF file
FPFrancesco Pardo
Francesco Pardo
BBBarbara Bordini
Barbara Bordini
FCFrancesco Castagnini
Francesco Castagnini
FGFederico Giardina
Federico Giardina
CFCesare Faldini
Cesare Faldini
FTFrancesco Traina
Francesco Traina
Background: Powder technology was developed to bring together the mechanical features and high porosity of titanium. However, the high porosity may theoretically compromise mechanical resistance. Literature is deficient about the use and safety profile of cementless femoral implants built using additive manufacturing (in particular electron beam melting technology, EBM). The purpose of this study was to evaluate the survival rates and the reason for revisions (especially implant breakage) of the first two EBM-built stems at a mid-term follow-up, using a joint arthroplasty registry. Methods: The registry of Prosthetic Orthopedic Implant (RIPO) was investigated about cementless stems implanted from 2010 to 2017. Stems built with EBM technology (Parva and Pulchra stems; Adler Ortho, Milan, Italy) were compared to all the other cementless stems implanted during the same period, acting as control group. The survival rates and reasons for revision were assessed. Results: No stem breakage occurred. At 5-year follow-up, the survival rates of the two cohorts were not statistically different (96.8% EBM stems, 98.0% standard cementless stems; p > 0.05). In the EBM stems, aseptic loosening occurred in 1.7% of the cases at the latest follow-up. Conclusions: This large cohort showed that mechanical resistance is not a concern in EBM stems at mid-term follow-up. However, larger populations and longer follow-ups are needed to further validate these results.