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Dr. Gasparri Roberto
Department of Thoracic Surgery, European Institute of Oncology, Via Giuseppe Ripamonti 435, 20141 Milan, Italy

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0 Lung
0 Lung Cancer
0 OMICS
0 early diagnosis
0 lung diseases

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Lung Cancer
early diagnosis
thoracic surgery

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Journal article
Published: 05 August 2021 in Chemosensors
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Lung cancer is characterized by a tremendously high mortality rate and a low 5-year survival rate when diagnosed at a late stage. Early diagnosis of lung cancer drastically reduces its mortality rate and improves survival. Exhaled breath analysis could offer a tool to clinicians to improve the ability to detect lung cancer at an early stage, thus leading to a reduction in the associated survival rate. In this paper, we present an electronic nose for the automatic analysis of exhaled breath. A total of five a-specific gas sensors were embedded in the electronic nose, making it sensitive to different volatile organic compounds (VOCs) contained in exhaled breath. Nine features were extracted from each gas sensor response to exhaled breath, identifying the subject breathprint. We tested the electronic nose on a cohort of 80 subjects, equally split between lung cancer and at-risk control subjects. Including gas sensor features and clinical features in a classification model, recall, precision, and accuracy of 78%, 80%, and 77% were reached using a fourfold cross-validation approach. The addition of other a-specific gas sensors, or of sensors specific to certain compounds, could improve the classification accuracy, therefore allowing for the development of a clinical tool to be integrated in the clinical pipeline for exhaled breath analysis and lung cancer early diagnosis.

ACS Style

Davide Marzorati; Luca Mainardi; Giulia Sedda; Roberto Gasparri; Lorenzo Spaggiari; Pietro Cerveri. MOS Sensors Array for the Discrimination of Lung Cancer and At-Risk Subjects with Exhaled Breath Analysis. Chemosensors 2021, 9, 209 .

AMA Style

Davide Marzorati, Luca Mainardi, Giulia Sedda, Roberto Gasparri, Lorenzo Spaggiari, Pietro Cerveri. MOS Sensors Array for the Discrimination of Lung Cancer and At-Risk Subjects with Exhaled Breath Analysis. Chemosensors. 2021; 9 (8):209.

Chicago/Turabian Style

Davide Marzorati; Luca Mainardi; Giulia Sedda; Roberto Gasparri; Lorenzo Spaggiari; Pietro Cerveri. 2021. "MOS Sensors Array for the Discrimination of Lung Cancer and At-Risk Subjects with Exhaled Breath Analysis." Chemosensors 9, no. 8: 209.

Perspective
Published: 16 April 2021 in Journal of Clinical Medicine
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Lung cancer is the leading cause of cancer deaths worldwide. Its early detection has the potential to significantly impact the burden of the disease. The screening and diagnostic techniques in current use suffer from limited specificity. The need therefore arises for a reliable biomarker to identify the disease earlier, which can be integrated into a test. This test would also allow for the recurrence risk after surgery to be stratified. In this context, urine could represent a non-invasive alternative matrix, with the urinary metabolomic profile offering a potential source for the discovery of diagnostic biomarkers. This paper aims to examine the current state of research and the potential for translation into clinical practice.

ACS Style

Roberto Gasparri; Giulia Sedda; Valentina Caminiti; Patrick Maisonneuve; Elena Prisciandaro; Lorenzo Spaggiari. Urinary Biomarkers for Early Diagnosis of Lung Cancer. Journal of Clinical Medicine 2021, 10, 1723 .

AMA Style

Roberto Gasparri, Giulia Sedda, Valentina Caminiti, Patrick Maisonneuve, Elena Prisciandaro, Lorenzo Spaggiari. Urinary Biomarkers for Early Diagnosis of Lung Cancer. Journal of Clinical Medicine. 2021; 10 (8):1723.

Chicago/Turabian Style

Roberto Gasparri; Giulia Sedda; Valentina Caminiti; Patrick Maisonneuve; Elena Prisciandaro; Lorenzo Spaggiari. 2021. "Urinary Biomarkers for Early Diagnosis of Lung Cancer." Journal of Clinical Medicine 10, no. 8: 1723.

Editorial
Published: 09 June 2020 in Journal of Clinical Medicine
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Starting from the work of Ulivi and colleagues, we aim to summarize the research area of biomarkers for early diagnosis and early stage lung cancer.

ACS Style

Roberto Gasparri; Giulia Sedda; Lorenzo Spaggiari. Biomarkers in Early Diagnosis and Early Stage Lung Cancer: The Clinician’s Point of View. Journal of Clinical Medicine 2020, 9, 1790 .

AMA Style

Roberto Gasparri, Giulia Sedda, Lorenzo Spaggiari. Biomarkers in Early Diagnosis and Early Stage Lung Cancer: The Clinician’s Point of View. Journal of Clinical Medicine. 2020; 9 (6):1790.

Chicago/Turabian Style

Roberto Gasparri; Giulia Sedda; Lorenzo Spaggiari. 2020. "Biomarkers in Early Diagnosis and Early Stage Lung Cancer: The Clinician’s Point of View." Journal of Clinical Medicine 9, no. 6: 1790.

Review
Published: 17 May 2020 in PROTEOMICS – Clinical Applications
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Objectives We summarized the current knowledge on proteomic biomarker analysis for the early diagnosis of lung cancer, underlining the diversity among the results and the current interest in translating research results into clinical practice. Methods We performed a MEDLINE®/PubMed® literature search to retrieve all the papers published in the last 10 years. Results Proteomics studies on lung cancer have gathered evidence on the potential role of biomarkers in early diagnosis. Although promising, none of them have proved to be sufficiently reliable to achieve validation. Conclusions Future research should evolve towards a multipanel analysis of proteins, considering the possibility that individual biomarkers might not be specific enough to diagnose lung cancer, but could be related to oncological conditions. This article is protected by copyright. All rights reserved

ACS Style

Roberto Gasparri; Giulia Sedda; Roberta Noberini; Tiziana Bonaldi; Lorenzo Spaggiari. Clinical Application of Mass Spectrometry‐Based Proteomics in Lung Cancer Early Diagnosis. PROTEOMICS – Clinical Applications 2020, 14, e1900138 .

AMA Style

Roberto Gasparri, Giulia Sedda, Roberta Noberini, Tiziana Bonaldi, Lorenzo Spaggiari. Clinical Application of Mass Spectrometry‐Based Proteomics in Lung Cancer Early Diagnosis. PROTEOMICS – Clinical Applications. 2020; 14 (5):e1900138.

Chicago/Turabian Style

Roberto Gasparri; Giulia Sedda; Roberta Noberini; Tiziana Bonaldi; Lorenzo Spaggiari. 2020. "Clinical Application of Mass Spectrometry‐Based Proteomics in Lung Cancer Early Diagnosis." PROTEOMICS – Clinical Applications 14, no. 5: e1900138.

Journal article
Published: 19 November 2019 in Journal of Clinical Medicine
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Background: Choriocarcinoma is a rare malignant disease that is usually associated with a gestational event. Lung metastasis with no evident primary origin and choriocarcinoma, which mimics features of non-small-cell lung cancer, might be misdiagnosed as adenocarcinoma or large-cell carcinoma. This is a pivotal clinical concern since the tumor can lead to various symptoms, seriously affecting the quality of life and can escalate rapidly, with a high mortality rate, compared to lung cancer. Methods: We reported a case of a 37-year-old woman with a history of one-year enhancement of beta-human chorionic gonadotropin levels and only a single nodule in the right upper lobe, with no abnormal findings on the gynecological investigation. Then we retrospectively examined all cases treated in the Division of Thoracic Surgery at the European Institute of Oncology in the last twenty years (from 1998 to 2018). Results: This was the first time in our experience that choriocarcinoma presentation was with a single nodule without a gynecological finding. Moreover, the differential diagnosis between lung carcinoma and choriocarcinoma was achieved only after surgical removal. Conclusions: As confirmed by our literature search, precise and expedited differential diagnosis is essential in choriocarcinoma care (both with single or multiple metastases), to successfully remove the tumor and increase the patient’s chances of survival.

ACS Style

Roberto Gasparri; Giulia Sedda; Daniela Brambilla; Lara Girelli; Cristina Diotti; Lorenzo Spaggiari. When a Differential Diagnosis Is Fundamental: Choriocarcinoma Mimicking Lung Carcinoma. Journal of Clinical Medicine 2019, 8, 2018 .

AMA Style

Roberto Gasparri, Giulia Sedda, Daniela Brambilla, Lara Girelli, Cristina Diotti, Lorenzo Spaggiari. When a Differential Diagnosis Is Fundamental: Choriocarcinoma Mimicking Lung Carcinoma. Journal of Clinical Medicine. 2019; 8 (11):2018.

Chicago/Turabian Style

Roberto Gasparri; Giulia Sedda; Daniela Brambilla; Lara Girelli; Cristina Diotti; Lorenzo Spaggiari. 2019. "When a Differential Diagnosis Is Fundamental: Choriocarcinoma Mimicking Lung Carcinoma." Journal of Clinical Medicine 8, no. 11: 2018.

Multicenter study
Published: 01 May 2019 in European Journal of Surgical Oncology
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Vascular injuries are among the most severe causes of unplanned conversion during VATS lobectomies. The study aimed to analyse the incidence of vascular injuries and their risk factors during VATS lobectomy. The Italian VATS lobectomy Registry was used to collect data from 66 Thoracic Surgery Units. From 2013 to October 2016 (out of more than 3,700 patients enrolled) only information from Units with an enrollment >100 VATS lobectomies were retrospectively analysed. Logistic regression analysis was performed on selected variables of the univariate analysis. Ten institutions contributed a total of 1,679 patients. Vascular injuries leading to conversion occurred in 44 (2.6%) patients. Years of experiences were inversely related to the risk of vascular injuries. Univariate analysis showed age, gender, surgical activity, Charlson Index Score and number of resected lymph nodes like significantly associated variables. Multivariate analysis revealed that number of resected lymph nodes, VATS experience ratio (number of VATS lobectomies/total lobectomies performed in the same year at same centre), and surgical activity of the centre were significantly associated with the risk of conversion. Unplanned thoracotomy was correlated with postoperative morbidity. Vascular injuries in VATS lobectomies represented a rare complication which could directly affect the postoperative outcomes. The predictive factors for conversion were multifactorial and depended on characteristics of centres and surgeons' seniority. Minimally invasive VATS lobectomy approaches did not influence the risk of vascular damages.

ACS Style

Luca Bertolaccini; Fabio Davoli; Alessandro Pardolesi; Jury Brandolini; Desideria Argnani; Alessandro Bertani; Andrea Droghetti; Alessandro Gonfiotti; Duilio Divisi; Roberto Crisci; Piergiorgio Solli; Mario Nosotti; Carlo Curcio; Dario Amore; Giuseppe Marulli; Samuele Nicotra; Andrea De Negri; Paola Maineri; Gaetano Di Rienzo; Camillo Lopez; Angelo Morelli; Francesco Londero; Lorenzo Spaggiari; Roberto Gasparri; Guido Baietto; Caterina Casadio; Maurizio Infante; Cristiano Benato; Marco Alloisio; Edoardo Bottoni; Giuseppe Cardillo; Francesco Carleo; Franco Stella; Giampiero Dolci; Francesco Puma; Damiano Vinci; Giorgio Cavallesco; Pio Maniscalco; Luca Ampollini; Paolo Carbognani; Alberto Terzi; Andrea Viti; Giampiero Negri; Alessandro Bandiera; Reinhold Perkmann; Francesco Zaraca; Claudio Andretti; Camilla Poggi; Felice Mucilli; Pierpaolo Camplese; Luca Luzzi; Marco Ghisalberti; Andrea Imperatori; Nicola Rotolo; Luigi Bortolotti; Giovanna Rizzardi; Massimo Torre; Alessandro Rinaldo; Armando Sabbatini; Majed Refai; Mauro Roberto Benvenuti; Diego Benetti; Alessandro Stefani; Pamela Natali; Paolo Lausi; Francesco Guerrera; Italian VATS Group. Conversion due to vascular injury during video-assisted thoracic surgery lobectomy: A multicentre retrospective analysis from the Italian video-assisted thoracic surgery group registry. European Journal of Surgical Oncology 2019, 45, 857 -862.

AMA Style

Luca Bertolaccini, Fabio Davoli, Alessandro Pardolesi, Jury Brandolini, Desideria Argnani, Alessandro Bertani, Andrea Droghetti, Alessandro Gonfiotti, Duilio Divisi, Roberto Crisci, Piergiorgio Solli, Mario Nosotti, Carlo Curcio, Dario Amore, Giuseppe Marulli, Samuele Nicotra, Andrea De Negri, Paola Maineri, Gaetano Di Rienzo, Camillo Lopez, Angelo Morelli, Francesco Londero, Lorenzo Spaggiari, Roberto Gasparri, Guido Baietto, Caterina Casadio, Maurizio Infante, Cristiano Benato, Marco Alloisio, Edoardo Bottoni, Giuseppe Cardillo, Francesco Carleo, Franco Stella, Giampiero Dolci, Francesco Puma, Damiano Vinci, Giorgio Cavallesco, Pio Maniscalco, Luca Ampollini, Paolo Carbognani, Alberto Terzi, Andrea Viti, Giampiero Negri, Alessandro Bandiera, Reinhold Perkmann, Francesco Zaraca, Claudio Andretti, Camilla Poggi, Felice Mucilli, Pierpaolo Camplese, Luca Luzzi, Marco Ghisalberti, Andrea Imperatori, Nicola Rotolo, Luigi Bortolotti, Giovanna Rizzardi, Massimo Torre, Alessandro Rinaldo, Armando Sabbatini, Majed Refai, Mauro Roberto Benvenuti, Diego Benetti, Alessandro Stefani, Pamela Natali, Paolo Lausi, Francesco Guerrera, Italian VATS Group. Conversion due to vascular injury during video-assisted thoracic surgery lobectomy: A multicentre retrospective analysis from the Italian video-assisted thoracic surgery group registry. European Journal of Surgical Oncology. 2019; 45 (5):857-862.

Chicago/Turabian Style

Luca Bertolaccini; Fabio Davoli; Alessandro Pardolesi; Jury Brandolini; Desideria Argnani; Alessandro Bertani; Andrea Droghetti; Alessandro Gonfiotti; Duilio Divisi; Roberto Crisci; Piergiorgio Solli; Mario Nosotti; Carlo Curcio; Dario Amore; Giuseppe Marulli; Samuele Nicotra; Andrea De Negri; Paola Maineri; Gaetano Di Rienzo; Camillo Lopez; Angelo Morelli; Francesco Londero; Lorenzo Spaggiari; Roberto Gasparri; Guido Baietto; Caterina Casadio; Maurizio Infante; Cristiano Benato; Marco Alloisio; Edoardo Bottoni; Giuseppe Cardillo; Francesco Carleo; Franco Stella; Giampiero Dolci; Francesco Puma; Damiano Vinci; Giorgio Cavallesco; Pio Maniscalco; Luca Ampollini; Paolo Carbognani; Alberto Terzi; Andrea Viti; Giampiero Negri; Alessandro Bandiera; Reinhold Perkmann; Francesco Zaraca; Claudio Andretti; Camilla Poggi; Felice Mucilli; Pierpaolo Camplese; Luca Luzzi; Marco Ghisalberti; Andrea Imperatori; Nicola Rotolo; Luigi Bortolotti; Giovanna Rizzardi; Massimo Torre; Alessandro Rinaldo; Armando Sabbatini; Majed Refai; Mauro Roberto Benvenuti; Diego Benetti; Alessandro Stefani; Pamela Natali; Paolo Lausi; Francesco Guerrera; Italian VATS Group. 2019. "Conversion due to vascular injury during video-assisted thoracic surgery lobectomy: A multicentre retrospective analysis from the Italian video-assisted thoracic surgery group registry." European Journal of Surgical Oncology 45, no. 5: 857-862.

Journal article
Published: 01 March 2019 in Clinical Lung Cancer
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Considering the acceptable morbidity and mortality rate and the long-term survival, PN should not be excluded for selected patients with stage IIIA-N2 NSCLC as a matter of principle.

ACS Style

Monica Casiraghi; Juliana Guarize; Alberto Sandri; Patrick Maisonneuve; Daniela Brambilla; Rosalia Romano; Domenico Galetta; Francesco Petrella; Roberto Gasparri; Cesare Gridelli; Filippo De Marinis; Lorenzo Spaggiari. Pneumonectomy in Stage IIIA-N2 NSCLC: Should It Be Considered After Neoadjuvant Chemotherapy? Clinical Lung Cancer 2019, 20, 97 -106.e1.

AMA Style

Monica Casiraghi, Juliana Guarize, Alberto Sandri, Patrick Maisonneuve, Daniela Brambilla, Rosalia Romano, Domenico Galetta, Francesco Petrella, Roberto Gasparri, Cesare Gridelli, Filippo De Marinis, Lorenzo Spaggiari. Pneumonectomy in Stage IIIA-N2 NSCLC: Should It Be Considered After Neoadjuvant Chemotherapy? Clinical Lung Cancer. 2019; 20 (2):97-106.e1.

Chicago/Turabian Style

Monica Casiraghi; Juliana Guarize; Alberto Sandri; Patrick Maisonneuve; Daniela Brambilla; Rosalia Romano; Domenico Galetta; Francesco Petrella; Roberto Gasparri; Cesare Gridelli; Filippo De Marinis; Lorenzo Spaggiari. 2019. "Pneumonectomy in Stage IIIA-N2 NSCLC: Should It Be Considered After Neoadjuvant Chemotherapy?" Clinical Lung Cancer 20, no. 2: 97-106.e1.

Letter
Published: 11 January 2019 in Surgical Innovation
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ACS Style

Giulia Sedda; Roberto Gasparri; Lorenzo Spaggiari. Comments on “Pilot Study: Detection of Gastric Cancer From Exhaled Air Analyzed With an Electronic Nose in Chinese Patients”. Surgical Innovation 2019, 26, 268 -269.

AMA Style

Giulia Sedda, Roberto Gasparri, Lorenzo Spaggiari. Comments on “Pilot Study: Detection of Gastric Cancer From Exhaled Air Analyzed With an Electronic Nose in Chinese Patients”. Surgical Innovation. 2019; 26 (2):268-269.

Chicago/Turabian Style

Giulia Sedda; Roberto Gasparri; Lorenzo Spaggiari. 2019. "Comments on “Pilot Study: Detection of Gastric Cancer From Exhaled Air Analyzed With an Electronic Nose in Chinese Patients”." Surgical Innovation 26, no. 2: 268-269.

Journal article
Published: 01 December 2018 in Shanghai Chest
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ACS Style

Roberto Gasparri; Giulia Sedda; Lorenzo Spaggiari. Volatile organic compounds and lung cancer: a tight link useful for diagnosis. Shanghai Chest 2018, 2, 95 -95.

AMA Style

Roberto Gasparri, Giulia Sedda, Lorenzo Spaggiari. Volatile organic compounds and lung cancer: a tight link useful for diagnosis. Shanghai Chest. 2018; 2 ():95-95.

Chicago/Turabian Style

Roberto Gasparri; Giulia Sedda; Lorenzo Spaggiari. 2018. "Volatile organic compounds and lung cancer: a tight link useful for diagnosis." Shanghai Chest 2, no. : 95-95.

Letter
Published: 10 September 2018 in Sensors
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New interest has grown in the respiratory disorder diagnosis and monitoring, throughout electronic nose technologies. This technology has several advantages compared to classic approach. In this short letter, we aim to emphasize electronic nose role in respiratory medicine.

ACS Style

Roberto Gasparri; Giulia Sedda; Lorenzo Spaggiari. The Electronic Nose’s Emerging Role in Respiratory Medicine. Sensors 2018, 18, 3029 .

AMA Style

Roberto Gasparri, Giulia Sedda, Lorenzo Spaggiari. The Electronic Nose’s Emerging Role in Respiratory Medicine. Sensors. 2018; 18 (9):3029.

Chicago/Turabian Style

Roberto Gasparri; Giulia Sedda; Lorenzo Spaggiari. 2018. "The Electronic Nose’s Emerging Role in Respiratory Medicine." Sensors 18, no. 9: 3029.

Multicenter study
Published: 20 March 2018 in European Journal of Cardio-Thoracic Surgery
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Based on the VATS Group data, video-assisted thoracic surgery LA proved to be safe and displayed good outcomes even when performed with an extended approach.

ACS Style

Alessandro Gonfiotti; Alessandro Bertani; Mario Nosotti; Domenico Viggiano; Stefano Bongiolatti; Luca Bertolaccini; Andrea Droghetti; Piergiorgio Solli; Roberto Crisci; Luca Voltolini; Carlo Curcio; Dario Amore; Giuseppe Marulli; Samuele Nicotra; Andrea De Negri; Paola Maineri; Gaetano Di Rienzo; Camillo Lopez; Duilio Divisi; Angelo Morelli; Emanuele Russo; Francesco Londero; Lorenzo Rosso; Lorenzo Spaggiari; Roberto Gasparri; Guido Baietto; Caterina Casadio; Maurizio Infante; Cristiano Benato; Marco Alloisio; Edoardo Bottoni; Andrea Giovanardi; Giuseppe Cardillo; Francesco Carleo; Franco Stella; Giampiero Dolci; Francesco Puma; Damiano Vinci; Giorgio Cavallesco; Pio Maniscalco; Desideria Argnani; Luca Ampollini; Paolo Carbognani; Alberto Terzi; Andrea Viti; Giampiero Negri; Alessandro Bandiera; Reinhold Perkmann; Francesco Zaraca; Mohsen Ibrahim; Camilla Poggi; Felice Mucilli; Pierpaolo Camplese; Luca Luzzi; Marco Ghisalberti; Andrea Imperatori; Nicola Rotolo; Luigi Bortolotti; Giovanna Rizzardi; Massimo Torre; Alessandro Rinaldo; Armando Sabbatini; Majed Refai; Mauro Roberto Benvenuti; Diego Benetti; Alessandro Stefani; Pamela Natali; Paolo Lausi; Francesco Guerrera; Italian VATS Group. Safety of lymphadenectomy during video-assisted thoracic surgery lobectomy: analysis from a national database†. European Journal of Cardio-Thoracic Surgery 2018, 54, 664 -670.

AMA Style

Alessandro Gonfiotti, Alessandro Bertani, Mario Nosotti, Domenico Viggiano, Stefano Bongiolatti, Luca Bertolaccini, Andrea Droghetti, Piergiorgio Solli, Roberto Crisci, Luca Voltolini, Carlo Curcio, Dario Amore, Giuseppe Marulli, Samuele Nicotra, Andrea De Negri, Paola Maineri, Gaetano Di Rienzo, Camillo Lopez, Duilio Divisi, Angelo Morelli, Emanuele Russo, Francesco Londero, Lorenzo Rosso, Lorenzo Spaggiari, Roberto Gasparri, Guido Baietto, Caterina Casadio, Maurizio Infante, Cristiano Benato, Marco Alloisio, Edoardo Bottoni, Andrea Giovanardi, Giuseppe Cardillo, Francesco Carleo, Franco Stella, Giampiero Dolci, Francesco Puma, Damiano Vinci, Giorgio Cavallesco, Pio Maniscalco, Desideria Argnani, Luca Ampollini, Paolo Carbognani, Alberto Terzi, Andrea Viti, Giampiero Negri, Alessandro Bandiera, Reinhold Perkmann, Francesco Zaraca, Mohsen Ibrahim, Camilla Poggi, Felice Mucilli, Pierpaolo Camplese, Luca Luzzi, Marco Ghisalberti, Andrea Imperatori, Nicola Rotolo, Luigi Bortolotti, Giovanna Rizzardi, Massimo Torre, Alessandro Rinaldo, Armando Sabbatini, Majed Refai, Mauro Roberto Benvenuti, Diego Benetti, Alessandro Stefani, Pamela Natali, Paolo Lausi, Francesco Guerrera, Italian VATS Group. Safety of lymphadenectomy during video-assisted thoracic surgery lobectomy: analysis from a national database†. European Journal of Cardio-Thoracic Surgery. 2018; 54 (4):664-670.

Chicago/Turabian Style

Alessandro Gonfiotti; Alessandro Bertani; Mario Nosotti; Domenico Viggiano; Stefano Bongiolatti; Luca Bertolaccini; Andrea Droghetti; Piergiorgio Solli; Roberto Crisci; Luca Voltolini; Carlo Curcio; Dario Amore; Giuseppe Marulli; Samuele Nicotra; Andrea De Negri; Paola Maineri; Gaetano Di Rienzo; Camillo Lopez; Duilio Divisi; Angelo Morelli; Emanuele Russo; Francesco Londero; Lorenzo Rosso; Lorenzo Spaggiari; Roberto Gasparri; Guido Baietto; Caterina Casadio; Maurizio Infante; Cristiano Benato; Marco Alloisio; Edoardo Bottoni; Andrea Giovanardi; Giuseppe Cardillo; Francesco Carleo; Franco Stella; Giampiero Dolci; Francesco Puma; Damiano Vinci; Giorgio Cavallesco; Pio Maniscalco; Desideria Argnani; Luca Ampollini; Paolo Carbognani; Alberto Terzi; Andrea Viti; Giampiero Negri; Alessandro Bandiera; Reinhold Perkmann; Francesco Zaraca; Mohsen Ibrahim; Camilla Poggi; Felice Mucilli; Pierpaolo Camplese; Luca Luzzi; Marco Ghisalberti; Andrea Imperatori; Nicola Rotolo; Luigi Bortolotti; Giovanna Rizzardi; Massimo Torre; Alessandro Rinaldo; Armando Sabbatini; Majed Refai; Mauro Roberto Benvenuti; Diego Benetti; Alessandro Stefani; Pamela Natali; Paolo Lausi; Francesco Guerrera; Italian VATS Group. 2018. "Safety of lymphadenectomy during video-assisted thoracic surgery lobectomy: analysis from a national database†." European Journal of Cardio-Thoracic Surgery 54, no. 4: 664-670.

Editorial
Published: 09 February 2018 in Journal of Clinical Medicine
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With this Editorial we want to present the Special Issue “Big Data and Precision Medicine Series I: Lung Cancer Early Diagnosis” to the scientific community, which aims to gather experts on the early detection of lung cancer in order to implement common efforts in the fight against cancer.

ACS Style

Roberto Gasparri; Giulia Sedda; Lorenzo Spaggiari. Comment from the Editor to the Special Issue: “Big Data and Precision Medicine Series I: Lung Cancer Early Diagnosis”. Journal of Clinical Medicine 2018, 7, 28 .

AMA Style

Roberto Gasparri, Giulia Sedda, Lorenzo Spaggiari. Comment from the Editor to the Special Issue: “Big Data and Precision Medicine Series I: Lung Cancer Early Diagnosis”. Journal of Clinical Medicine. 2018; 7 (2):28.

Chicago/Turabian Style

Roberto Gasparri; Giulia Sedda; Lorenzo Spaggiari. 2018. "Comment from the Editor to the Special Issue: “Big Data and Precision Medicine Series I: Lung Cancer Early Diagnosis”." Journal of Clinical Medicine 7, no. 2: 28.

Video audio media
Published: 01 January 2018 in Seminars in Thoracic and Cardiovascular Surgery
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We evaluated principal risk factors and different therapeutic approaches for post-pneumonectomy bronchopleural fistula (BPF), focusing on open-window thoracostomy (OWT). We retrospectively reviewed all patients treated by pneumonectomy for lung cancer from 1999 to 2014; we evaluated preoperative, operative, and postoperative data; time between operation; and fistula formation, size, treatment, and predicting factors of BPF. Cumulative incidence curves for the development of BPF were drawn according to the Kaplan-Meier method. Differences between groups were assessed with the log rank test. Multivariable Cox proportional hazards regression analysis was used to assess the independent risk factors for BPF. P values <0.05 were considered significant. BPF occurred in 60 of 733 patients (8.2%). Bronchial suture with Stapler (EndoGia) (P = 0.02), right side (P = 0.003), and low preoperative albumin levels (< 3.5 g/dL) (P = 0.02) were independent predicting factors of fistula. Early BPF was treated by thoracotomic (12) or thoracoscopic (2) debridement of necrotic tissue and BPF surgical repair. Late BPF was treated by bronchoscopic application of fibrin glue (3) or endobronchial stent (1), chest tube and cavity irrigation by povidone-iodine (15). OWT was performed in 27 patients, followed by muscle flap interposition in 7 of these 27. The survival time of patients after the treatment of BPF was 29.0 months. The overall survival of patients treated by OWT was 50% at 2 years and 27 (8%) at 4 years. Correct management of BPF depends on several factors. In case of failure of different initial therapeutic approaches, we could consider OWT, followed by myoplasty.

ACS Style

Antonio Mazzella; Alessandro Pardolesi; Patrick Maisonneuve; Francesco Petrella; Domenico Galetta; Roberto Gasparri; Lorenzo Spaggiari. Bronchopleural Fistula After Pneumonectomy: Risk Factors and Management, Focusing on Open-Window Thoracostomy. Seminars in Thoracic and Cardiovascular Surgery 2018, 30, 104 -113.

AMA Style

Antonio Mazzella, Alessandro Pardolesi, Patrick Maisonneuve, Francesco Petrella, Domenico Galetta, Roberto Gasparri, Lorenzo Spaggiari. Bronchopleural Fistula After Pneumonectomy: Risk Factors and Management, Focusing on Open-Window Thoracostomy. Seminars in Thoracic and Cardiovascular Surgery. 2018; 30 (1):104-113.

Chicago/Turabian Style

Antonio Mazzella; Alessandro Pardolesi; Patrick Maisonneuve; Francesco Petrella; Domenico Galetta; Roberto Gasparri; Lorenzo Spaggiari. 2018. "Bronchopleural Fistula After Pneumonectomy: Risk Factors and Management, Focusing on Open-Window Thoracostomy." Seminars in Thoracic and Cardiovascular Surgery 30, no. 1: 104-113.

Accepted manuscript
Published: 16 October 2017 in Journal of Breath Research
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Lung cancer is the leading cause of death for neoplasm. The lung cancer mortality is frequently associated with late diagnosis, therefore an early diagnosis is a key factor to significantly improve overall survival in high risk populations of asymptomatic patients. Conventional cancer screenings (low-dose computed tomography or chest x-ray) today offers early detection but are invasive and expensive. Up to date these studies evaluated the solid and topographic cancer structure and morphology. Today the concept of tumor has been remodeled and it has been defined as a disease that has its own genetic, biological and metabolic identity and on this new awareness we should base the new screening methods. Recent research has shown great reliability of new tests as exhaled breath analysis, serum biomarkers and urine analysis in early diagnosis of lung cancer. The analysis of new biomarkers associated with a high specificity of this new screening methods, that are non-invasive, safety, inexpensive and simple to perform, could allow a non-invasive approach that can determine a big change in the early diagnosis of cancer and survival rate. Furthermore, these new techniques put the patient at the core of a non-invasive diagnostic process and let to ensure a better quality of life during medical diagnosis. In this article, we want to analyze the possible benefits of these new and promising methods, suggesting a possible combination between them, to ensure, as soon as possible, an early and effective diagnosis of lung cancer with a special focus on the patient, in a new era of personalized medicine.

ACS Style

Roberto Gasparri; Rosalia Romano; Giulia Sedda; Alessandro Borri; Francesco Petrella; Domenico Galetta; Monica Casiraghi; Lorenzo Spaggiari. Diagnostic biomarkers for lung cancer prevention. Journal of Breath Research 2017, 12, 027111 .

AMA Style

Roberto Gasparri, Rosalia Romano, Giulia Sedda, Alessandro Borri, Francesco Petrella, Domenico Galetta, Monica Casiraghi, Lorenzo Spaggiari. Diagnostic biomarkers for lung cancer prevention. Journal of Breath Research. 2017; 12 (2):027111.

Chicago/Turabian Style

Roberto Gasparri; Rosalia Romano; Giulia Sedda; Alessandro Borri; Francesco Petrella; Domenico Galetta; Monica Casiraghi; Lorenzo Spaggiari. 2017. "Diagnostic biomarkers for lung cancer prevention." Journal of Breath Research 12, no. 2: 027111.

Withdrawal
Published: 01 June 2017 in The Journal of Thoracic and Cardiovascular Surgery
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This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal.

ACS Style

Antonio Mazzella; Alessandro Pardolesi; Patrick Maisonneuve; Francesco Petrella; Domenico Galetta; Roberto Gasparri; Lorenzo Spaggiari. WITHDRAWN: Bronchopleural fistula after pneumonectomy: Risk factors and management, focusing on open window thoracostomy. The Journal of Thoracic and Cardiovascular Surgery 2017, 1 .

AMA Style

Antonio Mazzella, Alessandro Pardolesi, Patrick Maisonneuve, Francesco Petrella, Domenico Galetta, Roberto Gasparri, Lorenzo Spaggiari. WITHDRAWN: Bronchopleural fistula after pneumonectomy: Risk factors and management, focusing on open window thoracostomy. The Journal of Thoracic and Cardiovascular Surgery. 2017; ():1.

Chicago/Turabian Style

Antonio Mazzella; Alessandro Pardolesi; Patrick Maisonneuve; Francesco Petrella; Domenico Galetta; Roberto Gasparri; Lorenzo Spaggiari. 2017. "WITHDRAWN: Bronchopleural fistula after pneumonectomy: Risk factors and management, focusing on open window thoracostomy." The Journal of Thoracic and Cardiovascular Surgery , no. : 1.

Journal article
Published: 01 January 2017 in Journal of Thoracic Oncology
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Domenico Galetta; Alessandro Borri; Roberto Gasparri; Francesco Petrella; Lorenzo Spaggiari. P1.08-024 Surgical Outcomes and Prognostic Factors in the Treatment of Adenosquamous Carcinoma of the Lung. Journal of Thoracic Oncology 2017, 12, S745 .

AMA Style

Domenico Galetta, Alessandro Borri, Roberto Gasparri, Francesco Petrella, Lorenzo Spaggiari. P1.08-024 Surgical Outcomes and Prognostic Factors in the Treatment of Adenosquamous Carcinoma of the Lung. Journal of Thoracic Oncology. 2017; 12 (1):S745.

Chicago/Turabian Style

Domenico Galetta; Alessandro Borri; Roberto Gasparri; Francesco Petrella; Lorenzo Spaggiari. 2017. "P1.08-024 Surgical Outcomes and Prognostic Factors in the Treatment of Adenosquamous Carcinoma of the Lung." Journal of Thoracic Oncology 12, no. 1: S745.

Journal article
Published: 01 January 2017 in Journal of Thoracic Oncology
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ACS Style

Domenico Galetta; Alessandro Borri; Roberto Gasparri; Francesco Petrella; Lorenzo Spaggiari. P1.08-031 Non-Small Cell Lung Cancer in Patients Aged 40 Years or Younger: Clinical, Surgical, and Long-Term Outcomes. Journal of Thoracic Oncology 2017, 12, S749 -S750.

AMA Style

Domenico Galetta, Alessandro Borri, Roberto Gasparri, Francesco Petrella, Lorenzo Spaggiari. P1.08-031 Non-Small Cell Lung Cancer in Patients Aged 40 Years or Younger: Clinical, Surgical, and Long-Term Outcomes. Journal of Thoracic Oncology. 2017; 12 (1):S749-S750.

Chicago/Turabian Style

Domenico Galetta; Alessandro Borri; Roberto Gasparri; Francesco Petrella; Lorenzo Spaggiari. 2017. "P1.08-031 Non-Small Cell Lung Cancer in Patients Aged 40 Years or Younger: Clinical, Surgical, and Long-Term Outcomes." Journal of Thoracic Oncology 12, no. 1: S749-S750.

Journal article
Published: 01 January 2017 in Journal of Thoracic Oncology
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Domenico Galetta; Alessandro Borri; Roberto Gasparri; Francesco Petrella; Lorenzo Spaggiari. P1.08-082 Surgical Techniques and Long-Term Results of the Pulmonary Artery Reconstruction in Patients with Lung Cancer. Journal of Thoracic Oncology 2017, 12, S781 .

AMA Style

Domenico Galetta, Alessandro Borri, Roberto Gasparri, Francesco Petrella, Lorenzo Spaggiari. P1.08-082 Surgical Techniques and Long-Term Results of the Pulmonary Artery Reconstruction in Patients with Lung Cancer. Journal of Thoracic Oncology. 2017; 12 (1):S781.

Chicago/Turabian Style

Domenico Galetta; Alessandro Borri; Roberto Gasparri; Francesco Petrella; Lorenzo Spaggiari. 2017. "P1.08-082 Surgical Techniques and Long-Term Results of the Pulmonary Artery Reconstruction in Patients with Lung Cancer." Journal of Thoracic Oncology 12, no. 1: S781.

Journal article
Published: 01 January 2017 in Journal of Thoracic Oncology
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ACS Style

Domenico Galetta; Alessandro Borri; Roberto Gasparri; Francesco Petrella; Lorenzo Spaggiari. P1.08-080 Bilobectomy for Lung Cancer: Analysis of Indications, Postoperative Results and Long-term Outcomes. Journal of Thoracic Oncology 2017, 12, S780 .

AMA Style

Domenico Galetta, Alessandro Borri, Roberto Gasparri, Francesco Petrella, Lorenzo Spaggiari. P1.08-080 Bilobectomy for Lung Cancer: Analysis of Indications, Postoperative Results and Long-term Outcomes. Journal of Thoracic Oncology. 2017; 12 (1):S780.

Chicago/Turabian Style

Domenico Galetta; Alessandro Borri; Roberto Gasparri; Francesco Petrella; Lorenzo Spaggiari. 2017. "P1.08-080 Bilobectomy for Lung Cancer: Analysis of Indications, Postoperative Results and Long-term Outcomes." Journal of Thoracic Oncology 12, no. 1: S780.

Journal article
Published: 01 January 2017 in Journal of Thoracic Oncology
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Extrapleural pneumonectomy (EPP) with resection of pericardium and diaphragm offers acceptable therapeutic results in patients with mesothelioma. We analyzed efficacy of biological bovine pericardial patch (BPP) versus artificial materials (Marlex/Goretex, Vicryl) for diaphragmatic and pericardial reconstruction after EPP.

ACS Style

Domenico Galetta; Alessandro Borri; Roberto Gasparri; Francesco Petrella; Lorenzo Spaggiari. P3.03-059 Diaphragmatic and Pericardial Reconstruction by Heterologous Pericardial Patch after Extrapleural Pneumonectomy for Mesothelioma. Journal of Thoracic Oncology 2017, 12, S1381 -S1382.

AMA Style

Domenico Galetta, Alessandro Borri, Roberto Gasparri, Francesco Petrella, Lorenzo Spaggiari. P3.03-059 Diaphragmatic and Pericardial Reconstruction by Heterologous Pericardial Patch after Extrapleural Pneumonectomy for Mesothelioma. Journal of Thoracic Oncology. 2017; 12 (1):S1381-S1382.

Chicago/Turabian Style

Domenico Galetta; Alessandro Borri; Roberto Gasparri; Francesco Petrella; Lorenzo Spaggiari. 2017. "P3.03-059 Diaphragmatic and Pericardial Reconstruction by Heterologous Pericardial Patch after Extrapleural Pneumonectomy for Mesothelioma." Journal of Thoracic Oncology 12, no. 1: S1381-S1382.