Female leadership plays a crucial role in organizations through improving performance and productivity and allowing businesses to achieve better results. Unfortunately, the number of women in leadership positions in business is still behind that of men, and progress is relatively slow. This study aims to determine the effect of external factors, such as family responsibility and networking, and internal factors, such as assertiveness, on female leadership aspirations. The research used quantitative research methods, with the sample being women within the reproductive age range in Indonesia. This study involved 258 female respondents. The data analysis used the partial least squares structural equation model (PLS-SEM) approach, using SmartPLS. The results of this study show that family responsibility has a significant negative effect on female leadership aspirations, while assertiveness has a significant positive effect, as does networking.