We study the potential of infrared (IR) heaters in combination with IR reflective walls to reduce heating energy demand in buildings. Using IR heaters increases radiant temperature. Combined with IR reflective walls, less radiant heat is absorbed by the surrounding walls, and more is reflected to and absorbed by the occupants. This allows for lower air temperatures while maintaining constant thermal comfort. Lower air temperatures result in heating energy savings. In simulations, we examine the impact of four parameters on the thermal comfort indicator Predicted Mean Vote (PMV): wall temperature, inlet air temperature, IR heater power, and IR emissivity of the walls. To reduce the number of data points needed, we use a Central Composite Design for the layout of the simulation plan. The results show that the PMV can be changed from 0.15 to 1.16 only by lowering the emissivity of the surrounding walls from 0.9 to 0.1. At high IR heater power and at low wall temperature the impact of the emissivity on the PMV becomes larger. From the simulation data, we derive a response surface function to determine the required IR heating power for any given room conditions, which could be used for automated IR heater control.