Zhanar Akhmetkarimova

Prof. Dr. Zhanar Akhmetkarimova

orcid

Research Focus & Metrics

Academic Career Length

15Years (2012-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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7 December 2022 in Polymers
Verified
Journal Article
Open access
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MSMadina Sarsenova
Madina Sarsenova
YRYerik Raimagambetov
Yerik Raimagambetov
AIAssel Issabekova
Assel Issabekova
MKMiras Karzhauov
Miras Karzhauov
GKGulshakhar Kudaibergen
Gulshakhar Kudaibergen
Vyacheslav OgayVyacheslav Ogay
Vyacheslav Ogay
The regeneration of cartilage and osteochondral defects remains one of the most challenging clinical problems in orthopedic surgery. Currently, tissue-engineering techniques based on the delivery of appropriate growth factors and mesenchymal stem cells (MSCs) in hydrogel scaffolds are considered as the most promising therapeutic strategy for osteochondral defects regeneration. In this study, we fabricated a heparin-conjugated fibrin (HCF) hydrogel with synovium-derived mesenchymal stem cells (SDMSCs), transforming growth factor-β1 (TGF-β1) and bone morphogenetic protein-4 (BMP-4) to repair osteochondral defects in a rabbit model. An in vitro study showed that HCF hydrogel exhibited good biocompatibility, a slow degradation rate and sustained release of TGF-β1 and BMP-4 over 4 weeks. Macroscopic and histological evaluations revealed that implantation of HCF hydrogel with SDMSCs, TGF-β1 and BMP-4 significantly enhanced the regeneration of hyaline cartilage and the subchondral bone plate in osteochondral defects within 12 weeks compared to hydrogels with SDMSCs or growth factors alone. Thus, these data suggest that combined delivery of SDMSCs with TGF-β1 and BMP-4 in HCF hydrogel may synergistically enhance the therapeutic efficacy of osteochondral defect repair of the knee joints.

2 April 2026 in Frontiers in Bioengineering and Biotechnology
Verified
Journal Article
Open access
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AAA. Atepileva
A. Atepileva
GKG. Kudaibergen
G. Kudaibergen
TKT. Krivoruchko
T. Krivoruchko
AZA. Zhulikeyeva
A. Zhulikeyeva
NAN. Amantay
N. Amantay
YAY. Alzhanov
Y. Alzhanov
Polysaccharides are renewable biopolymers widely used in biomedical and food systems because of their structural diversity, biodegradability, and biocompatibility. This review summarizes recent progress in the use of major polysaccharides, including alginate, chitosan, gellan gum, heparin, and cellulose, in drug delivery, tissue engineering, and food-related applications. Particular attention is given to structure function relationships, controlled release behavior, bioactivity, and material performance in sustainable packaging and functional food design. Current limitations related to processing, stability, and regulatory translation are also discussed. Overall, polysaccharide-based materials provide versatile platforms for the development of safer medical technologies and sustainable food systems.

18 September 2024 in Biomedicines
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Journal Article
Open access
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AAAliya Atepileva
Aliya Atepileva
Vyacheslav OgayVyacheslav Ogay
Vyacheslav Ogay
GKGulshakhar Kudaibergen
Gulshakhar Kudaibergen
GKGuldarigash Kaukabayeva
Guldarigash Kaukabayeva
ANAssiya Nurkina
Assiya Nurkina
ZAZhanar Akhmetkarimova
Zhanar Akhmetkarimova
Chronic wounds complicated by infection pose significant clinical challenges, necessitating comprehensive treatment approaches. The widespread use of antibiotics has led to resistant microorganisms, complicating traditional therapies. This study aims to develop and evaluate modified alginate wound dressings with enhanced antimicrobial and regenerative properties. Alginate dressings were synthesized with silver nanoparticles, cefepime, and fibroblast growth factor-2 (FGF-2). The two-stage therapy involved an initial antibacterial dressing followed by a regenerative dressing. In vitro tests demonstrated high antibacterial activity, with maximum inhibition zones for P. aeruginosa (41.3 ± 0.4 mm) and S. aureus (36.6 ± 1.8 mm). In vivo studies on rats with purulent wounds showed significant healing progression in the experimental group. Histological analysis revealed complete re-epithelialization, thicker neoepithelium, dense collagen deposition, and minimal inflammation in treated wounds. These findings suggest that the modified alginate dressings significantly enhance the reparative process and are promising for treating chronic infected wounds in both veterinary and medical practices.

1 April 2012 in Russian Journal of General Chemistry
Verified
Journal Article
Closed access
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SFS. D. Fazylov
S. D. Fazylov
NANurkenov Oralgazy Aktaevich
Nurkenov Oralgazy Aktaevich
ZAZhanar Akhmetkarimova
Zhanar Akhmetkarimova
DZD. R. Zhienbaeva
D. R. Zhienbaeva

22 June 2023 in Journal of Materials Science
Verified
Journal Article
Closed access
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GKGulshakhar Kudaibergen
Gulshakhar Kudaibergen
ZAZhanar Akhmetkarimova
Zhanar Akhmetkarimova
EYErtan Yildirim
Ertan Yildirim
Murat BaidarbekovMurat Baidarbekov
Murat Baidarbekov

1 September 2016 in Solid Fuel Chemistry
Verified
Journal Article
Closed access
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ZAZhanar Akhmetkarimova
Zhanar Akhmetkarimova
MBM. I. Baikenov
M. I. Baikenov
FMFeng-Yun Ma
Feng-Yun Ma