A gas chromatography coupled with mass spectrometry (GC/MS) method for the simultaneous determination of chlorpromazine and diazepam in pork samples, which are two of the most often used antipsychotics, has been developed and validated. The samples were prepared and purified by solid-phase extraction (SPE), and then were analyzed by GC/MS. Chromatography was performed using an HP-5 MS 5% phenyl–95% methylpolysiloxane fused silica capillary column (30 m × 0.25 mm; film thickness 0.25 μm). The method had a linear calibration curve over the range 10–500 ng mL⁻¹ (r > 0.99), recovery (>66.5% for chlorpromazine and >77.4% for diazepam), precision (%RSD < 11.5% for chlorpromazine and <9.5% for diazepam). The limit of quantification for both chlorpromazine and diazepam was 2.0 μg kg⁻¹. This method can result in faster analysis, lower solvent consumption and less workload per sample while maintaining or even improving sensitivity.

The purpose of this research was to determine the occurrence of 15 + 1 European priority polycyclic aromatic hydrocarbons (EUPAHs) in various types of tea purchased on Hangzhou city market in China in order to control their safety. The results indicated that the incidence rate of EUPAHs compounds was 97.4%. The total EUPAHs levels ranged from 1.2 μg/kg to 155.6 μg/kg, with a median of 27.1 μg/kg and a mean of 42.3 μg/kg. Cyclopental[cd]pyrene was not only the most frequently detected EUPAH but also detected at the highest concentrations with a mean of 12.2 μg/kg. The 4-membered and 5-membered ring EUPAHs were detected in nearly all of the tea types and accounted for 83.4% to 100.0% of the total EUPAHs mass distribution. The transfer percentages of EUPAHs from the various tea leaves to tea infusions and effect of infusion time were investigated as well. A transfer rate between 5.9% and 24.2% was found for the EUPAHs and these levels were within the maximum safe consumption limits for drinking water according to European Union regulations (EU Council Directive 98/83/EC).