Jakub Soja

Mr. Jakub Soja

orcid

Research Focus & Metrics

Academic Career Length

5Years (2022-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

View All Publications
20 June 2024 in Metabolites
Verified
Journal Article
Open access
PDF file
AZAgnieszka Ziółkiewicz
Agnieszka Ziółkiewicz
Przemysław Jan NizińskiPrzemysław Jan Niziński
Przemysław Jan Niziński
JSJakub Soja
Jakub Soja
TOTomasz Oniszczuk
Tomasz Oniszczuk
MCMaciej Combrzyński
Maciej Combrzyński
Anna OniszczukAnna Oniszczuk
Anna Oniszczuk
Chlorogenic acid (CGA) is a natural polyphenol found in coffee, tea, vegetables, and fruits. It exhibits strong antioxidant activity and possesses several other biological properties, including anti-inflammatory effects, antimicrobial activity, and insulin-sensitizing properties. Moreover, it may improve lipid and glucose metabolism. This review summarizes the available information on the therapeutic effect of CGA in metabolic dysfunction-associated steatotic liver disease (MASLD). As the literature search engine, the browsers in the PubMed, Scopus, Web of Science databases, and ClinicalTrials.gov register were used. Animal trials and clinical studies suggest that CGA has promising therapeutic potential in treating MASLD and hepatic steatosis. Its mechanisms of action include antioxidant, anti-inflammatory, and anti-apoptotic effects via the activation of the Nrf2 signaling pathway and the inhibition of the TLR4/NF-κB signaling cascade. Furthermore, the alleviation of liver disease by CGA also involves other important molecules such as AMPK and important physiological processes such as the intestinal barrier and gut microbiota. Nevertheless, the specific target cell and key molecule to which CGA is directed remain unidentified and require further study.

24 July 2025 in Molecules
Verified
Journal Article
Open access
PDF file
Przemysław Jan NizińskiPrzemysław Jan Niziński
Przemysław Jan Niziński
AHAnna M. Hawrył
Anna M. Hawrył
PPPaweł Polak
Paweł Polak
AKAdrianna Kondracka
Adrianna Kondracka
TOTomasz Oniszczuk
Tomasz Oniszczuk
Anna OniszczukAnna Oniszczuk
Anna Oniszczuk
Quercetin (QE) is a naturally occurring flavonoid found in many fruits, vegetables, and other plant-based foods. It is recognized for its diverse pharmacological activities. Among its many therapeutic potentials, its antidiabetic properties are of particular interest due to the growing worldwide prevalence of diabetes mellitus. QE improves glycemic control by enhancing insulin sensitivity, stimulating glucose uptake, and preserving pancreatic beta cell function. These effects are mediated by the modulation of key molecular pathways, including AMPK, PI3K/Akt, and Nrf2/ARE, as well as by the suppression of oxidative stress and pro-inflammatory cytokines, such as TNF-α and IL-6. Furthermore, QE mitigates the progression of diabetic complications such as nephropathy, retinopathy, and vascular dysfunction, reducing lipid peroxidation and protecting endothelial function. However, the clinical application of quercetin is limited by its low water solubility, poor bioavailability, and extensive phase II metabolism. Advances in formulation strategies, including the use of nanocarriers, co-crystals, and phospholipid complexes, have shown promise in improving its pharmacokinetics. This review elucidates the mechanistic basis of QE quercetin antidiabetic action and discusses strategies to enhance its therapeutic potential in clinical settings.

12 February 2023 in Materials
Verified
Journal Article
Open access
PDF file
KLKatarzyna Lisiecka
Katarzyna Lisiecka
AWAgnieszka Wójtowicz
Agnieszka Wójtowicz
Katarzyna SamborskaKatarzyna Samborska
Katarzyna Samborska
MMMarcin Mitrus
Marcin Mitrus
TOTomasz Oniszczuk
Tomasz Oniszczuk
Anna OniszczukAnna Oniszczuk
Anna Oniszczuk
The aim of this work was to evaluate the structure of novel potato-based snack foods supplemented with various levels of fresh carrot pulp by using X-ray micro-computed tomography, texture profile, and sensory analysis. Three different methods of extruded snack pellets expansion were used to obtain ready-to-eat crisps: deep-fat frying, microwave, and hot-air toasting. The obtained results revealed that the pellets expansion method affected the porosity, size of pores and wall thickness, texture properties, and notes of sensory analyses of the obtained crisps. Deep-fat frying had a similar influence to microwave heating on ready-to-eat crisps properties, and both methods were significantly different in comparison to hot-air toasting. Crisps based on snack pellets supplemented with the addition of fresh carrot pulp in the amount of 10 to 30% expansion through hot-air heating showed unsatisfactory expansion and texture, but it is highly advisable to use deep-fat frying and microwave heating to achieve attractive potato-carrot crisps.

10 June 2023 in Antioxidants
Verified
Journal Article
Open access
PDF file
MCMaciej Combrzyński
Maciej Combrzyński
TOTomasz Oniszczuk
Tomasz Oniszczuk
AWAgnieszka Wójtowicz
Agnieszka Wójtowicz
Beata BiernackaBeata Biernacka
Beata Biernacka
Karolina A. Wojtunik-KuleszaKarolina A. Wojtunik-Kulesza
Karolina A. Wojtunik-Kulesza
Anna OniszczukAnna Oniszczuk
Anna Oniszczuk
As new sources of proteins, edible insects may be excellent additives in a new generation of environmentally friendly food products that are nutritionally valuable, safe, sustainable, and are needed in today’s world. The aim of this study was to determine the effect of the application of cricket flour on extruded wheat-corn-based snack pellets’ basic composition, fatty acids profile, nutritional value, antioxidant activity and selected physicochemical properties. Results showed that the application of cricket flour had a significant impact on the composition and properties of snack pellets based on wheat-corn blends. In newly developed products, the enhanced level of protein and almost triple increase in crude fiber was found as an insect flour supplementation reached 30% level in the recipe. The level of cricket flour and the applied processing conditions (various moisture contents and screw speeds) significantly affect the water absorption and water solubility index and texture and color profile. Results revealed that cricket flour application significantly increased the total polyphenols content in the assessed samples in comparison to plain wheat-corn bases. Antioxidant activity was also noted to be elevated with increasing cricket flour content. These new types of snack pellets with cricket flour addition may be interesting products with high nutritional value and pro-health properties.

27 September 2024 in Applied Sciences
Verified
Journal Article
Open access
PDF file
JSJakub Soja
Jakub Soja
MCMaciej Combrzyński
Maciej Combrzyński
TOTomasz Oniszczuk
Tomasz Oniszczuk
Marek GancarzMarek Gancarz
Marek Gancarz
Anna OniszczukAnna Oniszczuk
Anna Oniszczuk
The article presents the possibilities of using by-products from the agri-food industry in the form of fruit and vegetable pomace as a supplementary ingredient to extruded food products in the form of snack pellets. In the recipe based on potato starch, pomace from apples, chokeberries, pumpkin, nigella seed and flaxseed were added in amounts of 10%, 20% and 30%. The prepared raw material blends were processed using a single-screw extruder-cooker with a plastification system L/D = 20 and variable screw speed. The aim of the research was to determine the effect of pomace addition on the extrusion-cooking process, i.e., efficiency and energy consumption, as well as on selected physical properties of the obtained food pellets, such as expansion index, bulk density and durability. The addition of selected pomace influenced the extrusion-cooking process and the physical properties of the extrudates. A percentage contribution ranging from 10 to 20% can optimize the extrusion-cooking process and improve the quality characteristics of the final product, while simultaneously utilizing by-products from the agri-food industry and reducing their negative environmental impact.

26 September 2023 in Applied Sciences
Verified
Journal Article
Open access
PDF file
MRMonika Różańska-Boczula
Monika Różańska-Boczula
AWAgnieszka Wójtowicz
Agnieszka Wójtowicz
MPMagdalena Piszcz
Magdalena Piszcz
JSJakub Soja
Jakub Soja
PLPiotr Lewko
Piotr Lewko
Kamila Kasprzak-DrozdKamila Kasprzak-Drozd
Kamila Kasprzak-Drozd
The market of extruded products is constantly growing and the incorporation of fruit items into their recipe, can made a crisp snack product a healthy one of acceptable flavor. The subject of this work is the evaluation of the effects of production screw speed, fruit type and amount on selected physical properties (expansion index, bulk density, water absorption and solubility, texture profile and color balance) of corn-based gluten-free crisps supplemented with various amounts (0–20%) of dried fruits (apple, white mulberry, goji berry, elderberry, blackberry) processed at variable screw speeds (80, 100 and 120 rpm). This work demonstrates that it is possible to obtain marketable extruded snacks with natural color coming from the incorporated dried fruits and with adequate expansion and texture if addition was up to 10% of all the tested fruits. Moreover, very good aeration, crispy texture and acceptable natural color was found if dried elderberry and blackberry were added to snacks even at 15 and 20%. Application of 15 or 20% of apple, white mulberry and goji berries showed similar color profiles and caused decrease in texture and expansion of snacks. The rotational screw speed effect differs significantly only in hardness and cutting force of the supplemented corn crisps.