Shailesh S Nayak

Mr. Shailesh S Nayak

orcid

Research Focus & Metrics

Academic Career Length

3Years (2024-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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31 August 2024 in Radiography
Verified
Journal Article
Open access
PRPriyanka
Priyanka
RKRajagopal Kadavigere
Rajagopal Kadavigere
SNShailesh S Nayak
Shailesh S Nayak
Obhuli Chandran MadhivananObhuli Chandran Madhivanan
Obhuli Chandran Madhivanan
ASA. Shirlal
A. Shirlal
SPSaikiran Pendem
Saikiran Pendem
Magnetic Resonance Imaging (MRI) has revolutionized the diagnosis and treatment of musculoskeletal disorders. Parallel imaging (PI) and compressed sensing (CS) techniques reduce scan time, but higher acceleration factors decrease image quality. Artificial intelligence has enhanced MRI reconstructions by integrating deep learning algorithms. Therefore, the study aims to review the impact of Artificial intelligence-assisted compressed sensing (AI-CS) and acceleration factors on scan time and image quality in musculoskeletal MRI. Database searches were completed across PubMed, Scopus, CINAHL, Web of Science, Cochrane Library, and Embase to identify relevant articles focusing on the application of AI-CS in musculoskeletal MRI between 2022 and 2024. We utilized the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines to extract data from the selected studies. Nine articles were included for the final review, with a total sample size of 730 participants. Of these, seven articles were rated as high, while two articles were considered to be of moderate quality. MRI examination with AI-CS showed scan time reduction of 18.9-38.8% for lumbar spine, 38-40% for shoulder, 54-75% for knee and 53-63% for ankle. AI-CS showed a significant reduction in scan time and improved image quality for 2D and 3D sequences in musculoskeletal MRI compared with PI and CS. Determining the optimal acceleration factor necessary to achieve images with higher image quality compared to traditional PI techniques is required before clinical implementation. Higher acceleration factors currently lead to reduced image scores, although advancements in AI-CS are expected to address the limitation. AI-CS in MRI improves patient care by shortening scan times, reducing patient discomfort and anxiety, and produces high quality images for accurate diagnosis.

5 December 2024 in Diagnostics
Verified
Journal Article
Open access
PDF file
SNShailesh S Nayak
Shailesh S Nayak
SPSaikiran Pendem
Saikiran Pendem
GMGirish R. Menon
Girish R. Menon
Niranjana SampathilaNiranjana Sampathila
Niranjana Sampathila
PKPrakashini K
Prakashini K
Background: Brain tumors present a complex challenge in clinical oncology, where precise diagnosis and classification are pivotal for effective treatment planning. Radiomics, a burgeoning field in neuro-oncology, involves extracting and analyzing numerous quantitative features from medical images. This approach captures subtle spatial and textural information imperceptible to the human eye. However, implementation in clinical practice is still distant, and concerns have been raised regarding the methodological quality of radiomic studies. Methodology: A systematic literature search was performed to identify original articles focused on the use of radiomics for brain tumors from 2015 based on the inclusion and exclusion criteria. The radiomic features train machine learning models for glioma classification, and data are split into training and testing subsets to validate the model accuracy, reliability, and generalizability. The present study systematically reviews the status of radiomic studies concerning brain tumors, also using the radiomics quality score (RQS) to assess the quality of the methodology used in each study. Results: A systematic search of PubMed identified 300 articles, with 18 studies meeting the inclusion criteria for qualitative synthesis. These studies collectively demonstrate the potential of radiomics-based machine learning models in accurately distinguishing between glioma subtypes and grades. Various imaging modalities, including MRI, PET/CT, and advanced techniques like ASL and DTI, were utilized to extract radiomic features for analysis. Machine learning algorithms such as deep learning networks, support vector machines, random forests, and logistic regression were applied to develop predictive models. Conclusions: The present study indicates high accuracies in glioma classification, outperforming traditional imaging methods and inexperienced radiologists in some cases. Further validation and standardization efforts are warranted to facilitate the clinical integration of radiomics into routine practice, ultimately enhancing glioma management and patient outcomes. Open science practices: Machine learning using MRI radiomic features provides a simple, noninvasive, and cost-effective method for glioma classification, enhancing transparency, reproducibility, and collaboration within the scientific community.

25 March 2025 in F1000Research
Verified
Journal Article
Open access
PDF file
SSSaroh S
Saroh S
SPSaikiran Pendem
Saikiran Pendem
PKPrakashini K
Prakashini K
SNShailesh S Nayak
Shailesh S Nayak
GMGirish R Menon
Girish R Menon
Divya BDivya B
Divya B
Introduction Meningioma is the most common brain tumor in adults. Magnetic resonance imaging (MRI) is the preferred imaging modality for assessing tumor outcomes. Radiomics, an advanced imaging technique, assesses tumor heterogeneity and identifies predictive markers, offering a non-invasive alternative to biopsies. Machine learning (ML) based radiomics models enhances diagnostic and prognostic accuracy of tumors. Comprehensive review on ML-based radiomics models for predicting meningioma recurrence and survival are lacking. Hence, the aim of the study is to summarize the performance measures of ML based radiomics models in the prediction of outcomes such as progression/recurrence (P/R) and overall survival analysis of meningioma. Methods Data bases such as Scopus, Web of Science, PubMed, and Embase were used to conduct a literature search in order to find pertinent original articles that concentrated on meningioma outcome prediction. PRISMA (Preferred reporting items for systematic reviews and meta-analysis) recommendations were used to extract data from selected studies. Results Eight articles were included in the study. MRI Radiomics-based models combined with clinical and pathological data showed strong predictive performance for meningioma recurrence. A decision tree model achieved 90% accuracy, outperforming an apparent diffusion coefficient (ADC) based model (83%). A support vector machine (SVM) model reached an area under curve (AUC) of 0.80 with radiomic features, improving to 0.88 with ADC integration. A combined clinico-pathological radiomics model (CPRM) achieved an AUC of 0.88 in testing. Key predictors of recurrence include ADC values, radiomic scores, ki-67 index, and Simpson grading. For predicting overall survival analysis of meningioma, the combined clinicopathological and radiomic features achieved an AUC of 0.78. Conclusion Integrating radiomics with clinical and pathological data through ML models greatly improved the outcome prediction for meningioma. These ML models surpass conventional MRI in predicting meningioma recurrence and aggressiveness, providing crucial insights for personalized treatment and surgical planning.

14 March 2024 in F1000Research
Verified
Journal Article
Open access
PDF file
SMSudeepta Maiti
Sudeepta Maiti
SNShailesh S Nayak
Shailesh S Nayak
KHKarthikeya D Hebbar
Karthikeya D Hebbar
SPSaikiran Pendem
Saikiran Pendem
Background Breast cancer (BC) is one of the main causes of cancer-related mortality among women. For clinical management to help patients survive longer and spend less time on treatment, early and precise cancer identification and differentiation of breast lesions are crucial. To investigate the accuracy of radiomic features (RF) extracted from dynamic contrast-enhanced Magnetic Resonance Imaging (DCE MRI) for differentiating invasive ductal carcinoma (IDC) from invasive lobular carcinoma (ILC). Methods This is a retrospective study. The IDC of 30 and ILC of 28 patients from Dukes breast cancer MRI data set of The Cancer Imaging Archive (TCIA), were included. The RF categories such as shape based, Gray level dependence matrix (GLDM), Gray level co-occurrence matrix (GLCM), First order, Gray level run length matrix (GLRLM), Gray level size zone matrix (GLSZM), NGTDM (Neighbouring gray tone difference matrix) were extracted from the DCE-MRI sequence using a 3D slicer. The maximum relevance and minimum redundancy (mRMR) was applied using Google Colab for identifying the top fifteen relevant radiomic features. The Mann-Whitney U test was performed to identify significant RF for differentiating IDC and ILC. Receiver Operating Characteristic (ROC) curve analysis was performed to ascertain the accuracy of RF in distinguishing between IDC and ILC. Results Ten DCE MRI-based RFs used in our study showed a significant difference (p <0.001) between IDC and ILC. We noticed that DCE RF, such as Gray level run length matrix (GLRLM) gray level variance (sensitivity (SN) 97.21%, specificity (SP) 96.2%, area under curve (AUC) 0.998), Gray level co-occurrence matrix (GLCM) difference average (SN 95.72%, SP 96.34%, AUC 0.983), GLCM interquartile range (SN 95.24%, SP 97.31%, AUC 0.968), had the strongest ability to differentiate IDC and ILC. Conclusions MRI-based RF derived from DCE sequences can be used in clinical settings to differentiate malignant lesions of the breast, such as IDC and ILC, without requiring intrusive procedures.

1 February 2024 in F1000Research
Verified
Journal Article
Open access
PDF file
SMSudeepta Maiti
Sudeepta Maiti
SNShailesh S Nayak
Shailesh S Nayak
KHKarthikeya D Hebbar
Karthikeya D Hebbar
SPSaikiran Pendem
Saikiran Pendem
Background Breast cancer (BC) is one of the main causes of cancer-related mortality among women. For clinical management to help patients survive longer and spend less time on treatment, early and precise cancer identification and differentiation of breast lesions are crucial. To investigate the accuracy of radiomic features (RF) extracted from dynamic contrast-enhanced Magnetic Resonance Imaging (DCE MRI) for differentiating invasive ductal carcinoma (IDC) from invasive lobular carcinoma (ILC). Methods This is a retrospective study. The IDC of 30 and ILC of 28 patients from Dukes breast cancer MRI data set of The Cancer Imaging Archive (TCIA), were included. The RF were extracted from the DCE-MRI sequence using a 3D slicer. The relevance of RF for differentiating IDC from ILC was evaluated using the maximum relevance minimum redundancy (mRMR) and Mann-Whitney test. Receiver Operating Characteristic (ROC) curve analysis was performed to ascertain the accuracy of RF in distinguishing between IDC and ILC. Results Ten DCE MRI-based RFs used in our study showed a significant difference (p <0.001) between IDC and ILC. We noticed that DCE RF, such as Gray level run length matrix (GLRLM) gray level variance (sensitivity (SN) 97.21%, specificity (SP) 96.2%, area under curve (AUC) 0.998), Gray level co-occurrence matrix (GLCM) difference average (SN 95.72%, SP 96.34%, AUC 0.983), GLCM interquartile range (SN 95.24%, SP 97.31%, AUC 0.968), had the strongest ability to differentiate IDC and ILC. Conclusions MRI-based RF derived from DCE sequences can be used in clinical settings to differentiate malignant lesions of the breast, such as IDC and ILC, without requiring intrusive procedures.

9 January 2025 in F1000Research
Verified
Journal Article
Open access
PDF file
RSRiyan Mohamed Sajer
Riyan Mohamed Sajer
SPSaikiran Pendem
Saikiran Pendem
RKRajagopal Kadavigere
Rajagopal Kadavigere
D.Dr. Priyanka .
Dr. Priyanka .
SNShailesh S Nayak
Shailesh S Nayak
VRVarsha Raghu
Varsha Raghu
Introduction Magnetic resonance imaging (MRI) is essential for brain imaging, but conventional methods rely on qualitative contrast, are time-intensive, and prone to variability. Magnetic resonance finger printing (MRF) addresses these limitations by enabling fast, simultaneous mapping of multiple tissue properties like T1, T2. Using dynamic acquisition parameters and a precomputed signal dictionary, MRF provides robust, qualitative maps, improving diagnostic precision and expanding clinical and research applications in brain imaging. Methods Database searches were performed through PubMed, Embase, Scopus, Web of science to identify relevant articles focusing on the application of MR finger printing in the adult brain. We utilized the preferred reporting items for systematic reviews and meta-analysis guidelines to extract data from the selected studies. Results Nine articles were included in the final review, with a total sample size of 332 participants. In healthy brains, notable regional, sex, age, and hemispheric variations were identified, particularly in the corpus callosum and thalamus. MRF effectively differentiated meningioma subtypes, glioma grades, and IDH mutation status, with T2 values providing particularly predictive for glioma classification. In brain metastases, significant relaxometry differences were noted between normal and lesional tissues. For multiple sclerosis, MRF values correlated with clinical and disability measures, distinguishing relapsing-remitting secondary progressive forms. In traumatic brain injury, longitudinal T1 changes strongly correlated with clinical recovery, surpassing T2 values. Conclusions The systematic review highlighted MRD as a groundbreaking technique that enhances neurological diagnosis by simultaneously quantifying T1 and T2 relaxation times. With reduced acquisition times, MRF outperforms conventional MRI in detecting subtle pathologies, distinguishing properties, and providing reliable biomarkers.