Neurological impairments are the leading cause of post-stroke mortality, while stroke-related cardiovascular diseases rank second in significance.This study investigates the potential protective effects of MitoTEMPO (2,2,6,6-tetramethyl-4-[[2-(triphenylphosphonio) acetyl] amino]-1-piperidinyloxy, monochloride, monohydrate), a mitochondria-specific antioxidant, against cardiac and neurological complications following stroke. The objective is to assess whether MitoTEMPO can be utilized as a protective agent for individuals with a high risk of stroke. 17-week-old male Wistar Albino rats were randomly assigned to three groups: SHAM, ischemia-reperfusion (IR), and MitoTEMPO + ischemia-reperfusion (MT + IR; MitoTEMPO injection 0.7 mg/kg/day for 14 days). The SHAM group underwent a sham operation, while the IR group underwent 1-hour middle cerebral artery occlusion (MCAO) followed by 3 days of reperfusion. Afterwards, noninvasive thoracic electrical bioimpedance (TEB) and electrocardiography (ECG) measurements were taken, and sample collection was performed for histological and biochemical examinations. Our TEB and ECG findings demonstrated that MitoTEMPO exhibited a protective effect on most parameters affected by IR compared to the SHAM group. Furthermore, our biochemical and histological data revealed a significant protective effect of MitoTEMPO against oxidative damage. The findings suggest that both IR-induced cardiovascular abnormalities and the protective effect of MitoTEMPO may involve G-protein coupled receptor (GPCR)-mediated signaling mechanisms. This study was conducted with limitations including a single gender, a uniform age group, a specific stroke model limited to MCA, and pre-scheduled only one IR period. In future studies, addressing these limitations may enable the implementation of preventive measures for individuals at high risk of stroke.

Anthropometric measurements are important in a wide range of areas, from athlete selection to performance analysis and medical exercise applications. With its portable and cost-effective structure, Microsoft Kinect offers significant advantages in measuring human movements and provides valuable data in the fields of sports science and medicine. The aim of this study is to compare certain anthropometric measurements of adolescent female weightlifters in the U-15 age category with Kinect V2 and traditional methods. Twelve athletes who won medals in international weightlifting championships were included in the study. Anthropometric evaluations of each athlete were performed using Kinect V2 and the traditional method. Differences between measurements were analyzed with Bland–Altman plots and Pearson correlation coefficients. Kinect was found to exhibit less variability and higher coherency in measurements of humerus, forearm, trochanter-tibiale laterale, tibial lengths, and shoulder width. It has been observed that the traditional method provides more coherence results in hand length measurements. Kinect was found to exhibit less variability and higher coherency in measurements of forearm, trochanter-tibiale laterale, tibial lengths, and shoulder width, indicating its potential as a reliable tool for these parameters. Notably, Kinect demonstrated high reliability for tibial length (ICC 0.918) and moderate reliability for trochanter-tibiale laterale (ICC 0.737), showing its effectiveness in these measurements. Additionally, Kinect exhibited lower variation and higher coherency in most measurements compared to manual methods, supporting its consistency and repeatability in anthropometric assessments. These results indicate that Kinect may be a suitable tool for some measurements but that traditional methods may be preferable for hand length measurements. These findings suggest that Kinect can be used effectively for certain anthropometric measurements in sports and medical science. Graphical Abstract

The importance of anthropometric measurements for monitoring the physical development of athletes and optimizing training programs is well known. Considering the limitations of traditional methods in terms of accuracy and consistency, the aim of this study is to investigate the potential of Kinect V2 as an alternative. This study wasperformed on 12 youth female weightlifters who won medals in the Youth European Weightlifting Championship. Humerus length, forearm length, hand length, trochanter-tibiale laterale length, tibial length and shoulder width measurements were performed with both Kinect V2 and manual methods. Statistical differences between groups were evaluated using the Mann–Whitney U test. The consistencies of the measurement methods were analyzed with Bland-Altman plots, correlations were determined with Pearson correlation coefficients, and reliability were evaluated with Intraclass Correlation Coefficient (ICC) values. Kinect V2 provided accuracy and consistency comparable to manual methods in measurements of humerus (ICC = 0.532), forearm (ICC = 0.600), and hand length (ICC = 0.760). While medium-level concordance was observed in trochanter-tibiale lateral length measurements (ICC = 0.749), high-level concordance and reliability were found in tibial length (ICC = 0.914) and shoulder width (ICC = 0.869) measurements. There were significant differences between the results of humerus length, forearm length and trochanter-tibiale laterale length obtained with both measurement methods. Therefore, measurements of these parameters require significant care. Findings of this study suggest that Kinect V2 can be a reliable tool for rapid and practical anthropometric assessments in sports settings, but highlight the importance of careful calibration and adjustments for specific measurements. Future studies should examine the use of this device more comprehensively across different sports and populations. Anthropometric measurements are important for monitoring the physical development of athletes and optimizing their training programs. Considering the limitations of traditional methods in terms of accuracy and consistency. Kinect analyzes the movements of athletes during sports education and training processes, making it possible to organize training programs according to individual needs. Kinect V2, which has a high potential for use, especially in medical exercise and clinical applications, also finds a wide range of applications in sports sciences. In this study, a comparative analysis of certain lower and upper extremity anthropometric measurements such as humerus length, forearm length, hand length, trochanter-tibiale laterale length, tibial length and shoulder width of female weightlifting athletes in the youth age category were performed using Kinect V2 and manual methods.

Microsoft Kinect is an increasingly common tool for low-cost and portable measurement of human movements. The aim of this study was to investigate the potential reliability and reproducibility of Microsoft Kinect Azure in the sit-and-reach test conducted under standardized test conditions in a controlled training environment with elite female weightlifters. The sit-and-reach test was performed with Microsoft Kinect Azure and manual methods and also the reliability and validity were analyzed by comparing the wrist, elbow, shoulder and trunk joint angle measurements with the digital goniometer. Twenty-one healthy female weightlifter athletes who won medals in international championships were included in the study. Sit-and-reach testing was performed using Microsoft Kinect Azure and manual methods in accordance with the standards of the American College of Sports Medicine. The flexion range of motions of each athlete’s wrist, elbow, shoulder and trunk joint angles were measured with a digital goniometer and Microsoft Kinect Azure. Statistical analyses were performed using IBM SPSS 25.0 and Python 3.9.12 software. Descriptive statistics were calculated for all variables, and differences between Kinect and manual methods were evaluated with the Mann-Whitney U test and Wilcoxon Signed-Rank Test. Linear relationships between measurements were analyzed with Spearman correlation coefficients. Intraclass Correlation Coefficient was calculated for the concordance analysis and presented with Bland-Altman plots. The level of significance was accepted as p < 0.05. The findings suggest that Kinect Azure may provide good reproducibility and agreement with manual goniometric measurements for joint angles under the specific structured conditions tested. For parameters such as the elbow, shoulder, wrist, trunk angles and distance traveled, high ICC values (> 0.90) indicated strong consistency between the methods. Kinect Azure may serve as a reliable alternative to manual measurement methods under standardized testing conditions. Further studies are recommended to examine its generalizability to other populations and test environments.

Accurate assessment of joint range of motion (ROM) is essential in both clinical and athletic contexts for monitoring mobility, guiding rehabilitation, and optimizing performance. Traditional tools such as goniometers are widely used but limited by operator dependency and static measurement constraints. Depth-sensing technologies offer a markerless alternative that may enhance practicality in field-based settings. This study examined the validity and reliability of the Microsoft Azure Kinect system compared with a digital goniometer for assessing hip and knee ROM in 30 elite female weightlifters from the Turkish National Team. Participants performed hip abduction, adduction, flexion, extension, and knee flexion, each measured using both tools. Agreement between systems was assessed using Pearson’s correlations, intraclass correlation coefficients [ICC (3,1)], and Bland-Altman analyses. No significant differences were found between methods (p > 0.05), with strong correlations (r = 0.974–0.997) and high intraclass correlation coefficients (ICC = 0.994–0.998), indicating excellent consistency. Bland-Altman analyses showed minimal bias and narrow limits of agreement. These findings support the Azure Kinect as a valid and reliable tool for lower-extremity ROM assessment and a viable alternative to traditional goniometers in field applications.

Toxic effects of silica nanoparticle of rats exposed intratympanically for 7 days were investigated using brainstem auditory evoked potential and distortion product otoacoustic emission techniques. The histopathological changes were evaluated with light microscopy and field emission-scanning electron microscopy were demonstrated in cochleas using based energy-dispersive X-ray spectroscopy. The reduction in the amplitude and prolongation at the peak latency and interpeak latencies of brainstem auditory evoked potential were observed. Silica nanoparticles significantly reduced distortion product otoacoustic emission amplitude in the 2, 3 and 4 kHz frequencies. In the light microscopic evaluation, the samples obtained from the experimental group showed a significant loss of hair cells. Field emission scanning electron microscope analysis of experimental group showed considerable hair cell damage compared to control group. The findings of this study show that intratympanic administration of silica nanoparticles may lead to hearing impairment by causing structural changes in cochlear hair cells.