Olegario Marín Machuca

Dr. Olegario Marín Machuca

orcid

Research Focus & Metrics

Academic Career Length

8Years (2019-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

View All Publications
10 May 2023 in Foods
Verified
Journal Article
Open access
PDF file
SMSheda Méndez
Sheda Méndez
RPRenzo Pepe-Victoriano
Renzo Pepe-Victoriano
HGHebert Hernan Soto Gonzales
Hebert Hernan Soto Gonzales
ACAbel Walter Zambrano Cabanillas
Abel Walter Zambrano Cabanillas
OMOlegario Marín Machuca
Olegario Marín Machuca
Rafael Felippe RatkeRafael Felippe Ratke
Rafael Felippe Ratke
The cyanobacterium Nostoc sp. contains considerable amounts of protein, iron, and calcium that could mitigate the problems of anemia and malnutrition in humans. However, the nutritional value of the edible species Nostoc sphaericum Vaucher ex Bornet & Flahault, which grows in the Moquegua region, is unknown. Descriptive research was developed, and samples were obtained from the community of Aruntaya, located in the region of Moquegua. Water samples were taken at two different points (spring and reservoir), and samples of the cyanobacteria were taken in the reservoir. The design used was completely randomized, with three repetitions. Sixteen characteristics associated with the water collected at two points were evaluated, and from the nutritional point of view, seven characteristics were evaluated in the collected algae. The physicochemical characteristics were determined using methods established in the Codex Alimentarius. For the morphological characterization at the macroscopic level, it was observed that the seaweed collected was spherical in shape, grayish-green in color, soft to the touch, and palatable. After carrying out the physicochemical and morphological characterization of the collected samples, it was verified that all were of N. sphaericum. When comparing the sixteen characteristics related to water at the two collection sites, highly significant differences (p < 0.01) were observed for most of the variables evaluated. The average data of the characteristics of the algae showed protein values of 28.18 ± 0.33%, carbohydrates of 62.07 ± 0.69%, fat of 0.71 ± 0.02%, fiber of 0.91 ± 0.02%, ash of 7.68 ± 0.10%, and moisture of 0.22 ± 0.01%. Likewise, calcium reported an average value of 377.80 ± 1.43 mg/100 g and iron of 4.76 ± 0.08 mg/100 g. High correlations (positive and negative) were obtained by evaluating seven characteristics associated with the reservoir water where the algae grew in relation to eight nutritional characteristics of the algae. In relation to the nutritional value, the amounts of protein, iron, and calcium exceed the main foods of daily intake. Therefore, it could be considered a nutritious food to combat anemia and malnutrition.

27 October 2023 in Vaccines
Verified
Journal Article
Open access
PDF file
OMOlegario Marín Machuca
Olegario Marín Machuca
RUY DIEGO CHACON VILLANUEVARUY DIEGO CHACON VILLANUEVA
RUY DIEGO CHACON VILLANUEVA
NANatalia Alvarez-Lovera
Natalia Alvarez-Lovera
Pedro Isaac Pesantes-GradosPedro Isaac Pesantes-Grados
Pedro Isaac Pesantes-Grados
LPLuis Alejandro Pérez-Timaná
Luis Alejandro Pérez-Timaná
Obert Marín SánchezObert Marín Sánchez
Obert Marín Sánchez
The COVID-19 pandemic has caused widespread infections, deaths, and substantial economic losses. Vaccine development efforts have led to authorized candidates reducing hospitalizations and mortality, although variant emergence remains a concern. Peru faced a significant impact due to healthcare deficiencies. This study employed logistic regression to mathematically model COVID-19’s dynamics in Peru over three years and assessed the correlations between cases, deaths, and people vaccinated. We estimated the critical time (tc) for cases (627 days), deaths (389 days), and people vaccinated (268 days), which led to the maximum speed values on those days. Negative correlations were identified between people vaccinated and cases (−0.40) and between people vaccinated and deaths (−0.75), suggesting reciprocal relationships between those pairs of variables. In addition, Granger causality tests determined that the vaccinated population dynamics can be used to forecast the behavior of deaths (p-value < 0.05), evidencing the impact of vaccinations against COVID-19. Also, the coefficient of determination (R2) indicated a robust representation of the real data. Using the Peruvian context as an example case, the logistic model’s projections of cases, deaths, and vaccinations provide crucial insights into the pandemic, guiding public health tactics and reaffirming the essential role of vaccinations and resource distribution for an effective fight against COVID-19.

24 December 2023 in Fishes
Verified
Journal Article
Open access
PDF file
RCRafael Octavio Crisóstomo
Rafael Octavio Crisóstomo
RPRenzo Pepe-Victoriano
Renzo Pepe-Victoriano
SMSheda Méndez
Sheda Méndez
ACAbel Walter Zambrano Cabanillas
Abel Walter Zambrano Cabanillas
OMOlegario Marín Machuca
Olegario Marín Machuca
MRMario Ruiz-Choque
Mario Ruiz-Choque
Obtaining viable Argopecten purpuratus seeds faces challenges, especiallyci the unpredictability of the marine environment and high production costs in hatcheries. However, improving the method of "Broodstock Conditioning In Hatcheries" is key to ensure permanent seed supplies by minimizing the dependence on marine conditions and by maximizing economic viability in hatcheries. In an effort to overcome these barriers, broodstock were conditioned into two different environments: (a) Natural Environment: Natural marine conditions located in Bahía Inglesa, Atacama Region, Chile. (b) Hatchery: Laboratory conditions to achieve gonadal maturation, spawning induction, fertilization and larval development. The purpose of this research was to evaluate how the type of reproductive conditioning affects the reproductive potential and nutritional quality of the progeny. Both methods were successful at inducing the necessary maturity for reproduction, obtaining viable gametes and larvae. On the other hand, it was observed that in the natural environment, the oocytes and D larvae reached a greater size and nutritional value, being the most significant differences with (p < 0.05): the size of the D larvae reached figures of 95.8 ± 3.1 μm and 91.2 ± 2.7 μm in the environment and hatchery, respectively; the lipid content in dry mass was 25.2 ± 3.1 mg g−1 and 13.5 ± 1.9 mg g−1 for the natural environment and hatchery, respectively. Although quality indicators in hatcheries were slightly lower compared to the natural environment, the possibility of conditioning A. purpuratus broodstock independently of environmental variability highlights the importance of further optimizing broodstock conditioning aspects in hatcheries that would allow more predictable and sustainable production.

19 September 2024 in Agronomy
Verified
Journal Article
Open access
PDF file
YDYadenis Ortega Díaz
Yadenis Ortega Díaz
LLLiliana Gomez Luna
Liliana Gomez Luna
YBYilan Fung Boix
Yilan Fung Boix
YFYadira Silveira Font
Yadira Silveira Font
Jorge González AguileraJorge González Aguilera
Jorge González Aguilera
CBCarlos Enrique Chinchay Barragán
Carlos Enrique Chinchay Barragán
Nitrogen-fixing cyanobacterial consortia are an alternative to the indiscriminate use of chemical fertilizers that affect the environment, fix atmospheric nitrogen, and can therefore be used as plant growth promoters, synthesize various substances such as auxins, vitamins, and total proteins, and fix atmospheric biofertilizers and soil conditioners. The present study aimed to obtain and develop, by biotechnological means, two consortia of cyanobacteria isolated from the root and rhizosphere of Carica papaya grown in sandy loam soil. The culture was carried out in Blue Green Medium without modified nitrogen (BG110), with aeration of 0.32 L min−1, at a light intensity of 48.83 μEm−2s−1, and a temperature of 22 ± 2 °C. Two consortia consisting of Nostoc commune, Aphanothece minutissima, Planktothrix sp. (C1), Nostoc commune, Calothrix sp., and Aphanothece minutissima (C2) were isolated and morphologically identified. The effective development of these consortia was verified at the laboratory level by obtaining biomass in dry weight as well as photosynthetic pigments, proteins, carbohydrates, and lipids. Germination parameters were determined in seeds of Cucumis sativus L. var. Market plus treated with the nitrogen-fixing cyanobacteria consortia, obtaining a higher germination percentage (>90%), greater root length (>6 cm), and higher vigour index I (513), II (13.02) for the C2 consortium. This broadens the spectrum of rhizosphere-derived microorganisms with potential as growth biostimulators.

27 November 2023 in Vaccines
Verified
Journal Article
Open access
PDF file
Obert Marín SánchezObert Marín Sánchez
Obert Marín Sánchez
Pedro Isaac Pesantes-GradosPedro Isaac Pesantes-Grados
Pedro Isaac Pesantes-Grados
LPLuis Alejandro Pérez-Timaná
Luis Alejandro Pérez-Timaná
OMOlegario Marín Machuca
Olegario Marín Machuca
Christian José SanchezChristian José Sanchez
Christian José Sanchez
RUY DIEGO CHACON VILLANUEVARUY DIEGO CHACON VILLANUEVA
RUY DIEGO CHACON VILLANUEVA
The monkeypox virus (MPXV) has caused an unusual epidemiological scenario—an epidemic within a pandemic (COVID-19). Despite the inherent evolutionary and adaptive capacity of poxviruses, one of the potential triggers for the emergence of this epidemic was the change in the status of orthopoxvirus vaccination and eradication programs. This epidemic outbreak of HMPX spread worldwide, with a notable frequency in Europe, North America, and South America. Due to these particularities, the objective of the present study was to assess and compare cases of HMPX in these geographical regions through logistic and Gompertz mathematical modeling over one year since its inception. We estimated the highest contagion rates (people per day) of 690, 230, 278, and 206 for the world, Europe, North America, and South America, respectively, in the logistic model. The equivalent values for the Gompertz model were 696, 268, 308, and 202 for the highest contagion rates. The Kruskal–Wallis Test indicated different means among the geographical regions affected by HMPX regarding case velocity, and the Wilcoxon pairwise test indicated the absence of significant differences between the case velocity means between Europe and South America. The coefficient of determination (R2) values in the logistic model varied from 0.8720 to 0.9023, and in the Gompertz model, they ranged from 0.9881 to 0.9988, indicating a better fit to the actual data when using the Gompertz model. The estimated basic reproduction numbers (R0) were more consistent in the logistic model, varying from 1.71 to 1.94 in the graphical method and from 1.75 to 1.95 in the analytical method. The comparative assessment of these mathematical modeling approaches permitted the establishment of the Gompertz model as the better-fitting model for the data and the logistic model for the R0. However, both models successfully represented the actual HMPX case data. The present study estimated relevant epidemiological data to understand better the geographic similarities and differences in the dynamics of HMPX.

10 October 2025 in Medical Sciences
Verified
Journal Article
Open access
PDF file
Pedro Isaac Pesantes-GradosPedro Isaac Pesantes-Grados
Pedro Isaac Pesantes-Grados
Nahía Escalante-CcoylloNahía Escalante-Ccoyllo
Nahía Escalante-Ccoyllo
OMOlegario Marín Machuca
Olegario Marín Machuca
ACAbel Walter Zambrano Cabanillas
Abel Walter Zambrano Cabanillas
HAHOMERO ANGO
HOMERO ANGO
RUY DIEGO CHACON VILLANUEVARUY DIEGO CHACON VILLANUEVA
RUY DIEGO CHACON VILLANUEVA
Background: Monkeypox (Mpox) is a re-emerging zoonotic disease caused by the monkeypox virus (MPXV). Transmission occurs primarily through direct contact with lesions or contaminated materials, with sexual transmission playing a significant role in recent outbreaks. In 2022, Mpox triggered a major global outbreak and was declared a Public Health Emergency of International Concern (PHEIC) by the World Health Organization (WHO), prompting renewed interest in effective control strategies. Methods: This study developed a compartmental SEIR-based model to assess the epidemiological impact of key interventions, including vaccination and isolation, while incorporating critical epidemiological parameters. Sensitivity analyses were conducted to examine (1) disease dynamics in relation to the basic reproduction number, and (2) how different parameters influence the curve of symptomatic infections. Real-world continental-scale data were used to validate the model and identify the parameters that most significantly affect epidemic progression and potential control of Mpox. Results: Results showed that the basic reproduction number was most influenced by the recovery rate, vaccination rate, vaccine effectiveness, and transmission rates of symptomatic and asymptomatic individuals. In contrast, the progression of symptomatic cases was highly sensitive to the case fatality rate and incubation rate. Conclusions: These findings highlight the importance of integrated public health strategies combining vaccination, isolation, and early transmission control to mitigate future Mpox outbreaks.