David W Graham

Prof. David W Graham

Newcastle University
orcid

Research Focus & Metrics

Academic Career Length

34Years (1993-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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21 December 2009 in Environmental Science & Technology
Verified
Journal Article
Closed access
CKCharles W. Knapp
Charles W. Knapp
Jan DolfingJan Dolfing
Jan Dolfing
PEPhillip A. I. Ehlert
Phillip A. I. Ehlert
David W GrahamDavid W Graham
David W Graham

1 August 2013 in Environmental Health Perspectives
Verified
Journal Article
Open access
APAmy Pruden
Amy Pruden
JLJoakim Larsson
Joakim Larsson
AAAlejandro Amézquita
Alejandro Amézquita
PCPeter Collignon
Peter Collignon
KBKristian K. Brandt
Kristian K. Brandt
YZYong-Guan Zhu
Yong-Guan Zhu
A peer-reviewed open access journal published by the National Institute of Environmental Health Sciences

30 May 2013 in Clinical Infectious Diseases
Verified
Journal Article
Open access
PDF file
RFRita L. Finley
Rita L. Finley
PCPeter Collignon
Peter Collignon
JLJoakim Larsson
Joakim Larsson
SMScott A. McEwen
Scott A. McEwen
XLXian-Zhi Li
Xian-Zhi Li
ETEdward Topp
Edward Topp
Antibiotic resistance and associated genes are ubiquitous and ancient, with most genes that encode resistance in human pathogens having originated in bacteria from the natural environment (eg, β-lactamases and fluoroquinolones resistance genes, such as qnr). The rapid evolution and spread of “new” antibiotic resistance genes has been enhanced by modern human activity and its influence on the environmental resistome. This highlights the importance of including the role of the environmental vectors, such as bacterial genetic diversity within soil and water, in resistance risk management. We need to take more steps to decrease the spread of resistance genes in environmental bacteria into human pathogens, to decrease the spread of resistant bacteria to people and animals via foodstuffs, wastes and water, and to minimize the levels of antibiotics and antibiotic-resistant bacteria introduced into the environment. Reducing this risk must include improved management of waste containing antibiotic residues and antibiotic-resistant microorganisms.

22 February 2018 in Frontiers in Environmental Science
Verified
Journal Article
Open access
PDF file
JBJoshua T. Bunce
Joshua T. Bunce
ENEdmond Ndam
Edmond Ndam
IOIrina D. Ofiteru
Irina D. Ofiteru
AMAndrew Moore
Andrew Moore
David W GrahamDavid W Graham
David W Graham
The removal of phosphorus (P) from domestic wastewater is primarily to reduce the potential for eutrophication in receiving waters, and is mandated and common in many countries. However, most P-removal technologies have been developed for use at larger wastewater treatment plants that have economies-of-scale, rigorous monitoring, and in-house operating expertise. Smaller treatment plants often do not have these luxuries, which is problematic because there is concern that P releases from small treatment systems may have greater environmental impact than previously believed. Here P-removal technologies are reviewed with the goal of determining which treatment options are amenable to small-scale applications. Significant progress has been made in developing some technologies for small-scale application, namely sorptive media. However, as this review shows, there is a shortage of treatment technologies for P-removal at smaller scales, particularly sustainable and reliable options that demand minimal operating and maintenance expertise or are suited to northern latitudes. In view of emerging regulatory pressure, investment should be made in developing new or adapting existing P-removal technologies, specifically for implementation at small-scale treatment works.

9 November 2011 in PLOS ONE
Verified
Journal Article
Open access
PDF file
CKCharles W. Knapp
Charles W. Knapp
SMSeánín M McCluskey
Seánín M McCluskey
BSBrajesh K Singh
Brajesh K Singh
CCColin D Campbell
Colin D Campbell
GHGordon Hudson
Gordon Hudson
David W GrahamDavid W Graham
David W Graham
The vast majority of antibiotic resistant genes (ARG) acquired by human pathogens have originated from the natural environment. Therefore, understanding factors that influence intrinsic levels of ARG in the environment could be epidemiologically significant. The selection for metal resistance often promotes AR in exposed organisms; however, the relationship between metal levels in nature and the intrinsic presence of ARG has not been fully assessed. Here, we quantified, using qPCR, the abundance of eleven ARG and compared their levels with geochemical conditions in randomly selected soils from a Scottish archive. Many ARG positively correlated with soil copper levels, with approximately half being highly significant (p<0.05); whereas chromium, nickel, lead, and iron also significantly correlated with specific ARG. Results show that geochemical metal conditions innately influence the potential for AR in soil. We suggest soil geochemical data might be used to estimate baseline gene presence on local, regional and global scales within epidemiological risk studies related to AR transmission from the environment.

1 November 2020 in Water Research
Verified
Journal Article
Open access
DPDavid Polo
David Polo
Marcos Quintela BalujaMarcos Quintela Baluja
Marcos Quintela Baluja
ACAlexander Corbishley
Alexander Corbishley
DJDavey Jones
Davey Jones
Andrew SingerAndrew Singer
Andrew Singer
Jesus L. RomaldeJesus L. Romalde
Jesus L. Romalde
• Presence of SARS-CoV-2 in feces and wastewater constitutes a paradigm shift in surveillance. • WBE has potential as a surveillance and predictive tool during the COVID-19 pandemic. • Validated protocols for concentration and quantification of SARS-CoV-2 and other markers are needed.