Reflectance anisotropy in remote sensing images can complicate the interpretation of spectral signature, and extracting precise structural information under these pixels is a promising approach. Low-altitude unmanned aerial vehicle (UAV) systems can capture high-resolution imagery even to centimeter-level detail, potentially simplifying the characterization of leaf anisotropic reflectance. We proposed a novel maize point cloud generation method that combines an advanced UAV cross-circling oblique (CCO) photography route with the Structure from the Motion-Multi-View Stereo (SfM-MVS) algorithm. A multi-spectral point cloud was then generated by fusing multi-spectral imagery with the point cloud using a DSM-based approach. The Rahman–Pinty–Verstraete (RPV) model was finally applied to establish maize leaf-level anisotropic reflectance models. Our results indicated a high degree of similarity between measured and estimated maize structural parameters (R² = 0.89 for leaf length and 0.96 for plant height) based on accurate point cloud data obtained from the CCO route. Most data points clustered around the principal plane due to a constant angle between the sun and view vectors, resulting in a limited range of view azimuths. Leaf reflectance anisotropy was characterized by the RPV model with R² ranging from 0.38 to 0.75 for five wavelength bands. These findings hold significant promise for promoting the decoupling of plant structural information and leaf optical characteristics within remote sensing data.