Background. Severe Acute Respiratory Syndrome-Related Coronavirus 2 (SARS-CoV-2) infection during pregnancy was associated with a number of adverse pregnancy outcomes, including miscarriage, preeclampsia, preterm birth, and stillbirth. The virus persistence can last for a long time, and the consequences of a previous coronavirus infection are currently under study. Objectives. This study aimed to establish the clinical features of the course of pregnancy and childbirth in women with a history of asymptomatic coronavirus disease 2019 (COVID-19). Methods. This study was conducted in the Regional Perinatal Center N3 of Turkestan city, Kazakhstan. A total of 229 participants were enrolled comprising individuals with (n = 133, exposed group) from August to September 2021 with a history of COVID-19 and without one in the same period in 2019 (n = 96, unexposed group). Results. There is a statistically significant strong association between a history of COVID-19 and the development of oligohydramnios (φ = 0.743, p < 0.001), and medium strength between a history of COVID-19 and the presence of anemia (φ = 0.254, p < 0.001), abnormal development of the placenta (φ = 0.254, p < 0.011), cord entanglement (φ = 0.343, p = 0.000), low birth weight (φ = 0.356, p < 0.001) and stillbirth (φ = 0.293, p < 0.001). Conclusions. The past COVID-19 infection in pregnant women has long-term consequences in the form of placenta abnormal development and oligohydramnios; and, as a result, the development of adverse perinatal outcomes

The early detection of Severe Combined Immunodeficiency (SCID) and X-linked agammaglobulinemia (XLA) prevents fatal outcomes. This study presents the first pilot TREC/KREC newborn screening (NBS) program in southern Kazakhstan, a high-birth-rate region, to establish local reference ranges and assess operational viability. A multiplex real-time PCR assay was used to quantify T-cell (TREC) and kappa-deleting recombination excision circles (KRECs) from dried blood spots of 5000 unselected neonates. Biomarkers were normalized to copies per ${10}^6$ cells using albumin as a diploid reference gene. Regional 0.5th percentile cut-offs were established (TREC < 3165 copies/${10}^6 \mathrm{c}\mathrm{e}\mathrm{l}\mathrm{l}\mathrm{s}$ and KREC < 2554 copies/${10}^{6 }$ cells), and gender and gestational age did not significantly impact biomarker levels. While a low birth weight (≤2500 g) significantly reduced KREC levels, the extreme lower distribution tails remained unaffected, validating the use of universal, unstratified thresholds. Applying these cut-offs yielded an optimal 1.0% initial recall rate. Consistent with global incidence rates, no true positive cases were identified. The established assay and universal percentile cut-offs demonstrate high levels of analytical reliability and demographic stability. This pilot confirms the regional pediatric healthcare infrastructure’s readiness for a routine, population-based NBS program without the need for complex algorithms.

Background. Gynecological disorders (GD) represent a major noncommunicable disease burden among women of reproductive age worldwide, yet remain under-researched among young women in Central Asia, particularly in Kazakhstan. This systematic review aims to identify the most common gynecological disorders among young women in Kazakhstan, assess associated risk factors, and explore barriers to healthcare access.

Introduction: Even though the COVID-19 pandemic has come to an end, several short-term and delayed consequences of coronavirus infection remain insufficiently studied, which determines the relevance of this study. The study aims to analyse the impact of coronavirus infection on the course of pregnancy and reproductive health of females of fertile age in different periods according to the data of medical institutions of Turkestan city.Methods: The following research methods were used in the study: bibliographic, discrete statistics, cluster, and frequency analysis.Results: In this study, 301 cases of pregnancy of females diagnosed with coronavirus infection of different severity were statistically analysed. The study examined several aspects related to the study group including duration of hospitalisation, number of previous pregnancies and deliveries, complications of pregnancy and delivery occurring on COVID-19, haematological parameters, and oxygen saturation levels of pregnant females. The main clinical features of pregnancies with COVID-19 were identified. Thus, the result of the study was an analysis of the presented statistical sample and a comprehensive review of the current literature on the short-term and delayed effects of coronavirus infection on the female reproductive system.Conclusions: The results obtained are of significant practical importance for specialists in obstetrics, gynaecology, reproductology and public health because they can serve as a basis for the development of effective clinical recommendations and strategies for managing the reproductive health of females who have undergone coronavirus infection

Background/Objectives: Long-run facility-level perinatal data from Central Asia are scarce. We described eleven years of stillbirth, neonatal, infant and perinatal mortality at one tertiary maternity center in Kazakhstan, and used the Birthweight and Age-at-death Boxes for Intervention and Evaluation System (BABIES) matrix to locate where feto-infant deaths concentrated. Methods: Retrospective ecological analysis of aggregated annual institutional records, 2015–2025: 102,481 total births, 101,544 live births, 937 stillbirths and 489 infant deaths. Rates were modeled by Poisson regression with the log birth denominator as offset, refitted as quasi-Poisson and negative binomial. Composite feto-infant mortality (antenatal and intrapartum stillbirth plus death at 0–27 days, per 1000 total births in each birthweight band) was examined by direct standardization and Kitagawa decomposition, using the nine years whose matrix cells reconciled with the registry. The study was not preregistered. Results: Infant mortality fell from 7.07 to 3.57 per 1000 live births (rate ratio 0.50, 95% CI 0.33–0.77) and stillbirth from 10.07 to 5.42 per 1000 total births (0.54, 0.38–0.76), an average annual decline near 8% for neonatal and infant mortality. Antenatal stillbirth declined; no clear change was detected for intrapartum stillbirth (1.11 to 1.04 per 1000; 0.94, 0.38–2.32). Births below 2500 g were 5.9% of all births but 71.1% of composite feto-infant deaths (rate ratio 39). Decomposition placed the reduction within birthweight bands rather than in the birthweight distribution, in single-year and pooled-period versions. Conclusions: The design is ecological and descriptive: it shows where feto-infant deaths are concentrated, not why. Intrapartum stillbirth and births below 2500 g are the groups in which any further reduction would have to be found.

Severe Acute Respiratory Syndrome-Related Coronavirus 2 (SARS-CoV-2) infection during pregnancy was associated with a number of adverse pregnancy outcomes, including miscarriage, preeclampsia, preterm birth, and stillbirth. The virus persistence can last for a long time, and the consequences of a previous coronavirus infection are currently under study. This study aimed to establish the clinical features of the course of pregnancy and childbirth in women with a history of asymptomatic coronavirus disease 2019 (COVID-19). This study was conducted in the Regional Perinatal Center N3 of Turkestan city, Kazakhstan from August to September 2021. A total of 229 participants were enrolled comprising individuals with (n=133, exposed group) or without a history of COVID-19 (n=96, unexposed group). There is a statistically significant strong relationship between a history of COVID-19 and the development of oligohydramnios (φ=0.743, p<0.001); medium strength between a history of COVID-19 and the presence of anemia, abnormal development of the placenta, cord entanglement, low birth weight and stillbirth (p<0.001). The past COVID-19 infection in pregnant women have long-term consequences in the form of placenta abnormal development and oligohydramnios, and as a result, the development of adverse perinatal outcomes.