This systematic literature review evaluated the methodological quality of studies measuring noise in neonatal intensive care units. A manual and also electronic search in the Medline, Scielo, Lilacs, BDENF, WHOLIS, BDTD, Science Direct, NCBI and Scirus databases resulted in 40 studies that met the criterion "measuring noise in neonatal units and/or incubators". Experts in neonatology and acoustics validated the critical analysis instrument, which obtained a mean = 7.9 (SD=1.3). The inter-observer reliability in 18 articles resulted in an Intra-class correlation coefficient (ICC) of 0.89 (CI 0.75-0.95). The quality indicators were 50% better in those studies that measured noise only in the unit's environment and associated measuring strategies to the physical area. The results showed great methodological variability, which hindered comparability and raised the probability of bias. The conditions required to ensure internal and external validity were observed in few studies.

O objetivo desse trabalho consistiu em identificar as principais preparações de uso tópico utilizadas no tratamento de feridas, com foco nas formulações manipuladas, e descrever as que já fazem parte do elenco de medicamentos disponibilizados pela Farmácia Universitária (FU), da Universidade Federal do Rio de Janeiro (UFRJ) à população. Esse trabalho utilizou uma revisão bibliográfica narrativa, desenvolvida pela avaliação de trabalhos selecionados em artigos científicos, a partir de critérios de inclusão e exclusão, complementado com um levantamento sobre as formulações de uso tópico preparadas pela FU/UFRJ. Dentre as opções terapêuticas citadas nos diferentes artigos e protocolos algumas formulações são passíveis de manipulação por farmácias magistrais, como os hidrocolóides, hidrogéis e sulfadiazina de prata. A FU/UFRJ manipula gel de carboximetilcelulose, papaína e sulfadiazina de prata. As farmácias magistrais podem contribuir no tratamento de feridas ofertando formulações com diferentes concentrações dos ativos, que melhor se adaptem ao paciente, aumentando as possibilidades terapêuticas. Palavras-chave: Feridas. Tratamento. Farmácia Universitária.

Skin tears are common acute wounds in older adults and are associated with morbidity, reduced quality of life, and increased healthcare burden. This randomized clinical trial evaluated two copaiba oleoresin polymeric hydrogels, CopaibaPolyHy-2 (2%) and Copai-baPolyHy-10 (10%), compared with a control hydrogel without active ingredient. A total of 120 participants were randomized equally among the three groups. Complete wound healing occurred in 70.0% of participants receiving CopaibaPolyHy-2, 72.5% receiving CopaibaPolyHy-10, and 67.5% receiving control treatment. No statistically significant dif-ferences were observed in complete healing rates for CopaibaPolyHy-2 versus control (RR 1.037; 95% CI 0.80–1.44) or CopaibaPolyHy-10 versus control (RR 1.070; 95% CI 0.81–1.43). Median healing times were 9, 13, and 10 days, respectively (p = 0.1472). Wound area reduction rates were 0.245, 0.160, and 0.200 cm²/day, respectively, with no significant be-tween-group difference (p = 0.6404). Although both copaiba formulations showed numer-ically favorable healing proportions, neither demonstrated superiority over the control hydrogel. These findings indicate that copaiba-based hydrogels were not associated with clinically or statistically significant improvements in skin tear healing in this population. Further studies should investigate optimized formulations, dosing strategies, and patient subgroups that may derive greater benefit. Larger multicenter trials may clarify potential clinical effects and therapeutic applicability.