Adrian Boloș

Dr. Adrian Boloș


Research Focus & Metrics

Academic Career Length

5Years (2022-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

View All Publications
10 January 2025 in Journal of Clinical Medicine
Verified
Journal Article
Open access
PDF file
Ramona DumitrescuRamona Dumitrescu
Ramona Dumitrescu
VBVanessa Bolchis
Vanessa Bolchis
SPSimona Popescu
Simona Popescu
AIAdriana Ivanescu
Adriana Ivanescu
ABAdrian Boloș
Adrian Boloș
Atena GaluscanAtena Galuscan
Atena Galuscan
Background: Diabetes mellitus is associated with various oral health complications that can negatively impact quality of life. Despite evidence of the relationship between diabetes and oral health issues, limited research exists on the perceptions, behaviors, and oral health-related quality of life (OHRQoL) of diabetic patients in Romania. This study aims to evaluate self-reported oral health, knowledge, behaviors, and OHRQoL among diabetic patients in western Romania. Methods: A cross-sectional study was conducted in early 2024 at Pius Brinzeu County Emergency Hospital, Timisoara, involving 121 patients with type 2 diabetes. Data were collected using self-administered questionnaires that assessed oral health status, behaviors, and OHRQoL, with the OHIP-14 instrument employed for quality-of-life measurement. Statistical analyses included descriptive statistics, multiple linear regression, and correlation analyses to identify the predictors of oral health knowledge and OHRQoL. Results: Participants (mean age: 63.24 years; 52.1% female; 60.5% urban residents) reported significant oral health challenges. Over half (56.2%) did not visit a dentist regularly, with financial constraints identified as the primary barrier (23.5%). Oral hygiene practices were suboptimal: only 38.0% brushed twice daily, while 78.5% used fluoride toothpaste. Auxiliary hygiene tools, such as mouthwash and toothpicks, were rarely used (13.22% and 11.57%, respectively). Regression analyses identified the significant predictors of oral health knowledge, including tooth mobility (β = 0.33, p < 0.01) and brushing frequency (β = −0.18, p < 0.05). The mean OHIP-14 score (0.55) indicated a moderate impact on OHRQoL, with domains such as psychological discomfort and social disability revealing nuanced challenges. Conclusions: Diabetic patients in Romania face oral health challenges and care barriers, emphasizing the need for preventive strategies, oral health education, and integrated diabetes care. Addressing these gaps can improve oral health outcomes and overall quality of life in this vulnerable population.

3 June 2022 in Materials
Verified
Journal Article
Open access
PDF file
RVRoxana Vasiliu
Roxana Vasiliu
Ion-Dragos UtuIon-Dragos Utu
Ion-Dragos Utu
LRLucian Rusu
Lucian Rusu
ABAdrian Boloș
Adrian Boloș
LPLiliana Porojan
Liliana Porojan
All-ceramic dental restorations have great advantages, such as highly esthetical properties, a less complex fabrication, and a similar abrasion resistance to enamel. Despite these advantages, ceramic materials are more prone to fracture due to their brittle microstructure. The main aim of this in vitro study was to determine the difference in hot-pressed and milled glass-ceramic mechanical properties such as fracture resistance and microhardness (VHN). Four types of ceramics, two hot-pressed and two milled, feldspathic glass-ceramics and zirconia-reinforced glass-ceramics were selected in this study and tested using the static loading test and Vicker’s testing. Hydrothermal aging, consisting of different baths with temperatures between 5 degrees Celsius and 55 degrees Celsius, was chosen as the in vitro aging method. Statistical analyses are performed using SPSS Statistics software at a significance level of p < 0.05. Micro-hardness values decrease after hydrothermal aging. The static loading test reveals a significant difference between the feldspathic hot-pressed glass-ceramic, which fractures at lower forces, and milled zirconia-reinforced lithium silicate glass-ceramic, which fractures at greater forces (N). Fractographic analysis of the fractured fragments resulted in the static loading test revealing different surface features about the crack origins and propagations under a stereomicroscope.

28 April 2026 in Microorganisms
Verified
Journal Article
Open access
PDF file
ABAdrian Boloș
Adrian Boloș
OBOtilia Cornelia Bolos
Otilia Cornelia Bolos
EMEdida Maghet
Edida Maghet
ADAlexandra Ioana Danila
Alexandra Ioana Danila
RBRaluca Briceag
Raluca Briceag
BBBogdan Andrei Bumbu
Bogdan Andrei Bumbu
Background and Objectives: Halitosis is a common condition with substantial psychosocial impact, frequently driven by intra-oral biofilm, tongue coating, and reduced salivary clearance. This study compared the short-term effectiveness of standardized counseling alone, probiotic lozenges containing Streptococcus salivarius K12, and a zinc-containing mouthrinse in adults with persistent intra-oral halitosis. Materials and Methods: In this 4-week, parallel-group, randomized pragmatic trial, 117 adults with bothersome halitosis for at least 3 months and baseline organoleptic score ≥ 2 were allocated 1:1:1 to standard care, probiotic lozenges, or zinc mouthrinse. All participants received standardized counseling and tongue cleaning instructions. The primary endpoint was change in volatile sulfur compounds (VSCs) measured by portable sulfide monitoring. Secondary outcomes included organoleptic score, Halitosis Associated Life-Quality Test (HALT), Oral Health Impact Profile-14 (OHIP-14), tongue coating, plaque, and salivary Solobacterium moorei quantified by qPCR. Results: Baseline demographic, clinical, and biochemical characteristics were comparable across groups. All interventions improved outcomes over 4 weeks, but improvements followed a consistent gradient favoring zinc mouthrinse, followed by probiotic lozenges, then standard care. Mean VSC reduction was −12.7 ± 33.9 ppb with standard care, −47.3 ± 42.2 ppb with probiotics, and −78.5 ± 36.3 ppb with zinc mouthrinse (p < 0.001). Organoleptic scores improved by −0.2 ± 0.7, −0.8 ± 0.8, and −1.2 ± 0.8, respectively (p < 0.001). HALT and OHIP-14 scores showed parallel reductions, and moderate/severe halitosis at week 4 remained most frequent in the standard care group (58.9%) and least frequent in the zinc group (20.5%; p = 0.004). Conclusions: Both active adjunctive strategies improved intra-oral halitosis beyond standardized counseling alone, but the zinc-containing mouthrinse produced the greatest short-term benefits across objective, clinician-rated, and patient-reported outcomes. These findings support zinc-based rinses as a practical short-term adjunct for managing persistent intra-oral halitosis in outpatient dental care. Durability after discontinuation and potential relapse beyond 4 weeks were not assessed in this trial.

31 March 2024 in Medicine in Evolution
Verified
Journal Article
Open access
PDF file
OBO. C. Bolos
O. C. Bolos
ABAdrian Boloș
Adrian Boloș
CSC. Savencu
C. Savencu
DBD. C. Bratu
D. C. Bratu
In the field of dental aesthetics, we aim to obtain restorations that imitate natural teeth. Using the right materials and technique is thus very important. Aim and objectives: to explore and evaluate the potential of biomimicry in direct aesthetic restoration of anterior teeth. Materials and methods: The direct restorations were realized with a nanohybrid composite resin- Filtek Ultimate (3M ESPE), using the celluloid strip technique. Results: The direct restoration of teeth affected by enamel fractures was successful, highlighting an aesthetic and natural appearance. Conclusions: Simplification and predictability are the key directions in the continuous improvement of the quality of direct restorations for tooth enamel fractures.

Verified
Journal Article
Open access
PDF file
RBRomina Georgiana Bita
Romina Georgiana Bita
OBOtilia Cornelia Bolos
Otilia Cornelia Bolos
EMEdida Maghet
Edida Maghet
ABAdrian Boloș
Adrian Boloș
RBRaluca Briceag
Raluca Briceag
BBBogdan Andrei Bumbu
Bogdan Andrei Bumbu
Background/Objectives: Halitosis in geriatric patients is multifactorial, but the joint contribution of prosthetic rehabilitation type and polypharmacy after routine dental procedures has rarely been quantified. We investigated how prosthesis type, polypharmacy, and salivary function were associated with volatile sulfur compound (VSC) burden and self-perceived halitosis in elderly dental patients. Methods: This cross-sectional study enrolled 88 patients aged ≥65 years, four weeks after completing routine dental procedures. Participants were stratified into three groups: complete denture wearers (n = 30), partial removable denture wearers (n = 28), and fixed prostheses/implants (n = 30). We measured unstimulated salivary flow rate (uSFR), tongue coating index (TCI), denture biofilm index, total VSCs (Halimeter®), organoleptic score (0–5), and self-perceived halitosis. Polypharmacy, comorbidities, and the Geriatric Oral Health Assessment Index (GOHAI) were recorded. Analyses included one- and two-way ANOVA, Spearman correlations, theory-informed multivariable linear and logistic regression, exploratory mediation analysis, and ROC curves. Results: Forty-two participants (47.7%) reported halitosis. Mean VSC differed across groups (complete dentures 278.2 ± 38.6 ppb; partial 211.2 ± 46.3 ppb; fixed 164.4 ± 43.9 ppb; ANOVA p < 0.001). uSFR correlated inversely with VSC (ρ = −0.61, p < 0.001) and TCI correlated positively (ρ = 0.56, p < 0.001). A significant prosthesis × polypharmacy interaction was observed (F = 3.74, p = 0.029, η2p = 0.082): polypharmacy was associated with higher VSC most clearly among partial and fixed prostheses wearers, whereas complete denture wearers showed high VSC levels regardless of polypharmacy status. Exploratory mediation findings were consistent with partial indirect association, with 45.9% of the polypharmacy–VSC association statistically explained by reduced uSFR; however, the cross-sectional design precludes causal or temporal interpretation. The full multivariable model showed apparent discrimination for self-perceived halitosis (AUC = 0.92), while the simplified four-item chairside composite model showed AUC = 0.89; neither estimate was optimism-corrected or externally validated. Conclusions: In elderly post-procedure patients, complete denture wearing, polypharmacy, and salivary hypofunction were independently and jointly associated with higher halitosis burden. Reduced salivary flow was consistent with a partial indirect statistical pathway in the polypharmacy–VSC association, supporting hydration counseling and meticulous prosthesis hygiene as low-cost geriatric interventions. Sensitivity analyses excluding implant-supported restorations, participants with MMSE scores of 24–26, and expanded mediation models including TCI and biofilm/plaque did not materially change the main inference.

10 June 2026 in Healthcare
Verified
Journal Article
Open access
PDF file
RBRomina Georgiana Bita
Romina Georgiana Bita
OBOtilia Cornelia Bolos
Otilia Cornelia Bolos
EMEdida Maghet
Edida Maghet
ABAdrian Boloș
Adrian Boloș
RBRaluca Briceag
Raluca Briceag
BBBogdan Andrei Bumbu
Bogdan Andrei Bumbu
Background and Objectives: Halitosis is a prevalent oral concern that meaningfully affects oral health-related quality of life (OHRQoL), yet how active dental treatment is associated with short-term changes in the objective–subjective halitosis–QoL nexus remains poorly quantified. Interpretation is complicated by the multifactorial nature of malodor and by baseline differences between patients selected for different dental procedures. We compared changes in volatile sulfur compound (VSC) emissions, organoleptic ratings, tongue-coating burden, and OHIP-14 across three contrasting treatment modalities and explored whether VSC change statistically accounted for OHRQoL change. Methods: In a non-randomized prospective comparative study, 119 adults (18–67 y) commencing one of three procedures were assessed at baseline and at 8 weeks: scaling and root planing (Group A, n = 42), fixed prosthodontic rehabilitation (Group B, n = 38), or fixed orthodontic appliance bonding (Group C, n = 39). Outcomes included Halimeter® VSC (ppb), Rosenberg organoleptic score (0–5), Winkel tongue-coating index (TCI), self-perceived halitosis, and OHIP-14 total and seven-domain scores. Mixed-design ANOVA, ANCOVA, prespecified multivariable regression, mediation (5000 bootstrap resamples), receiver operating characteristic analysis, and four-class latent class analysis were performed. A sensitivity-analysis framework including expanded covariate adjustment, propensity-score overlap weighting, and baseline-severity strata was also applied to address residual baseline imbalance. Secondary mediation, ROC, and latent-class analyses were considered exploratory. Results: At 8 weeks, VSCs fell by 116.4 ± 38.7 ppb in Group A and 35.4 ± 29.1 ppb in Group B but rose by 34.3 ± 28.6 ppb in Group C (p < 0.001). OHIP-14 improved by 10.3 and 4.9 points in A and B and worsened by 3.7 in C (p < 0.001). ΔVSC correlated with ΔOHIP-14 (ρ = 0.51, p < 0.001) and most strongly with the psychological discomfort domain (ρ = 0.58). VSC change mediated 35.1% of the periodontal-versus-orthodontic association on QoL (indirect β = −4.7; 95% CI −6.3 to −3.1). Because VSC and OHIP-14 changes were measured over the same interval, mediation was interpreted cautiously. A ΔVSC threshold of −63 ppb predicted clinically meaningful OHIP-14 improvement (AUC = 0.81). Latent class analysis identified four distinct responder phenotypes. The cutoff and responder classes were internally derived and require external validation. Sensitivity analyses preserved the direction of the primary contrasts, but residual confounding remains possible. Conclusions: Treatment modality was associated with the direction and magnitude of halitosis and QoL change, with orthodontic patients constituting a vulnerable subgroup. Targeted oral-hygiene reinforcement during fixed-appliance therapy is warranted.