Pulpitis, an inflammation of the dental pulp, is generated by bacterial invasion through different ways as caries. In the establishment and development of this disease, different biological processes are involved. Long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) are transcripts with regulatory capacity participating in different biological functions and have been implicated in different diseases. The aim of this narrative review is to critically analyze available evidence on the biological role of lncRNAs and circRNAs in pulpitis and discuss possible new research prospects. LncRNAs and circRNAs involved in pulpitis were explored, addressing their expression, molecular mechanisms, targets and biological effects studied in animal and in vitro models, as well as in studies in human patients. LncRNAs and circRNAs are emerging as key regulators of diverse biological functions in pulpitis including apoptosis, proliferation, differentiation, oxidative stress, autophagy, ferroptosis, inflammation and immune response. The molecular mechanisms performed by these non-coding RNAs (ncRNAs) involved interactions with miRNAs and the formation of regulatory networks in the context of pulpitis. Further studies more deeply analyzing the participation of lncRNAs and circRNAs in pulpitis will reveal the potential applications of these ncRNAs as biomarkers or their use in therapeutic strategies in pulp inflammation.

Infectious agents such as viruses, bacteria, and parasites can lead to cancer development. Infection with the helminthic parasite Schistosoma haematobium can cause cancer of the urinary bladder in humans, and infection with the parasites Clonorchis sinensis and Opisthorchis viverrini can promote cholangiocarcinoma. These three pathogens have been categorized as “group 1: carcinogenic to humans” by the International Agency for Research on Cancer (IARC). Additionally, the parasite Schistosoma japonicum has been associated with liver and colorectal cancer and classified as “group 2B: possibly carcinogenic to humans”. These parasites express regulatory non-coding RNAs as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), which modulate genic expression in different biological processes. In this review, we discuss the potential roles of miRNAS and lncRNAs encoded by helminthic parasites that are classified by the IARC as carcinogenic and possibly carcinogenic to humans. The miRNAs of these parasites may be involved in carcinogenesis by modulating the biological functions of the pathogen and the host and by altering microenvironments prone to tumor growth. miRNAs were identified in different host fluids. Additionally, some miRNAs showed direct antitumoral effects. Together, these miRNAs show potential for use in future therapeutic and diagnostic applications. LncRNAs have been less studied in these parasites, and their biological effects in the parasite–host interaction are largely unknown.

Background/Objectives: Dental caries and periodontal diseases are the most common illnesses in the oral cavity and represent a public health concern globally. In recent decades, diverse studies showed that Kefir, a traditional beverage that can be milk- or water-based, contains a complex microbial community and has health benefits. The goal of this review was to update the current knowledge of kefir consumption and its impact on oral health. Methods: The search of a combination of keywords—kefir; dental caries; probiotics; microbiota; periodontal diseases; biofilm; and oral health—was conducted using PubMed, Google Scholar, and Web of Science databases for studies in human subjects. Discussion: The research suggests that kefir consumption may aid in decreasing counts of microorganisms typically associated with oral illness. Conclusions: Kefir has the potential to inhibit certain oral pathogens and reduce biofilm formation by promoting diversity within the oral microbiota, suggesting that kefir could be a promising adjuvant treatment for dental caries and periodontal diseases by improving oral health.

La salud bucal depende no solo de la higiene, sino también del equilibrio de los microorganismos que habitan nuestra boca. Cuando se altera, puede surgir la enfermedad periodontal, infección crónica de dientes y encías frecuente en el sur-sureste de México. En esta región, bebidas tradicionales como el pozol y la taberna contienen probióticos naturales, que además de favorecer la digestión, pueden contribuir a la salud bucal. Incorporar alimentos fermentados a la dieta, junto con buenos hábitos de higiene, ayuda a mantener equilibrada la microbiota y reduce el riesgo de enfermedades orales, integrando tradición y ciencia en la alimentación cotidiana.

P53 is a tumor suppressor involved in cell-cycle regulation and DNA repair. Studies have shown that altered p53 expression in oral squamous cell carcinoma (OSCC) is associated with a poor prognosis and increased tumor aggressiveness, suggesting it could be considered a potential prognostic marker. A search was performed using keywords such as oral squamous cell carcinoma, TP53, and p53 therapies in the PubMed and Web of Science databases, with a timeframe from 2020 to 2025. In this review, we examined various therapies targeting p53 that have been proposed in recent years. These therapies have been tested in vitro, in vivo, and in some cases, through clinical trials. Their goal is to restore the conformation and activity of mutated p53 by identifying small molecules that restore p53 function and eliminate mutated cells. Although some of these therapies show promising results, further clinical studies are needed to assess their efficacy and safety in OSCC patients.