Irreversible electroporation (IRE) is a new minimally invasive tumor ablation technique which induces irreversible disruption of cell membrane integrity by changing the transmembrane potential resulting in cell death. Irreversible electroporation is currently undergoing clinical investigation as local tumor therapy for malignant liver and lung lesions. This is the first case report to describe the successful palliative ablation of a presacral recurrence of an endometrial cancer to achieve locoregional tumor control and pain relief.

Demographic development is accompanied by an increasingly aging society. Concerning medical education, the treatment of older people as well as the scientific research and exploration of ageing aspects in the coming years need to be considered. Aim of the study was to ascertain medical students’ knowledge, interest, and attitudes regarding older patients and geriatric medicine.

This study examines how different concentrations of arginine vasopressin (AVP) and its preservative chlorobutanol (ClB) impact the immune functions of human polymorphonuclear neutrophils (PMNs), which are crucial in the immune response, particularly in sepsis. Using a model to simulate the physiological, sepsis-related, and therapeutic AVP levels in plasma, we analysed how AVP and ClB affect PMN activities, including reactive oxygen species (ROS) production, NETosis, antigen expression, and migration. PMNs were isolated from whole human blood and assessed using flow cytometry and live cell imaging. The results indicated that neither AVP nor ClB significantly affected PMN viability, antigen expression, NETosis, or ROS production in response to N-Formylmethionine-leucyl-phenylalanine, or fMLP, and tumour necrosis factor alpha. In the migration assays, concentration-dependent effects were observed. At physiological AVP levels, PMN migration showed no reduction, while the sepsis-associated AVP levels initially reduced migration before returning to the baseline or even increasing. The therapeutic AVP concentrations showed similar migration to that in the controls, while high concentrations progressively inhibited migration. ClB, regardless of its concentration, enhanced PMN migration. These findings suggest that AVP during sepsis may impair PMN migration, potentially contributing to tissue damage and systemic complications. This highlights AVP’s role as a possible immune modulator in complex immune responses.