Pre-eclampsia (PE) is a severe pregnancy complication associated with increased maternal and fetal morbidity and mortality. In this retrospective study, we aimed to evaluate the predictive value of hemoglobin–albumin–lymphocyte–platelet score and fibrinogen/albumin ratio (FAR) for early diagnosis of PE. Medical records of 252 pregnant women categorized as severe pre-eclampsia, non-severe pre-eclampsia and control groups were analyzed. Biomarker levels including hemoglobin, albumin, lymphocytes, fibrinogen, creatinine, alanine transaminase, aspartate aminotransferase, and platelets were analyzed throughout the first trimester. The results showed that FAR was significantly higher in PE groups compared to controls and correlated with disease severity (area under curve = 0.65, sensitivity = 59%, specificity = 66%, P < .001). Albumin levels were moderately predictive for PE (area under curve = 0.70, sensitivity = 66%, specificity = 71%, P < .001). In contrast, the hemoglobin–albumin–lymphocyte–platelet score did not differ significantly between groups, indicating limited utility for early prediction. Elevated FAR is thought to result from increased fibrinogen levels due to inflammatory and procoagulant mechanisms, whereas decreased albumin levels reflect systemic inflammation associated with PE. Although FAR and albumin show potential as early biomarkers for PE, their diagnostic power alone is moderate. The findings suggest that these parameters may be more effective when combined with established markers such as placental growth factor and soluble fms-like tyrosine kinase-1. The study underlines the need for larger prospective studies to confirm these findings and explore additional biomarkers for improved PE prediction.

Background/Objectives: Vernix caseosa is a natural protective barrier with moisturizing, wound healing, and antioxidant properties. This study aimed to evaluate the effects of vernix caseosa on skin pigmentation and wound healing in cesarean section incisions. Methods: This randomized, double-blind, placebo-controlled trial was conducted at Ankara Etlik City Hospital, Gynecology and Obstetrics Clinic. A total of 210 first-time cesarean section patients were included. Vernix caseosa, collected from newborns, was applied to the incision site in half of the participants, while the other half received a placebo. Scar assessment was performed using the Manchester Scar Scale and the Patient and Observer Scar Assessment Scale (POSAS). Results: The vernix group showed significantly lower Manchester Scar Scale scores (9.00 ± 2.07 vs. 12.60 ± 2.72, p < 0.001) and POSAS total scores (53.57 ± 20.48 vs. 89.60 ± 26.54, p < 0.001) compared to the control group. These results suggest that vernix caseosa accelerates wound healing and improves cosmetic outcomes. Conclusions: Vernix caseosa emerges as a natural, effective, and low-cost method to promote wound healing in cesarean section incisions. Its medical and cosmetic benefits support its use in postoperative care. Future studies could further validate these findings in broader populations and explore additional clinical applications.

Objective: Pancreatic stone protein (PSP) is a secretory protein associated with systemic inflammation and β-cell stress. Given its reported association with type 2 diabetes mellitus, this study aimed to evaluate the relationship between serum PSP levels and gestational diabetes mellitus (GDM) and to assess its diagnostic performance. Methods: This single-center, prospective cohort study was conducted between June 2024 and May 2025. Eighty-four pregnant women at 24–28 weeks’ gestation were enrolled: 42 diagnosed with GDM according to Carpenter–Coustan criteria and 42 healthy controls. Serum PSP levels were measured using ELISA at the time of GDM diagnosis, and prior to treatment initiation. Group comparisons were performed using appropriate parametric and non-parametric tests. Diagnostic performance was evaluated by receiver operating characteristic (ROC) curve analysis. Results: Maternal weight was significantly higher in the GDM group (78.3 ± 10.0 kg vs. 68.4 ± 7.6 kg, p < 0.001). Serum PSP levels were significantly elevated in women with GDM compared to controls (8.89 ± 0.81 ng/mL vs. 7.72 ± 0.64 ng/mL, p < 0.001). Neonatal birth weight was also higher in the GDM group (3606 ± 507 g vs. 3355 ± 308 g, p = 0.008), while Apgar scores did not differ significantly. ROC analysis demonstrated an AUC of 0.883 (95% CI: 0.805–0.946, p < 0.001). At a cut-off value of 8.38 ng/mL, sensitivity was 76.2% and specificity was 85.7%. Conclusions: Serum PSP levels are significantly elevated in GDM and demonstrate good diagnostic performance. PSP may serve as a supportive biomarker reflecting β-cell stress in GDM, warranting further multicenter validation studies.

Aims: This study investigates the relationship between systemic inflammatory biomarkers-Systemic Immune-Inflammation Index (SII), Systemic Inflammation Response Index (SIRI), and Pan-Immune Inflammation Value (PIV)-and pregnancy outcomes following prophylactic cervical cerclage. Methods: A retrospective analysis was conducted on 60 pregnant women who underwent prophylactic McDonald cerclage between November 2022 and September 2024. Patients were divided into two groups based on whether they delivered at term (≥37 weeks) or preterm (

Background: This study aimed to evaluate the utility of inflammatory markers, including the systemic immune-inflammation index, systemic inflammatory response index, and pan-immune inflammatory value, in diagnosing ectopic pregnancy. Methods: A retrospective analysis was conducted on 105 patients diagnosed with ectopic pregnancy and 105 patients with intrauterine pregnancies treated at our hospital between November 2022 and September 2023. Ectopic pregnancy diagnoses were confirmed through ultrasonography. Data collected included age, gravida, parity, white blood cell count, neutrophil count, monocyte count, lymphocyte count, and platelet count. The inflammatory markers were calculated and compared between the groups using statistical software. Results: Significant differences were observed in white blood cell, neutrophil, monocyte, and lymphocyte counts. The systemic immune-inflammation index values were significantly higher in the ectopic pregnancy group (890.70±545.30) compared to the intrauterine pregnancy group (1121.50±537.59, p=0.004). Similarly, the systemic inflammatory response index and pan-immune inflammatory value were significantly elevated in the ectopic pregnancy group (systemic inflammatory response index: 70.31±29.70 vs. 89.07±32.49, p=0.000; pan-immune inflammatory value: 477.56±270.08 vs. 679.77±319.18, p=0.000). Receiver operating characteristic curve analysis showed moderate diagnostic accuracy for these markers with area under the curve values of 0.670, 0.670, and 0.710, respectively. Conclusions: Inflammatory markers such as the systemic immune-inflammation index, systemic inflammatory response index, and pan-immune inflammatory value show potential as diagnostic tools for ectopic pregnancy. Incorporating these markers into clinical practice could improve diagnostic accuracy, complementing traditional methods. Further research with larger sample sizes is required to validate these findings and enhance their clinical application.

Background/Objectives: Postpartum haemorrhage (PPH) remains a leading cause of maternal morbidity, and the relationship between labour-induction duration and haemorrhagic risk has not been translated into a practical intrapartum risk-stratification framework. We aimed to derive a clinically interpretable induction-duration threshold for PPH risk stratification and to explore an internally validated parsimonious clinical decision-support model. Methods: In this retrospective cohort of 1128 induced singleton labours at ≥37 weeks at a Turkish tertiary centre, laboratory-defined PPH was operationalised as a haemoglobin drop ≥ 2 g/dL. Multivariable logistic regression identified independent predictors; receiver operating characteristic (ROC) analysis with 2000-replicate bootstrap internal validation derived a duration threshold; calibration, decision curve analysis, and a probability-scaled nomogram were additionally evaluated. Results: PPH occurred in 143 patients (12.7%). Four predictors were independently associated with PPH: induction duration (adjusted odds ratio 1.243 per hour; 95% CI 1.191–1.298; p < 0.001), parity, emergency caesarean, and maternal age. Induction duration achieved an apparent area under the curve of 0.773 (optimism-corrected 0.773); a Youden-optimal threshold of 10.1 h yielded 86.7% (95% CI 80.2–91.3%) sensitivity and 96.8% (95% CI 95.0–97.9%) negative predictive value. The model showed favourable calibration and positive net clinical benefit on decision curve analysis. Conclusions: Induction duration was independently associated with PPH; the internally validated 10.1 h threshold therefore represents a hypothesis-generating risk-stratification benchmark—reflecting an association rather than a demonstrated causal effect—that requires prospective external validation in independent populations before clinical application. Whether this association is causal or reflects an underlying myometrial phenotype requires prospective study.