The relationship between neuroinflammation and depression is a complex area of research that has garnered significant attention in recent years. Neuroinflammation, characterized by the activation of glial cells and the release of pro-inflammatory cytokines, has been implicated in the pathophysiology of depression. The relationship between neuroinflammation and depression is bidirectional; not only can inflammation contribute to the onset of depressive symptoms, but depression itself can also exacerbate inflammatory responses, creating a vicious cycle that complicates treatment and recovery. The present comprehensive review aimed to explore the current findings on the interplay between neuroinflammation and depression, as well as the mechanisms, risk factors, and therapeutic implications. The mechanisms by which neuroinflammation induces depressive-like behaviors are diverse. Neuroinflammation can increase pro-inflammatory cytokines, activate the hypothalamus–pituitary–adrenal (HPA) axis, and impair serotonin synthesis, all of which contribute to depressive symptoms. Furthermore, the activation of microglia has been linked to the release of inflammatory mediators that can disrupt neuronal function and contribute to mood disorders. Stress-induced neuroinflammatory responses can lead to the release of pro-inflammatory cytokines that not only affect brain function but also influence behavior and mood. Understanding these mechanisms is crucial for developing targeted therapies that can mitigate the effects of neuroinflammation on mood disorders.

Background/Objectives: Diet is a primary and modifiable determinant of gut microbiota composition, diversity, and metabolic activity, thereby shaping microbial-derived metabolites, immune and inflammatory signalling, neuroendocrine regulation, and neural communication with the central nervous system. Western dietary patterns, characterised by high intake of ultra-processed foods, saturated fats, and low dietary fibre, are consistently associated with gut dysbiosis, impaired intestinal barrier function, chronic low-grade inflammation, and increased risk of depression, anxiety, cognitive impairment, and neurodegenerative disorders. Methods: This narrative review synthesises evidence from human observational studies, randomised controlled trials, animal models, and mechanistic investigations examining interactions among diet, gut microbiota, and mental health or neurobiological outcomes. Literature searches were conducted in PubMed, Scopus, and Web of Science for articles published up to December 2025. Results: The study highlights the therapeutic potential and limitations of dietary interventions, prebiotics, probiotics, and psychobiotics, and critically evaluates them. Also facilitates an improved understanding of diet–microbiome–brain interactions, which may help the development of personalised, nutrition-based strategies integrated into mental health prevention and clinical care. Conclusions: These findings support diet-based, microbiome-informed strategies as scalable adjuncts in mental health prevention and care.

Context: The increasing incidence of secondary caries and the failure of restorations have intensified research into dental restorative materials capable of actively interacting with the oral environment. In this context, antibacterial and bioregenerative nanomaterials have attracted growing scientific interest due to their potential to inhibit biofilm formation while simultaneously supporting mineral repair processes. Objective: This narrative review analyzes recent developments in nanostructured materials for restorative dentistry and oral health applications, with particular emphasis on antibacterial agents, bioactive systems, and emerging dual-function approaches that integrate multiple biological functions into restorative materials. Scope of the Review: The analyzed literature indicates that metallic nanoparticles, cationic monomers, and natural nanopolymers can reduce bacterial adhesion and metabolic activity under experimental conditions. In parallel, bioactive nanomaterials such as nanohydroxyapatite, bioactive glass, and calcium phosphate-based systems have demonstrated the ability to release remineralizing ions and to promote mineral deposition at the tooth–material interface. Dual-function hybrid materials aim to combine these antibacterial and bioregenerative effects within a single restorative system. Interpretative Perspective: Despite these advances, most available evidence derives from in vitro and preclinical studies, with significant heterogeneity across experimental models, evaluation methods, and outcome variables. This variability limits direct comparisons between studies and necessitates a cautious interpretation of claims regarding long-term antibacterial efficacy, functional tissue regeneration, and routine clinical applicability. Conclusions: Antibacterial and bioregenerative nanomaterials represent a relevant and continuously evolving research direction in restorative dentistry. Their successful clinical translation will depend on establishing standardized testing protocols, conducting comprehensive safety assessments, and generating clinically relevant evidence supporting long-term efficacy and biological compatibility. Their successful clinical translation will depend on establishing standardized testing protocols, conducting comprehensive safety assessments, and generating clinically relevant evidence supporting long-term efficacy and biological compatibility.

Background/Objectives: Curcuma longa is widely recognized for its antioxidant, antimicrobial, and wound-related biological effects. The present study aimed to compare two extracts prepared from organic turmeric powder (Curcuma longa), using distilled water (CUR-H₂O) and 96% ethanol (CUR-EtOH), in terms of extraction yield, phytochemical profile, antimicrobial activity, and in vitro biological behavior relevant to future oral-health-oriented applications. Methods: The extracts were prepared by maceration followed by ultrasound-assisted processing, concentration, and lyophilization. Their antioxidant potential (AOP) was evaluated by DPPH assay, total phenolic content (TPC) by the Folin–Ciocalteu method, and targeted polyphenolic profile by UHPLC-MS. Antimicrobial activity was assessed by broth microdilution against Streptococcus mutans, Streptococcus oralis, and Candida albicans. In vitro biological activity was investigated on HaCaT keratinocytes. Results: CUR-EtOH extract showed a higher extraction yield than CUR-H₂O (5.13% vs. 2.01%), higher AOP (69.54 ± 0.49% vs. 53.35 ± 0.30%), and a higher TPC (163.87 ± 0.32 vs. 78.05 ± 0.28 mg GAE/g dry extract). Consistent with these TPC results, UHPLC-MS revealed a richer targeted polyphenolic profile in CUR-EtOH extract, particularly in terms of p-coumaric and ferulic acid derivatives. CUR-EtOH extract was more active against the tested oral streptococci, especially S. mutans (MIC 10 µL vs. 60 µL for CUR-H₂O), whereas CUR-H₂O extract showed a slightly better antifungal effect against C. albicans (MIC 60 µL vs. 80 µL). In HaCaT cells, CUR-H₂O extract exhibited the more favorable compatibility profile, while CUR-EtOH extract showed stronger cytotoxicity, despite promoting faster wound-gap closure at 10 µg/mL. Conclusions: The extraction solvent strongly influenced both the chemical profile and biological behavior of the turmeric-powder-derived extracts. These findings suggest that solvent selection may be used to tailor the balance between antimicrobial efficacy and epithelial compatibility in future turmeric-powder-derived preparations intended for oral-health-oriented applications.

Background: The rapid evolution of dental adhesive systems presents both opportunities and challenges for clinical practice, particularly regarding the translation of emerging evidence into routine use. Aim: This study aimed to assess the knowledge, attitudes, and self-reported practices related to modern adhesive systems among Romanian dentists and to explore factors associated with their clinical decision-making. Materials and Methods: An observational cross-sectional study was conducted between November 2025 and February 2026 using a 115-item online questionnaire. A convenience sample of 372 Romanian dentists participated. Statistical analysis included descriptive statistics, chi-square and Kruskal–Wallis tests, and multivariate models (multiple linear regression, binary logistic regression, and multinomial logistic regression). Internal consistency of the knowledge scale was assessed using Cronbach’s alpha. Results: The knowledge scale demonstrated good reliability (Cronbach’s α = 0.873). Although 68.0% of respondents reported familiarity with universal adhesives, a discrepancy between awareness and reported clinical application was observed for several key concepts, including MMP inhibitors and hydrolytic stability. Notably, 14.8% of participants were unaware whether their preferred adhesive system contained 10-MDP. Continuing education frequency was the only independent predictor of higher knowledge scores (β = 1.63, p = 0.024), while greater clinical experience was inversely associated with rubber dam use (OR = 0.550, p = 0.024). Conclusions: The findings suggest a discrepancy between theoretical knowledge and the clinical implementation of modern adhesive concepts. Structured continuing education plays a critical role in improving knowledge and may help bridge this gap in clinical practice.

Introduction: Dietary habits adopted during young adulthood play a critical role in physical, emotional, and cognitive health. University students represent a particularly vulnerable group due to academic stress, lifestyle transitions, and increased autonomy, factors that may influence eating behaviors, body weight perception, and psychological well-being. This study aims to examine dietary habits among students and their associations with self-perceived body weight, lifestyle characteristics, and psychological factors within a biopsychosocial framework. Materials and Methods: A cross-sectional observational study was conducted using a structured, self-administered online questionnaire distributed to university students aged 18–30 years in Romania. The questionnaire assessed dietary habits, nutritional knowledge, lifestyle behaviors, and psychological variables, including perceived stress and body weight perception. Body mass index was calculated based on self-reported anthropometric data. Results: The findings indicated substantial variability in dietary behaviors, with a high prevalence of irregular meal patterns, frequent snacking, and engagement in weight-control practices. Irregular meal patterns were reported by approximately 62% of participants, while 47% had engaged in at least one weight-loss diet. Discrepancies between self-reported BMI and perceived body weight were observed in roughly 38% of cases, and 83% of respondents reported at least one psychological symptom (stress, anxiety, or low mood) related to eating behaviors. A positive correlation was observed between sleep duration and perceived rest quality (r = 0.364, p < 0.001). High frequencies of caffeinated beverage consumption were also observed. Additionally, 204 participants reported no alcohol consumption, while the variety of alcoholic beverages consumed was strongly correlated with alcohol intake frequency (r = 0.734, p < 0.001). Conclusions: Dietary habits among university students are closely interconnected with body weight perception, lifestyle behaviors, and psychological well-being. These findings emphasize the need for integrative health promotion strategies that address nutrition, emotional regulation, and lifestyle balance to support mental and cognitive health during young adulthood.