Background/Objectives: The Agenesis of maxillary lateral incisors occurs with a variable prevalence in different ethnic groups, and there is a need for a temporary replacement until maturity has been reached in patients for whom the replacement solution has been chosen. This study aims to analyze the scientific evidence available to date concerning the use of mini-screw implant (MSI)-supported pontics for the transitional management of permanent maxillary lateral incisors’ agenesis in developmental age subjects. Methods: Electronic research was conducted using four databases: PubMed, Clarivate Analytics/Web of Science Core Collection, Scopus, and the Wiley/Cochrane Library. Six studies were included in the final review. Data were extracted based on the first and second author, year of publication, study design, sample characteristics, mini-screw implant (MSI) characteristics, MSI insertion and loading protocol, characteristics of the prosthetic component, and outcomes during the follow-up time. Results: Clinical outcomes were proven positive in all studies. In only one study did MSIs show mobility and consequent failure after one month. Discoloration of the prosthetic part proved to be the main complication. Conclusions: The comparison with conventional removable prostheses and fixed dental prostheses revealed that MSI-supported pontics are a viable alternative and a promising temporary solution until the end of growth. Further studies to standardize protocols and assess long-term outcomes are needed.