Cardiovascular diseases are one of the leading causes of mortality and morbidity worldwide. The pathogenesis of this group of disorders is highly complex and involves interactions between various cell types and substances, among others, catestatin (CTS). In recent years, numerous researchers have expanded our knowledge about CTS’s role in development and its potential for the treatment of a variety of diseases. In this review, the authors discuss CTS’s importance in the pathogenesis of arterial hypertension, coronary artery disease, and heart failure. Moreover, we present CTS’s influence on heart and vessel function.