Prof. Dr. Mauricio Federico Erben
Facultad de Ciencias Exactas, National University of La Plata, La Plata, Buenos Aires, Argentina
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Dean of the Facultad de Ciencias Exactas UNLP - Full Profess...
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Academic Career Length
18Years (2009-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications11 September 2013 in Journal of Sulfur Chemistry
Journal Article
This review provides an overview of the chemistry, structure and potential applications of 1-(acyl/aroyl)-3-(mono-substituted) and 1-(acyl/aroyl)-3,3-(di-substituted) thioureas, with general formula R1C(O)N(1)HC(S)N(3)R2R3. In recent years, the title compounds have found extensive applications as ligands in coordination chemistry. The effect that nitrogen substituents exert on the intra- and intermolecular hydrogen-bonding interactions is discussed, including their role on the coordination properties displayed by these ligands. Novel applications of transition metal complexes bearing 1-(acyl/aroyl)-3-(mono- and di-substituted) thioureas are introduced. Biological aspects are also highlighted. As recently demonstrated, high-throughput screening assay and structure–activity analyses are feasible for this class of compounds. The chemical versatility of 1-(acyl)-3-(substituted) thiourea molecules and the derived metal complexes, together with the possibility of determining detailed structural properties, join biological applications in a promising interdisciplinary approach. The bibliography includes 382 references with emphasis on the literature appearing after 2007. GRAPHICAL ABSTRACT
1 May 2016 in Journal of Molecular Structure
Journal Article
ASAamer Saeed
Aamer SaeedSASaba Ashraf
Saba AshrafUFUlrich Flörke
Ulrich Flörke
ZEZuly Yuliana Delgado Espinoza
Zuly Yuliana Delgado Espinoza
Mauricio Federico ErbenHPHiram Pérez
Hiram Pérez
1 September 2015 in CrystEngComm
Journal Article
ASAamer Saeed
Aamer SaeedMBMichael Bolte
Michael Bolte
Mauricio Federico ErbenHPHiram Pérez
Hiram PérezThe conformationally congested species 1-(adamantane-1-carbonyl)-3-(2,4,6-trimethylphenyl)thiourea has been prepared and fully characterized by elemental analyses, FTIR, 1H NMR, 13C NMR and mass spectrometry. Its crystal structure was determined by single-crystal X-ray diffraction. The dihedral angle between the plane of the 2,4,6-trimethylphenyl group and the plane of the thiourea fragment was optimized by theoretical calculations applying the B3LYP/6-311++G(d,p) level for the purpose of investigating the conformational effects on the stabilization of the crystal packing. A detailed analysis of the intermolecular interactions in a series of six closely related phenylthiourea species bearing the 1-(adamantane-1-carbonyl) group has been performed based on the Hirshfeld surfaces and their associated two-dimensional fingerprint plots. The relative contributions of the main intermolecular contacts as well as the enrichment ratios derived from the Hirshfeld surface analysis establish the 1-acyl thiourea synthon to be a widespread contributor.
1 May 2015 in Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
Journal Article
ASAamer Saeed
Aamer SaeedAKAsma Khurshid
Asma Khurshid
MBMichael Bolte
Michael Bolte
AFAdolfo C. Fantoni
Adolfo C. Fantoni
Mauricio Federico ErbenJournal Article
DSDanish Shahzad
Danish ShahzadASAamer Saeed
Aamer SaeedFAFayaz Ali
Fayaz AliPCPervaiz Ali Channar
Pervaiz Ali ChannarQAQamar Abbas
Qamar Abbas
Hesham El-Seedi +6
A series of symmetrical salicylaldehyde-bishydrazine azo molecules, 5a–5h, have been synthesized, characterized by 1H-NMR and 13C-NMR, and evaluated for their in vitro α-glucosidase and α-amylase inhibitory activities. All the synthesized compounds efficiently inhibited both enzymes. Compound 5g was the most potent derivative in the series, and powerfully inhibited both α-glucosidase and α-amylase. The IC50 of 5g against α-glucosidase was 0.35917 ± 0.0189 µM (standard acarbose IC50 = 6.109 ± 0.329 µM), and the IC50 value of 5g against α-amylase was 0.4379 ± 0.0423 µM (standard acarbose IC50 = 33.178 ± 2.392 µM). The Lineweaver-Burk plot indicated that compound 5g is a competitive inhibitor of α-glucosidase. The binding interactions of the most active analogues were confirmed through molecular docking studies. Docking studies showed that 5g interacts with the residues Trp690, Asp548, Arg425, and Glu426, which form hydrogen bonds to 5g with distances of 2.05, 2.20, 2.10 and 2.18 Å, respectively. All compounds showed high mutagenic and tumorigenic behaviors, and only 5e showed irritant properties. In addition, all the derivatives showed good antioxidant activities. The pharmacokinetic evaluation also revealed promising results
1 April 2017 in Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
Journal Article
RCRaúl Ramos Cairo
Raúl Ramos Cairo
ASAna María Plutín Stevens
Ana María Plutín StevensTOTamires Donizeth de Oliveira
Tamires Donizeth de OliveiraABAlzir A. Batista
Alzir A. Batista
ECEduardo E. Castellano
Eduardo E. CastellanoMauricio Federico Erben +4
About Me
Born in Argentina in 1975, I earned a Bachelor’s in Chemistry (Physical Chemistry focus) from Universidad Nacional de La Plata (UNLP) in 2000 and a Ph.D. in Inorganic Chemistry from CEQUINOR in 2005 as a CONICET fellow. My research includes international stays in Germany, Cuba, and China, and the Brazilian synchrotron. Since 2007, I have been a CONICET researcher, now a Principal Investigator, with over 150 publications and numerous conference presentations.
With over 30 years of teaching experience, I am currently a Full Professor of Inorganic Chemistry. My research focuses on sulfur-containing compounds, their synthesis, and applications. A key achievement was developing compounds active against multidrug-resistant bacteria in cystic fibrosis patients, patented by CONICET and UNLP, and awarded the 2017 INNOVAR Prize.
I lecture globally, foster South-South collaborations, and have trained students at all academic levels. Recognitions include the UNLP Award (2010), the National Academy of Exact Sciences Award (2012), and the "María Cristina Giordano" Prize (2023). I am an alumni member of TWAS, representing Latin America and the Caribbean.
Beyond research, I engage in literacy programs for marginalized communities and have served in university governance, including as Dean of UNLP’s Facultad de Ciencias Exactas since 2018, reelected in 2022. My career reflects a commitment to science, education, and social development.
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