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Xanthones, polyphenolic compounds, are one of the most important classes in natural products, as they exhibit variety of pharmacological and health benefits, i.e., anti-obesity, antidiabetic, antioxidant, anti-Alzheimer, anti-inflammatory, and anticancer. Xanthones can be found in higher plants that are used as food sources, for example, Garcinia mangostana L. (the queen of fruits, mangosteen), a tropical fruit with reddish-purple pericarp that ca. 80% of it consists of xanthones. α-, β-, and γ-Mangostin are the major xanthones present in mangosteen that exhibit potential pharmacological activities. Mangosteen is used as popular food in beverages and in other health products. Also, it is traditionally used as a remedy in treating wounds, inflammation, and bacterial infections. Here in in this chapter, we draw the attention to xanthone compounds present in mangosteen showing their bioactivity and benefits on health, biosynthesis, drug discovery, registered patents, and physicochemical property space.
Hesham R. El-Seedi; Mohamed A. Salem; Omar M. Khattab; Aida Abd El-Wahed; Dina M. El-Kersh; Shaden A. M. Khalifa; Aamer Saeed; Mohamed M. Abdel-Daim; Nahid H. Hajrah; Muaaz M. Alajlani; Mohammed F. Halabi; Amir R. Jassbi; Syed G. Musharraf; Mohamed A. Farag. Dietary Xanthones. Handbook of Dietary Phytochemicals 2021, 325 -346.
AMA StyleHesham R. El-Seedi, Mohamed A. Salem, Omar M. Khattab, Aida Abd El-Wahed, Dina M. El-Kersh, Shaden A. M. Khalifa, Aamer Saeed, Mohamed M. Abdel-Daim, Nahid H. Hajrah, Muaaz M. Alajlani, Mohammed F. Halabi, Amir R. Jassbi, Syed G. Musharraf, Mohamed A. Farag. Dietary Xanthones. Handbook of Dietary Phytochemicals. 2021; ():325-346.
Chicago/Turabian StyleHesham R. El-Seedi; Mohamed A. Salem; Omar M. Khattab; Aida Abd El-Wahed; Dina M. El-Kersh; Shaden A. M. Khalifa; Aamer Saeed; Mohamed M. Abdel-Daim; Nahid H. Hajrah; Muaaz M. Alajlani; Mohammed F. Halabi; Amir R. Jassbi; Syed G. Musharraf; Mohamed A. Farag. 2021. "Dietary Xanthones." Handbook of Dietary Phytochemicals , no. : 325-346.
The discovery and identification of novel natural products of medicinal importance in the herbal medicine industry becomes a challenge. The complexity of this process can be reduced by dereplication strategies. The current study includes a method based on high-performance liquid chromatography (HPLC), using the evaporative light scattering detector (ELSD) to identify the 12 most common secondary metabolites in plant extracts. Twelve compounds including rutin, taxifolin, quercetin, apigenin, kaempferol, betulinic acid, oleanolic acid, betulin, lupeol, stigmasterol, and β-sitosterol were analyzed simultaneously. The polarity of the compounds varied greatly from highly polar (flavonoids) to non-polar (triterpenes and sterols). This method was also tested for HPLC-DAD and HPLC-ESI-MS/MS analysis. Oleanolic acid and ursolic acid could not be separated in HPLC-ELSD analysis but were differentiated using LC-ESI-MS/MS analysis due to different fragment ions. The regression values (R2 > 0.996) showed good linearity in the range of 50–1000 µg/mL for all compounds. The range of LOD and LOQ values were 7.76–38.30 µg/mL and 23.52–116.06 µg/mL, respectively. %RSD and % trueness values of inter and intraday studies were mostly <10%. This method was applied on 10 species of medicinal plants. The dereplication strategy has the potential to facilitate and shorten the identification process of common secondary metabolites in complex plant extracts.
Kiran Ali; Arslan Ali; Muhammad Khan; Saeedur Rahman; Shaheen Faizi; Muhammad Ali; Shaden Khalifa; Hesham El-Seedi; Syed Musharraf. Rapid Identification of Common Secondary Metabolites of Medicinal Herbs Using High-Performance Liquid Chromatography with Evaporative Light Scattering Detector in Extracts. Metabolites 2021, 11, 489 .
AMA StyleKiran Ali, Arslan Ali, Muhammad Khan, Saeedur Rahman, Shaheen Faizi, Muhammad Ali, Shaden Khalifa, Hesham El-Seedi, Syed Musharraf. Rapid Identification of Common Secondary Metabolites of Medicinal Herbs Using High-Performance Liquid Chromatography with Evaporative Light Scattering Detector in Extracts. Metabolites. 2021; 11 (8):489.
Chicago/Turabian StyleKiran Ali; Arslan Ali; Muhammad Khan; Saeedur Rahman; Shaheen Faizi; Muhammad Ali; Shaden Khalifa; Hesham El-Seedi; Syed Musharraf. 2021. "Rapid Identification of Common Secondary Metabolites of Medicinal Herbs Using High-Performance Liquid Chromatography with Evaporative Light Scattering Detector in Extracts." Metabolites 11, no. 8: 489.
The coronavirus pandemic has affected more than 150 million people, while over 3.25 million people have died from the coronavirus disease 2019 (COVID-19). As there are no established therapies for COVID-19 treatment, drugs that inhibit viral replication are a promising target; specifically, the main protease (Mpro) that process CoV-encoded polyproteins serves as an Achilles heel for assembly of replication-transcription machinery as well as down-stream viral replication. In the search for potential antiviral drugs that target Mpro, a series of cembranoid diterpenes from the biologically active soft-coral genus Sarcophyton have been examined as SARS-CoV-2 Mpro inhibitors. Over 360 metabolites from the genus were screened using molecular docking calculations. Promising diterpenes were further characterized by molecular dynamics (MD) simulations based on molecular mechanics-generalized Born surface area (MM-GBSA) binding energy calculations. According to in silico calculations, five cembranoid diterpenes manifested adequate binding affinities as Mpro inhibitors with ΔGbinding< −33.0 kcal/mol. Binding energy and structural analyses of the most potent Sarcophyton inhibitor, bislatumlide A (340), was compared to darunavir, an HIV protease inhibitor that has been recently subjected to clinical-trial as an anti-COVID-19 drug. In silico analysis indicates that 340 has a higher binding affinity against Mpro than darunavir with ΔGbinding values of −43.8 and −34.8 kcal/mol, respectively throughout 100 ns MD simulations. Drug-likeness calculations revealed robust bioavailability and protein-protein interactions were identified for 340; biochemical signaling genes included ACE, MAPK14 and ESR1 as identified based on a STRING database. Pathway enrichment analysis combined with reactome mining revealed that 340 has the capability to re-modulate the p38 MAPK pathway hijacked by SARS-CoV-2 and antagonize injurious effects. These findings justify further in vivo and in vitro testing of 340 as an antiviral agent against SARS-CoV-2.
Mahmoud Ibrahim; Alaa Abdelrahman; Mohamed Atia; Tarik Mohamed; Mahmoud Moustafa; Abdulrahim Hakami; Shaden Khalifa; Fahad Alhumaydhi; Faris Alrumaihi; Syed Abidi; Khaled Allemailem; Thomas Efferth; Mahmoud Soliman; Paul Paré; Hesham El-Seedi; Mohamed-Elamir Hegazy. Blue Biotechnology: Computational Screening of Sarcophyton Cembranoid Diterpenes for SARS-CoV-2 Main Protease Inhibition. Marine Drugs 2021, 19, 391 .
AMA StyleMahmoud Ibrahim, Alaa Abdelrahman, Mohamed Atia, Tarik Mohamed, Mahmoud Moustafa, Abdulrahim Hakami, Shaden Khalifa, Fahad Alhumaydhi, Faris Alrumaihi, Syed Abidi, Khaled Allemailem, Thomas Efferth, Mahmoud Soliman, Paul Paré, Hesham El-Seedi, Mohamed-Elamir Hegazy. Blue Biotechnology: Computational Screening of Sarcophyton Cembranoid Diterpenes for SARS-CoV-2 Main Protease Inhibition. Marine Drugs. 2021; 19 (7):391.
Chicago/Turabian StyleMahmoud Ibrahim; Alaa Abdelrahman; Mohamed Atia; Tarik Mohamed; Mahmoud Moustafa; Abdulrahim Hakami; Shaden Khalifa; Fahad Alhumaydhi; Faris Alrumaihi; Syed Abidi; Khaled Allemailem; Thomas Efferth; Mahmoud Soliman; Paul Paré; Hesham El-Seedi; Mohamed-Elamir Hegazy. 2021. "Blue Biotechnology: Computational Screening of Sarcophyton Cembranoid Diterpenes for SARS-CoV-2 Main Protease Inhibition." Marine Drugs 19, no. 7: 391.
Heavy metals accumulating in the human body produce physiological toxicity by interfering with the transport of human proteins and enzymes. Heavy metals detection is significant for food safety assurance. This review focuses on recent advances of heavy metals detection of food and agricultural products by surface-enhanced Raman spectroscopy (SERS). The article covers the SERS basic principles and advances in heavy metals detection, including mercury, arsenic, cadmium, lead, chromium among others. Insights in the potential of combining chemometrics and multivariate analysis with SERS and the exploration of novel SERS substrate platforms from both macro and micro scale are discussed. Finally, future application of SERS in heavy metal detection are prospected. SERS is a powerful and promising technique offering the advantages of simple sampling, rapid data collection and non-invasiveness. The findings of this study can allow better understanding of the heavy metals’ occurrence and the possibility of its detection using SERS.
Zhiming Guo; Ping Chen; Nermeen Yosri; Quansheng Chen; Hesham R. Elseedi; Xiaobo Zou; Hongshun Yang. Detection of Heavy Metals in Food and Agricultural Products by Surface-enhanced Raman Spectroscopy. Food Reviews International 2021, 1 -22.
AMA StyleZhiming Guo, Ping Chen, Nermeen Yosri, Quansheng Chen, Hesham R. Elseedi, Xiaobo Zou, Hongshun Yang. Detection of Heavy Metals in Food and Agricultural Products by Surface-enhanced Raman Spectroscopy. Food Reviews International. 2021; ():1-22.
Chicago/Turabian StyleZhiming Guo; Ping Chen; Nermeen Yosri; Quansheng Chen; Hesham R. Elseedi; Xiaobo Zou; Hongshun Yang. 2021. "Detection of Heavy Metals in Food and Agricultural Products by Surface-enhanced Raman Spectroscopy." Food Reviews International , no. : 1-22.
Bee pollen is a combination of plant pollen and honeybee secretions and nectar. The Bible and ancient Egyptian texts are documented proof of its use in public health. It is considered a gold mine of nutrition due to its active components that have significant health and medicinal properties. Bee pollen contains bioactive compounds including proteins, amino acids, lipids, carbohydrates, minerals, vitamins, and polyphenols. The vital components of bee pollen enhance different bodily functions and offer protection against many diseases. It is generally marketed as a functional food with affordable and inexpensive prices with promising future industrial potentials. This review highlights the dietary properties of bee pollen and its influence on human health, and its applications in the food industry.
Shaden Khalifa; Mohamed Elashal; Nermeen Yosri; Ming Du; Syed Musharraf; Lutfun Nahar; Satyajit Sarker; Zhiming Guo; Wei Cao; Xiaobo Zou; Aida Abd El-Wahed; Jianbo Xiao; Hany Omar; Mohamed-Elamir Hegazy; Hesham El-Seedi. Bee Pollen: Current Status and Therapeutic Potential. Nutrients 2021, 13, 1876 .
AMA StyleShaden Khalifa, Mohamed Elashal, Nermeen Yosri, Ming Du, Syed Musharraf, Lutfun Nahar, Satyajit Sarker, Zhiming Guo, Wei Cao, Xiaobo Zou, Aida Abd El-Wahed, Jianbo Xiao, Hany Omar, Mohamed-Elamir Hegazy, Hesham El-Seedi. Bee Pollen: Current Status and Therapeutic Potential. Nutrients. 2021; 13 (6):1876.
Chicago/Turabian StyleShaden Khalifa; Mohamed Elashal; Nermeen Yosri; Ming Du; Syed Musharraf; Lutfun Nahar; Satyajit Sarker; Zhiming Guo; Wei Cao; Xiaobo Zou; Aida Abd El-Wahed; Jianbo Xiao; Hany Omar; Mohamed-Elamir Hegazy; Hesham El-Seedi. 2021. "Bee Pollen: Current Status and Therapeutic Potential." Nutrients 13, no. 6: 1876.
The COVID-19 pandemic is a serious challenge for societies around the globe as entire populations have fallen victim to the infectious spread and have taken up social distancing. In many countries, people have had to self-isolate and to be confined to their homes for several weeks to months to prevent the spread of the virus. Social distancing measures have had both negative and positive impacts on various aspects of economies, lifestyles, education, transportation, food supply, health, social life, and mental wellbeing. On other hands, due to reduced population movements and the decline in human activities, gas emissions decreased and the ozone layer improved; this had a positive impact on Earth’s weather and environment. Overall, the COVID-19 pandemic has negative effects on human activities and positive impacts on nature. This study discusses the impact of the COVID-19 pandemic on different life aspects including the economy, social life, health, education, and the environment.
Shaden A. M. Khalifa; Mahmoud M. Swilam; Aida A. Abd El-Wahed; Ming Du; Haged H. R. El-Seedi; Guoyin Kai; Saad H. D. Masry; Mohamed M. Abdel-Daim; Xiaobo Zou; Mohammed F. Halabi; Sultan M. Alsharif; Hesham R. El-Seedi. Beyond the Pandemic: COVID-19 Pandemic Changed the Face of Life. International Journal of Environmental Research and Public Health 2021, 18, 5645 .
AMA StyleShaden A. M. Khalifa, Mahmoud M. Swilam, Aida A. Abd El-Wahed, Ming Du, Haged H. R. El-Seedi, Guoyin Kai, Saad H. D. Masry, Mohamed M. Abdel-Daim, Xiaobo Zou, Mohammed F. Halabi, Sultan M. Alsharif, Hesham R. El-Seedi. Beyond the Pandemic: COVID-19 Pandemic Changed the Face of Life. International Journal of Environmental Research and Public Health. 2021; 18 (11):5645.
Chicago/Turabian StyleShaden A. M. Khalifa; Mahmoud M. Swilam; Aida A. Abd El-Wahed; Ming Du; Haged H. R. El-Seedi; Guoyin Kai; Saad H. D. Masry; Mohamed M. Abdel-Daim; Xiaobo Zou; Mohammed F. Halabi; Sultan M. Alsharif; Hesham R. El-Seedi. 2021. "Beyond the Pandemic: COVID-19 Pandemic Changed the Face of Life." International Journal of Environmental Research and Public Health 18, no. 11: 5645.
Microplastics (MPs) are ubiquitous and persistent pollutants, and have been detected in a wide variety of media, from soils to aquatic systems. MPs, consisting primarily of polyethylene, polypropylene, and polyacrylamide polymers, have recently been found in 12% of samples of honey collected in Ecuador. Recently, MPs have also been identified in honey bees collected from apiaries in Copenhagen, Denmark, as well as nearby semiurban and rural areas. Given these documented exposures, assessment of their effects is critical for understanding the risks of MP exposure to honey bees. Exposure to polystyrene (PS)-MPs decreased diversity of the honey bee gut microbiota, followed by changes in gene expression related to oxidative damage, detoxification, and immunity. As a result, the aim of this perspective was to investigate whether wide-spread prevalence of MPs might have unintended negative effects on health and fitness of honey bees, as well as to draw the scientific community’s attention to the possible risks of MPs to the fitness of honey bees. Several research questions must be answered before MPs can be considered a potential threat to bees.
Yahya Al Naggar; Markus Brinkmann; Christie Sayes; Saad Al-Kahtani; Showket Dar; Hesham El-Seedi; Bernd Grünewald; John Giesy. Are Honey Bees at Risk from Microplastics? Toxics 2021, 9, 109 .
AMA StyleYahya Al Naggar, Markus Brinkmann, Christie Sayes, Saad Al-Kahtani, Showket Dar, Hesham El-Seedi, Bernd Grünewald, John Giesy. Are Honey Bees at Risk from Microplastics? Toxics. 2021; 9 (5):109.
Chicago/Turabian StyleYahya Al Naggar; Markus Brinkmann; Christie Sayes; Saad Al-Kahtani; Showket Dar; Hesham El-Seedi; Bernd Grünewald; John Giesy. 2021. "Are Honey Bees at Risk from Microplastics?" Toxics 9, no. 5: 109.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent for the COVID-19 pandemic, which generated more than 1.82 million deaths in 2020 alone, in addition to 83.8 million infections. Currently, there is no antiviral medication to treat COVID-19. In the search for drug leads, marine-derived metabolites are reported here as prospective SARS-CoV-2 inhibitors. Two hundred and twenty-seven terpene natural products isolated from the biodiverse Red-Sea ecosystem were screened for inhibitor activity against the SARS-CoV-2 main protease (Mpro) using molecular docking and molecular dynamics (MD) simulations combined with molecular mechanics/generalized Born surface area binding energy calculations. On the basis of in silico analyses, six terpenes demonstrated high potency as Mpro inhibitors with ΔG binding ≤ −40.0 kcal/mol. The stability and binding affinity of the most potent metabolite, erylosides B, were compared to the human immunodeficiency virus protease inhibitor, lopinavir. Erylosides B showed greater binding affinity towards SARS-CoV-2 Mpro than lopinavir over 100 ns with ΔG binding values of −51.9 vs. −33.6 kcal/mol, respectively. Protein–protein interactions indicate that erylosides B biochemical signaling shares gene components that mediate severe acute respiratory syndrome diseases, including the cytokine- and immune-signaling components BCL2L1, IL2, and PRKC. Pathway enrichment analysis and Boolean network modeling were performed towards a deep dissection and mining of the erylosides B target–function interactions. The current study identifies erylosides B as a promising anti-COVID-19 drug lead that warrants further in vitro and in vivo testing.
Mahmoud Ibrahim; Alaa Abdelrahman; Tarik Mohamed; Mohamed Atia; Montaser Al-Hammady; Khlood Abdeljawaad; Eman Elkady; Mahmoud Moustafa; Faris Alrumaihi; Khaled Allemailem; Hesham El-Seedi; Paul Paré; Thomas Efferth; Mohamed-Elamir Hegazy. In Silico Mining of Terpenes from Red-Sea Invertebrates for SARS-CoV-2 Main Protease (Mpro) Inhibitors. Molecules 2021, 26, 2082 .
AMA StyleMahmoud Ibrahim, Alaa Abdelrahman, Tarik Mohamed, Mohamed Atia, Montaser Al-Hammady, Khlood Abdeljawaad, Eman Elkady, Mahmoud Moustafa, Faris Alrumaihi, Khaled Allemailem, Hesham El-Seedi, Paul Paré, Thomas Efferth, Mohamed-Elamir Hegazy. In Silico Mining of Terpenes from Red-Sea Invertebrates for SARS-CoV-2 Main Protease (Mpro) Inhibitors. Molecules. 2021; 26 (7):2082.
Chicago/Turabian StyleMahmoud Ibrahim; Alaa Abdelrahman; Tarik Mohamed; Mohamed Atia; Montaser Al-Hammady; Khlood Abdeljawaad; Eman Elkady; Mahmoud Moustafa; Faris Alrumaihi; Khaled Allemailem; Hesham El-Seedi; Paul Paré; Thomas Efferth; Mohamed-Elamir Hegazy. 2021. "In Silico Mining of Terpenes from Red-Sea Invertebrates for SARS-CoV-2 Main Protease (Mpro) Inhibitors." Molecules 26, no. 7: 2082.
Centaurothamnus maximus (family Asteraceae), is a leafy shrub indigenous to the southwestern Arabian Peninsula. With a paucity of phytochemical data on this species, we set out to chemically characterize the plant. From the aerial parts, two newly identified guaianolides were isolated: 3β-hydroxy-4α(acetoxy)-4β(hydroxymethyl)-8α-(4-hydroxy methacrylate)-1αH,5αH, 6αH-gual-10(14),11(13)-dien-6,12-olide (1) and 15-descarboxy picrolide A (2). Seven previously reported compounds were also isolated: 3β, 4α, 8α-trihydroxy-4-(hydroxymethyl)-lαH, 5αH, 6βH, 7αH-guai-10(14),11(13)-dien-6,12-olide (3), chlorohyssopifolin B (4), cynaropikrin (5), hydroxyjanerin (6), chlorojanerin (7), isorhamnetin (8), and quercetagetin-3,6-dimethyl ether-4’-O-β-d-pyranoglucoside (9). Chemical structures were elucidated using spectroscopic techniques, including High Resolution Fast Atom Bombardment Mass Spectrometry (HR-FAB-MS), 1D NMR; 1H, 13C NMR, Distortionless Enhancement by Polarization Transfer (DEPT), and 2D NMR (1H-1H COSY, HMQC, HMBC) analyses. In addition, a biosynthetic pathway for compounds 1–9 is proposed. The chemotaxonomic significance of the reported sesquiterpenoids and flavonoids considering reports from other Centaurea species is examined.
Taha Hussien; Tarik Mohamed; Abdelsamed Elshamy; Mahmoud Moustafa; Hesham El-Seedi; Paul Pare; Mohamed-Elamir Hegazy. Guaianolide Sesquiterpene Lactones from Centaurothamnus maximus. Molecules 2021, 26, 2055 .
AMA StyleTaha Hussien, Tarik Mohamed, Abdelsamed Elshamy, Mahmoud Moustafa, Hesham El-Seedi, Paul Pare, Mohamed-Elamir Hegazy. Guaianolide Sesquiterpene Lactones from Centaurothamnus maximus. Molecules. 2021; 26 (7):2055.
Chicago/Turabian StyleTaha Hussien; Tarik Mohamed; Abdelsamed Elshamy; Mahmoud Moustafa; Hesham El-Seedi; Paul Pare; Mohamed-Elamir Hegazy. 2021. "Guaianolide Sesquiterpene Lactones from Centaurothamnus maximus." Molecules 26, no. 7: 2055.
The genus Centaurea is recognized in folk medicine for anti-inflammatory, anti-itch, antitussive, purgative, astringent, and tonic activities. To study the chemical determinant for antimicrobial activity essential oils (EOs), five Centaurea species were analyzed including: C. scoparia, C. calcitrapa, C. glomerata, C. lipii and C. alexandrina. Conventional hydro-distillation (HD) and microwave-assisted extraction (MAE), as new green technologies, were compared for the extraction of essential oils. GC/MS analysis identified 120 EOs including mostly terpenoid except from C. lipii and C. alexandrina in which nonterpenoids were the major constituents. Major terpenoids included spathulenol, caryophyllene oxide and alloaromadendrene oxide-2. To probe antibacterial activity, potential EO inhibitors of a bacterial type II DNA topoisomerase, DNA gyrase B were screened via an in silico molecular docking approach. Spathulenol and alloaromadendrene oxide-2 possessed the best binding affinity in the ATP- binding pocket of Gyrase B enzyme. Principal component analysis and agglomerative hierarchical clustering were used for sample classification and revealed that sesquiterpenes contributed the most for accessions classification. In vitro antimicrobial activity against Staphylococcus aureus, Escherichia coli and Aspergillus niger for all EOs were also evaluated. EOs from C. lipii, C. glomerata and C. calcitrapa exhibited significant MIC against S. aureus with an MIC value of 31.25 µg/mL.
Eman Reda; Zienab Shakour; Ali El-Halawany; El-SayedA El-Kashoury; Khaled Shams; Tarik Mohamed; Ibrahim Saleh; Abdelsamed Elshamy; Mohamed Atia; Ahmed El-Beih; Nahla Abdel-Azim; Hesham El-Seedi; Mohamed-Elamir Hegazy. Comparative Study on the Essential Oils from Five Wild Egyptian Centaurea Species: Effective Extraction Techniques, Antimicrobial Activity and In-Silico Analyses. Antibiotics 2021, 10, 252 .
AMA StyleEman Reda, Zienab Shakour, Ali El-Halawany, El-SayedA El-Kashoury, Khaled Shams, Tarik Mohamed, Ibrahim Saleh, Abdelsamed Elshamy, Mohamed Atia, Ahmed El-Beih, Nahla Abdel-Azim, Hesham El-Seedi, Mohamed-Elamir Hegazy. Comparative Study on the Essential Oils from Five Wild Egyptian Centaurea Species: Effective Extraction Techniques, Antimicrobial Activity and In-Silico Analyses. Antibiotics. 2021; 10 (3):252.
Chicago/Turabian StyleEman Reda; Zienab Shakour; Ali El-Halawany; El-SayedA El-Kashoury; Khaled Shams; Tarik Mohamed; Ibrahim Saleh; Abdelsamed Elshamy; Mohamed Atia; Ahmed El-Beih; Nahla Abdel-Azim; Hesham El-Seedi; Mohamed-Elamir Hegazy. 2021. "Comparative Study on the Essential Oils from Five Wild Egyptian Centaurea Species: Effective Extraction Techniques, Antimicrobial Activity and In-Silico Analyses." Antibiotics 10, no. 3: 252.
In search of anti-inflammatory compounds, novel scaffolds containing isonicotinoyl motif were synthesized via an efficient strategy. The compounds were screened for their in vitro anti-inflammatory activity. Remarkably high activities were observed for isonicotinates 5–6 and 8a–8b. The compound 5 exhibits an exceptional IC50 value (1.42 ± 0.1 µg/mL) with 95.9% inhibition at 25 µg/mL, which is eight folds better than the standard drug ibuprofen (11.2 ± 1.9 µg/mL). To gain an insight into the mode of action of anti-inflammatory compounds, molecular docking studies were also performed. Decisively, further development and fine tuning of these isonicotinates based scaffolds for the treatment of various aberrations is still a wide-open field of research.
Sana Yaqoob; Nourina Nasim; Rahila Khanam; Yan Wang; Almas Jabeen; Urooj Qureshi; Zaheer Ul-Haq; Hesham El-Seedi; Zi-Hua Jiang; Farooq-Ahmad Khan. Synthesis of Highly Potent Anti-Inflammatory Compounds (ROS Inhibitors) from Isonicotinic Acid. Molecules 2021, 26, 1272 .
AMA StyleSana Yaqoob, Nourina Nasim, Rahila Khanam, Yan Wang, Almas Jabeen, Urooj Qureshi, Zaheer Ul-Haq, Hesham El-Seedi, Zi-Hua Jiang, Farooq-Ahmad Khan. Synthesis of Highly Potent Anti-Inflammatory Compounds (ROS Inhibitors) from Isonicotinic Acid. Molecules. 2021; 26 (5):1272.
Chicago/Turabian StyleSana Yaqoob; Nourina Nasim; Rahila Khanam; Yan Wang; Almas Jabeen; Urooj Qureshi; Zaheer Ul-Haq; Hesham El-Seedi; Zi-Hua Jiang; Farooq-Ahmad Khan. 2021. "Synthesis of Highly Potent Anti-Inflammatory Compounds (ROS Inhibitors) from Isonicotinic Acid." Molecules 26, no. 5: 1272.
Type 2 diabetes mellitus (T2DM) and hypertension are common chronic diseases mainly associated with the development and progression of end-stage renal disease (ESRD) leading to morbidity and mortality. Gene polymorphisms linked to the renin–angiotensin (AGT)–aldosterone system (RAAS) were broadly inspected in patients with diabetic nephropathy (DN) and hypertension. This study aimed to investigate the association of AGT gene polymorphisms (rs699 and rs4762) with ESRD in T2DM hypertensive Egyptian patients. Genotyping of rs699 and rs4762 was conducted using the tetra-primers amplification refractory mutation system (ARMS-PCR). The allelic distribution analysis was performed on 103 healthy control subjects, 97 non-ESRD patients, and 104 patients with ESRD. The allelic frequencies of AGT gene polymorphisms (rs4762 and rs699) in all study participants were assessed. For the non-ESRD group, the frequencies of the alleles of AGT-rs4762 (χ 2 = 31.88, p < 0.001, OR = 5.17, CI 95%: 2.81–9.51) and AGT-rs699 (χ 2 = 4.85, p = 0.027, OR = 1.56, CI 95%: 1.05–2.33) were significantly associated with the non-ESRD group. However, for the ESRD group, the T allele was significantly higher than that in the controls (χ 2 = 24.97, p < 0.001, odds ratio (OR) = 4.35, CI 95%: 2.36–8.02). Moreover, AGT (rs699) genotypes showed no significant difference between the ESRD group and controls. In conclusion, AGT gene polymorphisms rs699 and rs4762 were associated with non-ESRD versus controls, without any significant risk observed in all patient groups. However, the AGT (rs4762) variant showed a significant risk in the ESRD group in comparison to controls in Egyptians.
Islam El-Garawani; Eman Shaheen; Hesham El-Seedi; Shaden Khalifa; Gaber Mersal; Mahmoud Emara; Zeinab Kasemy. Angiotensinogen Gene Missense Polymorphisms (rs699 and rs4762): The Association of End-Stage Renal Failure Risk with Type 2 Diabetes and Hypertension in Egyptians. Genes 2021, 12, 339 .
AMA StyleIslam El-Garawani, Eman Shaheen, Hesham El-Seedi, Shaden Khalifa, Gaber Mersal, Mahmoud Emara, Zeinab Kasemy. Angiotensinogen Gene Missense Polymorphisms (rs699 and rs4762): The Association of End-Stage Renal Failure Risk with Type 2 Diabetes and Hypertension in Egyptians. Genes. 2021; 12 (3):339.
Chicago/Turabian StyleIslam El-Garawani; Eman Shaheen; Hesham El-Seedi; Shaden Khalifa; Gaber Mersal; Mahmoud Emara; Zeinab Kasemy. 2021. "Angiotensinogen Gene Missense Polymorphisms (rs699 and rs4762): The Association of End-Stage Renal Failure Risk with Type 2 Diabetes and Hypertension in Egyptians." Genes 12, no. 3: 339.
Arabic gum (Acacia senegal, AG) is proven effective antioxidant and cytoprotective agent. The present study was designed to test this notion by investigating the possible role of AG against the radiographic contrast medium (Ioxitalamate, Telebrix-35®, TBX)-induced oxidative stress and genotoxicity. Albino rats were divided into four groups and supplied with either; distilled water, daily 10% (w/v) AG, an intravenous dose of TBX (1600 mg I/kg b.wt) and co-administration of TBX and AG. Rats were sacrificed and blood samples were collected to assess the genotoxicity employing the peripheral blood leucocytes fluorescent double staining; namely the acridine orange/ethidium bromide (AO/EB) staining and alkaline comet assay. Further, chromosomal analyses were done in bone marrow cells. Serum urea and creatinine levels, in addition to malondialdehyde (MDA), nitric oxide (NO), catalase (CAT) and glutathione (GSH) levels in kidney tissues were measured. Liquid chromatography-mass spectrophotometry (LC-MS-MS) was performed to identify the chemical composition of AG extract. Kidney functions, single/double-stranded DNA damage, chromosomal aberrations, mitotic index, MDA and NO levels were significantly (p < 0.001) increased in TBX-treated group compared to the control and AG-treated one. Meanwhile, CAT and GSH activities were significantly diminished and the AG supplementation significantly (p < 0.001) ameliorated these effects compared with the control and AG-treated groups. Five compounds have been identified using GNPS networking including 7,3′,4′-Trihydroxyisoflavone, Noscapine, Tetrahydropapaveroline, Costunolide, Hesperidin. In conclusion, results of the present study suggest that AG exerted a protective role against TBX-induced oxidative stress and genotoxicity which may be attributed to the active metabolites in the gum.
Islam El-Garawani; Sobhy Hassab El-Nabi; Ahmed El Kattan; Azza Sallam; Sabha Elballat; Shaimaa Abou-Ghanima; Islam H. El Azab; Hesham R. El-Seedi; Shaden A. M. Khalifa; Sawsan El-Shamy. The Ameliorative Role of Acacia senegal Gum against the Oxidative Stress and Genotoxicity Induced by the Radiographic Contrast Medium (Ioxitalamate) in Albino Rats. Antioxidants 2021, 10, 221 .
AMA StyleIslam El-Garawani, Sobhy Hassab El-Nabi, Ahmed El Kattan, Azza Sallam, Sabha Elballat, Shaimaa Abou-Ghanima, Islam H. El Azab, Hesham R. El-Seedi, Shaden A. M. Khalifa, Sawsan El-Shamy. The Ameliorative Role of Acacia senegal Gum against the Oxidative Stress and Genotoxicity Induced by the Radiographic Contrast Medium (Ioxitalamate) in Albino Rats. Antioxidants. 2021; 10 (2):221.
Chicago/Turabian StyleIslam El-Garawani; Sobhy Hassab El-Nabi; Ahmed El Kattan; Azza Sallam; Sabha Elballat; Shaimaa Abou-Ghanima; Islam H. El Azab; Hesham R. El-Seedi; Shaden A. M. Khalifa; Sawsan El-Shamy. 2021. "The Ameliorative Role of Acacia senegal Gum against the Oxidative Stress and Genotoxicity Induced by the Radiographic Contrast Medium (Ioxitalamate) in Albino Rats." Antioxidants 10, no. 2: 221.
The YPRKDETGAERT peptide (PME-1) identified from the Mytilus edulis proteins has been shown to promote the proliferation and differentiation of osteoblasts and it has good bone-forming activity in vitro and PME-1 was easily absorbed in the gastrointestinal tract.
Zhe Xu; Fengjiao Fan; Hui Chen; Pujie Shi; Dongyang Zhu; Meilian Yang; Zhenyu Wang; Hesham R. Ei-Seedi; Ming Du. Absorption and transport of aMytilus edulis-derived peptide with the function of preventing osteoporosis. Food & Function 2021, 12, 2102 -2111.
AMA StyleZhe Xu, Fengjiao Fan, Hui Chen, Pujie Shi, Dongyang Zhu, Meilian Yang, Zhenyu Wang, Hesham R. Ei-Seedi, Ming Du. Absorption and transport of aMytilus edulis-derived peptide with the function of preventing osteoporosis. Food & Function. 2021; 12 (5):2102-2111.
Chicago/Turabian StyleZhe Xu; Fengjiao Fan; Hui Chen; Pujie Shi; Dongyang Zhu; Meilian Yang; Zhenyu Wang; Hesham R. Ei-Seedi; Ming Du. 2021. "Absorption and transport of aMytilus edulis-derived peptide with the function of preventing osteoporosis." Food & Function 12, no. 5: 2102-2111.
Momordica charantia fruit is claimed to have healthy benefit. Despite this potential claim, the phytochemical study of this fruit is still lacking. Thus, this study aimed to evaluate the antioxidants profile of Momordica charantia (Cucurbitaceae) fruit. The antioxidant activity of the ethanolic extracts of various polarities was evaluated and the metabolites that are responsible for its activity were identified using metabolomics approach. Six different mixture of ethanol in water that are 0%, 20%, 40%, 60%, 80%, and 100% (v/v) was extracted using dveseeded fruit sample. Liquid chromatography-mass spectrometry-quadrupole time of flight and multivariate data analysis was used to identify the metabolites that were either antioxidants or pro-oxidants. The 80% ethanol extract exhibited the most antioxidant activity when tested in both 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) antioxidant assays. This extract showed the most intense LC-MS signals represented to ascorbic acid, margarolic acid, brevifolincarboxylic acid, quercetin 3-O-glycoside, kuguacin H, cucurbitacin E, 3-malonylmomordicin I, and goyaglycoside G correlating to the anti-oxidant activity. This study reports for the first time the existence of brevifolincarboxylic acid in this fruit, and the antioxidant activity of 3-malonylmomordicin I and goyaglycoside G. In addition, the loading plots revealed the unknown compounds possessing the antioxidant activity which are potential to be isolated in the future study.
Vikneswari Perumal; Alfi Khatib; Qamar Uddin Ahmed; Bisha Fathamah Uzir; Faridah Abas; Suganya Murugesu; Mohd Zuwairi Saiman; Riesta Primaharinastiti; Hesham El-Seedi. Antioxidants profile of Momordica charantia fruit extract analyzed using LC-MS-QTOF-based metabolomics. Food Chemistry: Molecular Sciences 2021, 2, 100012 .
AMA StyleVikneswari Perumal, Alfi Khatib, Qamar Uddin Ahmed, Bisha Fathamah Uzir, Faridah Abas, Suganya Murugesu, Mohd Zuwairi Saiman, Riesta Primaharinastiti, Hesham El-Seedi. Antioxidants profile of Momordica charantia fruit extract analyzed using LC-MS-QTOF-based metabolomics. Food Chemistry: Molecular Sciences. 2021; 2 ():100012.
Chicago/Turabian StyleVikneswari Perumal; Alfi Khatib; Qamar Uddin Ahmed; Bisha Fathamah Uzir; Faridah Abas; Suganya Murugesu; Mohd Zuwairi Saiman; Riesta Primaharinastiti; Hesham El-Seedi. 2021. "Antioxidants profile of Momordica charantia fruit extract analyzed using LC-MS-QTOF-based metabolomics." Food Chemistry: Molecular Sciences 2, no. : 100012.
The present study aimed to synthesize new metal complexes of diacetylmonoxime-N(4)antipyrinylthiosemicarbazone ligand and evaluate their antitumor activity. New complexes with ferric, cobalt, nickel and copper ions were prepared. Elemental, 1H Nuclear magnetic resonance, Mass spectroscopy, Electron paramagnetic resonance, Fourier Transform Infrared Spectroscopy, Ultraviolet–visible and thermal gravimetric analysis were used to characterize the obtained complexes 1–11. An in vivo tumor model was established to investigate the effect of the naked ligand and its metal complexes 2, 5 and 8. Ehrlich ascites carcinoma solid tumor was induced in mice through subcutaneous inoculation of Ehrlich ascites carcinoma cells. The volumes of the formed solid tumors, the alanine transaminase, aspartate transaminase, albumin concentration in the serum, as well as the levels of Ki67 and p53 proteins in tumor and liver tissues were detected. All the tested complexes, especially complex 5, possessed proliferative inhibition manifested as the reduction of the tumor volume, Alanine aminotransferase & Aspartate aminotransferase activity, and the level of the Ki67 protein. Additionally, they restored the albumin concentration to normal levels as well increased the level of pro-apoptotic p53 protein. In conclusion, the antitumor activity of the newly synthesized metal complexes against Ehrlich ascites carcinoma solid tumors was proved to be mediated by the inhibition of Ki67 and induction of p53 proteins.
Bishoy El-Aarag; Fathy El-Saied; Tarek Salem; Nesrin Khedr; Shaden A.M. Khalifa; Hesham R. El-Seedi. New metal complexes derived from diacetylmonoxime-n(4)antipyrinylthiosemicarbazone: Synthesis, characterization and evaluation of antitumor activity against Ehrlich solid tumors induced in mice. Arabian Journal of Chemistry 2021, 14, 102993 .
AMA StyleBishoy El-Aarag, Fathy El-Saied, Tarek Salem, Nesrin Khedr, Shaden A.M. Khalifa, Hesham R. El-Seedi. New metal complexes derived from diacetylmonoxime-n(4)antipyrinylthiosemicarbazone: Synthesis, characterization and evaluation of antitumor activity against Ehrlich solid tumors induced in mice. Arabian Journal of Chemistry. 2021; 14 (3):102993.
Chicago/Turabian StyleBishoy El-Aarag; Fathy El-Saied; Tarek Salem; Nesrin Khedr; Shaden A.M. Khalifa; Hesham R. El-Seedi. 2021. "New metal complexes derived from diacetylmonoxime-n(4)antipyrinylthiosemicarbazone: Synthesis, characterization and evaluation of antitumor activity against Ehrlich solid tumors induced in mice." Arabian Journal of Chemistry 14, no. 3: 102993.
Chemoselective hydrogenation of 2-furaldehyde to furfuryl alcohol using green solvents is an important research area to get eco-friendly fuels and fine chemicals. Herein, we report ruthenium nanoparticles (~1.8 nm) intercalated in montmorillonite as an efficient catalytic system, which can selectively hydrogenate 2-furaldehyde in a benign aqueous medium. The complete conversion was observed at 40 °C with 1 MPa H2, the selectivity of furfuryl alcohol being >99%, and turnover number 1165. After a catalytic run, the montmorillonite-supported ruthenium nanoparticles can be recycled and reused without losing their activity and selectivity.
Farooq-Ahmad Khan; Sana Yaqoob; Nourina Nasim; Yan Wang; Muhammad Usman; Anvarhusein A. Isab; Muhammad Altaf; Bing Sun; Islam H. El Azab; Hesham R. El-Seedi. Ruthenium Nanoparticles Intercalated in Montmorillonite (nano[email protected]) is Highly Efficient Catalyst for the Selective Hydrogenation of 2-Furaldehyde in Benign Aqueous Medium. Catalysts 2021, 11, 66 .
AMA StyleFarooq-Ahmad Khan, Sana Yaqoob, Nourina Nasim, Yan Wang, Muhammad Usman, Anvarhusein A. Isab, Muhammad Altaf, Bing Sun, Islam H. El Azab, Hesham R. El-Seedi. Ruthenium Nanoparticles Intercalated in Montmorillonite (nano[email protected]) is Highly Efficient Catalyst for the Selective Hydrogenation of 2-Furaldehyde in Benign Aqueous Medium. Catalysts. 2021; 11 (1):66.
Chicago/Turabian StyleFarooq-Ahmad Khan; Sana Yaqoob; Nourina Nasim; Yan Wang; Muhammad Usman; Anvarhusein A. Isab; Muhammad Altaf; Bing Sun; Islam H. El Azab; Hesham R. El-Seedi. 2021. "Ruthenium Nanoparticles Intercalated in Montmorillonite (nano[email protected]) is Highly Efficient Catalyst for the Selective Hydrogenation of 2-Furaldehyde in Benign Aqueous Medium." Catalysts 11, no. 1: 66.
Tyrosinase is a multi-copper enzyme found in plants, animals and microorganisms, plays a critical role in the melanogenesis and browning process critical to cosmetics and food industries. Many natural, semi-synthetic and synthetic inhibitors have been discovered. To this end, a small library of symmetrical Bis-Azo-Azamethine hybrids 5a–j was synthesized and characterized through spectroscopic and analytical data and explored for mushroom tyrosinase and free radical scavenging activity. All of the molecules 5a–j explicated better potential compared to the standard Kojic acid. On the whole, compound 5i having IC50 value 0.002 ± 0.004 µM was found to be the most potent derivative. The Kinetic studies were performed for 5i and indicating the mode of inhibition in a competitive manner. Structure Activity Relationship (SAR) analysis and docking studies were carried out. Thus compound 5i bearing bulky naphthyl groups was most potent and, The molecular docking indicated formation of two hydrogen bonds with Arg268 and one hydrophobic interaction with Glu322. The carbonyl oxygen of 5i interacts with Arg268 and form two hydrogen bonds having lengths 2.44 and 2.62 Å, respectively. In the same way, compounds 5a–j were appraised for DPPH free radical scavenging ability and five of them 5d, 5e, 5h, 5i and 5j were found to exhibit higher % scavenging potency compared with vitamin C, as the standard. Interesting compound 5i was again the most potent in the series. The current investigation points towards the role of naphthyl group in design of new inhibitors of melanogenesis and the antioxidants with improved efficacy. Communicated by Ramaswamy H. Sarma Graphical Abstract
Aamer Saeed; Atteeque Ahmed; Pervaiz Ali Channar; Ghulam Shabir; Abbas Hassan; Zia- Ur- Rehman; Qamar Abbas; Mubashir Hassan; Hussain Raza; Sung-Yum Seo; Hesham R. El-Seedi. Identification of novel C-2 symmetric Bis-Azo-Azamethine molecules as competitive inhibitors of mushroom tyrosinase and free radical scavengers: synthesis, kinetics, and molecular docking studies. Journal of Biomolecular Structure and Dynamics 2020, 1 -10.
AMA StyleAamer Saeed, Atteeque Ahmed, Pervaiz Ali Channar, Ghulam Shabir, Abbas Hassan, Zia- Ur- Rehman, Qamar Abbas, Mubashir Hassan, Hussain Raza, Sung-Yum Seo, Hesham R. El-Seedi. Identification of novel C-2 symmetric Bis-Azo-Azamethine molecules as competitive inhibitors of mushroom tyrosinase and free radical scavengers: synthesis, kinetics, and molecular docking studies. Journal of Biomolecular Structure and Dynamics. 2020; ():1-10.
Chicago/Turabian StyleAamer Saeed; Atteeque Ahmed; Pervaiz Ali Channar; Ghulam Shabir; Abbas Hassan; Zia- Ur- Rehman; Qamar Abbas; Mubashir Hassan; Hussain Raza; Sung-Yum Seo; Hesham R. El-Seedi. 2020. "Identification of novel C-2 symmetric Bis-Azo-Azamethine molecules as competitive inhibitors of mushroom tyrosinase and free radical scavengers: synthesis, kinetics, and molecular docking studies." Journal of Biomolecular Structure and Dynamics , no. : 1-10.
The usage of insects as a sustainable and functional natural products resource is a new promise in complementary and alternative medicine. The present study aimed to investigate the ability of Musca domestica (housefly) larval hemolymph (insect blood) to display the enhanced in vitro antioxidant and cytotoxic effects. The oxidative stress (OS) was elicited by inducing lipopolysaccharides (LPS) treatment as an exogenous stressor. Determination of superoxide dismutase 1 (SOD1), glutathione (GSH), malondialdehyde (MDA) and total antioxidant capacity (TAC), and mRNA and protein expressions of SOD1, was investigated as confirmatory markers of oxidative stress induction. Cytotoxicity on cancerous MCF-7 and normal Vero cells were also evaluated using an MTT assay at 24 h post-injection. The injection of LPS induced a significant (p < 0.05) increase in SOD, GSH and TAC, whereas, the MDA was diminished. Hemolymph was collected from normal and treated larvae after 6, 12 and 24 h. The M. domestica superoxide dismutase (MdSOD1) transcripts were significantly (p < 0.05) upregulated 6 and 12 h post-treatment, while a significant downregulation was observed after 24 h. Western blot analysis showed that MdSOD1 was expressed in the hemolymph of the treated larvae with an increase of 1.2 folds at 6 and 12 h and 1.6 folds at 24 h relative to the control group. LPS-treated larval hemolymphs exhibited significant cytotoxicity with respect to the untreated ones against MCF-7 while Vero cells showed no cytotoxicity for both hemolymphs. The DPPH free radical scavenging activity was examined and a significant antioxidant potential potency was observed at 6 h (50% maximal inhibitory concentration (IC50): 63.3 ± 3.51 µg/mL) when compared to the control M. domestica larval hemolymph (IC50: 611.7 ± 10.41 µg/mL). Taken together, M. domestica larval hemolymph exhibited enhanced antioxidant and consequently increased cytotoxic capacities under stressed conditions.
Islam El-Garawani; Hesham El-Seedi; Shaden Khalifa; Islam H. El Azab; Marwa Abouhendia; Shaymaa Mahmoud. Enhanced Antioxidant and Cytotoxic Potentials of Lipopolysaccharides-Injected Musca domestica Larvae. Pharmaceutics 2020, 12, 1111 .
AMA StyleIslam El-Garawani, Hesham El-Seedi, Shaden Khalifa, Islam H. El Azab, Marwa Abouhendia, Shaymaa Mahmoud. Enhanced Antioxidant and Cytotoxic Potentials of Lipopolysaccharides-Injected Musca domestica Larvae. Pharmaceutics. 2020; 12 (11):1111.
Chicago/Turabian StyleIslam El-Garawani; Hesham El-Seedi; Shaden Khalifa; Islam H. El Azab; Marwa Abouhendia; Shaymaa Mahmoud. 2020. "Enhanced Antioxidant and Cytotoxic Potentials of Lipopolysaccharides-Injected Musca domestica Larvae." Pharmaceutics 12, no. 11: 1111.
Based on experimental and computational data, a complex network of intermolecular interactions has been rationalized for antipyrine compounds.
Aamer Saeed; Asma Khurshid; Ulrich Flörke; Gustavo A. Echeverría; Oscar E. Piro; Diego M. Gil; Mariana Rocha; Antonio Frontera; Hesham R. El-Seedi; Amara Mumtaz; Mauricio F. Erben. Intermolecular interactions in antipyrine-like derivatives 2-halo-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)benzamides: X-ray structure, Hirshfeld surface analysis and DFT calculations. New Journal of Chemistry 2020, 44, 19541 -19554.
AMA StyleAamer Saeed, Asma Khurshid, Ulrich Flörke, Gustavo A. Echeverría, Oscar E. Piro, Diego M. Gil, Mariana Rocha, Antonio Frontera, Hesham R. El-Seedi, Amara Mumtaz, Mauricio F. Erben. Intermolecular interactions in antipyrine-like derivatives 2-halo-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)benzamides: X-ray structure, Hirshfeld surface analysis and DFT calculations. New Journal of Chemistry. 2020; 44 (45):19541-19554.
Chicago/Turabian StyleAamer Saeed; Asma Khurshid; Ulrich Flörke; Gustavo A. Echeverría; Oscar E. Piro; Diego M. Gil; Mariana Rocha; Antonio Frontera; Hesham R. El-Seedi; Amara Mumtaz; Mauricio F. Erben. 2020. "Intermolecular interactions in antipyrine-like derivatives 2-halo-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)benzamides: X-ray structure, Hirshfeld surface analysis and DFT calculations." New Journal of Chemistry 44, no. 45: 19541-19554.