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Despite research conducted worldwide, there is no treatment specifically targeting SARS-CoV-2 infection with efficacy proven by randomized controlled trials. A chance for a breakthrough is vaccinating most of the global population. Public opinion surveys on vaccine hesitancy prompted our team to investigate Polish healthcare workers’ (HCWs) attitudes towards the SARS-CoV-2 and influenza vaccinations. In-person and online surveys of HCWs: doctors, nurses, medical students, and other allied health professionals (n = 419) were conducted between 14 September 2020 and 5 November 2020. In our study, 68.7% of respondents would like to be vaccinated against COVID-19. The safety and efficacy of COVID-19 vaccinations would persuade 86.3% of hesitant and those who would refuse to be vaccinated. 3.1% of all respondents claimed that no argument would convince them to get vaccinated. 61.6% of respondents declared a willingness to receive an influenza vaccination, of which 83.3% were also inclined to receive COVID-19 vaccinations. Although most respondents—62.5% (262/419) indicated they trusted in the influenza vaccine more, more respondents intended to get vaccinated against COVID-19 in the 2020/2021 season. The study is limited by its nonrandom sample of HCWs but provides a preliminary description of attitudes towards SARS-CoV-2 vaccination.
Magdalena Grochowska; Aleksandra Ratajczak; Gabriela Zdunek; Aleksander Adamiec; Paweł Waszkiewicz; Wojciech Feleszko. A Comparison of the Level of Acceptance and Hesitancy towards the Influenza Vaccine and the Forthcoming COVID-19 Vaccine in the Medical Community. Vaccines 2021, 9, 475 .
AMA StyleMagdalena Grochowska, Aleksandra Ratajczak, Gabriela Zdunek, Aleksander Adamiec, Paweł Waszkiewicz, Wojciech Feleszko. A Comparison of the Level of Acceptance and Hesitancy towards the Influenza Vaccine and the Forthcoming COVID-19 Vaccine in the Medical Community. Vaccines. 2021; 9 (5):475.
Chicago/Turabian StyleMagdalena Grochowska; Aleksandra Ratajczak; Gabriela Zdunek; Aleksander Adamiec; Paweł Waszkiewicz; Wojciech Feleszko. 2021. "A Comparison of the Level of Acceptance and Hesitancy towards the Influenza Vaccine and the Forthcoming COVID-19 Vaccine in the Medical Community." Vaccines 9, no. 5: 475.
Preschool wheeze is highly prevalent; 30‐50 % of children have wheezed at least once before age six. Wheezing is not a disorder; it is a symptom of obstruction in the airways, and it is essential to identify the correct diagnosis behind this symptom. An increasing number of studies provide evidence for novel diagnostic tools for monitoring and predicting asthma in the pediatric population. Several techniques are available to measure airway obstruction and airway inflammation, including spirometry, impulse oscillometry, whole‐body plethysmography, bronchial hyperresponsiveness test, multiple breath washout test, measurements of exhaled NO, and analyses of various other biomarkers. This systematic review will cover the main lung function and biomarker techniques used in preschool children to diagnose and monitor airway obstruction and shed light on promising new techniques used in research for measuring airway inflammation. The difficulty of measuring lung function and the lack of large randomized controlled trials makes it difficult to establish guidelines for monitoring asthma in preschool children. If applicable, measuring FEV1 using spirometry is considered useful. For those unable to perform spirometry, whole‐body plethysmography and IOS may be useful. Bronchial reversibility to beta2‐agonist and hyperresponsiveness test with running exercise challenge may improve the sensitivity of these tests.
Varpu Elenius; Bo Chawes; Pekka L. Malmberg; Aleksander Adamiec; Marek Ruszczyński; Wojciech Feleszko; Tuomas Jartti; Eaaci Preschool Wheeze Task Force For Diagnostics Of Preschool Wheeze. Lung function testing and inflammation markers for wheezing preschool children: A systematic review for the EAACI Clinical Practice Recommendations on Diagnostics of Preschool Wheeze. Pediatric Allergy and Immunology 2020, 32, 501 -513.
AMA StyleVarpu Elenius, Bo Chawes, Pekka L. Malmberg, Aleksander Adamiec, Marek Ruszczyński, Wojciech Feleszko, Tuomas Jartti, Eaaci Preschool Wheeze Task Force For Diagnostics Of Preschool Wheeze. Lung function testing and inflammation markers for wheezing preschool children: A systematic review for the EAACI Clinical Practice Recommendations on Diagnostics of Preschool Wheeze. Pediatric Allergy and Immunology. 2020; 32 (3):501-513.
Chicago/Turabian StyleVarpu Elenius; Bo Chawes; Pekka L. Malmberg; Aleksander Adamiec; Marek Ruszczyński; Wojciech Feleszko; Tuomas Jartti; Eaaci Preschool Wheeze Task Force For Diagnostics Of Preschool Wheeze. 2020. "Lung function testing and inflammation markers for wheezing preschool children: A systematic review for the EAACI Clinical Practice Recommendations on Diagnostics of Preschool Wheeze." Pediatric Allergy and Immunology 32, no. 3: 501-513.
Background Asthma‐like symptoms in preschool children, such as wheezing and dyspnea,are common time‐, and resource‐consuming diagnostic and management challenges. Quality of wheezing and asthma recommendations vary. The purpose of this study, carried out by the EAACI Task Force for Preschool Wheeze, was to systematically review and assess the quality of guidelines for diagnosis and treatment of preschool wheezing and/or asthma. Methods The Cochrane Library, MEDLINE, and EMBASE were searched untilJune 2018. The methodological rigor, quality, and transparency of relevant guidelines were assessed with the use of the Appraisal of Guidelines for Research and Evaluation (AGREE II) tool. Results We identified 26 guidelines. The quality scores for each domain varied. Of all domains, clarity and presentation had the highest mean score, whereas applicability and stakeholder involvement had the lowest.The scores (median) for individual domains were as follows: Score and purpose 86%; Stakeholder involvement 49%; Rigor of development 54%; Clarity of presentation 85%; Applicability 51%; and Editorial independence 63%. Conclusion Although several guidelines on asthma management in children are available; however, their quality varies. Additionally, there is a considerable gap in reliable recommendations on the management and treatment of non‐asthmatic preschool wheeze.
Marek Ruszczyński; Dominika Ambrożej; Aleksander Adamiec; Klaudia Ryczaj; Varpu Elenius; Ozlem Cavkaytar; Paraskevi Maggina; Heidi Makrinioti; Nikolaos Papadopoulos; Gunilla Hedlin; Jon R. Konradsen; Bianca Schaub; Hermelijn Smits; Tuomas Jartti; Wojciech Feleszko; Eaaci Task Force On Clinical Practice Recommendations On Preschool Wheeze. Preschool wheezing and asthma in children: A systematic review of guidelines and quality appraisal with the AGREE II instrument. Pediatric Allergy and Immunology 2020, 32, 92 -105.
AMA StyleMarek Ruszczyński, Dominika Ambrożej, Aleksander Adamiec, Klaudia Ryczaj, Varpu Elenius, Ozlem Cavkaytar, Paraskevi Maggina, Heidi Makrinioti, Nikolaos Papadopoulos, Gunilla Hedlin, Jon R. Konradsen, Bianca Schaub, Hermelijn Smits, Tuomas Jartti, Wojciech Feleszko, Eaaci Task Force On Clinical Practice Recommendations On Preschool Wheeze. Preschool wheezing and asthma in children: A systematic review of guidelines and quality appraisal with the AGREE II instrument. Pediatric Allergy and Immunology. 2020; 32 (1):92-105.
Chicago/Turabian StyleMarek Ruszczyński; Dominika Ambrożej; Aleksander Adamiec; Klaudia Ryczaj; Varpu Elenius; Ozlem Cavkaytar; Paraskevi Maggina; Heidi Makrinioti; Nikolaos Papadopoulos; Gunilla Hedlin; Jon R. Konradsen; Bianca Schaub; Hermelijn Smits; Tuomas Jartti; Wojciech Feleszko; Eaaci Task Force On Clinical Practice Recommendations On Preschool Wheeze. 2020. "Preschool wheezing and asthma in children: A systematic review of guidelines and quality appraisal with the AGREE II instrument." Pediatric Allergy and Immunology 32, no. 1: 92-105.
Preschool children with wheezing disorders represent a diagnostic and therapeutic challenge, and consume disproportionately large amounts of healthcare resources1-3 . Most wheezing episodes are triggered by viral respiratory tract infections, occurring in 30% - 50% of all preschool children 4, 5 . In the majority of cases, episodes of wheezing are mild and transient and are managed in non-hospital settings, however, some infants develop recurrent episodes severe enough to require medical review, hospital admission, and further referral to specialist paediatricians for diagnosis and management.
Aleksander Adamiec; Dominika Ambrożej; Klaudia Ryczaj; Marek Ruszczynski; Varpu Elenius; Ozlem Cavkaytar; Gunilla Hedlin; Jon R. Konradsen; Paraskevi Maggina; Heidi Makrinioti; Nikolaos Papadopoulos; Bianca Schaub; Jürgen Schwarze; Chrysanthi Skevaki; Hermelijn H. Smits; Tuomas Jartti; Wojciech Feleszko; Eaaci Task Force On Clinical Practice Recommendations On Preschool Wheeze. Preschool wheezing diagnosis and management–Survey of physicians’ and caregivers’ perspective. Pediatric Allergy and Immunology 2019, 31, 206 -209.
AMA StyleAleksander Adamiec, Dominika Ambrożej, Klaudia Ryczaj, Marek Ruszczynski, Varpu Elenius, Ozlem Cavkaytar, Gunilla Hedlin, Jon R. Konradsen, Paraskevi Maggina, Heidi Makrinioti, Nikolaos Papadopoulos, Bianca Schaub, Jürgen Schwarze, Chrysanthi Skevaki, Hermelijn H. Smits, Tuomas Jartti, Wojciech Feleszko, Eaaci Task Force On Clinical Practice Recommendations On Preschool Wheeze. Preschool wheezing diagnosis and management–Survey of physicians’ and caregivers’ perspective. Pediatric Allergy and Immunology. 2019; 31 (2):206-209.
Chicago/Turabian StyleAleksander Adamiec; Dominika Ambrożej; Klaudia Ryczaj; Marek Ruszczynski; Varpu Elenius; Ozlem Cavkaytar; Gunilla Hedlin; Jon R. Konradsen; Paraskevi Maggina; Heidi Makrinioti; Nikolaos Papadopoulos; Bianca Schaub; Jürgen Schwarze; Chrysanthi Skevaki; Hermelijn H. Smits; Tuomas Jartti; Wojciech Feleszko; Eaaci Task Force On Clinical Practice Recommendations On Preschool Wheeze. 2019. "Preschool wheezing diagnosis and management–Survey of physicians’ and caregivers’ perspective." Pediatric Allergy and Immunology 31, no. 2: 206-209.
Many studies have been undertaken to reveal how tobacco smoke skews immune responses contributing to the development of chronic obstructive pulmonary disease (COPD) and other lung diseases. Recently, environmental tobacco smoke (ETS) has been linked with asthma and allergic diseases in children. This review presents the most actual knowledge on exact molecular mechanisms responsible for the skewed inflammatory profile that aggravates inflammation, promotes infections, induces tissue damage, and may promote the development of allergy in individuals exposed to ETS. We demonstrate how the imbalance between oxidants and antioxidants resulting from exposure to tobacco smoke leads to oxidative stress, increased mucosal inflammation, and increased expression of inflammatory cytokines (such as interleukin (IL)-8, IL-6 and tumor necrosis factor α ([TNF]-α). Direct cellular effects of ETS on epithelial cells results in increased permeability, mucus overproduction, impaired mucociliary clearance, increased release of proinflammatory cytokines and chemokines, enhanced recruitment of macrophages and neutrophils and disturbed lymphocyte balance towards Th2. The plethora of presented phenomena fully justifies a restrictive policy aiming at limiting the domestic and public exposure to ETS.
Agnieszka Strzelak; Aleksandra Ratajczak; Aleksander Adamiec; Wojciech Feleszko. Tobacco Smoke Induces and Alters Immune Responses in the Lung Triggering Inflammation, Allergy, Asthma and Other Lung Diseases: A Mechanistic Review. International Journal of Environmental Research and Public Health 2018, 15, 1033 .
AMA StyleAgnieszka Strzelak, Aleksandra Ratajczak, Aleksander Adamiec, Wojciech Feleszko. Tobacco Smoke Induces and Alters Immune Responses in the Lung Triggering Inflammation, Allergy, Asthma and Other Lung Diseases: A Mechanistic Review. International Journal of Environmental Research and Public Health. 2018; 15 (5):1033.
Chicago/Turabian StyleAgnieszka Strzelak; Aleksandra Ratajczak; Aleksander Adamiec; Wojciech Feleszko. 2018. "Tobacco Smoke Induces and Alters Immune Responses in the Lung Triggering Inflammation, Allergy, Asthma and Other Lung Diseases: A Mechanistic Review." International Journal of Environmental Research and Public Health 15, no. 5: 1033.