Novel approach has been constructed for preparing the amphiphilic star copolymer pH/reduction stimuli-responsive cross-linked micelles (SCMs) as a smart drug delivery system for the well-controlled anti-tumor drug doxorubicin (DOX) release. The SCMs had a low CMC value of 5.3 mg/L. The blank and DOX-loaded SCMs both had a spherical shape with sizes around 100–180 nm. In addition, the good stability and well pH/reduction-sensitivity of the SCMs were determined by dynamic light scattering (DLS) as well. The SCMs owned a low release of DOX in bloodstream and normal tissues while it had a fast release in tumor higher glutathione (GSH) concentration and/or lower pH value conditions, which demonstrates their pH/reduction dual-responsiveness. Furthermore, we conducted the thermodynamic analysis to study the interactions between the DOX and polymer micelles in the DOX release process. The values of the thermodynamic parameters at pH 7.4 and at pH 5.0 conditions indicated that the DOX release was endothermic and controlled mainly by the forces of an electrostatic interaction. At pH 5.0 with 10 mM GSH condition, electrostatic interaction, chemical bond, and hydrophobic interactions contributed together on DOX release. With the low cytotoxicity of blank SCMs and well cytotoxicity of DOX-loaded SCMs, the results indicated that the SCMs could form a smart cancer microenvironment-responsive drug delivery system. The release kinetic and thermodynamic analysis offer a theoretical foundation for the interaction between drug molecules and polymer matrices, which helps provide a roadmap for the oriented design and control of anti-cancer drug release for cancer therapy.

A flexible high-performance room temperature NH₃ sensor was fabricated using a PSS-rGO/PANI network, which was synthesized via supramolecular assembly, controlled freeze-drying technology, and a facile interfacial polymerization route.

The measurement of humidity is of great significance for precision instruments, semiconductor integrated circuits, and element manufacturing factories. The oxygen-containing groups and noble metals in graphene-based sensing materials can significantly influence their humidity-sensing performance. Herein, 1,3,5-benzenetricarboxylic acid-functionalized reduced graphene oxide (H3BTC-rGO) loaded with Ag nanocluster nanocomposites (H3BTC-rGO/Ag) was synthesized via a facile one-step reduction method. The H3BTC-rGO/Ag-based sensor exhibited excellent humidity-sensing performance, including a higher sensitivity of 88.9% and a faster response/recovery time of 9 s/16 s towards 50% RH than those of other GO-, rGO-, and H3BTC-rGO-based sensors. The proposed humidity sensor was tested in the range of 0% to 100% RH and showed excellent sensitivity even at a low relative humidity of 0–10% or a high relative humidity of 90–100%. In addition, the H3BTC-rGO/Ag-based sensor had excellent selectivity, reliable repeatability, and good stability over 30 days under different relative humidities. Compared with H3BTC-rGO-200, the H3BTC-rGO/Ag-0.25-based sensor exhibited a low hysteresis of less than ±5% RH. The high performance was ascribed to the high density of the carboxyl groups and good conductivity of H3BTC-rGO, as well as the catalytic role of the Ag nanoclusters, resulting in high water adsorption rates. The potential applications of the H3BTC-rGO/Ag-based humidity sensor in human exhalation monitoring are also discussed. This work provides a reference for the application of graphene-based flexible sensors in monitoring very wet and dry environments.

Purpose: Devices for step estimation are body-worn devices used to compute steps taken and/or distance covered by the user. Even though textiles or clothing are foremost to come to mind in terms of articles meant to be worn, their prominence among devices and systems meant for cadence is overshadowed by electronic products such as accelerometers, wristbands and smart phones. Athletes and sports enthusiasts using knee sleeves should be able to track their performances and monitor workout progress without the need to carry other devices with no direct sport utility, such as wristbands and wearable accelerometers. The purpose of this study thus is to contribute to the broad area of wearable devices for cadence application by developing a cheap but effective and efficient stride measurement system based on a knee sleeve.Design/methodology/approach: A textile strain sensor is designed by weft knitting silver-plated nylon yarn together with nylon DTY and covered elastic yarn using a 1 × 1 rib structure. The area occupied by the silver-plated yarn within the structure served as the strain sensor. It worked such that, upon being subjected to stress, the electrical resistance of the sensor increases and in turn, is restored when the stress is removed. The strip with the sensor is knitted separately and subsequently sewn to the knee sleeve. The knee sleeve is then connected to a custom-made signal acquisition and processing system. A volunteer was employed for a wearer trial.Findings: Experimental results establish that the number of strides taken by the wearer can easily be correlated to the knee flexion and extension cycles of the wearer. The number of peaks computed by the signal acquisition and processing system is therefore counted to represent stride per minute. Therefore, the sensor is able to effectively count the number of strides taken by the user per minute. The coefficient of variation of over-ground test results yielded 0.03%, and stair climbing also obtained 0.14%, an indication of very high sensor repeatability.Research limitations/implications: The study was conducted using limited number of volunteers for the wearer trials.Practical implications: By embedding textile piezoresistive sensors in some specific garments and or accessories, physical activity such as gait and its related data can be effectively measured.Originality/value: To the best of our knowledge, this is the first application of piezoresistive sensing in the knee sleeve for stride estimation. Also, this study establishes that it is possible to attach (sew) already-knit textile strain sensors to apparel to effectuate smart functionality.

It is difficult to simultaneously achieve surface-enhanced Raman scattering (SERS) and surface-enhanced fluorescence (SEF) for noble metals. Herein, a composite substrate is demonstrated based on the rational construction of Ag nanoparticles (Ag NPs) and inverse opal polydimethylsiloxane (PDMS) for surface Raman fluorescence dual enhancement. The well-designed Ag nanoparticle (Ag NP)-decorated inverse opal PDMS (AIOP) composite substrate is fabricated using the polystyrene (PS) photonic crystal method and the sensitization reduction technique. The inverse opal PDMS enhances the electromagnetic (EM) field by increasing the loading of Ag NPs and plasmonic coupling of Ag NPs, leading to SERS activity. The thin shell layer of polyvinyl pyrrolidone (PVP) in core–shell Ag NPs isolates the detected molecule from the Ag core to prevent the fluorescence resonance energy transfer and charge transfer to eliminate fluorescence quenching and enable SEF performance. Based on the blockage of the core–shell structure and the enhanced EM field originating from the inverse opal structure, the as-fabricated AIOP composite substrate shows dual enhancement in surface Raman fluorescence. The AIOP composite substrate in this work, which combines improved SERS activity and SEF performance, not only promotes the development of surface-enhanced spectroscopy but also shows promise for applications in flexible sensors.