Hammada scoparia (Pomel) is a powerful plant with important biological properties. In this study, we report on the green synthesis of silver-doped nickel and copper nanoparticles (NPs) in the presence of H. scoparia leaf extract using a self-propagating sol–gel autocombustion process. The synthesized NiO, CuO, Ag-NiO, and Ag-CuO NPs were characterized with Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). Afterward, they were tested for their antimicrobial activity as well as their potential to remove dyes from aqueous solutions using adsorption processes for malachite green (MG) and photocatalytic degradation for methylene blue (MB). Our results showed that the mass of the adsorbent had a significant effect on the adsorption rate, which increased to reach a maximum value of 98%. The Ag-CuO NP showed the best final conversion of MB (97.95%) compared to NiO, CuO, and Ag-NiO. In addition, we noted that the NPs doped with silver had the best performance in the removal of dyes. These results indicated that the photocatalytic performance was significantly improved after the addition of silver. Moreover, the antimicrobial activity showed that the studied NPs had moderate activity against the tested bacteria and a weak activity or were ineffective against Candida albicans. Therefore, the green synthesis of NPs from H. scoparia leaf extract is considered a sustainable alternative to removing dyes from aqueous solutions. However, further investigation should be performed on the other dyes to understand the overall effectiveness of these NPs.

The Zika virus (ZIKV) is classified as a type of the Flavivirus family, which includes various other significant viruses characterized by positive-sense, single-stranded RNA genomes. ZIKV is primarily transmitted to humans via mosquito vectors. While ZIKV infections are often asymptomatic, they can also result in mild flu-like symptoms or severe complications, posing a considerable threat to human health. Several studies have demonstrated that histone deacetylase 6 (HDAC6) inhibitors exhibit antiviral activity against the Zika virus. The current study employs computational chemistry and various in-silico techniques, including molecular docking, ADMET predictions, and molecular dynamics simulations. Initially, the pharmacokinetic and physicochemical properties of J27820 were assessed using ADMET analysis. The therapeutic potential of compounds J22352 and J27820 against three Zika virus (ZIKV) proteins (5H4I, 5TFR, and 6THV) was evaluated using molecular docking simulations. These simulations indicated that the studied compounds exhibited the highest binding affinities and strong interactions with the target proteins. To further assess the stability of the complexes and their interactions over time, 100 ns molecular dynamics simulations were performed. The results of this study highlight the significant advantages of J27820 and J22352, emphasizing their potential for targeted inhibition and promising opportunities for developing effective antiviral therapies against the Zika virus.