To achieve efficient prediction and optimization of the energy consumption of ship central cooling systems, this paper first constructed and validated a high-precision multi-physical domain simulation model of the ship central cooling system based on fluid heat transfer principles and the physical network method. Then, simulation experiments were designed using the Box–Behnken design (BBD) method to study the effects of five key parameters—main engine power, seawater temperature, seawater pump speed, low-temperature fresh water three-way valve opening, and low-temperature fresh water flow rate—on system energy consumption. Based on the simulation data, an energy consumption prediction model was constructed using response surface methodology (RSM). This prediction model exhibited excellent goodness of fit and prediction ability (coefficient of determination R² = 0.9688, adjusted R²_adj = 0.9438, predicted R²_pred = 0.8752), with a maximum relative error of only 1.2% compared to the simulation data, confirming its high accuracy. Sensitivity analysis based on this prediction model indicated that main engine power, seawater pump speed, seawater temperature, and three-way valve opening were the dominant single factors affecting energy consumption. Further analysis revealed a significant interaction between main engine power and seawater pump speed. This interaction resulted in non-linear changes in system energy consumption, which were particularly prominent under operating conditions such as high power. This study provides an accurate prediction model and theoretical guidance on the influence patterns of key parameters for the simulation-driven design, operational optimization, and energy saving of ship central cooling systems.

Zonal ship central cooling systems, which are primarily implemented in naval platforms and advanced specialized vessels to ensure high survivability, exhibit complex fluid–thermal interactions and multi-level valve networks, challenging conventional resilience analysis, especially under large-scale fault scenarios and dynamic topology reconfiguration. This paper presents a physics-informed dynamic resilience assessment and reconfiguration optimization method tailored for such systems. To address the high-dimensional reconfiguration search space, a physics-informed pruning mechanism combining topological reachability filtering and nodal continuity-based feasible-flow verification is introduced, eliminating 42.6% of invalid topologies and reducing optimization time by approximately 38%. Additionally, a cumulative thermal severity (CTS) metric is developed to capture transient thermal shock risks, quantitatively assessing deviation from the 50 °C system safety boundary at the most critical node. Simulation results for a main seawater pump failure scenario demonstrate that the proposed reconfiguration strategy, which coordinates cross-zone tie valves and leverages healthy zones’ pressure margins, shortens recovery time by 47%, suppresses peak temperature from 51.5 °C to 50.2 °C, reduces maximum over-temperature from 1.5 °C to 0.2 °C, and decreases CTS from 8.5 °C·s to 0.1 °C·s (a 98.8% reduction). These findings demonstrate that physics-informed pruning substantially reduces the computational burden of high-dimensional reconfiguration, while the proposed CTS metric enables quantitative assessment of transient thermal-shock risk. Together, they offer robust methodological guidance for resilience-oriented decision support and fault-tolerant design in complex shipboard fluid–thermal systems.