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Lotfi Aleya; Weikuan Gu; Scott Howard. Environmental factors and the epidemics of COVID-19. Environmental Science and Pollution Research 2021, 28, 40308 -40310.
AMA StyleLotfi Aleya, Weikuan Gu, Scott Howard. Environmental factors and the epidemics of COVID-19. Environmental Science and Pollution Research. 2021; 28 (30):40308-40310.
Chicago/Turabian StyleLotfi Aleya; Weikuan Gu; Scott Howard. 2021. "Environmental factors and the epidemics of COVID-19." Environmental Science and Pollution Research 28, no. 30: 40308-40310.
Botulism is a rare, acute, life-threatening neuro-paralysis. The digestive onset may raise diagnostic issues. The objective of our study was to analyze the clinical and epidemiological data of patients diagnosed with botulism and hospitalized in “Gavril Curteanu” Municipal Clinical Hospital (Oradea, Romania). Detection of the Clostridium botulinum neurotoxin (type B) in the laboratories of the National Institute of Medical-Military Research Development “Cantacuzino”, Bucharest, Romania (using the mouse bioassays method) confirmed the diagnostics. The statistical analysis was performed using the IBM SPSS software. Forty-eight patients with the diagnosis of foodborne botulism were hospitalized between 2012 and 2018 (36.92% of the total number of cases of botulism reported in Romania). The winter-spring period was the period when most cases were registered (36 patients, p=0.020). Women from rural areas were predominant (but not statistically significant), and the patients’ mean age was 39.93±12.59 years. The most common source/cause of botulism was the consumption of homemade ham. The incubation period was 26.68±22.94 h, and 2.25±1.68 days passed from the clinical onset to diagnosis. The results prove that botulism is still a public health issue, especially in areas where homemade products are prepared using inappropriate/unsafe recipes/procedures.
Nicoleta Negrut; Lotfi Aleya; Tapan Behl; Camelia C. Diaconu; Mihai A. Munteanu; Emilia E. Babes; Mirela M. Toma; Simona Bungau. Epidemiology of botulism in the north-western Romania—a 7-year survey. Environmental Science and Pollution Research 2021, 1 -7.
AMA StyleNicoleta Negrut, Lotfi Aleya, Tapan Behl, Camelia C. Diaconu, Mihai A. Munteanu, Emilia E. Babes, Mirela M. Toma, Simona Bungau. Epidemiology of botulism in the north-western Romania—a 7-year survey. Environmental Science and Pollution Research. 2021; ():1-7.
Chicago/Turabian StyleNicoleta Negrut; Lotfi Aleya; Tapan Behl; Camelia C. Diaconu; Mihai A. Munteanu; Emilia E. Babes; Mirela M. Toma; Simona Bungau. 2021. "Epidemiology of botulism in the north-western Romania—a 7-year survey." Environmental Science and Pollution Research , no. : 1-7.
Lotfi Aleya; Sahab Uddin; Simona G. Bungyǎu. Interdisciplinary medical research in the field of public and environmental health. Current Opinion in Environmental Science & Health 2021, 23, 100282 .
AMA StyleLotfi Aleya, Sahab Uddin, Simona G. Bungyǎu. Interdisciplinary medical research in the field of public and environmental health. Current Opinion in Environmental Science & Health. 2021; 23 ():100282.
Chicago/Turabian StyleLotfi Aleya; Sahab Uddin; Simona G. Bungyǎu. 2021. "Interdisciplinary medical research in the field of public and environmental health." Current Opinion in Environmental Science & Health 23, no. : 100282.
This article is an extensive collection of scientific literature related to the impact of fertilizers on soil microbial and enzymatic activity. Due to the significance of technology in quantitative and qualitative evaluation of agricultural production, this is a basic problem for the present and future of mankind, where the scientific data being of utmost importance related to the topic. The comparison, including pedo-enzymological evaluation of minerals along with organic fertilization, highlights significant differences between mineral and organic fertilizers, confirming the superiority of complex mineral-organic fertilization. Enzymatic indicators that describe and define the soil quality resulted from enzymatic activities value and provide valuable information regarding the soil fertility status. Moreover, soil enzyme responds to soil management as well as to environmental pollutants. Changes of environmental conditions and pollutants like heavy metals and other toxic substances result in a shift in the biological activity of the soil. These changes can destabilize the soil system and cause a decrease in the nutrient pools. To ensure the improvement of fertilization techniques, the properties of nanoparticles are exploited that can efficiently release nutrients to plant cells. Numerous researches were performed in order to follow the long-term effects of incorporating nanofertilizers into the soil, obtaining an exhaustive overview of this new technology over the development of sustainable agriculture.
Simona Bungau; Tapan Behl; Lotfi Aleya; Pascale Bourgeade; Badr Aloui-Sossé; Anamaria Lavinia Purza; Areha Abid; Alina Dora Samuel. Expatiating the impact of anthropogenic aspects and climatic factors on long-term soil monitoring and management. Environmental Science and Pollution Research 2021, 1 -23.
AMA StyleSimona Bungau, Tapan Behl, Lotfi Aleya, Pascale Bourgeade, Badr Aloui-Sossé, Anamaria Lavinia Purza, Areha Abid, Alina Dora Samuel. Expatiating the impact of anthropogenic aspects and climatic factors on long-term soil monitoring and management. Environmental Science and Pollution Research. 2021; ():1-23.
Chicago/Turabian StyleSimona Bungau; Tapan Behl; Lotfi Aleya; Pascale Bourgeade; Badr Aloui-Sossé; Anamaria Lavinia Purza; Areha Abid; Alina Dora Samuel. 2021. "Expatiating the impact of anthropogenic aspects and climatic factors on long-term soil monitoring and management." Environmental Science and Pollution Research , no. : 1-23.
Mohamed E. Abd El-Hack; Sameh A. Abdelnour; Ayman E. Taha; Asmaa F. Khafaga; Muhammad Arif; Tugay Ayasan; Ayman A. Swelum; Mohammad H. Abukhalil; Saad Alkahtani; Lotfi Aleya; Mohamed M. Abdel-Daim. Corrigendum to “Herbs as thermoregulation agents: A comprehensive review” [Sci. Total Environ. 703 (2020): 1–19/134399]. Science of The Total Environment 2021, 771, 145659 .
AMA StyleMohamed E. Abd El-Hack, Sameh A. Abdelnour, Ayman E. Taha, Asmaa F. Khafaga, Muhammad Arif, Tugay Ayasan, Ayman A. Swelum, Mohammad H. Abukhalil, Saad Alkahtani, Lotfi Aleya, Mohamed M. Abdel-Daim. Corrigendum to “Herbs as thermoregulation agents: A comprehensive review” [Sci. Total Environ. 703 (2020): 1–19/134399]. Science of The Total Environment. 2021; 771 ():145659.
Chicago/Turabian StyleMohamed E. Abd El-Hack; Sameh A. Abdelnour; Ayman E. Taha; Asmaa F. Khafaga; Muhammad Arif; Tugay Ayasan; Ayman A. Swelum; Mohammad H. Abukhalil; Saad Alkahtani; Lotfi Aleya; Mohamed M. Abdel-Daim. 2021. "Corrigendum to “Herbs as thermoregulation agents: A comprehensive review” [Sci. Total Environ. 703 (2020): 1–19/134399]." Science of The Total Environment 771, no. : 145659.
Mohamed E. Abd El-Hack; Sameh A. Abdelnour; Ayman E. Taha; Asmaa F. Khafaga; Muhammad Arif; Tugay Ayasan; Ayman A. Swelum; Mohammad H. Abukhalil; Saad Alkahtani; Lotfi Aleya; Mohamed M. Abdel-Daim. Corrigendum to “Herbs as thermoregulation agents: A comprehensive review” [Sci. Total Environ. 703 (2020) 1–19/134399]. Science of The Total Environment 2021, 767, 145624 .
AMA StyleMohamed E. Abd El-Hack, Sameh A. Abdelnour, Ayman E. Taha, Asmaa F. Khafaga, Muhammad Arif, Tugay Ayasan, Ayman A. Swelum, Mohammad H. Abukhalil, Saad Alkahtani, Lotfi Aleya, Mohamed M. Abdel-Daim. Corrigendum to “Herbs as thermoregulation agents: A comprehensive review” [Sci. Total Environ. 703 (2020) 1–19/134399]. Science of The Total Environment. 2021; 767 ():145624.
Chicago/Turabian StyleMohamed E. Abd El-Hack; Sameh A. Abdelnour; Ayman E. Taha; Asmaa F. Khafaga; Muhammad Arif; Tugay Ayasan; Ayman A. Swelum; Mohammad H. Abukhalil; Saad Alkahtani; Lotfi Aleya; Mohamed M. Abdel-Daim. 2021. "Corrigendum to “Herbs as thermoregulation agents: A comprehensive review” [Sci. Total Environ. 703 (2020) 1–19/134399]." Science of The Total Environment 767, no. : 145624.
The outbreak of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected the entire world with its infectious spread and mortality rate. The severe cases of coronavirus disease 2019 (COVID-19) are characterized by hypoxia and acute respiratory distress syndrome. In the absence of any specific treatment, just the preventive and supportive care options are available. Therefore, much focus is given to assess the available therapeutic options not only to avoid acute respiratory failure and hypoxia but also to reduce the viral load to control the severity of the disease. The antimalarial drug hydroxychloroquine (HCQ) is among the much-discussed drugs for the treatment and management of COVID-19 patients. This article reviews the therapeutic potential of HCQ in the treatment of COVID-19 based on the available in vitro and clinical evidence, current status of registered HCQ-based clinical trials investigating therapeutic options for COVID-19, and environmental implications of HCQ.
Rajnish Kumar; Anju Sharma; Janmejai Kumar Srivastava; Mohammed Haris Siddiqui; Sahab Uddin; Lotfi Aleya. Hydroxychloroquine in COVID-19: therapeutic promises, current status, and environmental implications. Environmental Science and Pollution Research 2021, 28, 40431 -40444.
AMA StyleRajnish Kumar, Anju Sharma, Janmejai Kumar Srivastava, Mohammed Haris Siddiqui, Sahab Uddin, Lotfi Aleya. Hydroxychloroquine in COVID-19: therapeutic promises, current status, and environmental implications. Environmental Science and Pollution Research. 2021; 28 (30):40431-40444.
Chicago/Turabian StyleRajnish Kumar; Anju Sharma; Janmejai Kumar Srivastava; Mohammed Haris Siddiqui; Sahab Uddin; Lotfi Aleya. 2021. "Hydroxychloroquine in COVID-19: therapeutic promises, current status, and environmental implications." Environmental Science and Pollution Research 28, no. 30: 40431-40444.
While countries are in a hurry to obtain SARS-CoV-2 vaccine, we are concerned with the availability of vaccine and whether a vaccine will be available to all in need. We predicted three possible scenarios for vaccine distributions and urge an international united action on the worldwide equitable access. In case the international community does not reach a consensus on how to distribute the vaccine to achieve worldwide equitable access, we call for a distribution plan that includes the employees in international transportation industries and international travelers to halt the disease transmission and promote the recovery of the global economy.
Zhuo Yu; Gang Wang; Emanuel Goldman; Barbara Zangerl; Ning Xie; Yanhong Cao; Jingyu Chen; Sara W. Day; Scott C. Howard; Marcello Maida; Kunal Ray; Monica M. Jablonski; Jiafu Ji; Arnold Postlethwaite; Weikuan Gu; Dianjun Sun; Lotfi Aleya. COVID-19 vaccine: Call for employees in international transportation industries and international travelers as the first priority in global distribution. Open Medicine 2021, 16, 134 -138.
AMA StyleZhuo Yu, Gang Wang, Emanuel Goldman, Barbara Zangerl, Ning Xie, Yanhong Cao, Jingyu Chen, Sara W. Day, Scott C. Howard, Marcello Maida, Kunal Ray, Monica M. Jablonski, Jiafu Ji, Arnold Postlethwaite, Weikuan Gu, Dianjun Sun, Lotfi Aleya. COVID-19 vaccine: Call for employees in international transportation industries and international travelers as the first priority in global distribution. Open Medicine. 2021; 16 (1):134-138.
Chicago/Turabian StyleZhuo Yu; Gang Wang; Emanuel Goldman; Barbara Zangerl; Ning Xie; Yanhong Cao; Jingyu Chen; Sara W. Day; Scott C. Howard; Marcello Maida; Kunal Ray; Monica M. Jablonski; Jiafu Ji; Arnold Postlethwaite; Weikuan Gu; Dianjun Sun; Lotfi Aleya. 2021. "COVID-19 vaccine: Call for employees in international transportation industries and international travelers as the first priority in global distribution." Open Medicine 16, no. 1: 134-138.
This review explores the correlation between specific aspects of antibiotic usage, their resistance development and environmental factors. The indiscriminate use of antibiotics led to environment contamination, selection and spreading of antibiotic-resistant organisms and alteration of the microbial ecosystems balance. Socio-behavioural environmental factors and changes in the natural environment are major contributors to resistance development. Resistant bacteria strains isolation in food, water, soil etc. demonstrates the environmental influence on the strains through antibiotics accumulation in the environment. It is difficult to assess the impact of antibiotic consumption on public health and the environment. Reducing irrational consumption, restoring microbial ecosystems, adopting methodologies to control antimicrobial resistance in case of in-hospital infections, implementation of measures included in national/international health policies are the main solutions for this problem.
Simona Bungau; Delia Mirela Tit; Tapan Behl; Lotfi Aleya; Dana Carmen Zaha. Aspects of excessive antibiotic consumption and environmental influences correlated with the occurrence of resistance to antimicrobial agents. Current Opinion in Environmental Science & Health 2020, 19, 100224 .
AMA StyleSimona Bungau, Delia Mirela Tit, Tapan Behl, Lotfi Aleya, Dana Carmen Zaha. Aspects of excessive antibiotic consumption and environmental influences correlated with the occurrence of resistance to antimicrobial agents. Current Opinion in Environmental Science & Health. 2020; 19 ():100224.
Chicago/Turabian StyleSimona Bungau; Delia Mirela Tit; Tapan Behl; Lotfi Aleya; Dana Carmen Zaha. 2020. "Aspects of excessive antibiotic consumption and environmental influences correlated with the occurrence of resistance to antimicrobial agents." Current Opinion in Environmental Science & Health 19, no. : 100224.
Abdel Hamid OI, Khayal EEH, Tolba SAR et al (2020) Maternal Δ-aminolevulinic acid dehydratase 1–2 genotype enhances fetal lead exposure and increases the susceptibility to the development of cerebral palsy. Environ Sci Pollut Res. https://doi.org/10.1007/s11356-020-10182-8 Article Google Scholar Mir RH, Sawhney G, Pottoo FH et al (2020) Role of environmental pollutants in Alzheimer’s disease: a review. Environ Sci Pollut Res. https://doi.org/10.1007/s11356-020-09964-x Article Google Scholar Niaz K, Shah SZA, Khan F, Bule M (2020) Ochratoxin A–induced genotoxic and epigenetic mechanisms lead to Alzheimer disease: its modulation with strategies. Environ Sci Pollut Res. https://doi.org/10.1007/s11356-020-08991-y Article Google Scholar Praveena SM, Munisvaradass R, Masiran R et al (2020) Phthalates exposure and attention-deficit/hyperactivity disorder in children: a systematic review of epidemiological literature. Environ Sci Pollut Res. https://doi.org/10.1007/s11356-020-10652-z Article Google Scholar Rahman MA, Rahman MS, Uddin MJ, Mamum-Or-Rashid ANM, Pang MG, Rhim H (2020) Emerging risk of environmental factors: insight mechanisms of Alzheimer’s diseases. Environ Sci Pollut Res. https://doi.org/10.1007/s11356-020-08243-z Article Google Scholar Salem EA, Saheen HM, Allam HK (2020) Secondhand tobacco smoke, does it have an impact on the neurobehavioral performance of the exposed children? Environ Sci Pollut Res. https://doi.org/10.1007/s11356-020-08989-6 Article Google Scholar Sana SS, Dogiparthi LK, Gangadhar L, Chakravorty A, Abhishek N (2020) Effects of microplastics and nanoplastics on marine environment and human health. Environ Sci Pollut Res. https://doi.org/10.1007/s11356-020-10573-x Article Google Scholar Download references Chrono-Environnement Laboratory, UMR CNRS 6249, Bourgogne Franche-Comté University, 25030, Besançon Cedex, France Lotfi Aleya Department of Pharmacy, Southeast University, Dhaka, Bangladesh Md. Sahab Uddin Pharmakon Neuroscience Research Network, Dhaka, Bangladesh Md. Sahab Uddin You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar Correspondence to Lotfi Aleya. The authors declare no conflict of interest. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Responsible editor: Philippe Garrigues Reprints and Permissions Aleya, L., Uddin, M.S. Environmental pollutants and the risk of neurological disorders. Environ Sci Pollut Res (2020). https://doi.org/10.1007/s11356-020-11272-3 Download citation Published: 23 October 2020 DOI: https://doi.org/10.1007/s11356-020-11272-3
Lotfi Aleya; Sahab Uddin. Environmental pollutants and the risk of neurological disorders. Environmental Science and Pollution Research 2020, 27, 44657 -44658.
AMA StyleLotfi Aleya, Sahab Uddin. Environmental pollutants and the risk of neurological disorders. Environmental Science and Pollution Research. 2020; 27 (36):44657-44658.
Chicago/Turabian StyleLotfi Aleya; Sahab Uddin. 2020. "Environmental pollutants and the risk of neurological disorders." Environmental Science and Pollution Research 27, no. 36: 44657-44658.
Microbial contamination and damaging effects due to environmental factors (temperature, humidity) of old books is an extremely important issue in the heritage preserving field, being a great threat to this unique cultural and literary treasure. This paper analysed the indoor environmental conditions, the microbiological characteristics of the air and the condition itself of 27 clerical books (from eighteenth to nineteenth centuries), randomly chosen from the library of Bistrița Monastery, Romania. The analysis revealed that most of the books were contaminated and damaged by moulds and yeasts. The statistical analysis (chi-square test) shows that the incidence of mould species was not coincidental. The most common isolated fungi discovered on old books were Penicillium spp. (40.7%), Cladosporium spp. (33.3%) and Fusarium spp. (29.6%). Fungal contamination was observed in 17 books. Microbiota air tests have shown possible contamination by air flow. Often, the measured temperature/humidity values are not in line with the requirements of the legislation in force, especially during the cold seasons, the average minimum temperature varying from 3 to 6 °C to an average maximum temperature of 22–25 °C; the values of relative humidity were between 27 and 77%. In terms of storage conditions, the recorded values of temperature and humidity are extremely harmful to the stored documents. Therefore, these indoor environmental conditions have to be improved, in order to reduce/eliminate potential sources of fungal contamination and to achieve optimal environmental preserving conditions.
Mirel Glevitzky; Lotfi Aleya; Mihaela Laura Vică; Gabriela-Alina Dumitrel; Mariana Avram; Delia Mirela Tit; Maria Popa; Viorel-Cristian Popa; Tapan Behl; Simona Bungau. Assessing the microbiological contamination along with environmental factors of old books in the 1490-founded Bistrița Monastery, Romania. Environmental Science and Pollution Research 2020, 28, 8743 -8757.
AMA StyleMirel Glevitzky, Lotfi Aleya, Mihaela Laura Vică, Gabriela-Alina Dumitrel, Mariana Avram, Delia Mirela Tit, Maria Popa, Viorel-Cristian Popa, Tapan Behl, Simona Bungau. Assessing the microbiological contamination along with environmental factors of old books in the 1490-founded Bistrița Monastery, Romania. Environmental Science and Pollution Research. 2020; 28 (7):8743-8757.
Chicago/Turabian StyleMirel Glevitzky; Lotfi Aleya; Mihaela Laura Vică; Gabriela-Alina Dumitrel; Mariana Avram; Delia Mirela Tit; Maria Popa; Viorel-Cristian Popa; Tapan Behl; Simona Bungau. 2020. "Assessing the microbiological contamination along with environmental factors of old books in the 1490-founded Bistrița Monastery, Romania." Environmental Science and Pollution Research 28, no. 7: 8743-8757.
Emerging research in the field of behavioral neuroscience has demonstrated the fundamental role of the cerebral organization. For brain development, various important functions are required for instance synaptic plasticity and neurogenesis. This property is described in terms of neuroplasticity. Neuroplasticity denotes the extraordinary ability of the brain for the recognition of its structure and function after an experience with some external stimuli and involves in the various behavioral process of the brain such as cognitive functions. It has multiple factors that can range from gene alteration to environmental factors. Environmental factors exert both negative and positive impact on cognitive functions of brain. Here we elaborate about the neuroplasticity, their mechanism and relation between environment and brain cells which includes remarkable effects on brain development after alteration in maternal care, under stressful conditions, sleep deprivation and enriched environment.
Ashish Mishra; Pooja Patni; Satisha Hegde; Lotfi Aleya; Devesh Tewari. Neuroplasticity and environment: A pharmacotherapeutic approach toward preclinical and clinical understanding. Current Opinion in Environmental Science & Health 2020, 19, 100210 .
AMA StyleAshish Mishra, Pooja Patni, Satisha Hegde, Lotfi Aleya, Devesh Tewari. Neuroplasticity and environment: A pharmacotherapeutic approach toward preclinical and clinical understanding. Current Opinion in Environmental Science & Health. 2020; 19 ():100210.
Chicago/Turabian StyleAshish Mishra; Pooja Patni; Satisha Hegde; Lotfi Aleya; Devesh Tewari. 2020. "Neuroplasticity and environment: A pharmacotherapeutic approach toward preclinical and clinical understanding." Current Opinion in Environmental Science & Health 19, no. : 100210.
Background Currently, the 2019-nCoV has spread to most countries of the world. Understanding the environmental factors that affect the spread of the disease COVID-19 infection is critical to stop the spread of the disease. The purpose of this study is to investigate whether population density is associated with the infection rate of the COVID-19. Methods We collected data from official webpages of cities in China and in the US. The data were uploaded on Excel spreadsheets for statistical analyses. We calculated the morbidity and population density of cities and regions in these two countries. We then examined the relationship between the morbidity and other factors. Results Our analysis indicated that the population density in cities in Hubei province where the COVID-19 was severe was associated with a higher percentage of morbidity, with an r value of 0.62. Similarly, in the US, the density of 51 states and territories is also associated with morbidity from COVID-19 with an r value of 0.55. In contrast, as a control group, there is no association between the morbidity and population density in 33 other regions of China, where the COVID-19 epidemic is well under control. Interestingly, our study also indicated that these associations were not influenced by the first case of COVID-19. The rate of morbidity and the number of days from the first case in the US has no association, with an r value of -0.1288. Conclusions Population density is positively associated with the percentage of patients with COVID-19 infection in the population. Our data support the importance of such as social distancing and travel restriction in the prevention of COVID-19 spread.
Heliang Yin; Tong Sun; Lan Yao; Yan Jiao; Li Ma; Lin Lin; J Carolyn Graff; Lotfi Aleya; Arnold Postlethwaite; Weikuan Gu; Hong Chen. Association between population density and infection rate suggests the importance of social distancing and travel restriction in reducing the COVID-19 pandemic. 2020, 1 .
AMA StyleHeliang Yin, Tong Sun, Lan Yao, Yan Jiao, Li Ma, Lin Lin, J Carolyn Graff, Lotfi Aleya, Arnold Postlethwaite, Weikuan Gu, Hong Chen. Association between population density and infection rate suggests the importance of social distancing and travel restriction in reducing the COVID-19 pandemic. . 2020; ():1.
Chicago/Turabian StyleHeliang Yin; Tong Sun; Lan Yao; Yan Jiao; Li Ma; Lin Lin; J Carolyn Graff; Lotfi Aleya; Arnold Postlethwaite; Weikuan Gu; Hong Chen. 2020. "Association between population density and infection rate suggests the importance of social distancing and travel restriction in reducing the COVID-19 pandemic." , no. : 1.
Clostridium difficile infection (CDI) is the most common infectious disease related to antibiotic-associated diarrhoea and is a current leading cause of morbidity/mortality, with substantial consequences for healthcare services and overall public health. Thus, we performed a retrospective epidemiological study of CDI for a long period (8 years), in an infectious hospital located in north-western Romania, which serves an entire county of the country (617,827 inhabitants). From 2011 to 2018, 877 patients were diagnosed with CDI; the mean incidence of this disease was 2.76 cases/10,000 patient-days, with an increasing trend in the annual incidence until 2016, at which point there was a decrease. The most commonly afflicted were patients in the 75–84 age group, observed in winter and spring. The results show that the antibiotics were administered in 679 (77.42%) subjects, within the last 3 months before CDI, statistically significant more than proton-pump inhibitors (PPIs)—128 (14.60%) and antidepressant medications—60 (6.84%), which were administered during the same period (p < 0.001). No medication was reported in 10 (6.84%) cases of CDI, in the last 3 months of the study. The fatality rate attained 4.1%, tripling in 2018 vs. 2011. CDI became a significant public health conundrum that can, nevertheless, be combatted through a judicious use of antibiotics.
Nicoleta Negrut; Delia Carmen Nistor-Cseppento; Shamim Ahmad Khan; Carmen Pantis; Teodor Andrei Maghiar; Octavian Maghiar; Selim Aleya; Marius Rus; Delia Mirela Tit; Lotfi Aleya; Abbas Rahdar; Simona Bungau. Clostridium difficile Infection Epidemiology over a Period of 8 Years—A Single Centre Study. Sustainability 2020, 12, 4439 .
AMA StyleNicoleta Negrut, Delia Carmen Nistor-Cseppento, Shamim Ahmad Khan, Carmen Pantis, Teodor Andrei Maghiar, Octavian Maghiar, Selim Aleya, Marius Rus, Delia Mirela Tit, Lotfi Aleya, Abbas Rahdar, Simona Bungau. Clostridium difficile Infection Epidemiology over a Period of 8 Years—A Single Centre Study. Sustainability. 2020; 12 (11):4439.
Chicago/Turabian StyleNicoleta Negrut; Delia Carmen Nistor-Cseppento; Shamim Ahmad Khan; Carmen Pantis; Teodor Andrei Maghiar; Octavian Maghiar; Selim Aleya; Marius Rus; Delia Mirela Tit; Lotfi Aleya; Abbas Rahdar; Simona Bungau. 2020. "Clostridium difficile Infection Epidemiology over a Period of 8 Years—A Single Centre Study." Sustainability 12, no. 11: 4439.
Alzheimer’s disease (AD) is the leading cause of dementia worldwide. Even though the number of AD patients is rapidly growing, there is no effective treatment for this neurodegenerative disorder. At present, implementation of effective treatment approaches for AD is vital to meet clinical needs. In AD research, priorities concern the development of disease-modifying therapeutic agents to be used in the early phases of AD and the optimization of the symptomatic treatments predominantly dedicated to the more advanced AD stages. Until now, available therapeutic agents for AD treatment only provide symptomatic treatment. Since AD pathogenesis is multifactorial, use of a multimodal therapeutic intervention addressing several molecular targets of AD-related pathological processes seems to be the most practical approach to modify the course of AD progression. It has been demonstrated through numerous studies, that the clinical efficacy of combination therapy (CT) is higher than that of monotherapy. In case of AD, CT is more effective, mostly when started early, at slowing the rate of cognitive impairment. In this review, we have covered the major studies regarding CT to combat AD pathogenesis. Moreover, we have also highlighted the safety, tolerability, and efficacy of CT in the treatment of AD.
Tanvir Kabir; Sahab Uddin; Abdullah Al Mamun; Philippe Jeandet; Lotfi Aleya; Rasha A. Mansouri; Ghulam Md Ashraf; Bijo Mathew; May N. Bin-Jumah; Mohamed M. Abdel-Daim. Combination Drug Therapy for the Management of Alzheimer’s Disease. International Journal of Molecular Sciences 2020, 21, 3272 .
AMA StyleTanvir Kabir, Sahab Uddin, Abdullah Al Mamun, Philippe Jeandet, Lotfi Aleya, Rasha A. Mansouri, Ghulam Md Ashraf, Bijo Mathew, May N. Bin-Jumah, Mohamed M. Abdel-Daim. Combination Drug Therapy for the Management of Alzheimer’s Disease. International Journal of Molecular Sciences. 2020; 21 (9):3272.
Chicago/Turabian StyleTanvir Kabir; Sahab Uddin; Abdullah Al Mamun; Philippe Jeandet; Lotfi Aleya; Rasha A. Mansouri; Ghulam Md Ashraf; Bijo Mathew; May N. Bin-Jumah; Mohamed M. Abdel-Daim. 2020. "Combination Drug Therapy for the Management of Alzheimer’s Disease." International Journal of Molecular Sciences 21, no. 9: 3272.
The neuroprotective effect of Kaempferol against cadmium chloride (CdCl2) -induced neurotoxicity is well reported. The silent information regulator 1 (SIRT1) and poly (ADP-Ribose) polymerase-1 (PARP1) are two related cellular molecules that can negatively affect the activity of each other to promote or inhibit cell survival, respectively. It is still largely unknown if the neurotoxicity of CdCl2 or the neuroprotection of Kaempferol are mediated by modulating SIRT1 and/or PAPR1 activities. In this study, we tested the hypothesis that CdCl2-induced memory deficit and hippocampal damage are associated with downregulation/inhibition of SIRT1 and activation of PAPR1, an effect that can be reversed by co-treatment with Kaempferol. Rats (n = 12/group) were divided into 4 groups as control, control + Kaempferol (50 mg//kg), CdCl2 (0.5 mg/kg), and CdCl2 + Kaempferol. All treatments were administered orally for 30 days daily. As compared to control rats, CdCl2 reduced rat's final body weights (21.8%) and their food intake (30%), induced oxidative stress and apoptosis in their hippocampi, and impaired their short and long-term recognition memory functions. Besides, the hippocampi of CdCl2-treated rats had higher levels of TNF-α (197%), and IL-6 (190%) with a concomitant increase in nuclear activity and levels of NF-κB p65 (721% & 554%). Besides, they showed reduced nuclear activity (53%) and levels (74%) of SIRT1, higher nuclear activity and levels of PARP1 (292% & 138%), increased nuclear levels of p53 (870%), and higher acetylated levels of NF-κB p65 (513%), p53 (644%), PARP1 (696%), and FOXO-2 (149%). All these events were significantly reversed in the CdCl2 + Kaempferol-treated rats. Of note, Kaempferol also increased levels of MnSOD (73.5%), and GSH (40%), protein levels of Bcl-2 (350%), and nuclear activity (67%) and levels (46%) of SIRT1 in the hippocampi of the control rats. In conclusion, Kaempferol ameliorates CdCl2-induced memory deficits and hippocampal oxidative stress, inflammation, and apoptosis by increasing SIRT1 activity and inhibiting PARP1 activity.
Attalla Farag El-Kott; Abd-El-Karim M. Abd-Lateif; Heba S. Khalifa; Kareem Morsy; Essam H. Ibrahim; May Bin-Jumah; Mohamed Abdel-Daim; Lotfi Aleya. Kaempferol protects against cadmium chloride-induced hippocampal damage and memory deficits by activation of silent information regulator 1 and inhibition of poly (ADP-Ribose) polymerase-1. Science of The Total Environment 2020, 728, 138832 .
AMA StyleAttalla Farag El-Kott, Abd-El-Karim M. Abd-Lateif, Heba S. Khalifa, Kareem Morsy, Essam H. Ibrahim, May Bin-Jumah, Mohamed Abdel-Daim, Lotfi Aleya. Kaempferol protects against cadmium chloride-induced hippocampal damage and memory deficits by activation of silent information regulator 1 and inhibition of poly (ADP-Ribose) polymerase-1. Science of The Total Environment. 2020; 728 ():138832.
Chicago/Turabian StyleAttalla Farag El-Kott; Abd-El-Karim M. Abd-Lateif; Heba S. Khalifa; Kareem Morsy; Essam H. Ibrahim; May Bin-Jumah; Mohamed Abdel-Daim; Lotfi Aleya. 2020. "Kaempferol protects against cadmium chloride-induced hippocampal damage and memory deficits by activation of silent information regulator 1 and inhibition of poly (ADP-Ribose) polymerase-1." Science of The Total Environment 728, no. : 138832.
Abdeen ZI, Ghoneim AI (2018) Improving of the Mg-Co nanoferrites efficiency for crude oil adsorption from aqueous solution by blending them with chitosan hydrogel. Environ Sci Pollut Res:1–11 Barkia I, Bouaziz HK, Boudawara TS, Aleya L, Gargouri AF, Saari N (2019) Acute oral toxicity study on Wistar rats fed microalgal protein hydrolysates from Bellerochea malleus. Environmental Science and Pollution Research, 1-8 El-Sayed A, Kamel M (2018) Advanced applications of nanotechnology in veterinary medicine. Environmental Science and Pollution Research, 1-14 El-Sayed A, Kamel M (2019) Advances in nanomedical applications: diagnostic, therapeutic, immunization, and vaccine production. Environ Sci Pollut Res:1–14 El Rouby WM, El-Dek S, Goher ME, Noaemy SG (2018) Efficient water decontamination using layered double hydroxide beads nanocomposites. Environmental Science and Pollution Research, 1-19 Elkeiy MM, Khamis AA, El-Gamal MM, Gazia MMA, Zalat ZA, El-Magd MA (2018) Chitosan nanoparticles from Artemia salina inhibit progression of hepatocellular carcinoma in vitro and in vivo. Environ Sci Pollut Res:1–13 Elsharkawy M, Derbalah A, Hamza A, El-Shaer A (2018a) Zinc oxide nanostructures as a control strategy of bacterial speck of tomato caused by Pseudomonas syringae in Egypt. Environ Sci Pollut Res, 1-9 Elsharkawy MM, Suga H, Shimizu M (2018b) Systemic resistance induced by Phoma sp. GS8-3 and nanosilica against cucumber mosaic virus. Environ Sci Pollut Res, 1-9 Fadda LM, Ali HM, Mohamed AM, Hagar H (2019) Prophylactic administration of carnosine and melatonin abates the incidence of apoptosis, inflammation, and DNA damage induced by titanium dioxide nanoparticles in rat livers. Environ Sci Pollut Res, 1-9 Hafez A, Nassef E, Fahmy M, Elsabagh M, Bakr A, Hegazi E (2019) Impact of dietary nano-zinc oxide on immune response and antioxidant defense of broiler chickens. Environ Sci Pollut Res:1–7 Kandeil MA, Mohammed ET, Hashem KS, Aleya L, Abdel-Daim MM (2019): Moringa seed extract alleviates titanium oxide nanoparticles (TiO 2-NPs)-induced cerebral oxidative damage, and increases cerebral mitochondrial viability. Environ Sci Pollut Res, 1-16 Maher S, Mahmoud M, Rizk M, Kalil H (2019) Synthetic melanin nanoparticles as peroxynitrite scavengers, photothermal anticancer and heavy metals removal platforms. Environ Sci Pollut Res:1–12 Naggar YA, Dabour K, Masry S, Sadek A, Naiem E, Giesy JP (2018) Sublethal effects of chronic exposure to CdO or PbO nanoparticles or their binary mixture on the honey bee (Apis millefera L.). Environ Sci Pollut Res, 1–12 Samak DH, El-Sayed YS, Shaheen HM, Ali H, El-Hack MEA, Noreldin AE, El-Naggar K, Abdelnour SA, Saied EM, El-Seedi HR (2018) Developmental toxicity of carbon nanoparticles during embryogenesis in chicken. Environ Sci Pollut Res:1–15 Sayed AE-DH, Watanabe-Asaka T, Oda S, Kashiwada S, Mitani H (2018) γ-H2AX foci as indication for the DNA damage in erythrocytes of medaka (Oryzias latipes) intoxicated with 4-nonylphenol. Environ Sci Pollut Res, 1-6 Sayour H, Kassem S, Canfarotta F, Czulak J, Mohamed M, Piletsky S (2019) Biocompatibility and biodistribution of surface-modified yttrium oxide nanoparticles for potential theranostic applications. Environ Sci Pollut Res, 1-13 Sharma N, Sharma M, Jamal QMS, Kamal MA, Akhtar S (2019) Nanoinformatics and biomolecular nanomodeling: a novel move en route for effective cancer treatment. Environ Sci Pollut Res:1–15 Zahin N, Anwar R, Tewari D, Kabir MT, Sajid A, Mathew B, Uddin MS, Aleya L, Abdel-Daim MM (2019) Nanoparticles and its biomedical applications in health and diseases: special focus on drug delivery. Environ Sci Pollut Res:1–18 Download references Correspondence to Lotfi Aleya. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Responsible editor: Philippe Garrigues Reprints and Permissions Aleya, L., Abdel-Daim, M.M. Advances in nanotechnology, nanopollution, nanotoxicology, and nanomedicine. Environ Sci Pollut Res (2020). https://doi.org/10.1007/s11356-020-08800-6 Download citation Published: 20 April 2020 DOI: https://doi.org/10.1007/s11356-020-08800-6
Lotfi Aleya; Mohamed Abdel-Daim. Advances in nanotechnology, nanopollution, nanotoxicology, and nanomedicine. Environmental Science and Pollution Research 2020, 27, 18963 -18965.
AMA StyleLotfi Aleya, Mohamed Abdel-Daim. Advances in nanotechnology, nanopollution, nanotoxicology, and nanomedicine. Environmental Science and Pollution Research. 2020; 27 (16):18963-18965.
Chicago/Turabian StyleLotfi Aleya; Mohamed Abdel-Daim. 2020. "Advances in nanotechnology, nanopollution, nanotoxicology, and nanomedicine." Environmental Science and Pollution Research 27, no. 16: 18963-18965.
Chlorpyrifos (CPF) is one of the popular crop pests that is widely used in the agriculture sector. In the aquaculture sector, several strategies were applied to mitigate the negative impacts of CPF on aquatic animals through the application of feed additives. Spirulina platensis (SP) is well reported as a functional feed additive to enhance the physiological, immunological, and anti-oxidative status in farmed fish. In the current study, fish were randomly stocked in five groups where the first and second groups reared in clean water without CPF toxicity and were fed the basal diet without SP or with SP at 1%, respectively. Meanwhile, the third, fourth, and fifth groups were exposed to CPF (15 μg/L) in rearing water and fed SP at 0, 0.5, and 1%, respectively. Under CPF exposure, SP displayed preventive and restorative impacts against toxicity in Nile tilapia. Fish fed SP-supplemented diet showed decreased alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), cholesterol, urea, and creatinine as well as increased total protein, albumin, superoxide dismutase (SOD), and catalase (CAT) activities. The outcomes suggested that SP is efficient in protecting Nile tilapia from CPF toxicity by increasing the antioxidative response. Due to the numerous pharmacological impacts of Spirulina platensis (SP), the effects of SP on the oxidative status of Nile tilapia farmed under chlorpyrifos (CPF) ambient toxicity were considered in this study. Fish (60 ± 6.1 g) was randomly stocked in five groups where the SP free diet was fed to the control group while the second one was fed 1% SP without CPF exposure. Additionally, CPF (15 μg/L) was added in water and fish were fed with SP at 0, 0.5, and 1% (third, fourth, and fifth groups, respectively). Samples of blood and gills, kidneys, and liver tissues were assayed for biochemical measurements. Fish exposed to CPF exhibited significant (p ≤ 0.05) increments of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), cholesterol, urea, creatinine, and malondialdehyde (MDA), while significantly decreased total protein, albumin, and antioxidative enzyme activities (superoxide dismutase (SOD) and catalase (CAT) were observed in tilapia exposed to CPF (p ≤ 0.05). In contrast, SP feeding resulted in decreased levels of ALT, AST, ALP, cholesterol, urea, and creatinine as well as increased total protein, albumin, SOD, and CAT activities. Based on the obtained results, it can be suggested that SP is efficient in protecting Nile tilapia from CPF toxicity by increasing the antioxidative response.
Mohamed M. Abdel-Daim; Mahmoud Dawood; Mohamed Elbadawy; Lotfi Aleya; Saad Alkahtani. Spirulina platensis Reduced Oxidative Damage Induced by Chlorpyrifos Toxicity in Nile Tilapia (Oreochromis niloticus). Animals 2020, 10, 473 .
AMA StyleMohamed M. Abdel-Daim, Mahmoud Dawood, Mohamed Elbadawy, Lotfi Aleya, Saad Alkahtani. Spirulina platensis Reduced Oxidative Damage Induced by Chlorpyrifos Toxicity in Nile Tilapia (Oreochromis niloticus). Animals. 2020; 10 (3):473.
Chicago/Turabian StyleMohamed M. Abdel-Daim; Mahmoud Dawood; Mohamed Elbadawy; Lotfi Aleya; Saad Alkahtani. 2020. "Spirulina platensis Reduced Oxidative Damage Induced by Chlorpyrifos Toxicity in Nile Tilapia (Oreochromis niloticus)." Animals 10, no. 3: 473.
Alzheimer’s disease (AD) is one of the utmost chronic neurodegenerative disorders, which is characterized from a neuropathological point of view by the aggregates of amyloid beta (Aβ) peptides that are deposited as senile plaques and tau proteins which form neurofibrillary tangles (NFTs). Even though advancement has been observed in order to understand AD pathogenesis, currently available therapeutic methods can only deliver modest symptomatic relief. Interestingly, naturally occurring dietary flavonoids have gained substantial attention due to their antioxidative, anti-inflammatory, and anti-amyloidogenic properties as alternative candidates for AD therapy. Experimental proof provides support to the idea that some flavonoids might protect AD by interfering with the production and aggregation of Aβ peptides and/or decreasing the aggregation of tau. Flavonoids have the ability to promote clearance of Aβ peptides and inhibit tau phosphorylation by the mTOR/autophagy signaling pathway. Moreover, due to their cholinesterase inhibitory potential, flavonoids can represent promising symptomatic anti-Alzheimer agents. Several processes have been suggested for the aptitude of flavonoids to slow down the advancement or to avert the onset of Alzheimer’s pathogenesis. To enhance cognitive performance and to prevent the onset and progress of AD, the interaction of flavonoids with various signaling pathways is proposed to exert their therapeutic potential. Therefore, this review elaborates on the probable therapeutic approaches of flavonoids aimed at averting or slowing the progression of the AD pathogenesis.
Sahab Uddin; Tanvir Kabir; Kamal Niaz; Philippe Jeandet; Christophe Clément; Bijo Mathew; Abdur Rauf; Kannan R.R. Rengasamy; Eduardo Sobarzo-Sánchez; Ghulam Md Ashraf; Lotfi Aleya. Molecular Insight into the Therapeutic Promise of Flavonoids against Alzheimer’s Disease. Molecules 2020, 25, 1267 .
AMA StyleSahab Uddin, Tanvir Kabir, Kamal Niaz, Philippe Jeandet, Christophe Clément, Bijo Mathew, Abdur Rauf, Kannan R.R. Rengasamy, Eduardo Sobarzo-Sánchez, Ghulam Md Ashraf, Lotfi Aleya. Molecular Insight into the Therapeutic Promise of Flavonoids against Alzheimer’s Disease. Molecules. 2020; 25 (6):1267.
Chicago/Turabian StyleSahab Uddin; Tanvir Kabir; Kamal Niaz; Philippe Jeandet; Christophe Clément; Bijo Mathew; Abdur Rauf; Kannan R.R. Rengasamy; Eduardo Sobarzo-Sánchez; Ghulam Md Ashraf; Lotfi Aleya. 2020. "Molecular Insight into the Therapeutic Promise of Flavonoids against Alzheimer’s Disease." Molecules 25, no. 6: 1267.
Heat stress (HS) has adverse effects on the body: it decreases body weight, feed efficiency, feed intake, carcass quality, and nutrient digestibility. Chromium (Cr) can prevent lipid peroxidation induced by HS through its strong antioxidant activities, especially when it is added to the poultry diet. It improves the action of insulin and nutrient metabolism (of lipids, proteins, nucleic acid, and carbohydrates) through activation of enzymes associated with such pathways. The results of the studies on Cr added to diets with concentrations of 0.05 mg Cr/kg of Cr-methionine led to improved feed efficiency and DM intake by cows and Holstein dairy calves exposed to high environmental temperatures. Moreover, calves that received Cr at levels of 0.05 mg/kg of body weight tended to have higher serum concentrations of glucose and higher ratios of insulin to glucose. In heat-stressed pigs, Cr addition (200 ppb) increased blood neutrophils by about 37%. Several studies have asserted that Cr can inhibit inflammation in lactating cows by promoting the release of Hsp72, assisting production of IL-10 and inhibiting degradation of IκBα in HS conditions. In addition, Cr supplementation was observed to possibly have positive impacts on both cell-mediated and humeral immunity in heat-stressed buffalo calves. Studies over the last two decades have shown with certainty that chromium supplementation has an impact on many variables in chickens. Moreover, Cr is believed to increase insulin action in insulin-sensitive tissues (i.e., adipose and muscles), resulting in increased farm animal productivity through the improvement of feed intake, growth rate, carcass quality, reproductive parameters and immune functions.
May Bin-Jumah; Mohamed E. Abd El-Hack; Sameh A. Abdelnour; Yasmeen A. Hendy; Hager A. Ghanem; Sara A. Alsafy; Asmaa Khafaga; Ahmed E. Noreldin; Hazem Shaheen; Dalia Samak; Maha A. Momenah; Ahmed Allam; Abdullah A. AlKahtane; Saad Alkahtani; Mohamed Abdel-Daim; Lotfi Aleya. Potential use of chromium to combat thermal stress in animals: A review. Science of The Total Environment 2020, 707, 135996 .
AMA StyleMay Bin-Jumah, Mohamed E. Abd El-Hack, Sameh A. Abdelnour, Yasmeen A. Hendy, Hager A. Ghanem, Sara A. Alsafy, Asmaa Khafaga, Ahmed E. Noreldin, Hazem Shaheen, Dalia Samak, Maha A. Momenah, Ahmed Allam, Abdullah A. AlKahtane, Saad Alkahtani, Mohamed Abdel-Daim, Lotfi Aleya. Potential use of chromium to combat thermal stress in animals: A review. Science of The Total Environment. 2020; 707 ():135996.
Chicago/Turabian StyleMay Bin-Jumah; Mohamed E. Abd El-Hack; Sameh A. Abdelnour; Yasmeen A. Hendy; Hager A. Ghanem; Sara A. Alsafy; Asmaa Khafaga; Ahmed E. Noreldin; Hazem Shaheen; Dalia Samak; Maha A. Momenah; Ahmed Allam; Abdullah A. AlKahtane; Saad Alkahtani; Mohamed Abdel-Daim; Lotfi Aleya. 2020. "Potential use of chromium to combat thermal stress in animals: A review." Science of The Total Environment 707, no. : 135996.