This work presents the synthesis of nanostructured TiO₂ modified with noble metal nanoparticles (Au, Ag) and lysozyme and coated on titanium foil. Moreover, the specific structural and functional properties of the resulting inorganic and hybrid materials were explored. The purpose of this study was to identify the key parameters for developing engineered coatings on titanium foil appropriate for efficient dental implants with intrinsic antibacterial activity. TiO₂ nanoparticles obtained using the sol–gel method were deposited on Ti foil and modified with Au/Ag nanoparticles. Morphological and structural investigations (scanning electron and atomic force microscopies, X-ray diffraction, photoluminescence, and UV–Vis spectroscopies) were carried out for the characterization of the resulting inorganic coatings. In order to modify their antibacterial activity, which is essential for safe dental implants, the following aspects were investigated: (a) singlet oxygen (¹O₂) generation by inorganic coatings exposed to visible light irradiation; (b) the antibacterial behavior emphasized by titania-based coatings deposited on titanium foil (TiO₂/Ti foil; Au–TiO₂/Ti foil, Ag–TiO₂/Ti foil); (c) the lysozyme bioactivity on the microbial substrate (Micrococcus lysodeicticus) after its adsorption on inorganic surfaces (Lys/TiO₂/Ti foil; Lys/Au–TiO₂/Ti foil, Lys/Ag–TiO₂/Ti foil); (d) the enzymatic activity of the above-mentioned hybrids materials for the hydrolysis reaction of a synthetic organic substrate usually used for monitoring the lysozyme biocatalytic activity, namely, 4-Methylumbelliferyl β-D-N,N′,N″-triacetylchitotrioside [4-MU-β- (GlcNAc)₃]. This was evaluated by identifying the presence of a fluorescent reaction product, 7-hydroxy-4-metyl coumarin (4-methylumbelliferone).

This work investigates photoactive inorganic powders (SiO₂, IrSiO₂, and IrO₂/IrSiO₂) and their derivatives modified with metallated porphyrin, focusing on their ability to generate reactive oxygen species (ROS) under visible light exposure. The core material, SiO₂, exhibits a tubular morphology and a high density of optically active defects. Modifiers such as metallic and iridium oxide nanoparticles, along with porphyrin, are employed to enhance light absorption and the generation of singlet oxygen (¹O₂) for potential biomedical applications. The time-dependent photogeneration of singlet oxygen is monitored using a Singlet Oxygen Green Sensor (SOSG), and its reactivity is evaluated in relation to DL α-Tocopherol through a spectrofluorimetric analysis. The photoactive materials, both before and after porphyrin modification, are characterized using Scanning Electron Microscopy (SEM), Atomic Force Microscopy (AFM), X-ray Diffraction (XRD), X-ray Fluorescence (XRF), UV–Vis Spectroscopy, X-ray Photoelectron Spectroscopy (XPS), N₂ adsorption–desorption measurements, and zeta potential measurements.

Objective. To compare clinical performance, osseointegration, esthetics, maintenance, and patient-reported outcomes of multibody dental implants versus standard implants for partial and full-arch rehabilitation. Materials and method. A mixed cohort of approximately 50 patients was assessed in a prospective arm (multibody implants) and a retrospective arm (standard implants). Minimally invasive (flapless) surgery was planned with panoramic radiographs and CBCT, and primary stability was measured using resonance frequency analysis (Penguin RFA; typical ISQ range: 55-80). Immediate or delayed (4-6 months) loading was selected according to initial stability and systemic/occlusal context. Clinics and patient identifiers were anonymized; numerical values were rounded. Main results. Three-to four-year survival was comparable between groups (approximately 94-96%), with early failures ranging between 4% and 6%. Multibody implants simplified the prosthetic workflow (fewer connections), reduced the risk of intermediate component loosening, and enabled more predictable maintenance. In cases suited for immediate loading, ISQ supported the clinical decision; delayed loading remained prevalent. High-performance polymer (PEEK/BioHPP) superstructures showed favorable biomechanical behavior and superior esthetics, although long-term monitoring is advisable. Conclusions. For extensive edentulism or challenging anatomy, multibody implants represent a safe and effective alternative to standard implants, with prosthetic and maintenance advantages. Careful case selection, digital CAD/CAM protocols, and objective stability monitoring via RFA are recommended.