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Prof. Margaritis Kostoglou
Department of Chemistry, Aristotle University of Thessaloniki, Greece

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0 Mathematical Modeling
0 Membrane Separations
0 Transport Phenomena
0 Heat and Mass Transfer
0 colloids and interfaces

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Journal article
Published: 06 August 2021 in Journal of Composites Science
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In the present study, polymer sponges based on poly(vinyl alcohol) (PVA) were prepared for the topical wound administration of chloramphenicol (CHL), an antibiotic widely used to treat bacterial infections. Nanocellulose fibrils (CNF) were homogenously dispersed in PVA sponges in three different ratios (2.5, 5, and 10 wt %) to improve the mechanical properties of neat PVA sponges. Infrared spectroscopy showed hydrogen bond formation between CNF and PVA, while scanning electron microscopy photos verified the successful dispersion of CNF to PVA sponges. The addition of CNF successfully enhanced the mechanical properties of PVA sponges, exhibiting higher compressive strength as the content of CNF increased. The PVA sponge containing 10 wt % CNF, due to its higher compression strength, was further studied as a matrix for CHL delivery in 10, 20, and 30 wt % concentration of the drug. X-ray diffraction showed that CHL was encapsulated in an amorphous state in the 10 and 20 wt % samples, while some crystallinity was observed in the 30 wt % ratio. In vitro dissolution studies showed enhanced CHL solubility after its incorporation in PVA/10 wt % CNF sponges. Release profiles showed a controlled release lasting three days for the sample containing 10 wt % CHL and 1.5 days for the other two samples. According to modelling, the release is driven by a pseudo-Fickian diffusion.

ACS Style

Evangelia Balla; Nikolaos Bikiaris; Stavroula Nanaki; Chrysanthi Papoulia; Konstantinos Chrissafis; Panagiotis Klonos; Apostolos Kyritsis; Margaritis Kostoglou; Alexandra Zamboulis; George Papageorgiou. Chloramphenicol Loaded Sponges Based on PVA/Nanocellulose Nanocomposites for Topical Wound Delivery. Journal of Composites Science 2021, 5, 208 .

AMA Style

Evangelia Balla, Nikolaos Bikiaris, Stavroula Nanaki, Chrysanthi Papoulia, Konstantinos Chrissafis, Panagiotis Klonos, Apostolos Kyritsis, Margaritis Kostoglou, Alexandra Zamboulis, George Papageorgiou. Chloramphenicol Loaded Sponges Based on PVA/Nanocellulose Nanocomposites for Topical Wound Delivery. Journal of Composites Science. 2021; 5 (8):208.

Chicago/Turabian Style

Evangelia Balla; Nikolaos Bikiaris; Stavroula Nanaki; Chrysanthi Papoulia; Konstantinos Chrissafis; Panagiotis Klonos; Apostolos Kyritsis; Margaritis Kostoglou; Alexandra Zamboulis; George Papageorgiou. 2021. "Chloramphenicol Loaded Sponges Based on PVA/Nanocellulose Nanocomposites for Topical Wound Delivery." Journal of Composites Science 5, no. 8: 208.

Research article
Published: 27 July 2021 in Langmuir
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Wetting of dehydrated Pseudomonas fluorescens biofilms grown on glass substrates by an external liquid is employed as a means to investigate the complex morphology of these biofilms along with their capability to interact with external fluids. The porous structure left behind after dehydration induces interesting droplet spreading on the external surface and imbibition into pores upon wetting. Static contact angles and volume loss by imbibition measured right upon droplet deposition indicate that biofilms of higher incubation times show a higher porosity and effective hydrophilicity. Furthermore, during subsequent rotation tests, using Kerberos device, these properties dictate a peculiar forced wetting/spreading behavior. As rotation speed increases a long liquid tail forms progressively at the rear part of the droplet, which stays pinned at all times, while only the front part of the droplet depins and spreads. Interestingly, the experimentally determined retention force for the onset of droplet sliding on biofilm external surface is lower than that on pure glass. An effort is made to describe such complex forced wetting phenomena by presenting apparent contact angles, droplet length, droplet shape contours, and edges position as obtained from detailed image analysis.

ACS Style

Michela Castigliano; Federica Recupido; Maria Petala; Margaritis Kostoglou; Sergio Caserta; Thodoris D. Karapantsios. Wetting of Dehydrated Hydrophilic Pseudomonas fluorescens Biofilms under the Action of External Body Forces. Langmuir 2021, 1 .

AMA Style

Michela Castigliano, Federica Recupido, Maria Petala, Margaritis Kostoglou, Sergio Caserta, Thodoris D. Karapantsios. Wetting of Dehydrated Hydrophilic Pseudomonas fluorescens Biofilms under the Action of External Body Forces. Langmuir. 2021; ():1.

Chicago/Turabian Style

Michela Castigliano; Federica Recupido; Maria Petala; Margaritis Kostoglou; Sergio Caserta; Thodoris D. Karapantsios. 2021. "Wetting of Dehydrated Hydrophilic Pseudomonas fluorescens Biofilms under the Action of External Body Forces." Langmuir , no. : 1.

Journal article
Published: 23 July 2021 in International Journal of Pharmaceutics
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Novel chitosan copolymers (CS-g-SBMA) grafted with [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide (SBMA) in various molar ratio 1.5:1, 5:1, 11.5:1 and 20:1, were synthesized in the present study. SBMA was selected as zwitterion molecule showing promising antibacterial properties. Grafted chitosan derivatives were fully characterized for their successful synthesis by NMR and FT-IR, for their crystallinity by XRD showing reduced crystallinity compared to CS alone. Furthermore, swelling studies were conducted with the grafted derivatives showing extensive swelling capacity (maximum degree of swelling up to 1800%) and water absorption was studied with differential scanning calorimetry and equilibrium water adsorption/desorption isotherms were analyzed. Caspofungin, a novel antifungal drug, was used to prepare a double-acting system, with both antibacterial and antifungal properties, proper for topical use. Drug loaded hydrogels were prepared with 10, 20 and 30 wt% drug content and the loaded hydrogels were fully characterized while antimicrobial studies showed enhanced properties. Caspofungin in vitro release showed an initial burst effect followed by a diffusion process while data analysis verified the initial burst release followed by a quasi Fickian diffusion-driven sustained release. Enhance antimicrobial properties was also observed in caspofungin-loaded hydrogels showing the successful fulfill of our scope; an amphiphilic system having great potential for the development of patches with inherent antimicrobial properties and prolonged antifungal properties.

ACS Style

Maria Lazaridou; Stavroula Nanaki; Alexandra Zamboulis; Chrysanthi Papoulia; Konstantinos Chrissafis; Panagiotis A. Klonos; Apostolos Kyritsis; Souzan Vergkizi-Nikolakaki; Margaritis Kostoglou; Dimitrios N. Bikiaris. Super absorbent chitosan-based hydrogel sponges as carriers for caspofungin antifungal drug. International Journal of Pharmaceutics 2021, 606, 120925 .

AMA Style

Maria Lazaridou, Stavroula Nanaki, Alexandra Zamboulis, Chrysanthi Papoulia, Konstantinos Chrissafis, Panagiotis A. Klonos, Apostolos Kyritsis, Souzan Vergkizi-Nikolakaki, Margaritis Kostoglou, Dimitrios N. Bikiaris. Super absorbent chitosan-based hydrogel sponges as carriers for caspofungin antifungal drug. International Journal of Pharmaceutics. 2021; 606 ():120925.

Chicago/Turabian Style

Maria Lazaridou; Stavroula Nanaki; Alexandra Zamboulis; Chrysanthi Papoulia; Konstantinos Chrissafis; Panagiotis A. Klonos; Apostolos Kyritsis; Souzan Vergkizi-Nikolakaki; Margaritis Kostoglou; Dimitrios N. Bikiaris. 2021. "Super absorbent chitosan-based hydrogel sponges as carriers for caspofungin antifungal drug." International Journal of Pharmaceutics 606, no. : 120925.

Journal article
Published: 06 July 2021 in Catalysts
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Over the last few decades, bio-based polymers have attracted considerable attention from both academic and industrial fields regarding the minimization of the environmental impact arising from the excessive use of petrochemically-based polymeric materials. In this context, poly(ethylene vanillate) (PEV), an alipharomatic polyester prepared from 4-(2-hydroxyethoxy)-3-methoxybenzoic acid, a monomer originating from lignin-derived vanillic acid, has shown promising thermal and mechanical properties. Herein, the effects of three different catalysts, namely titanium butoxide (TBT), titanium isopropoxide (TIS), and antimony trioxide (Sb2O3), on the synthesis of PEV via a two-stage melt polycondensation method are investigated. The progress of the reaction is assessed using various complementary techniques, such as intrinsic viscosity measurement (IV), end group analysis (AV), nuclear magnetic resonance spectroscopy (NMR), Fourier-transformed infrared spectroscopy (FTIR), and differential scanning calorimetry (DSC). The thermal stability of the produced polyesters is studied by evolved gas analysis mass spectrometry (EGA-MS). Moreover, as the discoloration in polymers affects their applications, color measurement is performed here. Finally, theoretical kinetic studies are carried out to rationalize the experimental observations.

ACS Style

Eleftheria Xanthopoulou; Alexandra Zamboulis; Zoi Terzopoulou; Margaritis Kostoglou; Dimitrios Bikiaris; George Papageorgiou. Effectiveness of Esterification Catalysts in the Synthesis of Poly(Ethylene Vanillate). Catalysts 2021, 11, 822 .

AMA Style

Eleftheria Xanthopoulou, Alexandra Zamboulis, Zoi Terzopoulou, Margaritis Kostoglou, Dimitrios Bikiaris, George Papageorgiou. Effectiveness of Esterification Catalysts in the Synthesis of Poly(Ethylene Vanillate). Catalysts. 2021; 11 (7):822.

Chicago/Turabian Style

Eleftheria Xanthopoulou; Alexandra Zamboulis; Zoi Terzopoulou; Margaritis Kostoglou; Dimitrios Bikiaris; George Papageorgiou. 2021. "Effectiveness of Esterification Catalysts in the Synthesis of Poly(Ethylene Vanillate)." Catalysts 11, no. 7: 822.

Journal article
Published: 23 June 2021 in Pharmaceutics
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The present study evaluates the use of newly synthesized poly(l-lactic acid)-co-poly(butylene adipate) (PLA/PBAd) block copolymers as microcarriers for the preparation of aripiprazole (ARI)-loaded long acting injectable (LAI) formulations. The effect of various PLA to PBAd ratios (95/5, 90/10, 75/25 and 50/50 w/w) on the enzymatic hydrolysis of the copolymers showed increasing erosion rates by increasing the PBAd content, while cytotoxicity studies revealed non-toxicity for all prepared biomaterials. SEM images showed the formation of well-shaped, spherical MPs with a smooth exterior surface and no particle’s agglomeration, while DSC and pXRD data revealed that the presence of PBAd in the copolymers favors the amorphization of ARI. FTIR spectroscopy showed the formation of new ester bonds between the PLA and PBAd parts, while analysis of the MP formulations showed no molecular drug–polyester matrix interactions. In vitro dissolution studies suggested a highly tunable biphasic extended release, for up to 30 days, indicating the potential of the synthesized copolymers to act as promising LAI formulations, which will maintain a continuous therapeutic level for an extended time period. Lastly, several empirical and mechanistic models were also tested, with respect to their ability to fit the experimental release data.

ACS Style

Vasiliki Karava; Aggeliki Siamidi; Marilena Vlachou; Evi Christodoulou; Nikolaos Bikiaris; Alexandra Zamboulis; Margaritis Kostoglou; Eleni Gounari; Panagiotis Barmpalexis. Poly(l-Lactic Acid)-co-poly(Butylene Adipate) New Block Copolymers for the Preparation of Drug-Loaded Long Acting Injectable Microparticles. Pharmaceutics 2021, 13, 930 .

AMA Style

Vasiliki Karava, Aggeliki Siamidi, Marilena Vlachou, Evi Christodoulou, Nikolaos Bikiaris, Alexandra Zamboulis, Margaritis Kostoglou, Eleni Gounari, Panagiotis Barmpalexis. Poly(l-Lactic Acid)-co-poly(Butylene Adipate) New Block Copolymers for the Preparation of Drug-Loaded Long Acting Injectable Microparticles. Pharmaceutics. 2021; 13 (7):930.

Chicago/Turabian Style

Vasiliki Karava; Aggeliki Siamidi; Marilena Vlachou; Evi Christodoulou; Nikolaos Bikiaris; Alexandra Zamboulis; Margaritis Kostoglou; Eleni Gounari; Panagiotis Barmpalexis. 2021. "Poly(l-Lactic Acid)-co-poly(Butylene Adipate) New Block Copolymers for the Preparation of Drug-Loaded Long Acting Injectable Microparticles." Pharmaceutics 13, no. 7: 930.

Journal article
Published: 28 May 2021 in International Journal of Thermal Sciences
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An experimental investigation of subcooled flow boiling heat transfer in an orthogonal macro channel (dh = 16 mm) is undertaken. An extraordinary heat transfer performance is observed when a single copper wire mesh screen covers the heating surface of the channel. Experiments are performed with deionized water, at a mass flux range of 100–410 kg/m2s and a heat flux range of 50–850 kW/m2. A series of highly subcooled flow boiling experiments demonstrates the existence of regions of heat transfer enhancement, compared to a smooth reference surface. The addition of the mesh layer triggers a self-sustained flow instability accompanied by intense pressure oscillations which allows for remarkably thermally steady state conditions to take place. While in several heat transfer studies, the appearance of pressure oscillations has been attributed with heat transfer deterioration, in the current study we observe that a self-sustained oscillatory flow leads altogether to heat transfer enhancement, baring close resemblance to the well-known microbubble emission boiling flow phenomenology and heat transfer. Aspects of temperature, pressure and flow regimes are presented and discussed accordingly.

ACS Style

Christos Argyropoulos; Thodoris D. Karapantsios; Margaritis Kostoglou. Exceptional heat transfer performance induced by intrinsic flow oscillations during subcooled flow boiling over a copper mesh surface. International Journal of Thermal Sciences 2021, 168, 107070 .

AMA Style

Christos Argyropoulos, Thodoris D. Karapantsios, Margaritis Kostoglou. Exceptional heat transfer performance induced by intrinsic flow oscillations during subcooled flow boiling over a copper mesh surface. International Journal of Thermal Sciences. 2021; 168 ():107070.

Chicago/Turabian Style

Christos Argyropoulos; Thodoris D. Karapantsios; Margaritis Kostoglou. 2021. "Exceptional heat transfer performance induced by intrinsic flow oscillations during subcooled flow boiling over a copper mesh surface." International Journal of Thermal Sciences 168, no. : 107070.

Journal article
Published: 25 May 2021 in Minerals
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Flotation in the mining industry is a very significant separation technique. It is known that fine and ultra-fine particles are difficult to float, leading to losses of valuable minerals, mainly due to their low collision efficiency with bubbles. Flotation of fine particles can be enhanced either by increasing the apparent particle size or by decreasing the bubble size. Literature review reveals that electroflotation resulted in higher recoveries of ultrafine particles as compared with dispersed-air flotation, because electrolytic bubbles are smaller in size. To this end, the best practical approach is to combine conventional air bubbles and micro-bubbles from water electrolysis. Therefore, the design, fabrication, and operation of a bench-scale micro-bubble generator through water electrolysis is proposed. Moreover, this electrolysis unit is adapted in a mechanical Denver-type flotation cell. The resulting hybrid flotation device is capable of producing bubbles within a wide range of diameters. The significance of this process is that micro-bubbles, attached tothe surface of fine particles, facilitate the attachment of conventional-sized bubbles and subsequently increase the flotation recovery of particles. Experimental flotation results so far on the hybrid device indicate the enhancement of fine particle recovery by approximately 10% with the addition of micro-bubbles.

ACS Style

Polyxeni Tsave; Margaritis Kostoglou; Thodoris Karapantsios; Nikolaos Lazaridis. A Hybrid Device for Enhancing Flotation of Fine Particles by Combining Micro-Bubbles with Conventional Bubbles. Minerals 2021, 11, 561 .

AMA Style

Polyxeni Tsave, Margaritis Kostoglou, Thodoris Karapantsios, Nikolaos Lazaridis. A Hybrid Device for Enhancing Flotation of Fine Particles by Combining Micro-Bubbles with Conventional Bubbles. Minerals. 2021; 11 (6):561.

Chicago/Turabian Style

Polyxeni Tsave; Margaritis Kostoglou; Thodoris Karapantsios; Nikolaos Lazaridis. 2021. "A Hybrid Device for Enhancing Flotation of Fine Particles by Combining Micro-Bubbles with Conventional Bubbles." Minerals 11, no. 6: 561.

Journal article
Published: 24 April 2021 in Colloids and Surfaces A: Physicochemical and Engineering Aspects
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The concept of a small volume emulsification device developed by the authors is further studied in the present work. Following suggestions of previous work, five different piston plates with orthogonal edges are constructed to oscillate inside a small cube-shaped cell. The different pistons yield several combinations of gap width and height between the plates and the walls of the cell. Their performance is assessed by performing emulsification experiments over an extensive range of piston stroke frequency and emulsification time for a specific non-coalescing system (fixed oil fraction and surfactant concentration). The resulting droplet size distributions are estimated by microscopy images analysis and by phase separation observations. The combined information from these techniques is necessary in order to register the broad size range of droplets. A semiquantitative analysis of the flow field in the gap reveals that droplet breakage process starts at the laminar boundary layers developed between the piston and the cell walls and allows characterization of this field. A theoretical analysis for the mechanism of droplet breakup is presented. The analysis of experimental results demonstrates that four of the five tested piston plates are appropriate for emulsification regarding the generated droplet size distribution and the choice among them requires additional criteria, e.g. energy requirements.

ACS Style

Angeliki P. Chondrou; Thodoris P. Karapantsios; Margaritis Kostoglou. Effect of width/height of the gap between piston and wall on the performance of a novel small volume emulsification device. Colloids and Surfaces A: Physicochemical and Engineering Aspects 2021, 622, 126702 .

AMA Style

Angeliki P. Chondrou, Thodoris P. Karapantsios, Margaritis Kostoglou. Effect of width/height of the gap between piston and wall on the performance of a novel small volume emulsification device. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2021; 622 ():126702.

Chicago/Turabian Style

Angeliki P. Chondrou; Thodoris P. Karapantsios; Margaritis Kostoglou. 2021. "Effect of width/height of the gap between piston and wall on the performance of a novel small volume emulsification device." Colloids and Surfaces A: Physicochemical and Engineering Aspects 622, no. : 126702.

Preprint content
Published: 20 March 2021
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The SARS-CoV-2 pandemic represents an unprecedented global crisis necessitating novel approaches for, amongst others, early detection of emerging variants relating to the evolution and spread of the virus. Recently, the detection of SARS-CoV-2 RNA in wastewater has emerged as a useful tool to monitor the prevalence of the virus in the community. Here, we propose a novel methodology, called lineagespot , for the detection of SARS-CoV-2 lineages in wastewater samples using next-generation sequencing. Our proposed method was tested and evaluated using NGS data produced by the sequencing of three wastewater samples from the municipality of Thessaloniki, Greece, covering three distinct time periods. The results showed a clear identification of trends in the presence of SARS-CoV-2 mutations in sewage data, and allowed for a robust inference between the variants evident through our approach and the variants observed in patients from the same area time periods. Lineagespot is an open-source tool, implemented in R, and is freely available on GitHub.

ACS Style

Nikolaos Pechlivanis; Maria Tsagiopoulou; Maria Christina Maniou; Anastasis Togkousidis; Evangelia Mouchtaropoulou; Taxiarchis Chassalevris; Serafeim Chaintoutis; Chrysostomos Dovas; Maria Petala; Margaritis Kostoglou; Thodoris Karapantsios; Stamatia Laidou; Elisavet Vlachonikola; Anastasia Chatzidimitriou; Agis Papadopoulos; Nikolaos Papaioannou; Anagnostis Argiriou; Fotis Psomopoulos. Detecting SARS-CoV-2 lineages and mutational load in municipal wastewater; a use-case in the metropolitan area of Thessaloniki, Greece. 2021, 1 .

AMA Style

Nikolaos Pechlivanis, Maria Tsagiopoulou, Maria Christina Maniou, Anastasis Togkousidis, Evangelia Mouchtaropoulou, Taxiarchis Chassalevris, Serafeim Chaintoutis, Chrysostomos Dovas, Maria Petala, Margaritis Kostoglou, Thodoris Karapantsios, Stamatia Laidou, Elisavet Vlachonikola, Anastasia Chatzidimitriou, Agis Papadopoulos, Nikolaos Papaioannou, Anagnostis Argiriou, Fotis Psomopoulos. Detecting SARS-CoV-2 lineages and mutational load in municipal wastewater; a use-case in the metropolitan area of Thessaloniki, Greece. . 2021; ():1.

Chicago/Turabian Style

Nikolaos Pechlivanis; Maria Tsagiopoulou; Maria Christina Maniou; Anastasis Togkousidis; Evangelia Mouchtaropoulou; Taxiarchis Chassalevris; Serafeim Chaintoutis; Chrysostomos Dovas; Maria Petala; Margaritis Kostoglou; Thodoris Karapantsios; Stamatia Laidou; Elisavet Vlachonikola; Anastasia Chatzidimitriou; Agis Papadopoulos; Nikolaos Papaioannou; Anagnostis Argiriou; Fotis Psomopoulos. 2021. "Detecting SARS-CoV-2 lineages and mutational load in municipal wastewater; a use-case in the metropolitan area of Thessaloniki, Greece." , no. : 1.

Journal article
Published: 01 February 2021 in Sustainability
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In water and wastewater, phosphate anions are considered critical contaminants because they cause algae blooms and eutrophication. The present work aims at studying the removal of phosphate anions from aqueous solutions using silica particles functionalized with polyethylenimine. The parameters affecting the adsorption process such as pH, initial concentration, adsorbent dose, and the presence of competitive anions, such as carbonate, nitrate, sulfate and chromate ions, were studied. Equilibrium studies were carried out to determine their sorption capacity and the rate of phosphate ions uptake. The adsorption isotherm data fitted well with the Langmuir and Sips model. The maximum sorption capacity was 41.1 mg/g at pH 5, which decreased slightly at pH 7. The efficiency of phosphate removal adsorption increased at lower pH values and by increasing the adsorbent dose. The maximum phosphate removal was 80% for pH 5 and decreased to 75% for pH 6, to 73% for pH 7 and to 70% for pH 8, for initial phosphate concentration at about 1 mg/L and for a dose of adsorbent 100 mg/L. The removal rate was increased with the increase of the adsorbent dose. For example, for initial phosphate concentration of 4 mg/L the removal rate increased from 40% to 80% by increasing the dose from 0.1 to 2.0 g/L at pH 7. The competitive anions adversely affected phosphate removal. Though they were also found to be removed to a certain extent. Their co-removal provided an adsorbent which might be very useful for treating waters with low-level multiple contaminant occurrence in natural or engineered aquatic systems.

ACS Style

Maria Xanthopoulou; Dimitrios Giliopoulos; Nikolaos Tzollas; Konstantinos Triantafyllidis; Margaritis Kostoglou; Ioannis Katsoyiannis. Phosphate Removal Using Polyethylenimine Functionalized Silica-Based Materials. Sustainability 2021, 13, 1502 .

AMA Style

Maria Xanthopoulou, Dimitrios Giliopoulos, Nikolaos Tzollas, Konstantinos Triantafyllidis, Margaritis Kostoglou, Ioannis Katsoyiannis. Phosphate Removal Using Polyethylenimine Functionalized Silica-Based Materials. Sustainability. 2021; 13 (3):1502.

Chicago/Turabian Style

Maria Xanthopoulou; Dimitrios Giliopoulos; Nikolaos Tzollas; Konstantinos Triantafyllidis; Margaritis Kostoglou; Ioannis Katsoyiannis. 2021. "Phosphate Removal Using Polyethylenimine Functionalized Silica-Based Materials." Sustainability 13, no. 3: 1502.

Journal article
Published: 11 December 2020 in Nanomaterials
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In the present work, the porous metal-organic framework (MOF) Basolite®F300 (Fe-BTC) was tested as a potential drug-releasing depot to enhance the solubility of the anticancer drug paclitaxel (PTX) and to prepare controlled release formulations after its encapsulation in amphiphilic methoxy poly(ethylene glycol)-poly(ε-caprolactone) (mPEG-PCL) nanoparticles. Investigation revealed that drug adsorption in Fe-BTC reached approximately 40%, a relatively high level, and also led to an overall drug amorphization as confirmed by differential scanning calorimetry (DSC) and X-ray diffraction (XRD). The dissolution rate of PTX-loaded MOF was substantially enhanced achieving a complete (100%) release within four days, while the neat drug only reached a 13% maximum rate (3–4 days). This PTX-Fe-BTC nanocomposite was further encapsulated into a mPEG-PCL matrix, a typical aliphatic amphiphilic copolyester synthesized in our lab, whose biocompatibility was validated by in vitro cytotoxicity tests toward human umbilical vein endothelial cells (HUVEC). Encapsulation was performed according to the solid-in-oil-in-water emulsion/solvent evaporation technique, resulting in nanoparticles of about 143 nm, slightly larger of those prepared without the pre-adsorption of PTX on Fe-BTC (138 nm, respectively). Transmission electron microscopy (TEM) imaging revealed that spherical nanoparticles with embedded PTX-loaded Fe-BTC nanoparticles were indeed fabricated, with sizes ranging from 80 to 150 nm. Regions of the composite Fe-BTC-PTX system in the infrared (IR) spectrum are identified as signatures of the drug-MOF interaction. The dissolution profiles of all nanoparticles showed an initial burst release, attributed to the drug amount located at the nanoparticles surface or close to it, followed by a steadily and controlled release. This is corroborated by computational analysis that reveals that PTX attaches effectively to Fe-BTC building blocks, but its relatively large size limits diffusion through crystalline regions of Fe-BTC. The dissolution behaviour can be described through a bimodal diffusivity model. The nanoparticles studied could serve as potential chemotherapeutic candidates for PTX delivery.

ACS Style

Nikolaos D. Bikiaris; Nina Maria Ainali; Evi Christodoulou; Margaritis Kostoglou; Thomas Kehagias; Emilia Papasouli; Emmanuel N. Koukaras; Stavroula G. Nanaki. Dissolution Enhancement and Controlled Release of Paclitaxel Drug via a Hybrid Nanocarrier Based on mPEG-PCL Amphiphilic Copolymer and Fe-BTC Porous Metal-Organic Framework. Nanomaterials 2020, 10, 2490 .

AMA Style

Nikolaos D. Bikiaris, Nina Maria Ainali, Evi Christodoulou, Margaritis Kostoglou, Thomas Kehagias, Emilia Papasouli, Emmanuel N. Koukaras, Stavroula G. Nanaki. Dissolution Enhancement and Controlled Release of Paclitaxel Drug via a Hybrid Nanocarrier Based on mPEG-PCL Amphiphilic Copolymer and Fe-BTC Porous Metal-Organic Framework. Nanomaterials. 2020; 10 (12):2490.

Chicago/Turabian Style

Nikolaos D. Bikiaris; Nina Maria Ainali; Evi Christodoulou; Margaritis Kostoglou; Thomas Kehagias; Emilia Papasouli; Emmanuel N. Koukaras; Stavroula G. Nanaki. 2020. "Dissolution Enhancement and Controlled Release of Paclitaxel Drug via a Hybrid Nanocarrier Based on mPEG-PCL Amphiphilic Copolymer and Fe-BTC Porous Metal-Organic Framework." Nanomaterials 10, no. 12: 2490.

Journal article
Published: 21 November 2020 in Processes
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Using moderate populations of filaments in the biomass of Membrane Bio-Reactors (MBRs) is a biological anti-fouling method which has been increasingly applied over the last few years. This study aims to quantify the effect of COD to TN ratio, Dissolved Oxygen (DO) concentration and temperature on filaments’ population and Trans-Membrane Pressure (TMP) in a pilot-scale MBR, with a view to reducing membrane fouling. The novelty of the present work concerns the development of a mathematical equation that correlates fouling rate (dTMP/dt) with the population of filamentous microorganisms, assessed by the Filament Index (FI), and with the concentration of the carbohydrate fraction of Soluble Microbial Products (SMPc). Apart from TMP and SMPc, other fouling-related biomass characteristics, such as sludge filterability and settleability, were also examined. It was shown that at high COD to TN ratio (10:1), low DO concentration in the filaments’ tank (0.5 ± 0.3 mg/L) and high temperature (24–30 °C), a moderate population of filaments is developed (FI = 1–2), which delays the TMP rise. Under these conditions, sludge filterability and settleability were also enhanced. Finally, TMP data analysis showed that the fouling rate is affected by FI and SMPc concentration mainly in the long-term fouling stage and increases exponentially with their increase.

ACS Style

Petros Gkotsis; Giannis Lemonidis; Manassis Mitrakas; Alexandros Pentedimos; Margaritis Kostoglou; Anastasios Zouboulis. Quantifying the Effect of COD to TN Ratio, DO Concentration and Temperature on Filamentous Microorganisms’ Population and Trans-Membrane Pressure (TMP) in Membrane Bio-Reactors (MBR). Processes 2020, 8, 1514 .

AMA Style

Petros Gkotsis, Giannis Lemonidis, Manassis Mitrakas, Alexandros Pentedimos, Margaritis Kostoglou, Anastasios Zouboulis. Quantifying the Effect of COD to TN Ratio, DO Concentration and Temperature on Filamentous Microorganisms’ Population and Trans-Membrane Pressure (TMP) in Membrane Bio-Reactors (MBR). Processes. 2020; 8 (11):1514.

Chicago/Turabian Style

Petros Gkotsis; Giannis Lemonidis; Manassis Mitrakas; Alexandros Pentedimos; Margaritis Kostoglou; Anastasios Zouboulis. 2020. "Quantifying the Effect of COD to TN Ratio, DO Concentration and Temperature on Filamentous Microorganisms’ Population and Trans-Membrane Pressure (TMP) in Membrane Bio-Reactors (MBR)." Processes 8, no. 11: 1514.

Review article
Published: 12 September 2020 in Advances in Colloid and Interface Science
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Process modeling is a valuable tool for process design and optimization. Nonetheless, the extent of its use depends on the physical complexity of each particular application. Flotation is one of the most complex processes to model. In particular, in mechanical flotation cells, turbulent flow prevails and promotes bubble particle collisions. Many size and time scales of both hydrodynamic and physicochemical nature have to be resolved to model the process. The only way to achieve this is a combination of co-current (pulp and froth) and sequential multiscale modeling. A generalized framework for modeling the pulp phase from the device scale to thin film scale separating bubbles and particles is presented here. The core of the model is the term describing the collision frequency between bubbles and particles. Existing approaches to derive this term are reviewed and critically commented demonstrating several inconsistencies. A unified and consistent approach for deriving this collision frequency term is described overcoming all the inconsistencies of previous approaches. Specific results are presented for the case of flotation of fine particles, being practically the only case for which a simplified collision frequency expression of algebraic complexity can be derived.

ACS Style

Margaritis Kostoglou; Thodoris D. Karapantsios; Sotiris Evgenidis. On a generalized framework for turbulent collision frequency models in flotation: The road from past inconsistencies to a concise algebraic expression for fine particles. Advances in Colloid and Interface Science 2020, 284, 102270 .

AMA Style

Margaritis Kostoglou, Thodoris D. Karapantsios, Sotiris Evgenidis. On a generalized framework for turbulent collision frequency models in flotation: The road from past inconsistencies to a concise algebraic expression for fine particles. Advances in Colloid and Interface Science. 2020; 284 ():102270.

Chicago/Turabian Style

Margaritis Kostoglou; Thodoris D. Karapantsios; Sotiris Evgenidis. 2020. "On a generalized framework for turbulent collision frequency models in flotation: The road from past inconsistencies to a concise algebraic expression for fine particles." Advances in Colloid and Interface Science 284, no. : 102270.

Journal article
Published: 21 August 2020 in Colloids and Interfaces
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In view of emerging research on forced wetting under complex applied forces, a simple model for a droplet shape evolution is developed here. In particular, the model refers to droplet spreading under quasisteady conditions. The corresponding linearized two-dimensional Young–Laplace equation is solved analytically resulting in a system of two equations that relates the droplet shape features to each other. Despite its simplicity, the final model produces a wealth of droplet behaviors when combined with the physical requirement that the contact angle should be within a particular range of values. Indicative results of the droplet behavior under several forces scenarios are examined here exhibiting why the present model is useful for designing experimental campaigns on forced spreading.

ACS Style

Margaritis Kostoglou; Thodoris D. Karapantsios. An Analytical Two-Dimensional Linearized Droplet Shape Model for Combined Tangential and Normal Body Forces. Colloids and Interfaces 2020, 4, 35 .

AMA Style

Margaritis Kostoglou, Thodoris D. Karapantsios. An Analytical Two-Dimensional Linearized Droplet Shape Model for Combined Tangential and Normal Body Forces. Colloids and Interfaces. 2020; 4 (3):35.

Chicago/Turabian Style

Margaritis Kostoglou; Thodoris D. Karapantsios. 2020. "An Analytical Two-Dimensional Linearized Droplet Shape Model for Combined Tangential and Normal Body Forces." Colloids and Interfaces 4, no. 3: 35.

Journal article
Published: 26 June 2020 in Pharmaceutics
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The aim of this work was to evaluate the effectiveness of neat chitosan (CS) and its derivatives with 2-acrylamido-2-methyl-1-propanesulfonic acid (AΑMPS) and [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide (MEDSP) as appropriate nanocarriers for the simultaneous ocular administration of dexamethasone sodium phosphate (DxP) and chloramphenicol (CHL). The derivatives CS-AΑMPS and CS-MEDSP have been synthesized by free-radical polymerization and their structure has been proved by Fourier-Transformed Infrared Spectroscopy (FT-IR) spectroscopy. Both derivatives exhibited low cytotoxicity, enhanced mucoadhesive properties and antimicrobial activity against Staphylococcus aureus (S.aureus) and Escherichia coli (E. coli). Encapsulation was performed via ionic crosslinking gelation using sodium tripolyphosphate (TPP) as the crosslinking agent. Dynamic light scattering measurements (DLS) showed that the prepared nanoparticles had bimodal distribution and sizes ranging from 50–200 nm and 300–800 nm. Drugs were encapsulated in their crystalline (CHL) or amorphous (DexSP) form inside nanoparticles and their release rate was dependent on the used polymer. The CHL dissolution rate was substantially enhanced compared to the neat drug and the release time was extended up to 7 days. The release rate of DexSP was much faster than that of CHL and was prolonged up to 3 days. Drug release modeling unveiled that diffusion is the main release mechanism for both drugs. Both prepared derivatives and their drug-loaded nanoparticles could be used for extended and simultaneous ocular release formulations of DexSP and CHL drugs.

ACS Style

Aikaterini Karava; Maria Lazaridou; Stavroula Nanaki; Georgia Michailidou; Evi Christodoulou; Margaritis Kostoglou; Hermis Iatrou; Dimitrios N. Bikiaris. Chitosan Derivatives with Mucoadhesive and Antimicrobial Properties for Simultaneous Nanoencapsulation and Extended Ocular Release Formulations of Dexamethasone and Chloramphenicol Drugs. Pharmaceutics 2020, 12, 594 .

AMA Style

Aikaterini Karava, Maria Lazaridou, Stavroula Nanaki, Georgia Michailidou, Evi Christodoulou, Margaritis Kostoglou, Hermis Iatrou, Dimitrios N. Bikiaris. Chitosan Derivatives with Mucoadhesive and Antimicrobial Properties for Simultaneous Nanoencapsulation and Extended Ocular Release Formulations of Dexamethasone and Chloramphenicol Drugs. Pharmaceutics. 2020; 12 (6):594.

Chicago/Turabian Style

Aikaterini Karava; Maria Lazaridou; Stavroula Nanaki; Georgia Michailidou; Evi Christodoulou; Margaritis Kostoglou; Hermis Iatrou; Dimitrios N. Bikiaris. 2020. "Chitosan Derivatives with Mucoadhesive and Antimicrobial Properties for Simultaneous Nanoencapsulation and Extended Ocular Release Formulations of Dexamethasone and Chloramphenicol Drugs." Pharmaceutics 12, no. 6: 594.

Journal article
Published: 12 May 2020 in Polymers
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Chitosan (CS) is a polymer extensively used in drug delivery formulations mainly due to its biocompatibility and low toxicity. In the present study, chitosan was used for nanoencapsulation of a budesonide (BUD) drug via the well-established ionic gelation technique and a slight modification of it, using also poly(vinyl alcohol) (PVA) as a surfactant. Scanning electron microscopy (SEM) micrographs revealed that spherical nanoparticles were successfully prepared with average sizes range between 363 and 543 nm, as were measured by dynamic light scattering (DLS), while zeta potential verified their positive charged surface. X-ray diffraction (XRD) patterns revealed that BUD was encapsulated in crystalline state in nanoparticles but with a lower degree of crystallinity than the neat drug, which was also proven by differential scanning calorimetry (DSC) and melting peak measurements. This could be attributed to interactions that take place between BUD and CS, which were revealed by FTIR and by an extended computational study. An in vitro release study of budesonide showed a slight enhancement in the BUD dissolution profile, compared to the neat drug. However, drug release was substantially increased by introducing PVA during the nanoencapsulation procedure, which is attributed to the higher amorphization of BUD on these nanoparticles. The release curves were analyzed using a diffusion model that allows estimation of BUD diffusivity in the nanoparticles.

ACS Style

Georgia Michailidou; Nina Maria Ainali; Eleftheria Xanthopoulou; Stavroula Nanaki; Margaritis Kostoglou; Emmanuel N. Koukaras; Dimitrios N. Bikiaris. Effect of Poly(vinyl alcohol) on Nanoencapsulation of Budesonide in Chitosan Nanoparticles via Ionic Gelation and Its Improved Bioavailability. Polymers 2020, 12, 1101 .

AMA Style

Georgia Michailidou, Nina Maria Ainali, Eleftheria Xanthopoulou, Stavroula Nanaki, Margaritis Kostoglou, Emmanuel N. Koukaras, Dimitrios N. Bikiaris. Effect of Poly(vinyl alcohol) on Nanoencapsulation of Budesonide in Chitosan Nanoparticles via Ionic Gelation and Its Improved Bioavailability. Polymers. 2020; 12 (5):1101.

Chicago/Turabian Style

Georgia Michailidou; Nina Maria Ainali; Eleftheria Xanthopoulou; Stavroula Nanaki; Margaritis Kostoglou; Emmanuel N. Koukaras; Dimitrios N. Bikiaris. 2020. "Effect of Poly(vinyl alcohol) on Nanoencapsulation of Budesonide in Chitosan Nanoparticles via Ionic Gelation and Its Improved Bioavailability." Polymers 12, no. 5: 1101.

Review
Published: 11 April 2020 in Advances in Colloid and Interface Science
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Flotation is a very important separation process in the mining industry. In addition, it finds important application as a water treatment process. The better design of flotation devices and operation strategies requires development of reliable and consistent mathematical models. Flotation is much more complex than typical unit processes, involving physicochemical interactions in small size scale and hydrodynamic interactions between bubbles, particles and liquid in a variety of size scales. The only feasible integrated approach to modeling the flotation process is by incorporating multiple scales. In the heart of such an approach there is a submodel for the frequency of collisions between bubbles and particles. Literature on this subject in the absence of intense turbulence is very extensive and there are many well-accepted models. Yet, the situation is quite different for the case of turbulence being an important collision mechanism, which is exactly what happens in industrial dispersed air flotation devices. The corresponding literature models are limited and focused on different aspects of the process. The present work is a review study attempting to unify these models in a general framework. The review is not restricted to presenting existing models but all relevant physical principles and fundamental theories are examined and assessed properly. In this respect, there are two levels of classification of literature material in this work. The first is a classification as general collision models and flotation models. It is important to critically examine the general collision models of engineering and physics literature since they constitute the basis on which flotation models rely. The second classification is with respect to the level of detail and sophistication of models (from distributed multibubble/multiparticle model to lumped models based on statistical theory of turbulence). The outcome of the work comes to the conclusion that existing models focus only to specific parts of the phenomena leading to bubble-particle collisions and for this, further improvement is needed to integrate them to obtain a better and more general picture. The material and comments presented in this work are meant as a decisive milestone towards this integration procedure.

ACS Style

Margaritis Kostoglou; Thodoris D. Karapantsios; Ourania Oikonomidou. A critical review on turbulent collision frequency/efficiency models in flotation: Unravelling the path from general coagulation to flotation. Advances in Colloid and Interface Science 2020, 279, 102158 .

AMA Style

Margaritis Kostoglou, Thodoris D. Karapantsios, Ourania Oikonomidou. A critical review on turbulent collision frequency/efficiency models in flotation: Unravelling the path from general coagulation to flotation. Advances in Colloid and Interface Science. 2020; 279 ():102158.

Chicago/Turabian Style

Margaritis Kostoglou; Thodoris D. Karapantsios; Ourania Oikonomidou. 2020. "A critical review on turbulent collision frequency/efficiency models in flotation: Unravelling the path from general coagulation to flotation." Advances in Colloid and Interface Science 279, no. : 102158.

Journal article
Published: 07 April 2020 in Polymers
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In the present study, novel block copolymers of poly(l-lactide)-block-poly(propylene adipate) (PLLA-b-PPAd) were synthesized in two ratios, 90/10 and 75/25 w/w and were further investigated as long-acting injectable (LAI) polymeric matrices in naltrexone base microparticle formulations. The synthesized polymers were characterized by 1H-NMR, 13C-NMR, FTIR, XRD, TGA and DSC. NMR and FTIR spectroscopies confirmed the successful synthesis of copolymers while DSC showed that these are block copolymers with well-defined and separated blocks. Microparticles were prepared by single emulsification method and were further characterized. Nanoparticles in the range of 0.4–4.5 μm were prepared as indicated by SEM, with copolymers giving the lowest particle size. By XRD and DSC it was found that naltrexone was present in the amorphous state in its microparticles. Dissolution study showed a drug release extending over seven days, indicating that these novel PLLA-b-PPAd copolymers could be promising matrices for naltrexone’s LAI formulations. It was evidenced that drug release depended on the copolymer composition. Model release studies showed that drug release is controlled by diffusion.

ACS Style

Stavroula Nanaki; Athina Viziridou; Alexandra Zamboulis; Margaritis Kostoglou; Georgios Z. Papageorgiou; Dimitrios N. Bikiaris. New Biodegradable Poly(l-lactide)-Block-Poly(propylene adipate) Copolymer Microparticles for Long-Acting Injectables of Naltrexone Drug. Polymers 2020, 12, 852 .

AMA Style

Stavroula Nanaki, Athina Viziridou, Alexandra Zamboulis, Margaritis Kostoglou, Georgios Z. Papageorgiou, Dimitrios N. Bikiaris. New Biodegradable Poly(l-lactide)-Block-Poly(propylene adipate) Copolymer Microparticles for Long-Acting Injectables of Naltrexone Drug. Polymers. 2020; 12 (4):852.

Chicago/Turabian Style

Stavroula Nanaki; Athina Viziridou; Alexandra Zamboulis; Margaritis Kostoglou; Georgios Z. Papageorgiou; Dimitrios N. Bikiaris. 2020. "New Biodegradable Poly(l-lactide)-Block-Poly(propylene adipate) Copolymer Microparticles for Long-Acting Injectables of Naltrexone Drug." Polymers 12, no. 4: 852.

Journal article
Published: 07 March 2020 in Pharmaceutics
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The objective of this study was to develop chitosan (CS) nanoparticles (NPs) loaded with deferoxamine mesylate (DFO) for slow release of this iron-chelating drug. Drug nanoencapsulation was performed via ionic gelation of chitosan using sodium tripolyphosphate (TPP) as cross-linker. Nanoparticles with a size ranging between 150 and 400 nm were prepared for neat CS/TPP with a 2/1 molar ratio while their yield was directly dependent on the applied stirring rate during the preparation process. DFO at different content (20, 45 and 75 wt %) was encapsulated into these nanoparticles. We found that drug loading correlates with increasing DFO content while the entrapment efficiency has an opposite behavior due to the high solubility of DFO. Hydrogen-bonding between amino and hydroxyl groups of DFO with reactive groups of CS were detected using FT-IR spectroscopy while X-ray diffraction revealed that DFO was entrapped in amorphous form in the CS nanoparticles. DFO release is directly dependent on the content of loaded drug, while model analysis revealed that the release mechanism of DFO for the CS/TPP nanoparticles is by diffusion. Treatment of murine RAW 264.7 macrophages with nanoencapsulated DFO promoted an increased expression of transferrin receptor 1 (TfR1) mRNA, a typical homeostatic response to iron deficiency. These data provide preliminary evidence for release of pharmacologically active DFO from the chitosan nanoparticles.

ACS Style

Maria Lazaridou; Evi Christodoulou; Maria Nerantzaki; Margaritis Kostoglou; Dimitra A. Lambropoulou; Angeliki Katsarou; Kostas Pantopoulos; Dimitrios N. Bikiaris. Formulation and In-Vitro Characterization of Chitosan-Nanoparticles Loaded with the Iron Chelator Deferoxamine Mesylate (DFO). Pharmaceutics 2020, 12, 238 .

AMA Style

Maria Lazaridou, Evi Christodoulou, Maria Nerantzaki, Margaritis Kostoglou, Dimitra A. Lambropoulou, Angeliki Katsarou, Kostas Pantopoulos, Dimitrios N. Bikiaris. Formulation and In-Vitro Characterization of Chitosan-Nanoparticles Loaded with the Iron Chelator Deferoxamine Mesylate (DFO). Pharmaceutics. 2020; 12 (3):238.

Chicago/Turabian Style

Maria Lazaridou; Evi Christodoulou; Maria Nerantzaki; Margaritis Kostoglou; Dimitra A. Lambropoulou; Angeliki Katsarou; Kostas Pantopoulos; Dimitrios N. Bikiaris. 2020. "Formulation and In-Vitro Characterization of Chitosan-Nanoparticles Loaded with the Iron Chelator Deferoxamine Mesylate (DFO)." Pharmaceutics 12, no. 3: 238.

Journal article
Published: 31 January 2020 in Colloids and Interfaces
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The aim of this study is the development of an emulsification device for two immiscible liquids with a total volume of approximately 3 mL. The heart of the device is a piston, with an aluminum plate fixed at its tip, which moves periodically up and down inside a rectangular cell. The plate geometry (uniform or non-uniform height) affects significantly both the emulsions stability and the size of the droplets of the prepared emulsions. Five parameters are examined during testing (surfactant type, surfactant concentration, proportion of immiscible liquids, piston stroke frequency, duration of emulsification) and all of them appear to have an important role in the resulting droplet size distribution. A macroscopic theoretical model is developed for the determination of the main hydrodynamic parameters of the innovative device. It is shown that the non-uniform height plate achieves higher shear rates when compared to the uniform height plate because of the smaller gap between the plate and the cell walls. However, the benefits of the higher shear rate are overturned by the larger effective breakage time encountered in the uniform height plate resulting from the larger surface area of its sides. The results of the emulsification experiments are analyzed using the parameter values derived by the developed model.

ACS Style

Angeliki P. Chondrou; Sotiris P. Evgenidis; Margaritis Kostoglou; Thodoris D. Karapantsios. An Innovative Miniature Pulsating Emulsification Device: Flow Characterization and Measurement of Emulsion Stability. Colloids and Interfaces 2020, 4, 7 .

AMA Style

Angeliki P. Chondrou, Sotiris P. Evgenidis, Margaritis Kostoglou, Thodoris D. Karapantsios. An Innovative Miniature Pulsating Emulsification Device: Flow Characterization and Measurement of Emulsion Stability. Colloids and Interfaces. 2020; 4 (1):7.

Chicago/Turabian Style

Angeliki P. Chondrou; Sotiris P. Evgenidis; Margaritis Kostoglou; Thodoris D. Karapantsios. 2020. "An Innovative Miniature Pulsating Emulsification Device: Flow Characterization and Measurement of Emulsion Stability." Colloids and Interfaces 4, no. 1: 7.