Accurately simulating the asymmetric spectral profiles of blue LEDs is crucial for photobiological research, yet it remains a challenge for traditional symmetric models. This study proposes a novel spectral simulation model that effectively captures these asymmetries. The proposed model structure is partly motivated by known broadening and dispersion mechanisms observed in real LED spectra; it employs a ‘base model + correction’ framework, where an Exponentially Modified Gaussian (EMG) function captures the primary spectral shape and falling edge and an Asymmetric Pseudo-Voigt (APV) function corrects the deviations on the rising edge. Requiring only the central wavelength and bandwidth as user inputs, the simulation results exhibit a high degree of agreement with the experimental data spectra. The model provides a rapid and robust tool for pre-evaluating light sources against regulatory criteria (e.g., >99% of the spectral intensity is in the 400–500 nm band), thereby enhancing the efficiency of experimental design in blue light protection studies.