Background The clinical problem in suspected aortoiliac graft infection (AGI) is to obtain proof of infection. Although ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography scanning (PET) has been suggested to play a pivotal role, an evidence-based interpretation is lacking. The objective of this retrospective study was to examine the feasibility and utility of ¹⁸F-FDG uptake heterogeneity characterized by textural features to diagnose AGI. Methods Thirty patients with a history of aortic graft reconstruction who underwent ¹⁸F-FDG PET/CT scanning were included. Sixteen patients were suspected to have an AGI (group I). AGI was considered proven only in the case of a positive bacterial culture. Positive cultures were found in 10 of the 16 patients (group Ia), and in the other six patients, cultures remained negative (group Ib). A control group was formed of 14 patients undergoing ¹⁸F-FDG PET for other reasons (group II). PET images were assessed using conventional maximal standardized uptake value (SUVmax), tissue-to-background ratio (TBR), and visual grading scale (VGS). Additionally, 64 different ¹⁸F-FDG PET based textural features were applied to characterize ¹⁸F-FDG uptake heterogeneity. To select candidate predictors, univariable logistic regression analysis was performed (α = 0.16). The accuracy was satisfactory in case of an AUC > 0.8. Results The feature selection process yielded the textural features named variance (AUC = 0.88), high grey level zone emphasis (AUC = 0.87), small zone low grey level emphasis (AUC = 0.80), and small zone high grey level emphasis (AUC = 0.81) most optimal for distinguishing between groups I and II. SUVmax, TBR, and VGS were also able to distinguish between these groups with AUCs of 0.87, 0.78, and 0.90, respectively. The textural feature named short run high grey level emphasis was able to distinguish group Ia from Ib (AUC = 0.83), while for the same task the TBR and VGS were not found to be predictive. SUVmax was found predictive in distinguishing these groups, but showed an unsatisfactory accuracy (AUC = 0.75). Conclusion Textural analysis to characterize ¹⁸F-FDG uptake heterogeneity is feasible and shows promising results in diagnosing AGI, but requires additional external validation and refinement before it can be implemented in the clinical decision-making process.

Access for endovascular repair of abdominal aortic aneurysms (EVAR) is obtained through surgical cutdown or percutaneously. The only devices suitable for percutaneous closure of the 20 French arteriotomies of the common femoral artery (CFA) are the Prostar™ and Proglide™ devices (Abbott Vascular). Positive effects of these devices seem to consist of a lower infection rate, and shorter operation time and hospital stay. This conclusion was published in previous reports comparing techniques in patients in two different groups (cohort or randomized). Access techniques were never compared in one and the same patient; this research simplifies comparison because patient characteristics will be similar in both groups. Percutaneous access of the CFA is compared to surgical cutdown in a single patient; in EVAR surgery, access is necessary in both groins in each patient. Randomization is performed on the introduction site of the larger main device of the endoprosthesis. The contralateral device of the endoprosthesis is smaller. When we use this type of randomization, both groups will contain a similar number of main and contralateral devices. Preoperative nose cultures and perineal cultures are obtained, to compare colonization with postoperative wound cultures (in case of a surgical site infection). Furthermore, patient comfort will be considered, using VAS-scores (Visual analog scale). Punch biopsies of the groin will be harvested to retrospectively compare skin of patients who suffered a surgical site infection (SSI) to patients who did not have an SSI. The PiERO trial is a multicenter randomized controlled clinical trial designed to show the consequences of using percutaneous access in EVAR surgery and focuses on the occurrence of surgical site infections. NTR4257 10 November 2013, NL44578.042.13.

The existing literature on mycotic aortic aneurysm is scarce and focuses on treatment. This study evaluates the clinical characteristics, diagnostics, treatment and outcome of patients with a mycotic abdominal aortic aneurysm treated in a tertiary referral center. A retrospective cohort study was conducted including all patients with a proven mycotic abdominal aortic aneurysm admitted between May 2010 and July 2020. Primary outcome was mortality and secondary outcome included complications such as vascular graft/endograft infection. Twenty-four patients with a mycotic abdominal aortic aneurysm were included. Patients had a mean age of 68 ± 9 years and 20 (83%) were male. Thirteen patients (57%) had positive preoperative blood cultures. Streptococcus pneumoniae was most frequently isolated by blood culturing, pus, and vascular, or perivascular tissue cultures (17%). In 19 (83%) patients the mycotic abdominal aortic aneurysm was located infrarenally, in three (13%) patients suprarenally, and in one (4%) patient juxtarenally. Median follow-up was 20 (7-42) months. In 8 patients (33%) vascular graft and or endograft infection was diagnosed after surgical repair. Ten (42%) patients died during the follow-up period. The main causes of death were vascular graft/endograft infection-related (n = 4) and rupture of the mycotic abdominal aortic aneurysm (n = 3). No patient characteristics could be identified as predictive for mortality. This study shows a large variation in presentation, diagnostic approaches, and surgical and antibiotic treatment of mycotic abdominal aortic aneurysm. The detailed information about the diagnostic approaches to this rare disease and its antibiotic and/or other treatment contributes to existing knowledge of mycotic abdominal aortic aneurysm. Because of the individual variation patients should be discussed in a multidisciplinary team with a vascular surgeon, infectious disease specialist, and clinical microbiologist.

Treatment of patch infection after carotid endarterectomy: a systematic review Tim M. Wikkeling, Senne A. van Gijssel, Maarten J. van der Laan, Clark J. Zeebregts, Ben R. Saleem

Vascular graft and endograft infections (VGEI) cause a serious morbidity and mortality burden. ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) imaging is frequently used in the diagnostic workup, but the additional value of abnormal (¹⁸F-FDG active and/or enlarged) locoregional lymph nodes is unknown. In this retrospective study, the additional diagnostic value of abnormal locoregional lymph nodes on ¹⁸F-FDG PET/CT imaging for VGEI was evaluated, including 54 patients with a culture-proven VGEI (defined according to the Management of Aortic Graft Infection [MAGIC] group classification) and 25 patients without VGEI. ¹⁸F-FDG PET/CT was qualitatively and quantitatively assessed for tracer uptake and pattern at the location of the vascular graft, and locoregional lymph node uptake and enlargement (>10 mm). ¹⁸F-FDG uptake intensity and pattern independently predicted the presence of VGEI by logistic regression (Χ²: 46.19, p < 0.001), with an OR of 7.38 (95% CI [1.65, 32.92], p = 0.009) and 18.32 (95% CI [3.95, 84.88], p < 0.001), respectively. Single visual assessment of abnormal locoregional lymph nodes predicted the presence of VGEI with a sensitivity of 35%, specificity of 96%, PPV of 95%, and NPV of 41%. The visual assessment of abnormal lymph nodes after qualitative assessment of ¹⁸F-FDG uptake intensity and pattern at the vascular graft location did not independently predict the presence of VGEI by logistic regression (Χ²: 3.60, p = 0.058; OR: 8.25, 95% CI [0.74, 63.37], p = 0.096). In conclusion, detection of abnormal locoregional lymph nodes on ¹⁸F-FDG PET/CT has a high specificity (96%) and PPV (95%) for VGEI. However, it did not add to currently used ¹⁸F-FDG PET/CT interpretation criteria.

Vascular graft or endograft infections (VGEIs) pose significant challenges due to their rarity and potential for severe complications. Direct identification of micro-organisms is highly recommended by the European Society for Vascular Surgery guidelines, yet standardised approaches are limited to the literature. Percutaneous drainage followed by lifelong suppressive antimicrobial therapy offers a viable alternative for high risk patients. This study evaluated the diagnostic and therapeutic implications of percutaneous cultures in abdominal and peripheral VGEIs and assessed the efficacy of conservative treatment when surgery is unfeasible. This was a retrospective cohort study of all patients admitted to a tertiary referral centre with suspected abdominal or peripheral VGEI, according to Management of Aortic Graft Infection Collaboration (MAGIC) criteria, and who underwent percutaneous procedures between 2017 and 2023. The diagnostic accuracy of percutaneous cultures was evaluated by comparing their results with the final diagnosis of VGEI based on MAGIC criteria, and analysing the sensitivity, specificity, positive predictive value, and negative predictive value. Additionally, the influence of percutaneous cultures on antibiotic therapy adjustment and conservative treatment choice was investigated. Survival outcomes were compared between patients who were conservatively treated and those who underwent total or partial surgical graft removal. The study included 69 patients: 45 with suspected abdominal VGEI and 24 with suspected peripheral VGEI. Percutaneous culture results statistically significantly correlated with VGEI diagnosis (p = .023 and p = .048, respectively), with a sensitivity and specificity of 50% and 70% in abdominal infections and 80% and 68% in peripheral infections, respectively. Percutaneous procedures statistically significantly impacted the choice of antibiotic therapy (p < .001 and p = .011). Overall survival for conservative treatment was comparable with surgical graft extraction (p= .63 and p = .25). Percutaneous cultures offer high specificity for VGEI diagnosis and can be used to guide effective personalised antibiotic therapy. For inoperable patients, drainage with lifelong antimicrobial treatment is a valuable conservative option.