The galvanic interaction between chalcopyrite and monoclinic pyrrhotite and its effect on flotation separation were studied using monomineral flotation tests, adsorption capacity tests, X-ray photoelectron spectroscopy (XPS) characterization, and scanning electron microscopy (SEM) test. These results showed that the interaction promoted the reduction of O₂ on the cathodic chalcopyrite surface and accelerated the generation of Fe(OH)₃, which was not conducive to collector adsorption; hence, the flotation recovery decreased by 10–16%. On the other hand, galvanic interaction accelerated the oxidation of S on the anodic monoclinic pyrrhotite surface to S₀ or SO₄²⁻ and produced a large amount of H⁺, thus preventing the formation of Fe(OH)₃. Meanwhile, the Cu²⁺ eluted from chalcopyrite surface activated monoclinic pyrrhotite; hence, the flotation recovery increased by 3–10%. Galvanic interaction reduced the floatability difference between the two minerals, and the separation difficulty was significantly increased. Even with an increase in the amount of lime, the separation could not be improved.

The paper systematically investigated the flotation behavior and interaction mechanisms of andalusite and quartz under sodium dodecyl sulfonate (SDS) through integrated experimental and computational approaches, including zeta potential measurements, Fourier-transform infrared (FTIR) spectroscopy, Materials Studio (MS)-based quantum chemical calculations, and single-mineral flotation tests. The results of zeta potential and infrared spectroscopy analysis indicated that SDS underwent strong chemical adsorption on the surface of andalusite, while the adsorption effect on the surface of quartz was not obvious. MS calculations showed that the {100} surface energy of andalusite was the lowest, and it was the most important dissociation surface. After SDS was adsorbed on the {100} surface of andalusite, the aluminum atoms on the surface of andalusite lost electrons, resulting in a significant increase in the number of positive charges they carried. The activity of oxygen atoms was enhanced, while the number of charges carried by silicon atoms changed relatively little. It was indicated that SDS adsorbed the active sites of Al atoms on the surface of andalusite. The results of the pure mineral flotation test further verified the accuracy of the previous test results, indicating that andalusite and quartz had a good flotation separation effect under the SDS system.