Introduction: Linezolid is a synthetic antimicrobial agent with a broad spectrum of activity against virtually all Gram-positive bacteria. Although linezolid is generally well tolerated, the prolonged use of linezolid can lead to myelosuppression, including neutropenia, thrombocytopenia, and anemia. The aim of this study was investigating the risk factors for thrombocytopenia in patients who received linezolid therapy. Methodology: This retrospective study was performed on patients who received linezolid therapy between July 2007 and December 2017. Thrombocytopenia was defined as either a platelets count of < 100×109/L or a 25% reduction from the baseline platelet count. Results: A total of 371 patients, (198 (53%) male and 173(47%) female were included into the study. Mean duration of therapy was 12.81 ± 5.19 days. Linezolid-induced thrombocytopenia was detected in a total of 111 patients. Using the univariate analysis advanced sex, serum urea concentration, baseline platelet level and low eGFR value were found to be risk factors for linezolid associated thrombocytopenia (p < 0.05). According to a multivariate analysis, patients undergoing carbapenem treatment combination therapy (p = 0.003) and with a baseline platelet level of < 200×109/L (p = 0.00) were found to have a high risk of developing thrombocytopenia. Conclusions: Several factors may influence of linezolid associated thrombocytopenia. Platelet count should be monitored during therapy and thrombocytopenia should be kept in mind in patients with baseline platelet level of < 200×109/L, low eGFR, linezolid-carbapenem combination therapy.

Background: A crucial balance exists between oxidant and antioxidant mechanisms in the functional immune system. We aimed to evaluate the contributions of balance between these systems to coronavirus disease 2019 (COVID‐19), a devastating pandemic caused by viral infection.Method: We analyzed serum oxidant and antioxidant stress parameters according to the clinical and demographic characteristics of children and adults with COVID‐19 and compared them against the values of healthy controls. Serum native thiol (NT), total thiol (TT), disulfide, total antioxidant status, total oxidant status, and ischemia‐modified albumin levels were evaluated and compared between groups.Results: A total of 79 children and 74 adults were evaluated in the present study, including 46 children and 40 adults with COVID‐19, 33 healthy children, and 34 healthy adults. TT, NT, and disulfide levels were significantly lower in the adult COVID‐19 group than in all other groups (p = .001, p = .001, and p = .005, respectively). Additionally, TT and NT levels were significantly lower in both pediatric and adult COVID‐19 cases with severe disease course than mild/moderate course. TT and NT levels were identified as predictors for the diagnosis of the adult COVID‐19 cases and as independent predictors for disease severity in both children and adults with COVID‐19.Conclusion: Parameters that reveal the oxidant and antioxidant capacity, including TT and NT, appear to be good candidates for the accurate prediction of the clinical course among patients with COVID‐19.

Amaç: Pandemi sürecinde görev alan sağlık çalışanlarının algıladıkları sosyal desteğin depresyon, anksiyete, stres düzeyleri ile arasında ilişki olup olmadığının saptanması ve ilişkili ise hangi faktörler ile ne düzeyde ilişkili olduğunun belirlenmesi amaçlanmıştır. Gereç ve Yöntem: S.B.Ankara Eğitim ve Araştırma Hastanesinde pandemi ile ilgili birimlerde görevlendirilen doktor ve hemşire/sağlık memurundan oluşan 197 kişi çalışmaya alınmıştır. Örneklem grubuna sosyodemografik veri formu, DASS-42 ve ÇBASDÖ uygulanmıştır. Bulgular: 197 katılımcının; %58,4’ü doktor, %41,6’sı hemşire/sağlık memuru, %65’i kadın, %50’si evli ve %40,4’ü COVID-19 servisinde, %24,1’i acil serviste, %22,3’ü COVID-19 yoğun bakım servisinde %11,2’si COVID-19 polikliniğinde çalışıyordu. Orta ve ileri düzeyde depresif belirti gösteren sağlık çalışanı oranı %53,3, anksiyete belirtisi gösterenler %53,8 ve stres belirtileri gösterenlerin oranı ise %48.7 di. Hemşirelerin doktorlardan istatistiksel olarak anlamlı düzeyde yüksek depresyon (p=0,041), anksiyete (p=0,013) ve stres puanlarına sahip oldukları (p=0,009), kadınların erkeklerden DASS-42 tüm alt ölçeklerinde istatistiksel olarak daha yüksek puan aldıkları saptandı. Haftalık çalışma süresi arttıkça depresyon puanlarında artış olduğu (p=0.012), 24 saatin üstünde haftalık çalışma saati olanlarda anksiyete düzeyleri yüksek bulundu (p