Andres C. Arana-Linares

Prof. Andres C. Arana-Linares

orcid

Research Focus & Metrics

Academic Career Length

2Years (2025-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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17 December 2025 in Polymers
Verified
Journal Article
Open access
PDF file
Andres C. Arana-LinaresAndres C. Arana-Linares
Andres C. Arana-Linares
ABAlvaro Barrera-Ocampo
Alvaro Barrera-Ocampo
ALArley Camilo Patiño LLano
Arley Camilo Patiño LLano
YCYhors Ciro
Yhors Ciro
Constain Hugo SalamancaConstain Hugo Salamanca
Constain Hugo Salamanca
Background: Biopolymer-based active packaging has experienced significant growth in the food industry due to its capacity to enhance product stability and reduce reliance on synthetic preservatives. However, its application in cosmetics remains limited, despite increasing consumer demand for sustainable and preservative-free solutions. Objective: This review evaluates the feasibility of transferring biopolymer-based active packaging technologies from the food sector to cosmetic applications, identifying relevant materials, processing methods, and implementation challenges. Methodology: A bibliographic search was conducted across nine databases (2000–2025) using the keywords “active packaging,” “antioxidant,” “antimicrobial,” and “biopolymers.” Results: The most recurrent biopolymers identified were chitosan, fish gelatin, zein, and kafirin, all of which exhibit biodegradability, film-forming capacity, and compatibility with natural additives. Although their intrinsic antioxidant and antimicrobial properties are limited, these can be enhanced through the incorporation of bioactive compounds. Processing techniques such as casting, coating, dry forming, and electrospinning were found to be the most effective, enabling customized packaging designs. Key challenges include cost, sensory attributes, mechanical limitations, and regulatory compliance. Conclusion: Active packaging systems based on biopolymers—either alone or combined with natural bioactive ingredients—offer a viable innovation pathway for the cosmetics industry. These systems support clean-label claims and ecological positioning, representing a strategic opportunity to adapt validated technologies from the food sector to meet emerging cosmetic market demands.

30 August 2025 in Pharmaceutics
Verified
Journal Article
Open access
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Andres C. Arana-LinaresAndres C. Arana-Linares
Andres C. Arana-Linares
PCPaola A Caicedo
Paola A Caicedo
MVMaria Francisca Villegas-Torres
Maria Francisca Villegas-Torres
Andrés Fernando González BarriosAndrés Fernando González Barrios
Andrés Fernando González Barrios
NCNatalie Cortés
Natalie Cortés
ABAlvaro Barrera-Ocampo
Alvaro Barrera-Ocampo
Background/Objectives: The rational design of modified-release matrix tablets requires a thorough understanding of granulometric analysis, compaction behavior, and drug release profile. In this study, we evaluated the physicochemical, granulometric, and mechanical properties of hydroxypropyl methylcellulose, polyethylene oxide, and ethylcellulose in galantamine matrix formulations. Methods: Spectroscopic (FTIR) and thermal (DSC) analyses demonstrated drug–polymer compatibility. We assessed flowability, cohesion, and aeration behavior through granulometric analysis and applied compressibility models (Kawakita, Heckel, Leuenberger) to characterize deformation mechanisms. Results: Hydroxypropyl methylcellulose showed superior compactability (Tmax = 4.61 MPa) and sustained drug release (85.4% at 12 h, DE% = 62.2%), while polyethylene oxide enabled gradual erosion and consistent delivery (88.7% at 12 h, DE% = 57.5%). In contrast, ethylcellulose exhibited high cohesiveness but poor matrix integrity, leading to premature drug release (76.6% at 1 h, DE% = 73.7%). Only hydroxypropyl methylcellulose and polyethylene oxide formulations met USP criteria. Conclusions: These results demonstrate that polymer selection critically influences powder behavior and matrix performance, underscoring the need for integrated granulometric and mechanical evaluation in the development of robust controlled-release systems.

5 February 2026 in Journal of Drug Delivery Science and Technology
Verified
Journal Article
Open access
Andres C. Arana-LinaresAndres C. Arana-Linares
Andres C. Arana-Linares
ABAlvaro Barrera-Ocampo
Alvaro Barrera-Ocampo
Constain Hugo SalamancaConstain Hugo Salamanca
Constain Hugo Salamanca

30 August 2026 in Antioxidants
Verified
Journal Article
Open access
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Andres C. Arana-LinaresAndres C. Arana-Linares
Andres C. Arana-Linares
ALArley Camilo Patiño LLano
Arley Camilo Patiño LLano
AAAna Liliana Giraldo Aguirre
Ana Liliana Giraldo Aguirre
Constain Hugo SalamancaConstain Hugo Salamanca
Constain Hugo Salamanca
AOAndres Olea
Andres Olea
Polyphenolic antioxidants are incorporated into pharmaceutical, dermopharmaceutical, and cosmetic products because of their capacity to modulate oxidative stress, inflammation, microbial imbalance, skin aging, wound repair, and tumor-related processes. However, formulation is constrained by chemical instability, limited bioavailability, insufficient skin permeation, and degradation during processing or storage. This review integrates the chemical characteristics, natural sources, extraction approaches, antioxidant mechanisms, and evaluation of curcumin and chlorogenic acid, and critically examines their delivery through liposomes, niosomes, ethosomes, and transethosomes. Curcumin is lipophilic and poorly water-soluble, whereas chlorogenic acid is hydrophilic but permeability-limited. Their antioxidant activity is discussed through hydrogen atom transfer, single-electron transfer, interruption of lipid peroxidation, metal chelation, and localization within lipid interfaces, together with chemical, biomimetic, and cellular assessment methods. Vesicular carriers can improve encapsulation, stability, release control, skin interaction, biological performance, and incorporation into semisolid dosage forms. However, these benefits are accompanied by formulation-dependent trade-offs involving manufacturing complexity and cost, long-term stability and reproducibility, excipient-related skin tolerability, scale-up, and an application scope that depends on the intended dermal-delivery endpoint. Therefore, efficacy depends on the interplay among antioxidant properties, vesicle architecture, excipient selection, and processing conditions. Curcumin-loaded vesicles are better documented than chlorogenic-acid-loaded systems, particularly for deformable carriers. Future progress requires quality-by-design strategies, standardized characterization, predictive skin models, long-term stability and safety studies, and scalable manufacturing. Overall, antioxidant-loaded vesicles represent multifunctional platforms for developing stable and effective pharmaceutical and cosmetic products.

3 August 2026
Verified
Book
Open access
PDF file
JZJorge Humberto Restrepo Zapata
Jorge Humberto Restrepo Zapata
DGDiego Gerardo Cuadros Gutierrez
Diego Gerardo Cuadros Gutierrez
Andres C. Arana-LinaresAndres C. Arana-Linares
Andres C. Arana-Linares
La Farmacotecnia y la Farmacia Magistral fundamentan los procesos científicos, metodológicos y tecnológicos para la preparación de formas farmacéuticas e industriales mediante la integración de la física, química, farmacodinamia, farmacocinética y biofarmacia, permitiendo analizar el comportamiento de los ingredientes farmacéuticos activos (IFA) y excipientes, ejecutar operaciones unitarias y garantizar el control de calidad bajo las normativas vigentes. Esta nueva edición actualiza sus prácticas de laboratorio con los recientes avances tecnológicos y regulatorios en productos farmacéuticos y cosméticos magistrales, capacitando a los futuros Tecnólogos en Regencia de Farmacia para elaborar fórmulas magistrales o preparados oficinales en servicios farmacéuticos hospitalarios y ambulatorios, así como para desempeñarse en el ámbito industrial e impulsar el desarrollo de la investigación aplicada.